#regeneration — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #regeneration, aggregated by home.social.
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Housing update highlights progress against key priorities
From delivering new homes and affordable housing to helping people avoid homelessness, work continues across Wirral to address…
#Liverpool #UnitedKingdom #UK #GB #England #Headlines #News #Europe #EU #Britain #GreatBritain #Housing #Regeneration
https://www.europesays.com/uk/1198800/ -
https://www.europesays.com/uk/1198800/ Housing update highlights progress against key priorities #Britain #England #GreatBritain #Housing #Liverpool #Regeneration #UK #UnitedKingdom
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RE: https://scicomm.xyz/@mustapipa/117137230074004940
If economics can be said to speak, it needs to shout LOUDLY about proper green regeneration (rather than plant-a-tree make-work): “Scientists found that natural #forest regeneration delivered substantial carbon and #biodiversity benefits and could be up to 96% cheaper than traditional tree-planting programs.” 🌳🌲🌴🎄
Fabulous news - thanks so much for sharing! 😀🙏🏻
#regeneration #forestRegeneration #costBenefit #carbonSink #RoI
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Sacred Sites As Refuges For Native Plant Diversity In An Urbanized Tropical Landscape [Madagascar]
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https://doi.org/10.1038/s44284-026-00489-x <-- shared paper
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H/T @nicolas Salliou | Senior scientist at ETH Zürich
“When [the authors] investigated the potential for blue-green infrastructures for the capital of Madagascar,… a large team surveyed plant communities along a rural-urban gradient.
They found that 12 Malagasy "sacred" hill settlements, situated in the core of a pre-colonial kingdom, are particularly precious as they host a high diversity of native plants. A key insights when one considers that Madagascar is a unique hotspot for biodiversity and human cultures…”
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“In fragmented and intensively managed remnant urban green spaces, enabling natural regeneration is crucial to sustain ecosystem functioning and associated services. Natural regeneration therefore offers an important lens into ecological resilience in human-modified landscapes. Here [the authors] present one of the most comprehensive field-based assessments of urban plant diversity in the Afrotropics, comprising over 25,000 naturally regenerating woody plant individuals of 206 species (39% native) across 329 vegetation patches in Antananarivo, Madagascar. Landscape-level native species diversity declined with greater building complexity, density and socio-economic development, whereas exotic species showed no consistent associations with determinants of urban characteristics. Native species richness was highest in ‘sacred’ forest fragments, many of which contain historic remains dating back to pre-colonial times. Notably, seven of the ten most species-rich patches were located in such sites. [Their] findings highlight the potentially important role of these sites in sustaining native species diversity and indicate how socio-cultural factors can present both opportunities and barriers for tropical urban conservation and restoration...”
#sacredsites #antananarivo #madagascar #vegetation #nativeplant #urban #greenspace #tropical #hillsettlements #spatialanalysis #survey #ecosystem #biodiversity #ecology #regeneration #humanimpacts #GIS #spatial #mapping #afrotropics #forest #forestfragments #precolonial #sustainability #diversity #native #sociocultural #restoration -
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#ClimaBalance #ClimateTech #Agroecology #Agroforestry #Permaculture #OrganicAgriculture #Regeneration #EcologicalRestoration
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Was macht 🌱 #Cannabis für die #Haut spannend?
Unsere Haut ist nicht nur Verpackung – sie hat ihr eigenes #EndocannabinoidSystem mit CB1- und CB2-#Rezeptoren (jup, wie das Gehirn, nur in dünner). Die steuern #Regeneration, #Immunsystem und auch, wie krass die Haut auf #Stress reagiert. Genau hier greifen #Cannabinoide wie #CBD und #THC ein: Sie können #Entzündungen runterfahren oder die Talgproduktion zügeln. Ziemlich clever, oder? 😀
https://www.cannabishelden.de/post/cannabis-hautkrankheiten-neurodermitis-akne
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"I'm not going to retire until I hit a million corals planted back on the reef. With the right conditions, we can do it in the next 3-5 years." ~ David Vaughan - Marine Biologist
#OceanConservation #CoralReefRestoration #MarineBiology #ProtectOurOceans #SustainableFuture #ReefRecovery #EnvironmentalStewardship #ClimateAction #SaveOurSeas #Regeneration
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432Hz + 963Hz + 528Hz Relaxing Slavic Blend - Gusli, Domra, Synth Pads and Electronic Beats🎶
https://www.youtube.com/watch?v=EyJqNAqFHPE
#healingmusic #relaxation #sleepmusic #meditation #ambient #folkloric #slavicculture #instrumental #focus #anxietyrelief #stressrelief #deepsleep #regeneration #432hz #963hz #528hz #peaceful #calming #музыкадлясна #расслабление #медитация #фольклор #инструментальнаямузыка #целительнаямузыка #спокойствие
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432Hz + 963Hz + 528Hz Relaxing Slavic Blend - Gusli, Domra, Synth Pads and Electronic Beats🎶
https://www.youtube.com/watch?v=EyJqNAqFHPE
#healingmusic #relaxation #sleepmusic #meditation #ambient #folkloric #slavicculture #instrumental #focus #anxietyrelief #stressrelief #deepsleep #regeneration #432hz #963hz #528hz #peaceful #calming #музыкадлясна #расслабление #медитация #фольклор #инструментальнаямузыка #целительнаямузыка #спокойствие
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432Hz + 963Hz + 528Hz | Feeling Anxious? Try This Healing Folk Sound 🙏
https://www.youtube.com/watch?v=zddrs5wnV_8
#healingmusic #relaxation #sleepmusic #meditation #ambient #folkloric #slavicculture #instrumental #focus #anxietyrelief #stressrelief #deepsleep #regeneration #432hz #963hz #528hz #peaceful #calming #музыкадлясна #расслабление #медитация #фольклор #инструментальнаямузыка #целительнаямузыка #спокойствие
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Delfine als perfekte Urlaubsbegleiter? 🐬 Olivia Röllin philosophiert, warum wir von den Meeresakrobaten Gelassenheit & Regeneration lernen können – sie machen das mit links! 🌊✨ #PhilosophierenUnterPalmen #Delfine #Regeneration #newz
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Permaculture Teacher Training for Palestinians
Community leaders advancing regeneration, food sovereignty, land restoration, and community building.
https://justpaste.it/tptp25#permaculture #Palestine #PDC #regeneration #foodsovereignty #landrestoration #communitybuilding #teachtheteachers #refugeesupport #ecologicaljustice #permaculturedesign #earthcare #peoplecare #solidarityworks #rebuildpalestine #sociocracy
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My next @preLights post is out. I saw this first preprint from the Storer lab a while back (thanks to a toot from @CellySally) and took some time over writing it but I think it was worth it!
I really enjoyed going back to some developmental biology with this study on how the ECM and mechanical environment influence limb regeneration. Also, nice that my PhD department, PDN, was heavily involved!
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Site investigation works to start on new city office development
Swansea Council say the works are due to start on Monday 17 March and could take over a week to complete.
The council say the work will help pave the way for a new Public Sector Hub scheme that’s aimed at helping boost city centre footfall.
The grassed area outside St David’s Church Hall will be fenced off while the works are ongoing and the council say that every effort will be made to minimise disruption.
Artist’s impression of the ‘public sector hub’ office development which will become the new home for Swansea Council
(Image: Swansea Council)The Public Sector Hub will include commercial floor space for shops and restaurants on the ground floor. Swansea Council and a range of other public sector partners will occupy office space above.
Made up of four floors above ground level and one floor below, the council say that hundreds of workers will be based at the Public Sector Hub.
The council and its regeneration partners Urban Splash will develop the proposed new building, with the council retaining ownership.
AdvertisementThis would form part of the first phase of the overall site’s redevelopment being led by Urban Splash, who are continuing to work on plans for the rest of the site.
The former St David’s Shopping Centre in Swansea which has been demolished to make way for the new developmentCllr Rob Stewart, Swansea Council Leader, said: “We all want our city centre to succeed and to have more shops and other businesses, but we know more footfall is needed to support our existing traders and attract new investment.
“That’s not just the case in Swansea – it’s the same in many other city and town centres across the UK because of challenges like online shopping.
“Schemes like the Public Sector Hub will combine with many others to locate thousands more jobs in the city centre, which will help boost spending there and encourage more shops to open up.
“This scheme will also enable the redevelopment of the Civic Centre site on the seafront. Our regeneration partners Urban Splash are working on detailed proposals for that site, which will be announced as soon as they’re finalised.”
The council say it’s anticipated construction on the Public Sector Hub itself will start on site by the end of 2025.
Advertisement(Lead image: Swansea Council)
#CllrRobStewart #construction #officeDevelopment #PublicSectorHub #regeneration #StDavidSShoppingCentre #Swansea #SwanseaCouncil #UrbanSplash
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... stemcell research @Vitruvian Project
#stemcell #regeneration #vitruvianproject #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stemcell research @Vitruvian Project
#stemcell #regeneration #vitruvianproject #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stemcell research @Vitruvian Project
#stemcell #regeneration #vitruvianproject #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stemcell research @Vitruvian Project
#stemcell #regeneration #vitruvianproject #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stemcell research @Vitruvian Project
#stemcell #regeneration #vitruvianproject #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stem cell/regeneration test #0167 ...
#stemcell #regeneration #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stem cell/regeneration test #0167 ...
#stemcell #regeneration #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stem cell/regeneration test #0167 ...
#stemcell #regeneration #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stem cell/regeneration test #0167 ...
#stemcell #regeneration #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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... stem cell/regeneration test #0167 ...
#stemcell #regeneration #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
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Meine #Regeneration läuft auf Hochtouren… 😅 Es war ein extrem schönes Erlebnis, letzten Sonntag an der #Duathlon #Weltmeisterschaft in #Zofingen teilzunehmen. 🤩 Ich bewältigte die Kurzdistanz und klassierte mich besser als ich es erwartete: 9. Rang von 29 in Alterskategorie, 70. von 230 im Gesamtklassement. Bin sehr happy und zufrieden. 😎
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In #ecosystems "adapted to frequent or intense #wildfires, such as #boreal and #Mediterranean #forests, the growing occurrence of extreme wildfires has caused severe disruptions and hampered ecosystems’ natural #regeneration capacity [...] In the Russian Federation [...], the extent of forestland affected by wildfires increased over fivefold between 2001 and 2021" [3]
"Wildfires also increasingly occur where natural fire activity is rare, such as in #TropicalRainforests" [3]
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Our lab presentations at #SICB2023
Ranny’s talk: Comparative transcriptomics reveals sex-specific differences in #Platynereis dumerilii (Tomorrow, Jan 4th)Bria’s talk: The cost or payout of #regeneration on growth and sexual maturation in Platynereis dumerilii (Tomorrow, 4th)
Duygu’s talk: Single-cell transcriptomics reveal specific gut regions in a freshwater #annelid (Thursday, 5th)
Ryan’s poster: Automating design of #fluorescent in situ probes for big data sets (Friday, 6th)
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CW: Using Human Pluripotent Stem Cells to Create Human Skeletal Muscle Organoids for Repair and Regeneration
Skeletal #muscle is a type of tissue that makes up a large part of the human body. It is made up of many different cells that are able to contract and move. Skeletal muscle has the ability to #repair itself when it is damaged due to #aging, exercise, or diseases like #MuscularDystrophy. A small group of cells called #SatelliteCell s help with the repair process. Scientists have been trying to create models to study how #Skeletalmuscle develops and regenerates. Recently, they have been using human pluripotent #StemCell to create 3D models of skeletal muscle tissue. However, these models have not been able to recreate the full process of muscle regeneration. In this research paper, the authors introduce a new method of using human pluripotent stem cells to create 3D models of skeletal muscle tissue that can retain the ability to repair itself.
Over the past decades, scientists have used #animalmodel to study #muscleregeneration, which is regulated by #stemcell s. These animal models have been very helpful in understanding the mechanisms of muscle #regeneration, but they don't always accurately reflect the same range of diseases that humans experience. Therefore, researchers have suggested creating reliable in vitro models using human muscle cells. ( #hPSC s) could be used to create 3D human skeletal muscle #organoid s ( #hSkMO s) that contain sustainable #stemcell and distinct myofibers with the same proteins and structure as adult muscles. Previous approaches to skeletal muscle differentiation have been developed using 2D #culture systems, but these lack the natural environment and #StemCell niche that are necessary to model adult #myogenesis and muscle #regeneration.
#Stemcell s ( #SC s) can be used to repair damaged muscle tissue. They explain that SCs can be activated in response to muscle injuries and that other #cell types can contribute to the process of #myogenesis. The author then goes on to explain that #cytokine s, such as IL-4, can influence the #InflammatorySystem and promote SCs differentiation, which helps with muscle regeneration. While #organoid s generated from #hPSC s have potential, they do not fully replicate the in vivo native microenvironment. To address this, treat the #hSkMO s with extrinsic #cytokine s to promote #muscle #regeneration . #hSkMO s might then be used to study aspects of human muscle #biology and to identify novel #therapeutic candidates for muscle-wasting disorders.
To create a 3D structure of muscle tissue. They used #WNT activator and #BMP inhibitors at the beginning of the differentiation process to induce paraxial #mesodermal #cell s. They then added #FGF2 to the Matrigel to promote the 3D structure. #HGF and IGF1 were added later to accelerate the #myogenic specification and further #myofiber differentiation. They optimized the timing of the Matrigel embedding to day seven. After this, they observed #neuralcell s and withdrew FGF2 to focus on muscle tissue development. They then prolonged the HGF and IGF1 treatment to propagate #myogenic #progenitor s. They found that 62% of the #tissue was #skeletalmuscle tissue and that it contained PAX7+ #myogenic #stem / #progenitor cells, MYOD+ activated/committed #myoblast s, and MYOG+ #myocyte s. They also found that 31% of PAX7+/Ki67− and 29% of MYOD−/PAX7+ non-dividing quiescent SCs were present in the mature #hSkMO s. This indicates that the #hSkMO s were able to effectively recreate #embryo nic #myogenesis and have regenerative potential. Future studies using #singlecell #RNA sequencing may be necessary to further characterize the different types of cells in #hSkMO s.
The stepwise process to generate human skeletal muscle organoid s (hSkMOs) from human pluripotent stem cells (hPSCs)
The process begins with dissociating #hPSC s into #singlecell s and allowing them to form #embryoid bodies ( #EB s) in low-attachment V-shaped 96-well plates. Then, paraxial #mesodermal differentiation is promoted with #WNT activation, BMP inhibition, and FGF2 signaling. The expression of pluripotency markers OCT4 and NANOG decreases, and the expression of #mesoderm markers Brachyury, T-Box transcription factor 6 (TBX6), and mesogenin 1 (MSGN1) increases. To further characterize paraxial #mesoderm al differentiation, TBX6 is #immunostain ed. After paraxial #mesodermal induction, the #organoid s are embedded with growth factor-reduced Matrigel and transferred to a six-well plate on an orbital shaker. Growth factors are then added to the #myogenic specification media, and #hSkMO s are cultured until the day of analysis. The orbital shaker improves the viability, survival, and differentiation of hSkMOs by increasing the penetration rate of oxygen and nutrients into the core area of hSkMOs. The #hSkMOs gradually grow to more than 1.5 mm in diameter by day 60, appearing round-shaped, uniformly sized, and having relatively homogenous morphology. PAX3 and PAX7 are #myogenic progenitor markers, and their expression is verified by qRT-PCR and #cryo sections. The #myogenic cells appear as clusters, and approximately 9% of PAX7+ cells are double-positive for Ki67 at day 30, demonstrating that proliferating cells are #myogenic #progenitor s in hSkMOs. This indicates that the in vitro #hSkMO #culturesystem is able to recapitulate the features of embryonic skeletal #muscle development.
The different types of #SkeletalMuscle stem/progenitor cells that are involved in myogenesis, the process of muscle formation.
The researchers used qRT-PCR analysis and #immunohistochemistry to identify and characterize the different types of cells. They found that PAX3 and PAX7 (SC markers) were the major population during the early stage of #myogenesis, and that MYOD (proliferating and activated SC marker) and MYOG (differentiated myocyte marker) increased over time. They also observed that MYOD−/PAX7+, MYOD+/PAX7+, and MYOD+/Ki67+ cells accounted for 29%, 6%, and 8% of the putative quiescent, activated, and proliferating #SC s, respectively. MYOD+/PAX7− cells constituted 39% of differentiating myoblasts, and MYOG−/PAX7+ cells constituted 23% of putative quiescent SCs. MYOG+/PAX7− cells accounted for 30% of differentiated #myocyte s, and 8% and 6% of the MYOG+ cells in #hSkMO s co-expressed PAX7 and Ki67, respectively. This data shows that the researchers were able to identify and characterize different types of skeletal muscle stem/progenitor cells during #myogenesis.
The text is discussing the results of a research study that used hSkMOs (human skeletal muscle #organoid s) to study the development of skeletal muscle #tissue. The study found that the #hSkMO s grew exponentially in size within two months, and the growth rate then steadily decreased. The researchers then used scanning electron microscopy (SEM) imaging and confocal microscopy to examine the cytoarchitecture of the hSkMOs. They found that the hSkMOs contained a large population of terminally differentiated #myogenic cells and a small population of preserved myogenic stem/progenitor cells. They also found that the hSkMOs contained a substantial proportion of TITIN+ muscle cells and MAP2-positive #neuron s. To further characterize the presence of sustainable stem cells within the mature hSkMOs, they quantified the amount of dormant stem cells by #confocal #microscopy imaging. The results showed that approximately 56%, 31%, and 5% of PAX7+/Ki67- putative dormant stem cells existed throughout the differentiation of hSkMOs at days 30, 70, and 130, respectively. This indicates that the hSkMOs contained mature skeletal muscle properties and had the potential for #regeneration .
The researchers wanted to see if the #hSkMO s (human #skeletal muscle #organoid s) had the ability to regenerate #muscle #tissue after damage. To test this, they treated the hSkMOs with a cardiotoxin (CTX) which is known to induce muscle inflammation and damage. They then observed a decrease in PAX7+ and MYOD+ cells in the hSkMOs. To further test the #regenerative potential of the #hSkMO s, they added interleukin-4 (IL-4) to the medium to promote #muscleregeneration. After 14 days, they observed a significant increase in MYOG+ myocytes in the CTX-injured hSkMOs with the treatment of IL-4 compared to the CTX-injured hSkMOs without the treatment. This suggests that the hSkMOs have the potential to regenerate muscle tissue after damage.
Generation of Skeletal Muscle Organoids from Human Pluripotent Stem Cells to Model Myogenesis and Muscle Regeneration
Authors :
Min-Kyoung Shin , Jin Seok Bang , Jeoung Eun Lee , Hoang-Dai Tran , Genehong Park , Dong Ryul Lee and Junghyun Jo
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#funfact | You can remove all the #birds and still have a #forest, but if you remove all the #fungi, the forest will #die.
Fungi help #breakdown the #materials in the stressed and dead #trees as part of a complex #nutrient cycle that is vital to #regeneration and a healthy forested #ecosystem
Without fungi to aid in #decomposition, all life in the #forest would soon be buried under a mountain of dead #plant matter.
#funfacts #fungifacts #fungi #algae #mushrooms #plants #MushroomsOfMastodon #ancientalliances #history #mastodon #MastoArt #fungikingdom #fungioftheday #bracket #mushroom #nature #mycodon #mosstodon #mycology #fungiverse #fungus #nature #mastodonmushroom
