#ctdna — Public Fediverse posts

🩸 Liquid Biopsy - Feb 2026

• Urine biopsies detect minimal residual disease in bladder cancer
• Pan-cancer analysis identifies 14,202 methylation regions for cancer detection
• Multi-omics integration boosts sensitivity in the PROMISE study
• M-PACT classifies pediatric CNS tumors from low-input cfDNA
• High ctDNA tumor fraction linked to worse survival in germ cell tumors
• Hyaluronan mediates CTC clustering in triple-negative breast cancer

https://pir.sh/32p17rmgwv

#LiquidBiopsy #ctDNA

🧪 Liquid Biopsy — Jan 2026

• Post-treatment ctDNA predicts recurrence across multiple cancers
• Baseline mutation status refines prognosis in advanced disease
• CTCs and EV-derived signals guide therapy response

https://pir.sh/A5kgYmGg4m

#LiquidBiopsy #ctDNA

B.C. research: New blood test could 'transform' cancer treatment | CTV News https://bc.ctvnews.ca/new-blood-test-could-transform-cancer-treatment-b-c-research-1.6006877 https://bc.ctvnews.ca/mobile/new-blood-test-could-transform-cancer-treatment-b-c-research-1.6006877?cache=yesclipId10406200text/html;charset=utf-80404/7.263352 “researchers at #BCCancer and the Vancouver #Prostate Centre said they've developed a new blood test that provides "unprecedented" insight into a patient's cancer make-up.

"analyzes the DNA that #metastatic #cancers shed into the bloodstream, known as circulating tumour DNA or #ctDNA,"

helps to reveal characteristics that are unique to each patient's cancer, “

Moving from the simplistic definition of #ESR1 and #PIK3CA mutated metastatic #BreastCancer to a more granular resolution of single codon variants thanks to #ctDNA and #LiquidBiopsy for a more precise biological and clinical profiling of #MBC

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-023-01718-0

A great read on #DrugResistance in #cancer, in Nature, by Vasan, Baselga, and Hyman. Sure, 2019 is four years ago, so there will be updates, e.g. on mapping #CancerDependency or the role of #ctDNA in early detection or monitoring. But the framework for understanding drug resistance is here.

https://www.nature.com/articles/s41586-019-1730-1

Although it doesn't say it, I think it may be #OpenAccess since I'm not logged in to my institution right now but can reach full text anyway.

#tumour #tumor

Please RT: #WeAreHiring - Exciting 2yr #postdoc on
@AlCRIproject
funded by
@hea_irl
on #liquidbiopsies (#CTCs #EV #ctDNA), #vibrationalspectroscopy (#Raman #FTIR) and #machinelearning for #cancer in collaboration with
@CluB_Cancer1
Deadline 24 July! https://euraxess.ie/jobs/122141

What is the role of palbociclib and #ctDNA in patients with HER2-positive #BreastCancer with active brain metastases? Results from a phase II single-arm study. #PrecisionMedicine #bcsm #liquidbiopsy

https://www.clinical-breast-cancer.com/article/S1526-8209(22)00283-X/fulltext

#ESR1 mutations in the docking site of Selective Estrogen Receptor Degraders and Modulators #SERD differentially impact on drug affinity across agents. Integrating #ctDNA and #pharmacodynamics. #PrecisionMedicine #BreastCancer

#introductions

Hi, I'm a Senior Bioinformatician at SAGA Diagnostics working on #cancer diagnostics, #genomics, #ctDNA, and #liquidbiopsy. I did my PhD at Lund University working on large-scale #breastcancer #transcriptomics, and I’m still affiliated with LU working on cancer-related projects.

Before #bioinformatics I worked a lot on the #FreeBSD operating system. Nowadays I mostly contribute to #Bioconda (core team), #condaforge (R stack co-maintainer), and other bioinf / #datasci projects.