#tumour — Public Fediverse posts

Brain tumour campaign for Bryan raises over £69k in 24 hours

A CAMPAIGN to raise £150,000 for well-known local figure Bryan Peterson’s brain tumour treatment has raised over £69,000…
#NewsBeep #News #Health #Brain #Bryan #GB #Peterson #research #tumour #UK #UnitedKingdom
https://www.newsbeep.com/uk/489852/

Scientists have developed a simple DNA blood test
that can predict how well patients with breast cancer will respond to treatment.

More than 2 million people globally each year are diagnosed with the disease,
which is the world’s most prevalent cancer.
Although treatments have improved in recent decades, it is not easy to know which ones will work best for which patients.
Now researchers have designed a #liquid #biopsy that tells doctors how likely a patient is to respond to a specific treatment -- even before it begins.

The test has the potential to be gamechanging because it means patients could be offered alternative options, and avoid treatments that won’t help them, boosting their chances of beating the disease.

The test, developed by a team at the Institute of Cancer Research, London (ICR),
analyses #circulating #tumour #DNA (ctDNA), which is released into the blood of patients by cancer cells.
Researchers measured these microscopic levels of cancer DNA in blood samples from 167 patients.
The test was trialled before treatment began and again four weeks later, after a single treatment cycle.
There was a strong association between low levels of ctDNA at the start of treatment, and treatment response, according to the team.
A similar association was seen with the results taken at four weeks.
https://www.theguardian.com/science/2026/jan/18/simple-blood-test-can-predict-which-breast-cancer-treatment-will-work-best-study-finds?CMP=Share_iOSApp_Other

Scientists have developed a simple DNA blood test
that can predict how well patients with breast cancer will respond to treatment.

More than 2 million people globally each year are diagnosed with the disease,
which is the world’s most prevalent cancer.
Although treatments have improved in recent decades, it is not easy to know which ones will work best for which patients.
Now researchers have designed a #liquid #biopsy that tells doctors how likely a patient is to respond to a specific treatment -- even before it begins.

The test has the potential to be gamechanging because it means patients could be offered alternative options, and avoid treatments that won’t help them, boosting their chances of beating the disease.

The test, developed by a team at the Institute of Cancer Research, London (ICR),
analyses #circulating #tumour #DNA (ctDNA), which is released into the blood of patients by cancer cells.
Researchers measured these microscopic levels of cancer DNA in blood samples from 167 patients.
The test was trialled before treatment began and again four weeks later, after a single treatment cycle.
There was a strong association between low levels of ctDNA at the start of treatment, and treatment response, according to the team.
A similar association was seen with the results taken at four weeks.
https://www.theguardian.com/science/2026/jan/18/simple-blood-test-can-predict-which-breast-cancer-treatment-will-work-best-study-finds?CMP=Share_iOSApp_Other

Scientists have developed a simple DNA blood test
that can predict how well patients with breast cancer will respond to treatment.

More than 2 million people globally each year are diagnosed with the disease,
which is the world’s most prevalent cancer.
Although treatments have improved in recent decades, it is not easy to know which ones will work best for which patients.
Now researchers have designed a #liquid #biopsy that tells doctors how likely a patient is to respond to a specific treatment -- even before it begins.

The test has the potential to be gamechanging because it means patients could be offered alternative options, and avoid treatments that won’t help them, boosting their chances of beating the disease.

The test, developed by a team at the Institute of Cancer Research, London (ICR),
analyses #circulating #tumour #DNA (ctDNA), which is released into the blood of patients by cancer cells.
Researchers measured these microscopic levels of cancer DNA in blood samples from 167 patients.
The test was trialled before treatment began and again four weeks later, after a single treatment cycle.
There was a strong association between low levels of ctDNA at the start of treatment, and treatment response, according to the team.
A similar association was seen with the results taken at four weeks.
https://www.theguardian.com/science/2026/jan/18/simple-blood-test-can-predict-which-breast-cancer-treatment-will-work-best-study-finds?CMP=Share_iOSApp_Other

Scientists have developed a simple DNA blood test
that can predict how well patients with breast cancer will respond to treatment.

More than 2 million people globally each year are diagnosed with the disease,
which is the world’s most prevalent cancer.
Although treatments have improved in recent decades, it is not easy to know which ones will work best for which patients.
Now researchers have designed a #liquid #biopsy that tells doctors how likely a patient is to respond to a specific treatment -- even before it begins.

The test has the potential to be gamechanging because it means patients could be offered alternative options, and avoid treatments that won’t help them, boosting their chances of beating the disease.

The test, developed by a team at the Institute of Cancer Research, London (ICR),
analyses #circulating #tumour #DNA (ctDNA), which is released into the blood of patients by cancer cells.
Researchers measured these microscopic levels of cancer DNA in blood samples from 167 patients.
The test was trialled before treatment began and again four weeks later, after a single treatment cycle.
There was a strong association between low levels of ctDNA at the start of treatment, and treatment response, according to the team.
A similar association was seen with the results taken at four weeks.
https://www.theguardian.com/science/2026/jan/18/simple-blood-test-can-predict-which-breast-cancer-treatment-will-work-best-study-finds?CMP=Share_iOSApp_Other

Scientists have developed a simple DNA blood test
that can predict how well patients with breast cancer will respond to treatment.

More than 2 million people globally each year are diagnosed with the disease,
which is the world’s most prevalent cancer.
Although treatments have improved in recent decades, it is not easy to know which ones will work best for which patients.
Now researchers have designed a #liquid #biopsy that tells doctors how likely a patient is to respond to a specific treatment -- even before it begins.

The test has the potential to be gamechanging because it means patients could be offered alternative options, and avoid treatments that won’t help them, boosting their chances of beating the disease.

The test, developed by a team at the Institute of Cancer Research, London (ICR),
analyses #circulating #tumour #DNA (ctDNA), which is released into the blood of patients by cancer cells.
Researchers measured these microscopic levels of cancer DNA in blood samples from 167 patients.
The test was trialled before treatment began and again four weeks later, after a single treatment cycle.
There was a strong association between low levels of ctDNA at the start of treatment, and treatment response, according to the team.
A similar association was seen with the results taken at four weeks.
https://www.theguardian.com/science/2026/jan/18/simple-blood-test-can-predict-which-breast-cancer-treatment-will-work-best-study-finds?CMP=Share_iOSApp_Other

Novel keyhole technique used to remove head tumour:
https://www.bbc.com/news/articles/c98yg1n9j83o
#medical #surgery #operation #tumour #cranium #medicine

"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"

https://link.springer.com/article/10.1007/s11684-024-1081-7

Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.

#scRNAseq #tumour #Neuroblastoma #pseudotime

Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a #HighThroughput personalized #TCR discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific #neoantigens."

https://www.nature.com/articles/s41587-024-02210-6

#cancer #tumour #Tcells
#science

#Tasmaniandevil facial #tumour hasn’t let up https://cosmosmagazine.com/nature/animals/tasmanian-devil-facial-tumour-study/

In 2021, a study showed that 25 years of #DFTD’s spread had a massive impact on the Tasmanian devil population. The number of devils on the island of Tasmania shrank from 53,000 in 1996 to only 17,000 in 2021. The same study suggested that DFTD covered more than 90% of the devils’ range in Tasmania. As a result, #Australia’s largest remaining marsupial carnivore was listed as endangered.

Delighted that our #cancer #research has been selected for the cover image of December’s Life Science Alliance! In our article we show how gain of function mutations to the #ionchannel KCNQ3 may promote #tumour growth in oesophageal adenocarcinoma

Delighted that our #cancer #research has been selected for the cover image of December’s Life Science Alliance! In our article we show how gain of function mutations to the #ionchannel KCNQ3 may promote #tumour growth in oesophageal adenocarcinoma

Delighted that our #cancer #research has been selected for the cover image of December’s Life Science Alliance! In our article we show how gain of function mutations to the #ionchannel KCNQ3 may promote #tumour growth in oesophageal adenocarcinoma

Delighted that our #cancer #research has been selected for the cover image of December’s Life Science Alliance! In our article we show how gain of function mutations to the #ionchannel KCNQ3 may promote #tumour growth in oesophageal adenocarcinoma

A great read on #DrugResistance in #cancer, in Nature, by Vasan, Baselga, and Hyman. Sure, 2019 is four years ago, so there will be updates, e.g. on mapping #CancerDependency or the role of #ctDNA in early detection or monitoring. But the framework for understanding drug resistance is here.

https://www.nature.com/articles/s41586-019-1730-1

Although it doesn't say it, I think it may be #OpenAccess since I'm not logged in to my institution right now but can reach full text anyway.

#tumour #tumor

Come and work with us - job opening at the Molenaar research group in the Princess Máxima Center for pediatric oncology, looking for a #bioinformatician / #DataScientist.

Together with my colleagues and me you will research #neuroblastoma, with a focus on #tumour #microenvironment and the #immune compartment using a range of #sequencing data and other high-throughput data.

#CancerResearch #scRNAseq
#FediJobs #JobOffer

For further information, see the vacancy below:
https://werkenbijprinsesmaximacentrum.nl/en/vacancy/bioinformatics-research-scientist/

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

Yesterday, in the afternoon plenty of #scRNAseq work, a.o. Céline Delloye-Bourgeois showing her group's latest work on #neuroblastoma development and #metastatic progression. Including some of our own scRNA-seq data. Very cool.

Furthermore, more #SingleCell, also spatial, sequencing on #tumour heterogeneity and early stages. And work on cells that persist during/after #therapy, dubbed persister cells.

#anr2023

An impressive keynote lecture by Chris Marine on #melanoma and the role of the #tumour #microenvironment, and MES-like cells in #metastasis and #drug #resistance.

#anr2023

Recent work from University of Basel in Nature Communications looking into #Tcell #exhaustion, indicating a role for the SNX9 #gene. Knocking out this gene led to phenotypical and functional changes, e.g. Tmem differentiation, IFNg production, reduced #tumour growth, and improved survival in certain models.

https://www.nature.com/articles/s41467-022-35583-w

#Tcells #Cancer #Immunology #lymphocytes #CancerImmunology #SingleCell #scRNAseq #RNAseq

Found via @sflorg