#hpai — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #hpai, aggregated by home.social.
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Update: The patient has died.
"Concerning" #BirdFlu mutations in Louisiana patient underscores #pandemic potential of #H5N1
By Nicole Karlis, Published December 31, 2024
"In 2024, at least 66 human cases of bird flu have been reported in the United States, each one raising the risk of another pandemic like COVID-19. So far, most cases have been described as 'mild,' which means they weren't hospitalized. No patients have died, though infections years ago had a very high mortality rate. Symptoms have typically included #PinkEye, but not serious respiratory distress.
"However, a patient recently made headlines in Louisiana for being a more severe case. The patient, who is reportedly over the age of 65, was hospitalized and in critical condition due to severe respiratory symptoms.
"Last week, the U.S. Centers for Disease Control and Prevention (CDC) said a genetic analysis suggests the virus mutated inside the patient to possibly make it a more severe illness in humans. The agency called the mutation 'concerning,' as it may allow the virus to better bind to receptors in humans' upper airways. This would make it easier to jump from person to person, sparking major outbreaks or even a pandemic. However, the public health agency said that the risk to the general public from the outbreak 'has not changed and remains low.' ['Cuz, shop till you drop!]
"The CDC also stated that these mutations HAVE NOT [emphasis mine] been detected in the bird flock that infected the patient, which would make the situation 'more concerning.' [Just like the case in British Columbia]
"'These changes would be more concerning if found in animal hosts or in early stages of infection (e.g., within a few days of symptom onset) when these changes might be more likely to facilitate spread to close contacts,' the CDC said in its report. 'Notably, in this case, no transmission from the patient in Louisiana to other persons has been identified.'"
https://www.salon.com/2024/12/31/concerning-bird-flu-mutations-in-louisiana-patient-underscores-potential-of-h5n1/
#HPAI #H5N1 #BirdFlu #Flu #BirdFluMutations -
Update: The patient has died.
"Concerning" #BirdFlu mutations in Louisiana patient underscores #pandemic potential of #H5N1
By Nicole Karlis, Published December 31, 2024
"In 2024, at least 66 human cases of bird flu have been reported in the United States, each one raising the risk of another pandemic like COVID-19. So far, most cases have been described as 'mild,' which means they weren't hospitalized. No patients have died, though infections years ago had a very high mortality rate. Symptoms have typically included #PinkEye, but not serious respiratory distress.
"However, a patient recently made headlines in Louisiana for being a more severe case. The patient, who is reportedly over the age of 65, was hospitalized and in critical condition due to severe respiratory symptoms.
"Last week, the U.S. Centers for Disease Control and Prevention (CDC) said a genetic analysis suggests the virus mutated inside the patient to possibly make it a more severe illness in humans. The agency called the mutation 'concerning,' as it may allow the virus to better bind to receptors in humans' upper airways. This would make it easier to jump from person to person, sparking major outbreaks or even a pandemic. However, the public health agency said that the risk to the general public from the outbreak 'has not changed and remains low.' ['Cuz, shop till you drop!]
"The CDC also stated that these mutations HAVE NOT [emphasis mine] been detected in the bird flock that infected the patient, which would make the situation 'more concerning.' [Just like the case in British Columbia]
"'These changes would be more concerning if found in animal hosts or in early stages of infection (e.g., within a few days of symptom onset) when these changes might be more likely to facilitate spread to close contacts,' the CDC said in its report. 'Notably, in this case, no transmission from the patient in Louisiana to other persons has been identified.'"
https://www.salon.com/2024/12/31/concerning-bird-flu-mutations-in-louisiana-patient-underscores-potential-of-h5n1/
#HPAI #H5N1 #BirdFlu #Flu #BirdFluMutations -
#Genomic Characterization of #HPAI #H5N1 Virus Newly Emerged in Dairy #Cattle, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2380421
B3.13 viruses underwent 2 #reassortment events since 2023 & exhibit critical #mutations in #HA, #M1, & #NS #genes but lack critical mutations in #PB2 & PB1 genes, which enhance virulence or adaptation to #mammals. #PB2 E627 K mutation in a #human case associated with cattle underscores the potential for rapid evolution post-infection...
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#Genomic Characterization of #HPAI #H5N1 Virus Newly Emerged in Dairy #Cattle, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2380421
B3.13 viruses underwent 2 #reassortment events since 2023 & exhibit critical #mutations in #HA, #M1, & #NS #genes but lack critical mutations in #PB2 & PB1 genes, which enhance virulence or adaptation to #mammals. #PB2 E627 K mutation in a #human case associated with cattle underscores the potential for rapid evolution post-infection...
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Novel #Genotypes of #HPAI #H5N1 Clade 2.3.4.4b Viruses, #Germany, November 2023, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/8/24-0103_article
Several #subtypes & many different genotypes of HPAI viruses of subtype #H5 clade 2.3.4.4b have repeatedly caused #outbreaks in Germany. 4 new HPAI genotypes emerged in Nov 2023 after #reassortment with low pathogenicity precursors, replacing genotype BB, which had dominated in Europe since 2022.
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Novel #Genotypes of #HPAI #H5N1 Clade 2.3.4.4b Viruses, #Germany, November 2023, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/8/24-0103_article
Several #subtypes & many different genotypes of HPAI viruses of subtype #H5 clade 2.3.4.4b have repeatedly caused #outbreaks in Germany. 4 new HPAI genotypes emerged in Nov 2023 after #reassortment with low pathogenicity precursors, replacing genotype BB, which had dominated in Europe since 2022.
