#zebrafish — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #zebrafish, aggregated by home.social.
-
Light just made a fish’s heart beat faster
Scientists used a laser to vibrate a fish’s ear stone—without making any sound—and still sent its heart rate soaring.
-
Axon diameter is important for neuronal conduction speed, but how is it regulated? This study reports a high-resolution imaging-based chemical screening pipeline for a #zebrafish #axon, identifying candidate regulators of axon diameter @PLOSBiology https://plos.io/4pufQmL
-
Two of our researchers recently received an NWO ENW grant 🎊 The projects are titled "Turning the toxins of the tubercle bacillus against itself", and "It takes two: Development of bivalent anti-inflammatory corticosteroid drugs". As you can see, our 'green' biology institute is also involved in topics of a more medical nature! Want to know more? Read about the projects on our website: https://www.ru.nl/en/research/research-news/enw-m-and-enw-xs-grants-for-research-into-molecules-malaria-and-more
#microbiology #animalbiology #tubercule #corticosteroids #zebrafish -
Single-molecule #m6A profiling reveals position-dependent #mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis
#zebrafish #nanopore #paper
https://www.biorxiv.org/content/10.64898/2026.07.03.736379v1 -
What are the mechanisms allowing #zebrafish to #regenerate their neurons after spinal cord injury? This study by Alberto Docampo-Seara, Catherine Becker, Thomas Becker &co shows that a protein in #microglia regulates regenerative #neurogenesis in multiple ways
-
#Regeneration of fins and limbs relies on shared cellular playbook
Immune cells, blood and repair #genes act in concert across three regenerating #vertebrates
Team cut fins off #bichirs and tracked #gene activity at wound after one, three and seven days, which revealed types of cells present and activity. Team compared data to similar new and existing data about #axolotl, salamander that regrows limbs, and #zebrafish, a that can regrow tips of fins
https://www.sciencenews.org/article/regeneration-of-fins-and-limbs-relies-on-a-shared-cellular-playbook
https://archive.ph/l7NI2 -
Now diving into the processing and transformation of raw olfactory stimulation of sensory neurons to the output of the olfactory neuropils via projection neurons, see these two papers, one in fly and one in zebrafish. The former shows how PNs respond to the derivative of the input, which is essential for tracking stimuli up a gradient, and the latter shows how the LNs perform a whitening of the olfactory input (to decorrelate the inputs into the otherwise multiply stimulated olfactory receptors and their corresponding sensory neurons) which optimally prepares similar stimuli for separation:
Kim AJ, Lazar AA, Slutskiy YB. Projection neurons in Drosophila antennal lobes signal the acceleration of odor concentrations. Elife. 2015 May 14;4:e06651.
https://elifesciences.org/articles/6651Wanner AA, Friedrich RW. Whitening of odor representations by the wiring diagram of the olfactory bulb. Nature neuroscience. 2020 Mar;23(3):433-42.
https://www.nature.com/articles/s41593-019-0576-z4/4
-
And in flies in particular, all papers signed by Rachel Wilson as the senior author (now a professor at Harvard Medical School) in the early 2000s are absolutely outstanding, on probing with electrophysiology and genetics the various synapses in the fruit fly olfactory system, e.g., the sensory neuron (ORN or OSN, synonyms) to the projection neurons (PNs), or the local neurons (LNs), or the LNs to each other or to the PNs, and the PNs back to the LNs. She's written a couple of reviews on the subject that are very accessible for the curious student.
Click on "Publications" and expand them, to find the ones published in Current Opinion in Neurobiology or in the Annual Review Neuroscience:
https://neuro.hms.harvard.edu/faculty-staff/rachel-wilson... like e.g., this one:
Wilson RI. Early olfactory processing in Drosophila: mechanisms and principles. Annual review of neuroscience. 2013 Jul 8;36(1):217-41.
https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-062111-150533Rachel's more recent work is on neural networks in the fly for spatial navigation.
3/4
-
On that, the work from Lucia Prieto-Godino in (then) Richard Benton's lab on "undead" neurons is critical, demonstrating that, beyond the genes encoding olfactory receptors, there is a much larger pool of pseudogenes (genes that aren't normally expressed) that, when rescued, result in additional, distinct yet functional glomeruli in the first-order neuropil for olfaction (the antennal lobe in an insect; the olfactory bulb in a vertebrate).
Prieto-Godino LL, Silbering AF, Khallaf MA, Cruchet S, Bojkowska K, Pradervand S, Hansson BS, Knaden M, Benton R. Functional integration of “undead” neurons in the olfactory system. Science advances. 2020 Mar 11;6(11):eaaz7238.
https://www.science.org/doi/abs/10.1126/sciadv.aaz7238Lucia is now a lab head at The Crick, studying with comparative connectomics the evolution of olfactory circuits and more, in fruit flies.
2/4
-
An undergraduate student asked me about olfactory sensory processing and this is what I replied. What have I missed of major importance, from the perspective of a senior undergrad?
The olfactory system is indeed fascinating, one that challenged researchers for some time. The first major break through came from Richard Axel's lab by the hand of the then student Leslie Vosshall, now professor at Rockefeller in New York and prominent HHMI Vicepresident and mosquito researcher.
Vosshall LB, Amrein H, Morozov PS, Rzhetsky A, Axel R. A spatial map of olfactory receptor expression in the Drosophila antenna. Cell. 1999 Mar 5;96(5):725-36.
https://www.cell.com/cell/fulltext/S0092-8674(00)80582-6A search for "Vosshall Axel" in Google Scholar will surface related papers:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=vosshall+axel&btnG=A conceptual breakthrough in olfactory coding came from the study of receptors by several groups, in both flies and mice, and later in zebrafish, but what I find compelling is the development of the primacy hypothesis for olfactory receptors by Rinberg's and Koulakov's labs:
Wilson CD, Serrano GO, Koulakov AA, Rinberg D. A primacy code for odor identity. Nature communications. 2017 Nov 14;8(1):1477.
https://www.nature.com/articles/s41467-017-01432-4The above relates to the ability of animals to have a small number of olfactory receptors (like a fly larva) or more (an adult fruit fly) or many more (like moths and bees), or even more (like in a dog's nose), and yet the system works. More receptors support a less coarse encoding of odours, and vice versa. But the system for olfactory sensing is flexible and therefore evolvable.
1/4
-
Very amusing to see how the vertebrate developmental neurobiology field is converging with #Drosophila and insects in general with regard to the mechanisms of brain development:
"Together, these findings suggest a lineage-based mechanism for scalable positional information that complements diffusion-based mechanisms and offers a general framework for tissue patterning."
That sentence has been used for decades to describe fruit fly brain development.
-
Researchers Jolie Smeets and Marnix Gorissen, within the European #HYPIEND project, investigate how endocrine-disrupting chemicals ( #EDCs) affect #hormone regulation and behaviour of individual #zebrafish larvae. They wrote this interesting blog about their work! https://hypiend.eu/swimming-in-chemicals-what-zebrafish-can-teach-us-about-our-health/
-
BiO is proud to partner with the European Zebrafish Society to offer travel grants for the 13th European Zebrafish Meeting (EZM2026) - 7-11 July 2026 in Vienna, Austria. This travel grant is designed to provide financial support for early-career researchers based in the Global South.
More information and an application form can be found on the EZS website: https://www.ezsociety.org/grants-EZM2026
-
23/ 🐠 Dive into the depths of zebrafish development with Zebrahub-Multiome! #DevelopmentalBiology #SingleCell #Multiomics #Zebrafish
-
17/ 🎯 Lastly, Explore #zebrafish 's regulatory landscape of 640K+ chromatin accessibility peaks organized by cell-type and temporal patterns. Each cluster annotated using LLM with motif enrichment, developmental dynamics, and biological context. zebrahub.sf.czbiohub.org/slt?name=mul...
-
#KnowledgeBit: The #Zebrafish, a popular #Aquarium fish, is an important and widely used vertebrate #Model #Organism in scientific research, for example in drug development, in particular pre-clinical development.
It is also notable for its regenerative abilities, and has been modified by researchers to produce many #Transgenic (genetically modified organisms) strains.
-
Wie gestrest is, merkt dat in het lijf: allerlei systemen, zoals het immuunsysteem, worden beïnvloed. Biologen Marcel Schaaf en Erin Faught van de Radboud Universiteit onderzoeken hoe dat werkt. Uit nieuw onderzoek blijkt hoe stress het gedrag verandert door gebruik te maken van twee verschillende receptoren.
Lees meer: https://www.ru.nl/onderzoek/onderzoeksnieuws/stress-kan-een-positief-effect-hebben-op-het-immuunsysteem
#biologie #immuunsysteem #zebravis #zebrafish -
PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of CalgarySee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/
#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=4911 -
🐟 Zebrafish can heal spinal cord
A research team at the University of Cologne has discovered that zebrafish can regenerate their spinal cord after an injury and restore their motor function. The findings could provide a long-term approach for developing therapies for humans.Read more ▶️ https://uni.koeln/ML6WN
📰 https://www.sciencedirect.com/science/article/pii/S2211124725012409
#uniköln #unicologne #Research #Zebrafish #SpinalCord #Healing #Therapy
-
Surprisingly, mouse sperm can locate and swim through the tiny opening in #zebrafish eggs known as the micropyle, suggesting that some mechanisms guiding sperm toward eggs may be shared across distant species.
https://elifesciences.org/digests/106303/cross-species-insemination?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
"Algorithmic dissection of optic flow memory in larval zebrafish", Tanaka & Portgues 2025
https://www.sciencedirect.com/science/article/pii/S0960982225011133 -
Read Biology Open's Issue 8
On the cover: A zebrafish cx41.8tq/tq mutant embryo treated with H202, stained to visualise the expression of gata2b, which marks haemogenic endothelium along the trunk of the embryo.
Read now: https://journals.biologists.com/bio/issue/14/8
#Biology #Research #Zebrafish #Academia #Writing #Communication #Science
-
"Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits", Ruetten et al. 2025 (Misha Ahrens lab)
https://www.biorxiv.org/content/10.1101/2025.08.20.670374v3.full -
Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:
"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2 -
PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of CalgarySee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/
#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=2468 -
How do genes that keep melanocytes alive affect #melanoma?
Using a #zebrafish line with mitfa-driven Cas9, researchers show that knocking out survival genes can sometimes fuel more aggressive tumour traits.
https://elifesciences.org/reviewed-preprints/100257?utm_source=mastdon&utm_medium=social&utm_campaign=organic -
PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of CalgarySee the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/
#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=1761 -
Sensorimotor decision-making in #zebrafish
doi: https://doi.org/10.1101/2025.08.12.669772 -
the second: ''Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1to 3.''; J Toxicol Sci, 2016. https://doi.org/10.2131/jts.41.1
"Physiologically, cytochrome P450 (CYP) enzymes, specifically CYP families 1-3, play a pivotal role in drug metabolism. And yet, information regarding activity of CYP, its isoforms, and conjugation enzymes in zebrafish is either scarce or conflicting."