#lymphocytes — Public Fediverse posts

T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356

T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356

T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356

T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356

T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356

https://www.europesays.com/be-fr/40553/ ces cellules du système immunitaire qui jouent un rôle clé dans la lutte contre le cancer #BE #BEFr #Belgique #Belgium #cancer #CellulesNK #CellulesT #Health #immunothérapie #lymphocytes #PréventionCancer #Santé #SantéImmunitaire #SystèmeImmunitaire

Continuons notre revue des lauréats de nos prix avec Basile Stamatopoulos de l'ULB @ULBRecherche qui a reçu le Crédit de Recherche de la Fondation Bekales pour son projet d'explorer le répertoire des #lymphocytes T dans la #leucémie lymphoïde chronique https://youtu.be/y2vi_hWtaI4 #cancer #oncology

Continuons notre revue des lauréats de nos prix avec Basile Stamatopoulos de l'ULB @ULBRecherche qui a reçu le Crédit de Recherche de la Fondation Bekales pour son projet d'explorer le répertoire des #lymphocytes T dans la #leucémie lymphoïde chronique https://youtu.be/y2vi_hWtaI4 #cancer #oncology

Continuons notre revue des lauréats de nos prix avec Basile Stamatopoulos de l'ULB @ULBRecherche qui a reçu le Crédit de Recherche de la Fondation Bekales pour son projet d'explorer le répertoire des #lymphocytes T dans la #leucémie lymphoïde chronique https://youtu.be/y2vi_hWtaI4 #cancer #oncology

Normal values for lymphocytes and causes of their increase/decrease in blood #lymphocytes #infection
... Continue to: https://youtube.com/shorts/nK6EbWTEXMM?si=nWi5DwNeMmwH0FC8

Normal values for lymphocytes and causes of their increase/decrease in blood #lymphocytes #infection
... Continue to: https://youtube.com/shorts/nK6EbWTEXMM?si=nWi5DwNeMmwH0FC8

Normal values for lymphocytes and causes of their increase/decrease in blood #lymphocytes #infection
... Continue to: https://youtube.com/shorts/nK6EbWTEXMM?si=nWi5DwNeMmwH0FC8

Normal values for lymphocytes and causes of their increase/decrease in blood #lymphocytes #infection
... Continue to: https://youtube.com/shorts/nK6EbWTEXMM?si=nWi5DwNeMmwH0FC8

Normal values for lymphocytes and causes of their increase/decrease in blood #lymphocytes #infection
... Continue to: https://youtube.com/shorts/nK6EbWTEXMM?si=nWi5DwNeMmwH0FC8

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

Study approval All participants provided written informed consent for participation in the study. Ethical approval was obtained from…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #HumanitiesandSocialSciences #Lymphocytes #multidisciplinary #Neurology #Science
https://www.newsbeep.com/us/197062/

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

Study approval All participants provided written informed consent for participation in the study. Ethical approval was obtained from…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #HumanitiesandSocialSciences #Lymphocytes #multidisciplinary #Neurology #Science
https://www.newsbeep.com/us/197062/

SciTech Chronicles. . . . . . . . . . . . . . . . . . . . .Jan 24, 2025

https://bit.ly/stc012425

#Buses #autonomous #Imagry #Level-4 #self-generated #map #mitochondria #lymphocytes #immunotherapy #mtDNA #senescence #open-source #Cost #Security #Documentation #Customizability #Sustainability #LLM #Clone #Fudan #Meta #Alibaba #Frontier #AI #Bees #Hive #AprilTags #Pollen #foraging

SciTech Chronicles. . . . . . . . . . . . . . . . . . . . .Jan 24, 2025

https://bit.ly/stc012425

#Buses #autonomous #Imagry #Level-4 #self-generated #map #mitochondria #lymphocytes #immunotherapy #mtDNA #senescence #open-source #Cost #Security #Documentation #Customizability #Sustainability #LLM #Clone #Fudan #Meta #Alibaba #Frontier #AI #Bees #Hive #AprilTags #Pollen #foraging

SciTech Chronicles. . . . . . . . . . . . . . . . . . . . .Jan 24, 2025

https://bit.ly/stc012425

#Buses #autonomous #Imagry #Level-4 #self-generated #map #mitochondria #lymphocytes #immunotherapy #mtDNA #senescence #open-source #Cost #Security #Documentation #Customizability #Sustainability #LLM #Clone #Fudan #Meta #Alibaba #Frontier #AI #Bees #Hive #AprilTags #Pollen #foraging

Immunological #findings of West Caucasian #bat #virus in an accidental host http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1

In #hamsters, #WCBV was highly pathogenic, determining 100% #lethality and mild #encephalitis. In comparison with Duvenhage virus (DUVV) and #RABV, we found that WCBV displayed an intermediate ability to promote cellular antiviral response, produce pro-inflammatory #cytokines, recruit and activate #lymphocytes in the hamsters central nervous system.

Immunological #findings of West Caucasian #bat #virus in an accidental host http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1

In #hamsters, #WCBV was highly pathogenic, determining 100% #lethality and mild #encephalitis. In comparison with Duvenhage virus (DUVV) and #RABV, we found that WCBV displayed an intermediate ability to promote cellular antiviral response, produce pro-inflammatory #cytokines, recruit and activate #lymphocytes in the hamsters central nervous system.

Immunological #findings of West Caucasian #bat #virus in an accidental host http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1

In #hamsters, #WCBV was highly pathogenic, determining 100% #lethality and mild #encephalitis. In comparison with Duvenhage virus (DUVV) and #RABV, we found that WCBV displayed an intermediate ability to promote cellular antiviral response, produce pro-inflammatory #cytokines, recruit and activate #lymphocytes in the hamsters central nervous system.

Immunological #findings of West Caucasian #bat #virus in an accidental host http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1

In #hamsters, #WCBV was highly pathogenic, determining 100% #lethality and mild #encephalitis. In comparison with Duvenhage virus (DUVV) and #RABV, we found that WCBV displayed an intermediate ability to promote cellular antiviral response, produce pro-inflammatory #cytokines, recruit and activate #lymphocytes in the hamsters central nervous system.

Immunological #findings of West Caucasian #bat #virus in an accidental host http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1

In #hamsters, #WCBV was highly pathogenic, determining 100% #lethality and mild #encephalitis. In comparison with Duvenhage virus (DUVV) and #RABV, we found that WCBV displayed an intermediate ability to promote cellular antiviral response, produce pro-inflammatory #cytokines, recruit and activate #lymphocytes in the hamsters central nervous system.

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/

“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/

“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/

“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/

“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/

-- A lower frequency of circulating B #lymphocytes by mass cytometry (CyTOF) was observed in the multidomain #deficit cluster. Circulating #fibroblast growth factor 21 (FGF21) was significantly elevated in the #mental/cognitive predominant and the multidomain clusters. Future efforts to link #PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

-- A lower frequency of circulating B #lymphocytes by mass cytometry (CyTOF) was observed in the multidomain #deficit cluster. Circulating #fibroblast growth factor 21 (FGF21) was significantly elevated in the #mental/cognitive predominant and the multidomain clusters. Future efforts to link #PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

-- A lower frequency of circulating B #lymphocytes by mass cytometry (CyTOF) was observed in the multidomain #deficit cluster. Circulating #fibroblast growth factor 21 (FGF21) was significantly elevated in the #mental/cognitive predominant and the multidomain clusters. Future efforts to link #PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

-- A lower frequency of circulating B #lymphocytes by mass cytometry (CyTOF) was observed in the multidomain #deficit cluster. Circulating #fibroblast growth factor 21 (FGF21) was significantly elevated in the #mental/cognitive predominant and the multidomain clusters. Future efforts to link #PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

-- A lower frequency of circulating B #lymphocytes by mass cytometry (CyTOF) was observed in the multidomain #deficit cluster. Circulating #fibroblast growth factor 21 (FGF21) was significantly elevated in the #mental/cognitive predominant and the multidomain clusters. Future efforts to link #PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

Raman spectroscopy of lymphocytes from patients with the Epstein-Barr virus infection.
28 October 2023, #PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-3483453/v1
#ramaneffect #lymphocytes #epsteinbarr

Raman spectroscopy of lymphocytes from patients with the Epstein-Barr virus infection.
28 October 2023, #PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-3483453/v1
#ramaneffect #lymphocytes #epsteinbarr

Raman spectroscopy of lymphocytes from patients with the Epstein-Barr virus infection.
28 October 2023, #PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-3483453/v1
#ramaneffect #lymphocytes #epsteinbarr

Raman spectroscopy of lymphocytes from patients with the Epstein-Barr virus infection.
28 October 2023, #PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-3483453/v1
#ramaneffect #lymphocytes #epsteinbarr

"Administration of MTA-depleting enzymes reverses this immunosuppressive effect, increasing #tumor-infiltrating #lymphocytes and drastically impairing tumor growth and importantly, synergizes well with immune checkpoint inhibitor (ICI) therapy. As several studies have shown ICI resistance in 9p21/MTAP null/low patients, we propose that MTA degrading #therapeutics may have substantial therapeutic benefit in these patients by enhancing ICI effectiveness."

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00321-5

"Administration of MTA-depleting enzymes reverses this immunosuppressive effect, increasing #tumor-infiltrating #lymphocytes and drastically impairing tumor growth and importantly, synergizes well with immune checkpoint inhibitor (ICI) therapy. As several studies have shown ICI resistance in 9p21/MTAP null/low patients, we propose that MTA degrading #therapeutics may have substantial therapeutic benefit in these patients by enhancing ICI effectiveness."

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00321-5

"Administration of MTA-depleting enzymes reverses this immunosuppressive effect, increasing #tumor-infiltrating #lymphocytes and drastically impairing tumor growth and importantly, synergizes well with immune checkpoint inhibitor (ICI) therapy. As several studies have shown ICI resistance in 9p21/MTAP null/low patients, we propose that MTA degrading #therapeutics may have substantial therapeutic benefit in these patients by enhancing ICI effectiveness."

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00321-5

"Administration of MTA-depleting enzymes reverses this immunosuppressive effect, increasing #tumor-infiltrating #lymphocytes and drastically impairing tumor growth and importantly, synergizes well with immune checkpoint inhibitor (ICI) therapy. As several studies have shown ICI resistance in 9p21/MTAP null/low patients, we propose that MTA degrading #therapeutics may have substantial therapeutic benefit in these patients by enhancing ICI effectiveness."

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00321-5

AAAS: "Doctors have long considered the thymus expendable. But could removing it be fatal?" There are 2 main categories of lymphocytes, both key players in the immune system. B-lymphocytes—named after an anatomically similar organ called the Bursa of Fabricus in chickens—which when activated convert to plasma cells, each one pouring out one specific type of antibody. T-lymphocytes—named after the thymus—have multple subtypes + are involved in surveillance + attack against foreign invaders like bacteria + viruses, but also our own cells that turn cancerous. But they are also capable of attacking our own healthy tissue, which is called autoimmune disease, such as inflammatory bowel disease. Okay, so the thymus is very active in children, but begins to shrink + mostly stops producing cells in adulthood. sort of the attitude of 'been there, done that, let's go grab a beer.' Or does it? Turns out what used to be taught in med schools is probably wrong. "Harvard University hematologist David Scadden and his colleagues analyzed medical records from nearly 2300 people who had undergone chest surgeries at Massachusetts General Hospital." Half had undergone thymectomy, usually performed to treat thymus cancer or certain autoimmune diseases such as myasthenia gravis, in which T-cells attack muscles + cause episodic weakness. But the team found that "compared with the other chest surgery patients, those who underwent a thymectomy were almost three times more likely to die from a variety of causes, from infectious disease to cancer, during the next 5 years." Also had a doubled risk of various cancers, often more aggressive ones compared to people who retained their thymuses. Examination of  the bloodstream showed lesser lymphocyte variety + more infalmmatory molecules. So pat yourself not on your back but rather on top of your upper sternum, because the thymus lies directly below it. Besides, that's easier to do, especially if your shoulders are stiff.   #immunesystem    #thymus    #lymphocytes

AAAS: "Doctors have long considered the thymus expendable. But could removing it be fatal?" There are 2 main categories of lymphocytes, both key players in the immune system. B-lymphocytes—named after an anatomically similar organ called the Bursa of Fabricus in chickens—which when activated convert to plasma cells, each one pouring out one specific type of antibody. T-lymphocytes—named after the thymus—have multple subtypes + are involved in surveillance + attack against foreign invaders like bacteria + viruses, but also our own cells that turn cancerous. But they are also capable of attacking our own healthy tissue, which is called autoimmune disease, such as inflammatory bowel disease. Okay, so the thymus is very active in children, but begins to shrink + mostly stops producing cells in adulthood. sort of the attitude of 'been there, done that, let's go grab a beer.' Or does it? Turns out what used to be taught in med schools is probably wrong. "Harvard University hematologist David Scadden and his colleagues analyzed medical records from nearly 2300 people who had undergone chest surgeries at Massachusetts General Hospital." Half had undergone thymectomy, usually performed to treat thymus cancer or certain autoimmune diseases such as myasthenia gravis, in which T-cells attack muscles + cause episodic weakness. But the team found that "compared with the other chest surgery patients, those who underwent a thymectomy were almost three times more likely to die from a variety of causes, from infectious disease to cancer, during the next 5 years." Also had a doubled risk of various cancers, often more aggressive ones compared to people who retained their thymuses. Examination of  the bloodstream showed lesser lymphocyte variety + more infalmmatory molecules. So pat yourself not on your back but rather on top of your upper sternum, because the thymus lies directly below it. Besides, that's easier to do, especially if your shoulders are stiff.   #immunesystem    #thymus    #lymphocytes

AAAS: "Doctors have long considered the thymus expendable. But could removing it be fatal?" There are 2 main categories of lymphocytes, both key players in the immune system. B-lymphocytes—named after an anatomically similar organ called the Bursa of Fabricus in chickens—which when activated convert to plasma cells, each one pouring out one specific type of antibody. T-lymphocytes—named after the thymus—have multple subtypes + are involved in surveillance + attack against foreign invaders like bacteria + viruses, but also our own cells that turn cancerous. But they are also capable of attacking our own healthy tissue, which is called autoimmune disease, such as inflammatory bowel disease. Okay, so the thymus is very active in children, but begins to shrink + mostly stops producing cells in adulthood. sort of the attitude of 'been there, done that, let's go grab a beer.' Or does it? Turns out what used to be taught in med schools is probably wrong. "Harvard University hematologist David Scadden and his colleagues analyzed medical records from nearly 2300 people who had undergone chest surgeries at Massachusetts General Hospital." Half had undergone thymectomy, usually performed to treat thymus cancer or certain autoimmune diseases such as myasthenia gravis, in which T-cells attack muscles + cause episodic weakness. But the team found that "compared with the other chest surgery patients, those who underwent a thymectomy were almost three times more likely to die from a variety of causes, from infectious disease to cancer, during the next 5 years." Also had a doubled risk of various cancers, often more aggressive ones compared to people who retained their thymuses. Examination of  the bloodstream showed lesser lymphocyte variety + more infalmmatory molecules. So pat yourself not on your back but rather on top of your upper sternum, because the thymus lies directly below it. Besides, that's easier to do, especially if your shoulders are stiff.   #immunesystem    #thymus    #lymphocytes

A biotechnology company designing immunotherapies for solid tumor cancers with a patient's white blood cells is raising $80 million in its initial public offering or IPO.

https://sciencebusiness.technewslit.com/?p=45015

#News #Press #Science #Business #Biotechnology #Cancer #SolidTumor #Finance #Immunotherapy TCells #ClinicalTrial #Lymphocytes #Investment #IPO #ImmuneSystem #Licensing #VentureCapital

A biotechnology company designing immunotherapies for solid tumor cancers with a patient's white blood cells is raising $80 million in its initial public offering or IPO.

https://sciencebusiness.technewslit.com/?p=45015

#News #Press #Science #Business #Biotechnology #Cancer #SolidTumor #Finance #Immunotherapy TCells #ClinicalTrial #Lymphocytes #Investment #IPO #ImmuneSystem #Licensing #VentureCapital

A biotechnology company designing immunotherapies for solid tumor cancers with a patient's white blood cells is raising $80 million in its initial public offering or IPO.

https://sciencebusiness.technewslit.com/?p=45015

#News #Press #Science #Business #Biotechnology #Cancer #SolidTumor #Finance #Immunotherapy TCells #ClinicalTrial #Lymphocytes #Investment #IPO #ImmuneSystem #Licensing #VentureCapital

A biotechnology company designing immunotherapies for solid tumor cancers with a patient's white blood cells is raising $80 million in its initial public offering or IPO.

https://sciencebusiness.technewslit.com/?p=45015

#News #Press #Science #Business #Biotechnology #Cancer #SolidTumor #Finance #Immunotherapy TCells #ClinicalTrial #Lymphocytes #Investment #IPO #ImmuneSystem #Licensing #VentureCapital

#xkcd: #Lymphocytes

https://xkcd.com/2749/

#xkcd: #Lymphocytes

https://xkcd.com/2749/

#xkcd: #Lymphocytes

https://xkcd.com/2749/

#xkcd: #Lymphocytes

https://xkcd.com/2749/

#xkcd: #Lymphocytes

https://xkcd.com/2749/

"T cell-specific Ahr knockout leads to recovery driven by a decrease in T cell fitness...Our study demonstrates a newly emerging role for aryl hydrocarbon receptor (AHR) in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002000#:~:text=Our%20study%20demonstrates%20a%20newly%20emerging%20role%20for%20AHR%20in%20mediating%20the%20interdependence%20between%20T%20lymphocytes%20and%20the%20microbiota%2C%20while%20simultaneously%20identifying%20new%20potential%20molecular%20targets%20for%20the%20treatment%20of%20MS%20and%20other%20autoimmune%20diseases.

#multiplesclerosis #lymphocytes #autoimmune