#mechanotransduction — Public Fediverse posts

📰 "The Double-Edged Nature of β-Catenin: From Multicellular Innovation to Cancer Vulnerability"
https://doi.org/doi:10.1152/ajpcell.00175.2026
https://pubmed.ncbi.nlm.nih.gov/42126086/
#Mechanotransduction #Cell

📰 "The Double-Edged Nature of β-Catenin: From Multicellular Innovation to Cancer Vulnerability"
https://doi.org/doi:10.1152/ajpcell.00175.2026
https://pubmed.ncbi.nlm.nih.gov/42126086/
#Mechanotransduction #Cell

📰 "Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction"
https://doi.org/doi:10.64898/2026.03.02.709101
https://pubmed.ncbi.nlm.nih.gov/41846998/
#Mechanotransduction #Cadherin #Force

📰 "Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction"
https://doi.org/doi:10.64898/2026.03.02.709101
https://pubmed.ncbi.nlm.nih.gov/41846998/
#Mechanotransduction #Cadherin #Force

📰 "VE-Cadherin-Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension-Sensitive Intermediate State"
https://doi.org/doi:10.1002/advs.202516423
https://pubmed.ncbi.nlm.nih.gov/41709866/
#Mechanotransduction #Cadherin #Cell

📰 "VE-Cadherin-Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension-Sensitive Intermediate State"
https://doi.org/doi:10.1002/advs.202516423
https://pubmed.ncbi.nlm.nih.gov/41709866/
#Mechanotransduction #Cadherin #Cell

📰 "Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration"
https://doi.org/doi:10.1021/acsami.5c06161
https://pubmed.ncbi.nlm.nih.gov/40550785/
#Mechanotransduction #Extracellular #Mechanical

📰 "Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis"
https://doi.org/doi:10.1063/5.0255473
https://pubmed.ncbi.nlm.nih.gov/40502441/
#Mechanotransduction #Extracellular #Cytoskeleton #Mechanical

📰 "Mathematical Modelling of Mechanotransduction via RhoA Signalling Pathways"
https://arxiv.org/abs/2501.04407 #Mechanotransduction #Physics.Bio-Ph #Q-Bio.Cb #Math.Na #Cs.Na #Cell

📰 "Insights into new mechanosensitive behaviors of G protein-coupled receptors"
https://arxiv.org/abs/2503.00965 #Mechanotransduction #Physics.Bio-Ph #Extracellular #Q-Bio.Cb #Q-Bio.Sc

📰 "Mechanical Responses of the Giant Nesprin-2"
https://www.biorxiv.org/content/10.1101/2025.05.30.657030v1?rss=1 #Mechanotransduction #Cytoskeleton #Mechanical

📰 "Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction"
https://doi.org/doi:10.1126/scisignal.adx0682
https://pubmed.ncbi.nlm.nih.gov/40359263/
#Mechanotransduction #Mechanical #Cadherin

📰 "E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding"
https://doi.org/doi:10.1126/scisignal.adr7926
https://pubmed.ncbi.nlm.nih.gov/40359261/
#Mechanotransduction #Mechanical #Cadherin

📰 "Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction"
https://doi.org/doi:10.1126/scisignal.adx0682
https://pubmed.ncbi.nlm.nih.gov/40359263/
#Mechanotransduction #Mechanical #Cadherin

📰 "E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding"
https://doi.org/doi:10.1126/scisignal.adr7926
https://pubmed.ncbi.nlm.nih.gov/40359261/
#Mechanotransduction #Mechanical #Cadherin

📰 "Dynamic Mechanical Stimulation of Thermoresponsive Nanofibers for Activation of Fibroblasts in Skin Repair"
https://doi.org/doi:10.1002/adhm.202500277
https://pubmed.ncbi.nlm.nih.gov/40357898/
#Mechanotransduction #Mechanical #Adhesion

📰 "Extracellular Matrix Stiffness: Mechanotransduction and Mechanobiological Response-Driven Strategies for Biomedical Applications Targeting Fibroblast Inflammation"
https://doi.org/doi:10.3390/polym17060822
https://pubmed.ncbi.nlm.nih.gov/40292716/
#Mechanotransduction #Extracellular #Mechanical

📰 "Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D Hydrogels"
https://doi.org/doi:10.1101/2025.04.11.648340
https://pubmed.ncbi.nlm.nih.gov/40291699/
#Mechanotransduction #Extracellular #Mechanical #Matrix

📰 "Optogenetic control of mechanotransduction based on light-induced homodimerization of talin"
https://www.biorxiv.org/content/10.1101/2025.04.17.649301v1?rss=1 #Mechanotransduction #Mechanical #Cell

📰 "Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells"
https://doi.org/doi:10.1021/acsnano.5c03122
https://pubmed.ncbi.nlm.nih.gov/40232231/
#Mechanotransduction #Mechanical #Cell

📰 "EGFR-Mediated Mechanotransduction in Aortic Valve Cells: A Key Pathway in Response to Wall Shear Stress"
https://www.biorxiv.org/content/10.1101/2025.03.10.642402v1?rss=1 #Mechanotransduction #Mechanical #Cell

📰 "E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding"
https://www.biorxiv.org/content/10.1101/2025.03.06.641828v1?rss=1 #Mechanotransduction #Mechanical #Cadherin

📰 "E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding"
https://www.biorxiv.org/content/10.1101/2025.03.06.641828v1?rss=1 #Mechanotransduction #Mechanical #Cadherin

📰 "Injectable hydrogel with miR-222-engineered extracellular vesicles ameliorates myocardial ischemic reperfusion injury via mechanotransduction"
https://doi.org/doi:10.1016/j.xcrm.2025.101987
https://pubmed.ncbi.nlm.nih.gov/40037358/
#Mechanotransduction #Extracellular #Mechanical

📰 "Insights into new mechanosensitive behaviors of G protein-coupled receptors"
https://arxiv.org/abs/2503.00965 #Mechanotransduction #Physics.Bio-Ph #Extracellular #Q-Bio.Cb #Q-Bio.Sc

📰 "Axonal Mechanotransduction Drives Cytoskeletal Responses to Physiological Mechanical Forces"
https://doi.org/doi:10.1101/2025.02.11.637689
https://pubmed.ncbi.nlm.nih.gov/39990487/
#Mechanotransduction #Cytoskeletal #Mechanical

📰 "Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction"
https://doi.org/doi:10.1038/s41467-025-56343-6
https://pubmed.ncbi.nlm.nih.gov/39885125/
#Mechanotransduction #Mechanical #Cell

📰 "Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction"
https://doi.org/doi:10.1016/j.jconrel.2025.01.065
https://pubmed.ncbi.nlm.nih.gov/39863022/
#Mechanotransduction #Extracellular #Mechanical

📰 "Electrical and Mechanical Modeling of Uterine Contractions Analysis Using Connectivity Methods and Graph Theory"
https://arxiv.org/abs/2501.10544 #Mechanotransduction #Physics.Med-Ph #Mechanical #Matrix

📰 "MicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction"
https://doi.org/doi:10.1021/acsnano.4c14874
https://pubmed.ncbi.nlm.nih.gov/39787443/
#Mechanotransduction #Extracellular #Mechanical

📰 "Mathematical Modelling of Mechanotransduction via RhoA Signalling Pathways"
https://arxiv.org/abs/2501.04407 #Mechanotransduction #Physics.Bio-Ph #Q-Bio.Cb #Math.Na #Cs.Na #Cell

Just Published!

Mechanobiology

https://link.springer.com/book/10.1007/978-3-031-45379-3

This conference proceedings includes a selection of the science discussed at the 4th International Symposium on Mechanobiology.

This collection reflects the diverse and multidisciplinary nature of mechanobiology research spanning length scales and organ systems.

Enjoy!

Chapter 4 is available as open access.

#Biophysics #Mechanotransduction #TissueMechanics #Bioengineering #IonChannels #Books

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

Check out this interesting article!

"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"

https://link.springer.com/chapter/10.1007/5584_2023_773

#Angiogenesis #Biofilm #Mechanotransduction

From their abstract:
"Emerging evidence suggests that understanding of #timescales may be important in resolving this issue, but that further work is needed to understand the role of adhesive strengthening across scales."

Same the conclusion as in our theory paper https://doi.org/10.1371/journal.pcbi.1009812 : the interplay of #cadherin #adhesion & cortical #actomyosin timescales triggers emergent phenomena in terms of #tissue mechanics. If one adds #mechanotransduction on top of that then expect awesome effects.

"Single-molecule magnetic tweezers to capture over a million individual transitions as a single talin protein unfolds and refolds under force in equilibrium. When observed at classically probed timescales, talin folds in an apparently uncomplicated two-state manner. As the sampling time extends from minutes to days, the underlying energy landscape exhibits gradually larger signatures of complexity, involving a finite number of well-defined rare conformations.[...]The physiological relevance of each distinct conformation can be connected to the binding of the cytoskeletal protein vinculin, suggesting an extra layer of complexity in talin-mediated mechanotransduction."
https://www.nature.com/articles/s41567-022-01808-4
#StructuralBiology #Talin #Vinculin #MechanoTransduction #MechanoBiology #Cytoskeleton