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#functionalgenomics — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #functionalgenomics, aggregated by home.social.

  1. 🐰🧬 The Easter bunny delivered early! The March 2026 Gene Ontology release is here with some impressive goodies:

    📊 38,560 GO terms
    🔬 8,883,119 annotations
    🌍 5,557 species
    💾 1,703,116 gene products

    Your functional genomics just got a spring upgrade! Whether you're doing pathway analysis or comparative studies, this release has you covered.

    🔗 current.geneontology.org
    💬 community.alliancegenome.org/t

    #GeneOntology #Bioinformatics #OpenScience #FunctionalGenomics #Research #OpenData #AcademicMastodon

  2. #Candida albicans is a leading opportunistic fungal #pathogen of humans. Ci Fu, Leah Cowen &co expand the GRACE #Calbicans #FunctionalGenomics resource, identifying genes important for temperature-dependent fitness & highlighting its power to reveal vulnerabilities @PLOSBiology plos.io/3Wft0Xg

  3. 🧬 How do AlphaFold2 and ESMFold stack up when it comes to functional annotation?

    🔗 AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2025.01

    📚 CSBJ: csbj.org/

    #AlphaFold2 #ESMFold #AIinScience #ProteinStructure #Enzymes #Pfam #UniProt #AlphaFold #HumanProteome #FunctionalAnnotation #AIinBiology #ComputationalBiology #FunctionalGenomics

  4. That's a wrap! Sally Temple, Taylor Bertucci and Kate Tubbesing all spoke at the annual #NIHfunded Alzheimer's Disease Sequencing Project #FunctionalGenomics meeting at the @Gladstone Institutes.

    #ADSP #FunGen #Alzheimers
    #organoid #neurovascular

  5. Today, I reread Fulco et al's 2019 paper on "Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbation" nature.com/articles/s41588-019 Still one of my favorites, because the authors combined innovative functional genomics with down-to-earth computational approaches - and obtained a highly usable method to predict enhancer -> gene interactions (the ABC model). #functionalgenomics #epigenetics #literature #science

  6. A Commentary by Lars Steinmetz & Daniel Schraivogel discusses the technical advancements made by image-enabled cell sorting & highlights new experimental strategies in #functionalgenomics & #singlecell research ➡️ bit.ly/3lyFeLv
    #SystemsBiology

  7. It's been years in the making (literally, my PR was ~ two years old 😅 ), but I finally updated Crispulator.jl to work with #julialang 1.0+.

    It's ready to help you simulate your pooled #CRISPR screens for #functionalgenomics so that you can make sure they'll work before you pour many months into them!

    Check out the refreshed docs: tamasnagy.com/Crispulator.jl/d

  8. #introduction
    Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
    Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
    I mainly do #ComputationalBiology and supervise a team that does the wet work.
    Trying to create a focused work engagement in this account

  9. #introduction
    Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
    Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
    I mainly do #ComputationalBiology and supervise a team that does the wet work.
    Trying to create a focused work engagement in this account

  10. #introduction
    Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
    Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
    I mainly do #ComputationalBiology and supervise a team that does the wet work.
    Trying to create a focused work engagement in this account