#alternativesplicing — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #alternativesplicing, aggregated by home.social.
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Postdoctoral Fellow - RNA Biology, Functional Genomics
National Cancer InstituteSee the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-institute-27778-postdoctoral-fellow-rna-biology-functional-genomics/
#alternativesplicing #cancer #functionalgenomics #premRNAsplicingregulation #rnabiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/national-cancer-institute-27778-postdoctoral-fellow-rna-biology-functional-genomics/?fsp_sid=11609 -
Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @PLOSBiology plos.io/4tjuKgI
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https://www.europesays.com/ie/283298/ Source of gastrointestinal problems in myotonic dystrophy #AlternativeSplicing #digestion #DM1 #DMPK #Éire #GastrointestinalDysmotility #GI #Health #IE #Ireland #MBNL #MuscleBlindLike #MyotonicDystrophyType1 #PNAS #ProceedingsOfTheNationalAcademyOfSciences #RNA #SmoothMuscle #Stomach #ThomasCooper
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🧬 Can combining LLMs with full-length RNA isoforms unlock hidden cellular diversity?
🔗 Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.008
📚 CSBJ: https://www.csbj.org/
#LargeLanguageModels #Genomics #CellBiology #SingleCellRNASequencing #AlternativeSplicing #LLMs #SystemsBiology
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Postdoctoral Scholar in Molecular Neuroscience and RNA Biology
The University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/
#alternativesplicing #neurodevelopmentaldisorders #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/?fsp_sid=5261 -
Postdoctoral Scholar in Molecular Neuroscience and RNA Biology
The University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/
#alternativesplicing #neurodevelopmentaldisorders #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/?fsp_sid=3616 -
Postdoctoral Scholar in Molecular Neuroscience and RNA Biology
The University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/
#alternativesplicing #neurodevelopmentaldisorders #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/?fsp_sid=3427 -
Postdoctoral Scholar in Molecular Neuroscience and RNA Biology
The University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/
#alternativesplicing #neurodevelopmentaldisorders #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/?fsp_sid=2013 -
Postdoctoral Scholar in Molecular Neuroscience and RNA Biology
The University of ChicagoSee the full job description on jobRxiv: https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/
#alternativesplicing #neurodevelopmentaldisorders #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-university-of-chicago-27778-postdoctoral-scholar-in-molecular-neuroscience-and-rna-biology/?fsp_sid=921 -
Interesting.
From the original research article*:
"...we inferred that the AluY insertion may mediate an alternative splicing (AS) event of the hominoid TBXT in an unusual way. This AluY element is not inserted in the vicinity of a splice site; instead, it is >500 bp from exon 6 of TBXT, the nearest coding exon (Fig. 1b). As such, it would not be expected, by itself, to lead to an AS event, as found for other individual intronic Alu elements near exon boundaries that directly affect splicing32,33,34. However, we noted the presence of another Alu element (AluSx1) in the reverse orientation in intron 5 of TBXT that is shared among all monkeys and apes (simians). Together, the AluY and AluSx1 elements form an exon-flanking inverted repeat pair (Fig. 1b). We therefore posited that during transcription, the hominoid-specific AluY element pairs with the simian-shared AluSx1 element to form a stem–loop structure in TBXT pre-mRNA and traps exon 6 in the loop (Fig. 1c). An inferred model of the RNA secondary structure supported the interaction between these two Alu elements35 (Extended Data Fig. 2). The secondary structure of the transcript may conjoin the splice donor and receptor site of exons 5 and 7, respectively, and promote the skipping of exon 6, thereby leading to a hominoid-specific and in-frame AS isoform: TBXTΔexon6 (Fig. 1c). "
* https://www.nature.com/articles/s41586-024-07095-8
#Genetics #AlternativeSplicing #SpinalCord #NeuralTubeDefects
#SpinaBifida #TetheredCord -
#AlternativeSplicing during development. #scRNAseq of mouse #oocyte to #blastocyst reveals large-scale isoform switching & #TransposableElement regulation during the maternal-to-zygotic gene transition #PLOSBiology https://plos.io/4bBFFu1
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#PopGen #EvolMol #ThalerConference #MustWatch #AlternativeSplicing #SplicingErrors #DriftBarrier Amazing talk by @duret_lbbe here on the SEEM youtube channel 👇
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#PopGen #EvolMol #ThalerConference #MustWatch #AlternativeSplicing #SplicingErrors #DriftBarrier Amazing talk by @duret_lbbe here on the SEEM youtube channel 👇
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#PopGen #EvolMol #ThalerConference #MustWatch #AlternativeSplicing #SplicingErrors #DriftBarrier Amazing talk by @duret_lbbe here on the SEEM youtube channel 👇
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#PopGen #EvolMol #ThalerConference #MustWatch #AlternativeSplicing #SplicingErrors #DriftBarrier Amazing talk by @duret_lbbe here on the SEEM youtube channel 👇
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Just read "Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans" by Benitiere et al @duret_lbbe, very nice and careful argument that most alternative splicing in e.g. vertebrates is non functional and accumulates neutrally. https://doi.org/10.1101/2022.12.09.519597 #MolecularEvolution #AlternativeSplicing #Neutralism