#spinalcord — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #spinalcord, aggregated by home.social.
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Postdoctoral Fellow - Spinal Cord Injury/Animal Model
University of ArizonaSee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-arizona-27778-postdoctoral-fellow-spinal-cord-injury-animal-model/
#animalmodels #biomaterials #cellculture #neurotrauma #spinalcord #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-arizona-27778-postdoctoral-fellow-spinal-cord-injury-animal-model/?fsp_sid=11345 -
Hi #neuromastodon, today the latest preprint of an extremely cool, 100% Uruguay-based team has been released :mate:
A filopodia-based dendritic mechanosensory compartment in CSF-contacting neurons
There we show that, contrary to what zebrafish has taught, these spinal cord neurons from adult mice (CSF-cN) lack cilia. Furthermore, they show multiple filopodia and are able to sense mechanical stimuli through PKD2L1. That, and other nice stuff.
If you didn't know what to read this weekend, here you have it:
https://www.biorxiv.org/content/10.64898/2026.04.09.713694v1
Hope you enjoy it.
#neuro #neurons #spinal #spinalcord #cellbiology #biology #uruguay #science #research #preprint #openaccess #microscopy #electrophysiology #neuroscience #iibce #pedeciba
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Otro pequeño orgullo de nuestro laboratorio del #iibce ya está en @biorxiv_neursci .
Un importante volumen de trabajo sobre las conexinas en la reparación de la médula espinal.
Gran equipo #MadeInUruguay lo hizo posible, gracias a financiación extranjera de #WingsForLife.#neuroscience #neuromastodon #medulaeespinal #conexinas #neurociencia #biology #biologia #investigacion #ciencia #Uruguay #spinalcordinjury #spinalcord #research #pedeciba @SocNeuroUy #preprint #biorxiv
https://www.biorxiv.org/content/10.64898/2026.01.16.699895v1.full.pdf+html
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🧠 New paper by Wimalasena, Pandarinath, AuYong et al: #spinal #interneuron populations form a low-dimensional #manifold that robustly organizes step cycles.
Distinct regions of the manifold mark flexion–extension transitions, and a specific “hold region” tightly controls cycle duration. Deletions emerge as failures to enter the flexor region, giving a dynamical signature of disrupted CPG function.
🌍 https://doi.org/10.1038/s41467-025-64629-y
#Neuroscience #Locomotion #SpinalCord #PopulationDynamics #CompNeuro
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🐟 Zebrafish can heal spinal cord
A research team at the University of Cologne has discovered that zebrafish can regenerate their spinal cord after an injury and restore their motor function. The findings could provide a long-term approach for developing therapies for humans.Read more ▶️ https://uni.koeln/ML6WN
📰 https://www.sciencedirect.com/science/article/pii/S2211124725012409
#uniköln #unicologne #Research #Zebrafish #SpinalCord #Healing #Therapy
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Feel like I’ve been run over by a bus. Currently back in bed trying to rest.
Spinal cord injury is a right pain, but I try not to feel sorry for myself. There are people with bigger problems than mine.
If only every day was predictable, this is probably the worst I felt for a month or so, normally the Gabapentin keeps a lid on things.
Going to force myself out in the car to go and buy some farm cider, and enjoy the drive with the roof down.
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Non-invasive zaps to the spinal cord can treat paralysis—but no one knows why - Enlarge / Trial participant Sherown Campbell manipulating a Rubik's Cub... - https://arstechnica.com/?p=2026123 #spinalcordinjury #non-invasive #quadriplegia #tetraplegia #spinalcord #stimulator #paralysis #science #health #hand #arm
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Interesting.
From the original research article*:
"...we inferred that the AluY insertion may mediate an alternative splicing (AS) event of the hominoid TBXT in an unusual way. This AluY element is not inserted in the vicinity of a splice site; instead, it is >500 bp from exon 6 of TBXT, the nearest coding exon (Fig. 1b). As such, it would not be expected, by itself, to lead to an AS event, as found for other individual intronic Alu elements near exon boundaries that directly affect splicing32,33,34. However, we noted the presence of another Alu element (AluSx1) in the reverse orientation in intron 5 of TBXT that is shared among all monkeys and apes (simians). Together, the AluY and AluSx1 elements form an exon-flanking inverted repeat pair (Fig. 1b). We therefore posited that during transcription, the hominoid-specific AluY element pairs with the simian-shared AluSx1 element to form a stem–loop structure in TBXT pre-mRNA and traps exon 6 in the loop (Fig. 1c). An inferred model of the RNA secondary structure supported the interaction between these two Alu elements35 (Extended Data Fig. 2). The secondary structure of the transcript may conjoin the splice donor and receptor site of exons 5 and 7, respectively, and promote the skipping of exon 6, thereby leading to a hominoid-specific and in-frame AS isoform: TBXTΔexon6 (Fig. 1c). "
* https://www.nature.com/articles/s41586-024-07095-8
#Genetics #AlternativeSplicing #SpinalCord #NeuralTubeDefects
#SpinaBifida #TetheredCord -
Walking naturally after spinal cord injury using a brain–spine interface
A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis. Here, we restored this communication with a digital bridge between the brain and spinal cord that enabled an individual with chronic tetraplegia to stand and walk naturally in community settings.
#Neuroscience #Neurology #Brain #SpinalCord #SpinalCordInjury #Paralysis #BrainSpineInterface #DigitalBridge #Neurotechnology #Neurotech
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Wireless Brain-Spine Interface: A Leap Towards Reversing Paralysis
Researchers have designed a wireless brain-spine interface enabling a paralyzed man to walk naturally again. The ‘digital bridge’ comprises two electronic implants — one on the brain and another on the spinal cord — that decode brain signals and stimulate the spinal cord to activate leg muscles.
Remarkably, the patient experienced significant recovery in sensory perceptions and motor skills.#Neuroscience #Neurology #Brain #SpinalCord #SpinalCordInjury #Paralysis #BrainSpineInterface #DigitalBridge #Neurotechnology #Neurotech
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Features That May Make Motor Neurons Vulnerable to ALS
Motor neurons are distinguished by a set of genes that may enable the large size of the motor neuron cell body and lengthy axon, but also underlie their vulnerability to degeneration. Their molecular profile was defined by genes involved in cytoskeletal structure, which gives the cell shape and organizes the structures within; neurofilament genes related to cell size; and genes linked to the onset of ALS.
#Neuroscience #SpinalCord #Neuron #Motorneuron #MotorneuronDisease #ALS #NeurodegenerativeDiseases #NeurologicalDiseases #Transcriptomics
https://neurosciencenews.com/als-motor-neurons-genetics-22436/
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When building an embryo, timing is everything - The repeated light and dark pattern you can see down the side of this embryo is caused by the prese... - https://arstechnica.com/?p=1707953 #developmentalbiology #spinalcord #vertebrae #science #biology #embryo
