#zebrafish — Public Fediverse posts

#Regeneration of fins and limbs relies on shared cellular playbook
Immune cells, blood and repair #genes act in concert across three regenerating #vertebrates
Team cut fins off #bichirs and tracked #gene activity at wound after one, three and seven days, which revealed types of cells present and activity. Team compared data to similar new and existing data about #axolotl, salamander that regrows limbs, and #zebrafish, a that can regrow tips of fins
https://www.sciencenews.org/article/regeneration-of-fins-and-limbs-relies-on-a-shared-cellular-playbook
https://archive.ph/l7NI2

Now diving into the processing and transformation of raw olfactory stimulation of sensory neurons to the output of the olfactory neuropils via projection neurons, see these two papers, one in fly and one in zebrafish. The former shows how PNs respond to the derivative of the input, which is essential for tracking stimuli up a gradient, and the latter shows how the LNs perform a whitening of the olfactory input (to decorrelate the inputs into the otherwise multiply stimulated olfactory receptors and their corresponding sensory neurons) which optimally prepares similar stimuli for separation:

Kim AJ, Lazar AA, Slutskiy YB. Projection neurons in Drosophila antennal lobes signal the acceleration of odor concentrations. Elife. 2015 May 14;4:e06651.
https://elifesciences.org/articles/6651

Wanner AA, Friedrich RW. Whitening of odor representations by the wiring diagram of the olfactory bulb. Nature neuroscience. 2020 Mar;23(3):433-42.
https://www.nature.com/articles/s41593-019-0576-z

4/4

#neuroscience #olfaction #Drosophila #mouse #zebrafish

And in flies in particular, all papers signed by Rachel Wilson as the senior author (now a professor at Harvard Medical School) in the early 2000s are absolutely outstanding, on probing with electrophysiology and genetics the various synapses in the fruit fly olfactory system, e.g., the sensory neuron (ORN or OSN, synonyms) to the projection neurons (PNs), or the local neurons (LNs), or the LNs to each other or to the PNs, and the PNs back to the LNs. She's written a couple of reviews on the subject that are very accessible for the curious student.

Click on "Publications" and expand them, to find the ones published in Current Opinion in Neurobiology or in the Annual Review Neuroscience:
https://neuro.hms.harvard.edu/faculty-staff/rachel-wilson

... like e.g., this one:
Wilson RI. Early olfactory processing in Drosophila: mechanisms and principles. Annual review of neuroscience. 2013 Jul 8;36(1):217-41.
https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-062111-150533

Rachel's more recent work is on neural networks in the fly for spatial navigation.

3/4

#neuroscience #olfaction #Drosophila #mouse #zebrafish

On that, the work from Lucia Prieto-Godino in (then) Richard Benton's lab on "undead" neurons is critical, demonstrating that, beyond the genes encoding olfactory receptors, there is a much larger pool of pseudogenes (genes that aren't normally expressed) that, when rescued, result in additional, distinct yet functional glomeruli in the first-order neuropil for olfaction (the antennal lobe in an insect; the olfactory bulb in a vertebrate).

Prieto-Godino LL, Silbering AF, Khallaf MA, Cruchet S, Bojkowska K, Pradervand S, Hansson BS, Knaden M, Benton R. Functional integration of “undead” neurons in the olfactory system. Science advances. 2020 Mar 11;6(11):eaaz7238.
https://www.science.org/doi/abs/10.1126/sciadv.aaz7238

Lucia is now a lab head at The Crick, studying with comparative connectomics the evolution of olfactory circuits and more, in fruit flies.

2/4

#neuroscience #olfaction #Drosophila #mouse #zebrafish

An undergraduate student asked me about olfactory sensory processing and this is what I replied. What have I missed of major importance, from the perspective of a senior undergrad?

The olfactory system is indeed fascinating, one that challenged researchers for some time. The first major break through came from Richard Axel's lab by the hand of the then student Leslie Vosshall, now professor at Rockefeller in New York and prominent HHMI Vicepresident and mosquito researcher.

Vosshall LB, Amrein H, Morozov PS, Rzhetsky A, Axel R. A spatial map of olfactory receptor expression in the Drosophila antenna. Cell. 1999 Mar 5;96(5):725-36.
https://www.cell.com/cell/fulltext/S0092-8674(00)80582-6

A search for "Vosshall Axel" in Google Scholar will surface related papers:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=vosshall+axel&btnG=

A conceptual breakthrough in olfactory coding came from the study of receptors by several groups, in both flies and mice, and later in zebrafish, but what I find compelling is the development of the primacy hypothesis for olfactory receptors by Rinberg's and Koulakov's labs:

Wilson CD, Serrano GO, Koulakov AA, Rinberg D. A primacy code for odor identity. Nature communications. 2017 Nov 14;8(1):1477.
https://www.nature.com/articles/s41467-017-01432-4

The above relates to the ability of animals to have a small number of olfactory receptors (like a fly larva) or more (an adult fruit fly) or many more (like moths and bees), or even more (like in a dog's nose), and yet the system works. More receptors support a less coarse encoding of odours, and vice versa. But the system for olfactory sensing is flexible and therefore evolvable.

1/4

#neuroscience #olfaction #Drosophila #mouse #zebrafish

Very amusing to see how the vertebrate developmental neurobiology field is converging with #Drosophila and insects in general with regard to the mechanisms of brain development:

"Together, these findings suggest a lineage-based mechanism for scalable positional information that complements diffusion-based mechanisms and offers a general framework for tissue patterning."

That sentence has been used for decades to describe fruit fly brain development.

#neurobiology #DevBiol #zebrafish #mouse

Researchers Jolie Smeets and Marnix Gorissen, within the European #HYPIEND project, investigate how endocrine-disrupting chemicals ( #EDCs) affect #hormone regulation and behaviour of individual #zebrafish larvae. They wrote this interesting blog about their work! https://hypiend.eu/swimming-in-chemicals-what-zebrafish-can-teach-us-about-our-health/

BiO is proud to partner with the European Zebrafish Society to offer travel grants for the 13th European Zebrafish Meeting (EZM2026) - 7-11 July 2026 in Vienna, Austria. This travel grant is designed to provide financial support for early-career researchers based in the Global South.

More information and an application form can be found on the EZS website: https://www.ezsociety.org/grants-EZM2026

#zebrafish #ecr #globalsouth

23/ 🐠 Dive into the depths of zebrafish development with Zebrahub-Multiome! #DevelopmentalBiology #SingleCell #Multiomics #Zebrafish

17/ 🎯 Lastly, Explore #zebrafish 's regulatory landscape of 640K+ chromatin accessibility peaks organized by cell-type and temporal patterns. Each cluster annotated using LLM with motif enrichment, developmental dynamics, and biological context. zebrahub.sf.czbiohub.org/slt?name=mul...

#KnowledgeBit: The #Zebrafish, a popular #Aquarium fish, is an important and widely used vertebrate #Model #Organism in scientific research, for example in drug development, in particular pre-clinical development.

It is also notable for its regenerative abilities, and has been modified by researchers to produce many #Transgenic (genetically modified organisms) strains.

https://knowledgezone.co.in/kbits/637e14eb0e37878b3f1aacd0

Wie gestrest is, merkt dat in het lijf: allerlei systemen, zoals het immuunsysteem, worden beïnvloed. Biologen Marcel Schaaf en Erin Faught van de Radboud Universiteit onderzoeken hoe dat werkt. Uit nieuw onderzoek blijkt hoe stress het gedrag verandert door gebruik te maken van twee verschillende receptoren.
Lees meer: https://www.ru.nl/onderzoek/onderzoeksnieuws/stress-kan-een-positief-effect-hebben-op-het-immuunsysteem
#biologie #immuunsysteem #zebravis #zebrafish

PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of Calgary

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/

#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=4911

🐟 Zebrafish can heal spinal cord
A research team at the University of Cologne has discovered that zebrafish can regenerate their spinal cord after an injury and restore their motor function. The findings could provide a long-term approach for developing therapies for humans.

Read more ▶️ https://uni.koeln/ML6WN

📰 https://www.sciencedirect.com/science/article/pii/S2211124725012409

#uniköln #unicologne #Research #Zebrafish #SpinalCord #Healing #Therapy

Surprisingly, mouse sperm can locate and swim through the tiny opening in #zebrafish eggs known as the micropyle, suggesting that some mechanisms guiding sperm toward eggs may be shared across distant species.
https://elifesciences.org/digests/106303/cross-species-insemination?utm_source=mastodon&utm_medium=social&utm_campaign=organic

"Algorithmic dissection of optic flow memory in larval zebrafish", Tanaka & Portgues 2025
https://www.sciencedirect.com/science/article/pii/S0960982225011133

#neuroscience #zebrafish #CompNeurosci

Read Biology Open's Issue 8

On the cover: A zebrafish cx41.8tq/tq mutant embryo treated with H202, stained to visualise the expression of gata2b, which marks haemogenic endothelium along the trunk of the embryo.

Read now: https://journals.biologists.com/bio/issue/14/8

#Biology #Research #Zebrafish #Academia #Writing #Communication #Science

"Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits", Ruetten et al. 2025 (Misha Ahrens lab)
https://www.biorxiv.org/content/10.1101/2025.08.20.670374v3.full

#zebrafish #neuroscience

Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:

"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2

#neuroscience #zebrafish #thalamus

Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:

"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2

#neuroscience #zebrafish #thalamus

Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:

"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2

#neuroscience #zebrafish #thalamus

Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:

"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2

#neuroscience #zebrafish #thalamus

Emre Yaksi's lab found the fish thalamus and its sensory relays to the fish cortex, aka the pallium:

"Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain", Trinh et al. 2025
https://www.biorxiv.org/content/10.1101/2025.09.15.675867v2

#neuroscience #zebrafish #thalamus

PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of Calgary

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/

#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=2468

How do genes that keep melanocytes alive affect #melanoma?

Using a #zebrafish line with mitfa-driven Cas9, researchers show that knocking out survival genes can sometimes fuel more aggressive tumour traits.
https://elifesciences.org/reviewed-preprints/100257?utm_source=mastdon&utm_medium=social&utm_campaign=organic

PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of Calgary

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/

#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=1761

Sensorimotor decision-making in #zebrafish
doi: https://doi.org/10.1101/2025.08.12.669772

the second: ''Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1to 3.''; J Toxicol Sci, 2016. https://doi.org/10.2131/jts.41.1

"Physiologically, cytochrome P450 (CYP) enzymes, specifically CYP families 1-3, play a pivotal role in drug metabolism. And yet, information regarding activity of CYP, its isoforms, and conjugation enzymes in zebrafish is either scarce or conflicting."

#zebrafish

one added reference: ''Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.''; BMC Genomics, 2010. https://doi.org/10.1186/1471-2164-11-643

"Zebrafish have a total of 94 CYP genes, distributed among 18 gene families found also in mammals. There are 32 genes in CYP families 5 to 51, most of which are direct orthologs of human CYPs that are involved in endogenous functions including synthesis or inactivation of regulatory molecules."

#zebrafish

PhD Student and Postdoc Positions in Tissue Patterning and Regeneration
University of Calgary

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/

#cellsignaling #developmentalbiology #fibroblast #regeneration #zebrafish #ScienceJobs #hiring #r...
https://jobrxiv.org/job/university-of-calgary-27778-phd-student-and-postdoc-positions-in-tissue-patterning-and-regeneration/?fsp_sid=732

🐟 Ahead of #HIConference25, researchers & imaging experts met up to tackle challenges in zebrafish image & video analysis, from AI models to portable tools and standardization.

Catch a glimpse of the workshop here 👉 https://bit.ly/Zebra-WS-Recap

@KIT_Karlsruhe @ufz_de @helmholtz

#imaging #zebrafish #AI #synergies

9-Jul-2025
Repairing the heart: If #zebrafish can do it, why not #humans?
Researchers identify #genes that help zebrafish regenerate #heart muscle, with implications for human #therapy

https://www.eurekalert.org/news-releases/1090648 #science #regeneration #medicine

How do group B #Streptococcus bacteria cross the endothelial cells of the blood-brain barrier cause #meningitis? This study shows that the #bacteria perforate and lyse #EndothelialCells in the brain #BloodVessels, facilitating brain invasion in #zebrafish @PLOSBiology https://plos.io/4lb8a5U

Great vibes, exciting science! 🐟

Today, the #zebrafish community in @association met for the 1st time at #HIconference2025. We kicked things off with energy, ideas & tools for better zebrafish #imaging.

Thanks to all who joined & our co-hosts @ufz & BER at @KIT_Karlsruhe!

#HelmholtzImaging #FAIRdata

The calcium surge that starts #embryogenesis varies across species. This Primer explores a @PLOSBiology study of #zebrafish, revealing that protease-activated receptors mediate a calcium signal that initiates #egg activation before #sperm entry. Paper: https://plos.io/467nrzY Primer: https://plos.io/3TuRvy1

Animal development requires #egg activation, which is initiated by calcium waves, but how does this happen? This study shows that protease activation of the Par2a receptor on the #zebrafish egg surface is required for successful #fertilization @PLOSBiology https://plos.io/467nrzY

Animal development requires #egg activation, which is initiated by calcium waves, but how does this happen? This study shows that protease activation of the Par2a receptor on the #zebrafish egg surface is required for successful #fertilization @PLOSBiology https://plos.io/467nrzY

Animal development requires #egg activation, which is initiated by calcium waves, but how does this happen? This study shows that protease activation of the Par2a receptor on the #zebrafish egg surface is required for successful #fertilization @PLOSBiology https://plos.io/467nrzY

Animal development requires #egg activation, which is initiated by calcium waves, but how does this happen? This study shows that protease activation of the Par2a receptor on the #zebrafish egg surface is required for successful #fertilization @PLOSBiology https://plos.io/467nrzY

Animal development requires #egg activation, which is initiated by calcium waves, but how does this happen? This study shows that protease activation of the Par2a receptor on the #zebrafish egg surface is required for successful #fertilization @PLOSBiology https://plos.io/467nrzY

#DidYouKnow: The #Zebrafish, a popular #Aquarium fish, is an important and widely used vertebrate #Model #Organism in scientific research, for example in drug development, in particular pre-clinical development.

It is also notable for its regenerative abilities, and has been modified by researchers to produce many #Transgenic (genetically modified organisms) strains.

https://knowledgezone.co.in/kbits/637e14eb0e37878b3f1aacd0

Check out our simple solution for imaging between the #zebrafish eyes (or other hard-to reach sample regions) during #lightsheet microscopy:
https://www.biorxiv.org/content/10.1101/2024.04.05.588276v2

#DidYouKnow: The #Zebrafish, a popular #Aquarium fish, is an important and widely used vertebrate #Model #Organism in scientific research, for example in drug development, in particular pre-clinical development.

It is also notable for its regenerative abilities, and has been modified by researchers to produce many #Transgenic (genetically modified organisms) strains.

https://knowledgezone.co.in/kbits/637e14eb0e37878b3f1aacd0

Nice papers that #neutrophils can also be epigenetically reprogrammed by infection - stemming from effects on stem cells.

Both use #zebrafish as model

#Shigella: https://www.science.org/doi/full/10.1126/sciadv.adf9706

#Salmonella: https://www.science.org/doi/10.1126/sciadv.adf9904
#trainedimmunity #immunology #epigenetics

A discoverer of neuroscience therapies and a genomics data science company are developing machine learning models to predict clinical trial outcomes for ADHD drugs.

https://sciencebusiness.technewslit.com/?p=45117

#News #Press #Science #Business #Collaboration #Biotechnology #Algorithms #MachineLearning #Zebrafish #DrugDiscovery #ClincialTrials #Preclinical #ADHD #Neuroscience #Europe

Hello Mastodon! #introduction

I’m Ashley Connors, a PhD candidate at NC State University. I study how #PFAS affect the #ImmuneSystem but I’m also interested in #toxicology and #immunology more broadly. I’m here to interact with and learn from folks who care about #pollution and other #EnvironmentalHealth issues.

#tox #research #zebrafish #macrophage #immunotoxicology #introductions #NCSU #NCState #academia #science

My postdoc work at Isaac Bianco's lab is finally out on @eLife !
https://elifesciences.org/articles/78381

Combining #lightsheet volumetric functional imaging and a spiking network simulation, we were able to show that a simple connectivity motif in the #zebrafish #optictectum explains multiple features in ongoing population dynamics, their impact on trial-to-trial variability, and trends in experience dependent behavior.

It is a neat example of how #networkdynamics can explain why neuronal and behavioural responses vary, or how past activity sets the ever-changing background for new input (that, in turn, will make its own long-lasting splash)

December's #EditorsChoice was written by Dr Kristen Kwan at #UniversityofUtah to a highlight of a #ResourceArticle by Dr Pui-Ying Lam at #MedicalCollegeofWisconsin that describes a new system for in vivo #imaging of adult #zebrafish relative, D. cerebrum, to allow longitudinal assessment of disease processes, particularly #immune responses in the #brain 🐟🧠

⚡https://journals.biologists.com/dmm/article/15/12/dmm050027/286152/
📰https://journals.biologists.com/dmm/article/15/12/dmm049753/286133/

#introduction I’m Anne, Professor in #neuroscience at Fribourg University. In our #Drosophila lab, we work on neuronal circuits for reproductive behavior and acoustic communication, sex differences of the nervous system and the signaling function of seminal fluid. I like #arthopods #sexualselection #matechoice #spermcompetition #microscopy and #connectomics
Used to work with #zebrafish #development #axonguidance
Also teaching and keen on #embryology and #histology for medical students...

Novel gene linked to brain size in autistic people

https://www.spectrumnews.org/news/novel-gene-linked-to-brain-size-in-autistic-people/

#SimonsSimplexCollection #denovomutations #macrocephaly #brainsize #zebrafish #autism #News