#drugresistance — Public Fediverse posts

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

https://www.europesays.com/britain/27364/ Economic evaluation of artificial intelligence for cancer detection in the UK breast screening programme #Biomedicine #CancerResearch #DrugResistance #Epidemiology #general #HealthCareEconomics #HealthPolicy #MolecularMedicine #Oncology #PopulationScreening #UK #UnitedKingdom

https://www.europesays.com/ie/452010/ Fred Hutch study dramatically expands therapeutic range of approved kinase drugs #BrainCancer #DnaMutation #DrugResistance #Éire #Glioblastoma #HumanBiology #IE #Ireland #Kinase #LungCancer #RareCancers #TaranGujral #Technology

https://www.europesays.com/uk/880640/ Implementing whole genome and transcriptome sequencing for cancer patients in routine healthcare: a comprehensive guide to costing #Biomedicine #CancerGenomics #CancerResearch #DrugResistance #Epidemiology #general #Health #Healthcare #MolecularMedicine #oncology #TumourBiomarkers #UK #UnitedKingdom

https://www.europesays.com/ie/425770/ Implementing whole genome and transcriptome sequencing for cancer patients in routine healthcare: a comprehensive guide to costing #Biomedicine #CancerGenomics #CancerResearch #DrugResistance #Éire #Epidemiology #general #Health #HealthCare #Healthcare #IE #Ireland #MolecularMedicine #oncology #TumourBiomarkers

Implementing whole genome and transcriptome sequencing for cancer patients in routine healthcare: a comprehensive guide to costing

Kazdal D, Endris V, Allgauer M, Kriegsmann M, Leichsenring J, Volckmar AL, et al. Spatial and temporal heterogeneity…
#NewsBeep #News #Healthcare #AU #Australia #Biomedicine #Cancergenomics #CancerResearch #DrugResistance #epidemiology #general #Health #MolecularMedicine #oncology #Tumourbiomarkers
https://www.newsbeep.com/au/593049/

Implementing whole genome and transcriptome sequencing for cancer patients in routine healthcare: a comprehensive guide to costing

Kazdal D, Endris V, Allgauer M, Kriegsmann M, Leichsenring J, Volckmar AL, et al. Spatial and temporal heterogeneity…
#NewsBeep #News #Healthcare #AU #Australia #Biomedicine #Cancergenomics #CancerResearch #DrugResistance #epidemiology #general #Health #MolecularMedicine #oncology #Tumourbiomarkers
https://www.newsbeep.com/au/593049/

Vegetarian diets and cancer risk: pooled analysis of 1.8 million women and men in nine prospective studies on three continents

Study population The study design and data harmonisation process have been described in detail elsewhere [17]. Briefly, prospective…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #Biomedicine #Cancerepidemiology #CancerResearch #DrugResistance #Epidemiology #general #MolecularMedicine #Oncology
https://www.newsbeep.com/us/493443/

India Fights Harder Against Superbugs

https://newsletter.tf/india-superbugs-medicine-resistance/

India faces a big problem with superbugs that resist medicine. Learn how the country is trying to stop them and why it matters for everyone.

#Superbugs, #IndiaHealth, #Antibiotics, #OneHealth, #DrugResistance

India's Growing Battle Against Superbugs: A Complex Challenge

https://newsletter.tf/india-superbugs-medicine-resistance/

India is battling superbugs, germs resistant to medicine, with a 'One Health' plan and new drug development.

#Superbugs, #IndiaHealth, #Antibiotics, #OneHealth, #DrugResistance

India Fights Harder Against Superbugs

India is working hard to fight superbugs, which are germs that don't die with normal medicine. This is a serious health issue. The country is using a plan called 'One Health' to help protect people, animals, and the environment. New medicines are also being made to help.

https://newsletter.tf/india-superbugs-medicine-resistance/

#Superbugs, #IndiaHealth, #Antibiotics, #OneHealth, #DrugResistance

The Guardian view on antibiotics: recent breakthroughs are great news, but humanity is losing the bigger race | Editorial https://www.theguardian.com/commentisfree/2025/dec/29/the-guardian-view-on-antibiotics-recent-breakthroughs-are-great-news-but-humanity-is-losing-the-bigger-race #Antibiotics #Drugs #Science #DrugResistance #Health #InfectiousDiseases #Gonorrhoea #MedicalResearch #PharmaceuticalsIndustry #Doctors #WorldHealthOrganization #ArtificialIntelligenceAi #...

The Guardian view on antibiotics: recent breakthroughs are great news, but humanity is losing the bigger race | Editorial https://www.theguardian.com/commentisfree/2025/dec/29/the-guardian-view-on-antibiotics-recent-breakthroughs-are-great-news-but-humanity-is-losing-the-bigger-race #Antibiotics #Drugs #Science #DrugResistance #Health #InfectiousDiseases #Gonorrhoea #MedicalResearch #PharmaceuticalsIndustry #Doctors #WorldHealthOrganization #ArtificialIntelligenceAi #...

The Guardian view on antibiotics: recent breakthroughs are great news, but humanity is losing the bigger race | Editorial https://www.theguardian.com/commentisfree/2025/dec/29/the-guardian-view-on-antibiotics-recent-breakthroughs-are-great-news-but-humanity-is-losing-the-bigger-race #Antibiotics #Drugs #Science #DrugResistance #Health #InfectiousDiseases #Gonorrhoea #MedicalResearch #PharmaceuticalsIndustry #Doctors #WorldHealthOrganization #ArtificialIntelligenceAi #...

The Guardian view on antibiotics: recent breakthroughs are great news, but humanity is losing the bigger race | Editorial https://www.theguardian.com/commentisfree/2025/dec/29/the-guardian-view-on-antibiotics-recent-breakthroughs-are-great-news-but-humanity-is-losing-the-bigger-race #Antibiotics #Drugs #Science #DrugResistance #Health #InfectiousDiseases #Gonorrhoea #MedicalResearch #PharmaceuticalsIndustry #Doctors #WorldHealthOrganization #ArtificialIntelligenceAi #...

The Guardian view on antibiotics: recent breakthroughs are great news, but humanity is losing the bigger race | Editorial https://www.theguardian.com/commentisfree/2025/dec/29/the-guardian-view-on-antibiotics-recent-breakthroughs-are-great-news-but-humanity-is-losing-the-bigger-race #Antibiotics #Drugs #Science #DrugResistance #Health #InfectiousDiseases #Gonorrhoea #MedicalResearch #PharmaceuticalsIndustry #Doctors #WorldHealthOrganization #ArtificialIntelligenceAi #...

New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea https://www.theguardian.com/global-development/2025/dec/16/health-antibiotic-resistance-drugs-superbugs-sexually-transmitted-gonorrhoea #Pharmaceuticalsindustry #WorldHealthOrganization #Infectiousdiseases #Globaldevelopment #Fertilityproblems #Medicalresearch #Drugresistance #Globalhealth #Sexualhealth #Microbiology #Gonorrhoea #Worldnews #Business #Society #Science #Health #USnews #Drugs

New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea https://www.theguardian.com/global-development/2025/dec/16/health-antibiotic-resistance-drugs-superbugs-sexually-transmitted-gonorrhoea #Pharmaceuticalsindustry #WorldHealthOrganization #Infectiousdiseases #Globaldevelopment #Fertilityproblems #Medicalresearch #Drugresistance #Globalhealth #Sexualhealth #Microbiology #Gonorrhoea #Worldnews #Business #Society #Science #Health #USnews #Drugs

New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea https://www.theguardian.com/global-development/2025/dec/16/health-antibiotic-resistance-drugs-superbugs-sexually-transmitted-gonorrhoea #Pharmaceuticalsindustry #WorldHealthOrganization #Infectiousdiseases #Globaldevelopment #Fertilityproblems #Medicalresearch #Drugresistance #Globalhealth #Sexualhealth #Microbiology #Gonorrhoea #Worldnews #Business #Society #Science #Health #USnews #Drugs

New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea https://www.theguardian.com/global-development/2025/dec/16/health-antibiotic-resistance-drugs-superbugs-sexually-transmitted-gonorrhoea #Pharmaceuticalsindustry #WorldHealthOrganization #Infectiousdiseases #Globaldevelopment #Fertilityproblems #Medicalresearch #Drugresistance #Globalhealth #Sexualhealth #Microbiology #Gonorrhoea #Worldnews #Business #Society #Science #Health #USnews #Drugs

New antibiotics hailed as ‘turning point’ in treating drug-resistant gonorrhoea https://www.theguardian.com/global-development/2025/dec/16/health-antibiotic-resistance-drugs-superbugs-sexually-transmitted-gonorrhoea #Pharmaceuticalsindustry #WorldHealthOrganization #Infectiousdiseases #Globaldevelopment #Fertilityproblems #Medicalresearch #Drugresistance #Globalhealth #Sexualhealth #Microbiology #Gonorrhoea #Worldnews #Business #Society #Science #Health #USnews #Drugs

Antibiotic resistance: how a pioneering trial is using old drugs to save babies from sepsis https://www.theguardian.com/global-development/2025/nov/25/antibiotic-resistance-trial-kemri-old-drugs-babies-newborn-sepsis #Globaldevelopment #Medicalresearch #Drugresistance #Globalhealth #Antibiotics #Children #Society #Science #Sepsis #Africa #Health

🔬 Could a tiny imbalance in ATP binding be the key to drug resistance in cancer?

🔗 Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.064

📚 CSBJ: https://www.csbj.org/

#DrugResistance #MolecularDynamics #StructuralBiology #MembraneProteins #CancerResearch #Pharmacology #DrugDiscovery #ChemotherapyResistance #ProteinDynamics #Pgp #ABCB1 #Biophysics

Deaths linked to antibiotic-resistant superbugs rose 17% in England in 2024 https://www.theguardian.com/society/2025/nov/13/deaths-linked-to-antibiotic-resistant-superbugs-rose-17-in-england-in-2024 #Drugresistance #Antibiotics #Science #Society #England #Health #UKnews #Drugs #NHS

"Across the world, the spread of dangerous infections that do not respond to antibiotics has been increasing by as much as 15 percent a year, affecting treatment for urinary tract infections, gonorrhea, E. coli and other pathogens that kill millions of people annually, according to a report released Monday by the World Health Organization.

The report documents how countries are grappling with the challenge of so-called antimicrobial resistance. It found that one in six infections in 2023 was resistant to the current roster of antibiotic drugs. The drug resistance involves 40 percent of the most common antibiotics used against these infections.

Southeast Asia and the eastern Mediterranean had the highest rates of resistance, with one in three infections resistant to antibiotics. That is roughly double the worldwide average and more three times the rates in Europe and the Western Pacific.
Overall, antimicrobial resistance was more prevalent in low- and middle-income countries, especially those with weak health care systems."

https://www.nytimes.com/2025/10/13/health/who-antibiotic-drug-resistance.html

#WHO #Antibiotics #DrugResistance #PublicHealth

Unintended #chemotherapy consequences can drive #drugresistance

https://www.nature.com/articles/d42473-025-00242-3

Always a privilege, when we can contribute to research projects with our RCCL collection cell lines. #Cancer #Resistance #DrugResistance

https://www.nature.com/articles/s41420-025-02740-1

Postdoctoral Associate Position at University of Pittsburgh
University of Pittsburgh

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-pittsburgh-27778-postdoctoral-associate-position-at-university-of-pittsburgh/

#cancer #drugresistance #mousegenetics #prostatecancer #proteinkinase #signaltransduction #stroke #ScienceJobs #hiring #res...
https://jobrxiv.org/job/university-of-pittsburgh-27778-postdoctoral-associate-position-at-university-of-pittsburgh/?fsp_sid=3714

Postdoctoral Associate Position at University of Pittsburgh
University of Pittsburgh

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-pittsburgh-27778-postdoctoral-associate-position-at-university-of-pittsburgh/

#cancer #drugresistance #mousegenetics #prostatecancer #proteinkinase #signaltransduction #stroke #ScienceJobs #hiring #res...
https://jobrxiv.org/job/university-of-pittsburgh-27778-postdoctoral-associate-position-at-university-of-pittsburgh/?fsp_sid=3154

Laboratory Sciences Professional (Open Rank: Entry to Senior)
University of Colorado Anschutz Medical Campus

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-colorado-anschutz-medical-campus-27778-laboratory-sciences-professional-open-rank-entry-to-senior/

#breastcancer #cancerbiology #drugresistance #multiomics ...
https://jobrxiv.org/job/university-of-colorado-anschutz-medical-campus-27778-laboratory-sciences-professional-open-rank-entry-to-senior/?fsp_sid=2769

Laboratory Sciences Professional (Open Rank: Entry to Senior)
University of Colorado Anschutz Medical Campus

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-colorado-anschutz-medical-campus-27778-laboratory-sciences-professional-open-rank-entry-to-senior/

#breastcancer #cancerbiology #drugresistance #multiomics #...
https://jobrxiv.org/job/university-of-colorado-anschutz-medical-campus-27778-laboratory-sciences-professional-open-rank-entry-to-senior/?fsp_sid=956

Laboratory Sciences Professional (Open Rank: Entry to Senior)
University of Colorado Anschutz Medical Campus

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-colorado-anschutz-medical-campus-27778-laboratory-sciences-professional-open-rank-entry-to-senior/

#breastcancer #cancerbiology #drugresistance #multiomics #...
https://jobrxiv.org/job/university-of-colorado-anschutz-medical-campus-27778-laboratory-sciences-professional-open-rank-entry-to-senior/?fsp_sid=410

https://www.europesays.com/uk/210493/ India restricts sale of off-patent TB medicines to government channels to combat drug resistance #Bedaquiline #DCGI #Delamanid #DrugResistance #Health #India #Isoniazid #Medication #RestrictedSale #Rifapentine #TBDrugs #Tuberculosis #UK #UnitedKingdom

#Fungal infections are hard to treat due to #DrugResistance. @blake_billmyre &co use a high-throughput #TNseq system in #Cryptococcus neoformans to identify >1400 essential genes & reveal a role for #mitochondrial genes in #fluconazole sensitivity @PLOSBiology https://plos.io/4dz3iVm

AI chatbot deployed to target drug resistance
#Tech #Health #AI #AMR #DrugResistance #GlobalHealth #HealthTech #OneHealth #PolicyInnovation #Healthcare #LowIncomeCountries #TechnologyForGood #Chatbot
https://the-14.com/ai-chatbot-deployed-to-target-drug-resistance/

On the worsening #AntiMalarial #DrugResistance in #Africa

#malaria #drugs #artemisinin #PlasmodiumFalciparum #Plasmodium #falciparum #protozoa #Anopheles #mosquito

https://www.dw.com/en/africa-antimalarial-drug-resistance-on-the-rise/a-64306141

New paper collab with WPI!

"A correlative study of the genomic underpinning of virulence traits and drug tolerance of Candida auris"

https://journals.asm.org/doi/10.1128/iai.00103-24

#bioinformatics #rnaseq #genomics #drugresistance #candida #PathogenGenomics #hostpathogen

Experts sound the alarm over #drugresistant #fungal infection detected in US

Story by Matthew Dooley, December 4, 2023

"Experts are sounding the alarm about a highly contagious #fungaldisease that's becoming resistant to common drugs. They warn this could make illnesses like #thrush much harder to treat.

"Medical professionals have warned that the world is not prepared for the growing threat of fungal infections.

"These can range from common conditions like #ringworm and thrush to life-threatening bloodstream infections caused by #CandidaAlbicans and #CandidaAuris.

"David Denning, a professor at the University of Manchester, previously spoke to The Mirror about a drug-resistant form of #ringworm. He explained how this fungus can easily spread in schools and homes.

"He said: 'Skin fungal infections are transmitted from one person to another in schools, homes and with intimate contact. This new #TerbinafineResistant fungus is a new species called #TrichophytonIndotineae and [was] first identified in India.

"Experts believe the rise in resistant fungi is due to overuse of over-the-counter #antifungal creams, misuse of #TopicalSteroid creams, incorrect prescription of antifungal drugs, as well as patients not sticking to prescribed courses of antifungal medication."

Full article: https://www.msn.com/en-us/health/medical/experts-sound-the-alarm-over-drug-resistant-fungal-infection-detected-in-us/ar-AA1kYAGN?rc=1&ocid=winp1taskbar&cvid=385d94e96b274f72942909e01780ddbc&ei=5

#Fungal #DrugResistance

One more dead in horrific eye drop outbreak that now spans 18 states - Enlarge (credit: Getty | UniversalImagesGroup)

Another person ... - https://arstechnica.com/?p=1940772 #pseudomonasaeruginosa #drugresistance #eyeinfection #globalpharma #vim-ges-crpa #blindness #bacteria #eyedrops #ezricare #outbreak #science #health #delsam #death #cdc #fda

Two more dead as patients report horrifying details of eye drop outbreak - Enlarge (credit: Getty | UniversalImagesGroup)

Two more people... - https://arstechnica.com/?p=1926844 #pseudomonasaeruginosa #infectiousdisease #drugresistance #antibiotics #infection #eyedrops #ezricare #outbreak #science #cdc #eye #fda

Extremely drug-resistant germ found in eye drops infects 55 in 12 states; 1 dead - Enlarge (credit: Getty | UniversalImagesGroup)

This story will... - https://arstechnica.com/?p=1914592 #extensivelydrugresistant #pseudomonasaeruginosa #artificialtears #drugresistance #delsampharma #eyeinfection #publichealth #vim-ges-crpa #infection #ezricare #outbreak #science #death

#Shigella infections known as shigellosis can cause a #fever, abdominal #cramping, tenesmus and #diarrhea that is #bloody.
The bacteria can be spread by a fecal-oral route, person-to-person contact, and contaminated food and water.
While typically shigellosis affects young children, the CDC says it has started to see more of the #antimicrobial-#resistant infections in adult populations – especially in men who have sex with men, people experiencing homelessness, international travelers and people living with HIV.
#drugresistance #shingella #cdc

Hi tooters, time for a belated #introduction.

I work on the #EvolutionaryEcology of host-parasite interactions using #Malaria as a model system. I mostly work on #AvianMalaria, but I occasionally dabble in human and #RodentMalaria.

I’m particularly interested in exploring the genetic and environmental sources of heterogeneity in parasite #Virulence and within-host dynamics. Also keen on #DrugResistance and parasite #PhenotypicPlasticity. Oh, and #Mosquitos, obviously 😎

A great read on #DrugResistance in #cancer, in Nature, by Vasan, Baselga, and Hyman. Sure, 2019 is four years ago, so there will be updates, e.g. on mapping #CancerDependency or the role of #ctDNA in early detection or monitoring. But the framework for understanding drug resistance is here.

https://www.nature.com/articles/s41586-019-1730-1

Although it doesn't say it, I think it may be #OpenAccess since I'm not logged in to my institution right now but can reach full text anyway.

#tumour #tumor

Super gonorrhea rate quickly triples in China, now 40x higher than US - Enlarge / A billboard from the AIDS Healthcare Foundation is seen on Su... - https://arstechnica.com/?p=2013217 #sexuallytransmittedinfection #antibioticresistance #bacterialinfection #drugresistance #ceftriaxone #antibiotic #gonorrhea #science #health #china #cdc #sti

https://www.iflscience.com/bye-bye-superbugs-new-antibiotic-is-virtually-resistance-proof-75231
#sciencebitches #science #drugresistance #antibiotics