#tumour — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tumour, aggregated by home.social.
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Scientists have developed a simple DNA blood test
that can predict how well patients with breast cancer will respond to treatment.More than 2 million people globally each year are diagnosed with the disease,
which is the world’s most prevalent cancer.
Although treatments have improved in recent decades, it is not easy to know which ones will work best for which patients.
Now researchers have designed a #liquid #biopsy that tells doctors how likely a patient is to respond to a specific treatment -- even before it begins.The test has the potential to be gamechanging because it means patients could be offered alternative options, and avoid treatments that won’t help them, boosting their chances of beating the disease.
The test, developed by a team at the Institute of Cancer Research, London (ICR),
analyses #circulating #tumour #DNA (ctDNA), which is released into the blood of patients by cancer cells.
Researchers measured these microscopic levels of cancer DNA in blood samples from 167 patients.
The test was trialled before treatment began and again four weeks later, after a single treatment cycle.
There was a strong association between low levels of ctDNA at the start of treatment, and treatment response, according to the team.
A similar association was seen with the results taken at four weeks.
https://www.theguardian.com/science/2026/jan/18/simple-blood-test-can-predict-which-breast-cancer-treatment-will-work-best-study-finds?CMP=Share_iOSApp_Other -
Novel keyhole technique used to remove head tumour:
https://www.bbc.com/news/articles/c98yg1n9j83o
#medical #surgery #operation #tumour #cranium #medicine -
"Researchers from RMIT University in Australia and Indian institutions unveiled a novel gold-based drug that shows significant promise in the fight against cancer. The drug has demonstrated the ability to slow #tumour growth while selectively targeting cancer cells more effectively than traditional #chemotherapy agents."
https://interestingengineering.com/health/gold-based-drug-slows-cancer -
"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"
https://link.springer.com/article/10.1007/s11684-024-1081-7
Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.
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Ania, National Cancer Institute, Kyiv, 2015
“Ania is a six-year-old girl who grew up in a small town outside the exclusion zone. People who grew up in the contaminated areas are having #children, and there’s a lot of genetic mutation and illness related to radiation. Ania was suffering from a malignant bone #tumour. She was a strong, positive child, passionate about art and drawing. The doctors told me she had little hope of survival. I don’t know if she is still alive or not.”
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Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a #HighThroughput personalized #TCR discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific #neoantigens."
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#Tasmaniandevil facial #tumour hasn’t let up https://cosmosmagazine.com/nature/animals/tasmanian-devil-facial-tumour-study/
In 2021, a study showed that 25 years of #DFTD’s spread had a massive impact on the Tasmanian devil population. The number of devils on the island of Tasmania shrank from 53,000 in 1996 to only 17,000 in 2021. The same study suggested that DFTD covered more than 90% of the devils’ range in Tasmania. As a result, #Australia’s largest remaining marsupial carnivore was listed as endangered.
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Anyone who supports me to pay for services and assistance that are not covered by insurance in order to at least take away my financial worries while fighting my cancer can do so here:
My Amazon Wishlist:
https://www.amazon.de/hz/wishlist/ls/MLYVBXM60LR6?ref_=wl_shareMy GoFoundMe Page:
https://gofund.me/bdc717c7My Paypal Account:
https://www.paypal.com/pools/c/92opGMV4OBOf course and that would be much more appreciate if you like and share my posts.
Thank you very much for any support.
Roland
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Delighted that our #cancer #research has been selected for the cover image of December’s Life Science Alliance! In our article we show how gain of function mutations to the #ionchannel KCNQ3 may promote #tumour growth in oesophageal adenocarcinoma
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A great read on #DrugResistance in #cancer, in Nature, by Vasan, Baselga, and Hyman. Sure, 2019 is four years ago, so there will be updates, e.g. on mapping #CancerDependency or the role of #ctDNA in early detection or monitoring. But the framework for understanding drug resistance is here.
https://www.nature.com/articles/s41586-019-1730-1
Although it doesn't say it, I think it may be #OpenAccess since I'm not logged in to my institution right now but can reach full text anyway.
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Come and work with us - job opening at the Molenaar research group in the Princess Máxima Center for pediatric oncology, looking for a #bioinformatician / #DataScientist.
Together with my colleagues and me you will research #neuroblastoma, with a focus on #tumour #microenvironment and the #immune compartment using a range of #sequencing data and other high-throughput data.
#CancerResearch #scRNAseq
#FediJobs #JobOfferFor further information, see the vacancy below:
https://werkenbijprinsesmaximacentrum.nl/en/vacancy/bioinformatics-research-scientist/ -
My #Information #List is getting heavyweight! So much random factiness my Solo Synthesist is going crazy following leads that appeal to me.
I'm in danger of my head blowing up far sooner than my #Brain #Tumour escaping control!! 😂 😎
It's wonder-filled this place, a trove of treasures!
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"Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma"
Nice new work based on #scRNAseq from our Drost group colleagues at the #PrincessMaximaCenter. a.o., a potential role of #NECTIN3 and #TIGIT in #tumour-induced T cell dysfunction.
https://www.nature.com/articles/s41467-023-38886-8 -
Meet Valentina Zuco, first author of a new paper from Nadia Zaffaroni @IstTumori & colleagues that demonstrated the efficacy of new drug combination for desmoplastic small round cell #tumour in #PatientDerivedXenograft
Interview & research article below:
👩🏼🔬https://journals.biologists.com/dmm/article/16/6/dmm050313/316732/
📰https://journals.biologists.com/dmm/article/16/6/dmm049649/316733/ -
"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".
An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.
https://www.nature.com/articles/s43018-022-00405-x
Sadly, not open access.
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Well there was always 30% change my tumour would come back and it has as the lesions on my liver are the return of my Tumour.
I did not see the Oncologist today but a Consultant who told me what would happen next which will be a PET CT Scan possibility followed by surgery to remove the tumours off my liver.
So it all start again but at least this time I know what I am in for and like last time it has not hit me yet but I will survive it again.
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That session was concluded by Caroline Hochheuser showing our own #scRNAseq work, comparing primary #tumour to bone marrow #metastasis from the same patients. 🤩
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Yesterday, in the afternoon plenty of #scRNAseq work, a.o. Céline Delloye-Bourgeois showing her group's latest work on #neuroblastoma development and #metastatic progression. Including some of our own scRNA-seq data. Very cool.
Furthermore, more #SingleCell, also spatial, sequencing on #tumour heterogeneity and early stages. And work on cells that persist during/after #therapy, dubbed persister cells.
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An impressive keynote lecture by Chris Marine on #melanoma and the role of the #tumour #microenvironment, and MES-like cells in #metastasis and #drug #resistance.
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https://www.nature.com/articles/s41586-023-06036-1
"The degree of functional connectivity between #glioblastoma and the normal #brain negatively affects both patient survival and performance in language tasks. These data demonstrate that high-grade gliomas functionally remodel #neural circuits in the #human brain, which both promotes #tumour progression and impairs #cognition."
