#regeneration — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #regeneration, aggregated by home.social.
-
Housing update highlights progress against key priorities
From delivering new homes and affordable housing to helping people avoid homelessness, work continues across Wirral to address…
#Liverpool #UnitedKingdom #UK #GB #England #Headlines #News #Europe #EU #Britain #GreatBritain #Housing #Regeneration
https://www.europesays.com/uk/1198800/ -
https://www.europesays.com/uk/1198800/ Housing update highlights progress against key priorities #Britain #England #GreatBritain #Housing #Liverpool #Regeneration #UK #UnitedKingdom
-
A volcano of their very own: Mount Elephant
Showers of fiery red, molten volcanic bombs streaking through the air, rivers of flowing lava across the land. This chaotic, noisy and spectacular scene is not Hawaii or Iceland today but Victoria, 180,000 years ago.
At 240 m above sea level the almost perfect cone of Mount Elephant, on Eastern Maar Country at Derrinallum, is one remnant of this explosive time in the state’s history. For millions of years molten rock erupted from over 400 fissures, rifts and cones across Western Victoria, many witnessed and recorded by First Peoples.
Huge volumes of lava flowed across the land. The rock, basalt, was used by settlers to build stone walls and houses, and was crushed for developing roads and farm tracks.
Twenty-five years ago, members of the communities surrounding Mount Elephant rallied to protect this extraordinary place.
“It has a lot of meaning to the community – it really came from the heart. At some of the meetings people were in tears,” says Lesley Brown, Treasurer of the Mount Elephant Committee of Management, volunteers who have been caring for the mountain since it became a Trust for Nature reserve.”
Originally from Melbourne, Lesley moved to Derrinallum to become a dairy farmer with her husband. When Mount Elephant came up for sale in 2000, the community held several meetings to discuss purchasing Mount Elephant. The desire to keep the mountain as part of the community and for recreation was overwhelming, and for Mount Elephant to be restored to its state before European colonisation.
Assisted by a then-Trustee and community member, Trust for Nature formed a partnership to raise $200,000 to purchase Mount Elephant and manage the reserve. Volunteers door-knocked in the local community, a media campaign was launched, and through this $100,000 was raised in five months by the community. Trust for Nature contributed to the balance.
“It was the right thing to do,” Lesley says. “The previous owners wanted it to go to the community. If we hadn’t bought it some other private owners would have.”
The answer involved artistic detective work, using the paintings and sketches of Austrian-born painter Eugene von Guerard. These show that the mountain was likely covered in a woodland of banksias, she oaks, Blackwoods and Manna Gums, with shrubby Sweet Bursaria, Tree Violet and native grasses growing amongst the trees. This is a rare habitat today in Victoria, and much of what remains is degraded. A management plan developed by the Centre for Environmental Management, University of Ballarat, documents the plants and animals that would have lived on Mount Elephant, and how to restore it.
Over the past 25 years volunteers have planted thousands of trees and grasses. Rabbits have been baited and warrens removed. Weeds have been sprayed. The changes have been remarkable: from hundreds and thousands of rabbits, there are now only a handful.
“When we first started there was nothing – it was brown and full of rabbit warrens. Now it’s green and there are lots of trees. People said, ‘You’ll never get rid of the rabbits, you’ll never get rid of the weeds’ – but we have,” says Lesley.
Wildlife is returning, including Wedge-tailed Eagles, wallabies, and kangaroos. This is posing an interesting dilemma: the kangaroos are eating freshly planted trees, which now need to be guarded and fenced. But both are signs that Mount Elephant’s recovery is well on the way.
Walking tracks have been installed, and a visitor center open on Sunday a ernoons, and at other times by request, provides information about this fascinating place and the work that goes into looking after it. Lesley is particularly energised by the people who visit Mount Elephant, including groups of students from local schools and the commitment of the Mount Elephant committee.
“How many people have the opportunity to do what we have done?” says Lesley. “We just get on with the job and then you look back and think ‘The trees are growing, we did that’. It’s a legacy to leave behind for the future, so that future generations can continue to enjoy this place.”
This article has been entirely reproduced from the original here: https://trustfornature.org.au/a-volcano-of-their-very-own-mount-elephant/
Check out the Trust For Nature website and see some of the other great work they are doing all over Australia.
And perhaps even consider signing up to help support their work.- A volcano of their very own: Mount Elephant
- Unique conservation course for First Peoples celebrates 10 years
- Celebrating the caretakers of Ralph Illidge Sanctuary
- Victorian landholders to lead massive conservation effort
- Haven of abundance
-
Researchers have decoded the signaling pathway that inhibits #nerve #regeneration in #diabetes and have developed a therapeutic peptide that could transform the treatment—and possibly even the prevention—of diabetic nerve damage.
#Biomedical #Pharmaceutical #sflorg
https://www.sflorg.com/2025/11/bmed11272501.html -
#Transport for #London has awarded #Haringey, #Lewisham and #Southwark up to £10m each over four years to deliver borough-led schemes under the Better Bus Partnerships programme. The funding will support measures to cut journey times by up to 30 per cent, improve reliability and make buses a more attractive alternative to private cars. Planned work includes new bus priority lanes, better management of roadworks, upgraded stops and safer walking links to stations. The three boroughs were selected through a competitive process and will now work with #TfL on detailed #planning through 2026, with delivery expected from 2027. TfL says the programme will boost customer experience and support wider goals for cleaner, greener travel. Borough leaders welcomed the investment, highlighting the importance of reliable #buses for residents who do not own cars and the role of improved services in supporting #regeneration, better connections and safer, more accessible streets.
https://tfl-newsroom.prgloo.com/news/three-london-boroughs-win-tfl-funding-to-transform-local-bus-networks -
Spirituality & Religious Studies @spiritualityreligiousstudies.wordpress.com@spiritualityreligiousstudies.wordpress.com ·Eternal Security
This is also known as “once saved, always saved.” It’s the belief giving Christian believers with an absolute assurance of their final salvation.
Its development, especially in Protestantism, has given rise to a plethora of different interpretations. Especially when defining aspects of determinism, libertarian free will & the significance of personal perseverance.
In the early 5th century, Augustinian soteriology views of predestination by predetermination came about, they didn’t validate Eternal Security. Soteriology is the doctrine of salvation.
By the 16th century, this idea became meshed into the theology of John Calvin & other reformers. Calvinist circles initially embraced Eternal Security under the name of “perseverance of the saints.” Eventually, the name became a synonym of the Calvinist doctrine of perseverance independent of its practical interpretations.
Then in the early 20th century, Eternal Security started to become a defining doctrine of Southern Baptist traditionalism. Around the same time, it also became a part of Plymouth Brethren theology. In this, the 2 forms represents its main form today.
In the 1980s, the Free Grace movement voiced that Eternal Grace was independent of the idea of the “Hyper-Grace” idea.
Eternal Security is based on the faith that the believer is an elect by divine determination. This is in Calvinist circles & has the minority worldview.
In some non-Calvinist circles & the prevailing worldview, Eternal Security is based on the faith that regeneration leads to unconditional perseverance & then salvation.
In other non-Calvinist circles & currently growing in the Free Grace views, Eternal Security is based on the faith that regeneration leads to salvation independent of perseverance.
Make a one-time donation
Your contribution is appreciated.
Donate
Make a monthly donation
Your contribution is appreciated.
Donate monthly
Make a yearly donation
Your contribution is appreciated.
Donate yearly
Rate this:
#16thCentury #1980s #5thCentury #Augustinians #Calvinist #Christian #Determinism #DivineDetermination #Early20thCentury #EternalSecurity #FreeGraceMovement #HyperGrace #JohnCalvin #LibertarianFreeWill #Perseverance #PerseveranceOfTheSaints #PlymouthBrethen #Predestination #Protestantism #Reformers #Regeneration #Salvation #Soteriology #SouthernBaptist #SouthernBaptistTraditionalism
-
Axolotls May Hold the Key to Regrowing Limbs
#HackerNews #Axolotls #Regeneration #Science #LimbRegrowth #Biotechnology #Conservation
-
Permaculture Teacher Training for Palestinians
Community leaders advancing regeneration, food sovereignty, land restoration, and community building.
https://justpaste.it/tptp25#permaculture #Palestine #PDC #regeneration #foodsovereignty #landrestoration #communitybuilding #teachtheteachers #refugeesupport #ecologicaljustice #permaculturedesign #earthcare #peoplecare #solidarityworks #rebuildpalestine #sociocracy
-
Permaculture Teacher Training for Palestinians
Community leaders advancing regeneration, food sovereignty, land restoration, and community building.
https://justpaste.it/tptp25#permaculture #Palestine #PDC #regeneration #foodsovereignty #landrestoration #communitybuilding #teachtheteachers #refugeesupport #ecologicaljustice #permaculturedesign #earthcare #peoplecare #solidarityworks #rebuildpalestine #sociocracy
-
Permaculture Teacher Training for Palestinians
Community leaders advancing regeneration, food sovereignty, land restoration, and community building.
https://justpaste.it/tptp25#permaculture #Palestine #PDC #regeneration #foodsovereignty #landrestoration #communitybuilding #teachtheteachers #refugeesupport #ecologicaljustice #permaculturedesign #earthcare #peoplecare #solidarityworks #rebuildpalestine #sociocracy
-
Permaculture Teacher Training for Palestinians
Community leaders advancing regeneration, food sovereignty, land restoration, and community building.
https://justpaste.it/tptp25#permaculture #Palestine #PDC #regeneration #foodsovereignty #landrestoration #communitybuilding #teachtheteachers #refugeesupport #ecologicaljustice #permaculturedesign #earthcare #peoplecare #solidarityworks #rebuildpalestine #sociocracy
-
Upon the event of my pathetically over-booked #apotheosis I #need to be addressed as #Dahl #E #Pardon.
It will streamline the new character sheet #regeneration #process considerably.
-
Michael Cieply: Two Weeks Out, The Academy Museum Preps A Cautious But Correct ‘Hollywoodland’ Opening
#Commentary #News #AcademyMuseumOfMotionPictures #Antisemitism #BillKramer #DaraJaffe #Gaza #Hollywoodland #JacquelineStewart #Jews #JohnWaters #MichaelCieply #NealGabler #ReGeneration -
... stemcell research @Vitruvian Project
#stemcell #regeneration #vitruvianproject #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
-
... stem cell/regeneration test #0167 ...
#stemcell #regeneration #organ #labgrown #dna #sciencehorror #sciencefiction #horror #horrorart #aiia #macabre #horrormovies #darkart #nightmare
-
Was können wir gegen die #Klimakrise tun?
Mit dieser Frage beschäftige ich mich seit etwa 4 Jahren sehr intensiv.
Ich habe eine Liste der meiner Meinung nach wichtigsten 11 Videos zusammengestellt. (je 10-30 Minuten, meist englisch)
Die Reihenfolge ist bewusst gewählt.Ich würde mich über Feedback freuen!
Was fehlt noch?
Was könnte weggelassen oder ausgetauscht werden?https://youtube.com/playlist?list=PLZbVXUbMwDCq9abFCbbrswfZhKRwQR5i_
#klimakrise #klimawandel #systemchange #klimakatastrophe #klimalösungen #playlist #video #videos #lösung #commons #commoning #systemwandel #regeneration #regenerative #sharing #library #verleih #zukunft #krise
-
Wird von der Leber ein Teil entfernt, kann der Körper fehlendes Gewebe nachwachsen lassen. Womöglich hängt diese Regeneration auch von den vorhandenen Bakterien im Darm ab.
Darmbakterien können Leberzellwachstum beeinflussen
#Leber #Leberzelle #Regeneration #Transplantation #Lebertransplantation #Darmbakterien #Mikrobiom #Medizin -
So this is my introduction. For many years I worked in amenity horticulture (parks, public gardens etc), until I did my back in, and now I have an indoor job, with no heavy lifting. I finally decided to learn how to grow things, and make compost, although I have no garden. I help a mate with his allotment, and do voluntary work at a forest garden (The Welcome Garden, near St Marys Chuch in Walthamstow). I'm learning about #permaculture #regeneration #gardening #forestgardens, and I love reading.
-
CW: Using Human Pluripotent Stem Cells to Create Human Skeletal Muscle Organoids for Repair and Regeneration
Skeletal #muscle is a type of tissue that makes up a large part of the human body. It is made up of many different cells that are able to contract and move. Skeletal muscle has the ability to #repair itself when it is damaged due to #aging, exercise, or diseases like #MuscularDystrophy. A small group of cells called #SatelliteCell s help with the repair process. Scientists have been trying to create models to study how #Skeletalmuscle develops and regenerates. Recently, they have been using human pluripotent #StemCell to create 3D models of skeletal muscle tissue. However, these models have not been able to recreate the full process of muscle regeneration. In this research paper, the authors introduce a new method of using human pluripotent stem cells to create 3D models of skeletal muscle tissue that can retain the ability to repair itself.
Over the past decades, scientists have used #animalmodel to study #muscleregeneration, which is regulated by #stemcell s. These animal models have been very helpful in understanding the mechanisms of muscle #regeneration, but they don't always accurately reflect the same range of diseases that humans experience. Therefore, researchers have suggested creating reliable in vitro models using human muscle cells. ( #hPSC s) could be used to create 3D human skeletal muscle #organoid s ( #hSkMO s) that contain sustainable #stemcell and distinct myofibers with the same proteins and structure as adult muscles. Previous approaches to skeletal muscle differentiation have been developed using 2D #culture systems, but these lack the natural environment and #StemCell niche that are necessary to model adult #myogenesis and muscle #regeneration.
#Stemcell s ( #SC s) can be used to repair damaged muscle tissue. They explain that SCs can be activated in response to muscle injuries and that other #cell types can contribute to the process of #myogenesis. The author then goes on to explain that #cytokine s, such as IL-4, can influence the #InflammatorySystem and promote SCs differentiation, which helps with muscle regeneration. While #organoid s generated from #hPSC s have potential, they do not fully replicate the in vivo native microenvironment. To address this, treat the #hSkMO s with extrinsic #cytokine s to promote #muscle #regeneration . #hSkMO s might then be used to study aspects of human muscle #biology and to identify novel #therapeutic candidates for muscle-wasting disorders.
To create a 3D structure of muscle tissue. They used #WNT activator and #BMP inhibitors at the beginning of the differentiation process to induce paraxial #mesodermal #cell s. They then added #FGF2 to the Matrigel to promote the 3D structure. #HGF and IGF1 were added later to accelerate the #myogenic specification and further #myofiber differentiation. They optimized the timing of the Matrigel embedding to day seven. After this, they observed #neuralcell s and withdrew FGF2 to focus on muscle tissue development. They then prolonged the HGF and IGF1 treatment to propagate #myogenic #progenitor s. They found that 62% of the #tissue was #skeletalmuscle tissue and that it contained PAX7+ #myogenic #stem / #progenitor cells, MYOD+ activated/committed #myoblast s, and MYOG+ #myocyte s. They also found that 31% of PAX7+/Ki67− and 29% of MYOD−/PAX7+ non-dividing quiescent SCs were present in the mature #hSkMO s. This indicates that the #hSkMO s were able to effectively recreate #embryo nic #myogenesis and have regenerative potential. Future studies using #singlecell #RNA sequencing may be necessary to further characterize the different types of cells in #hSkMO s.
The stepwise process to generate human skeletal muscle organoid s (hSkMOs) from human pluripotent stem cells (hPSCs)
The process begins with dissociating #hPSC s into #singlecell s and allowing them to form #embryoid bodies ( #EB s) in low-attachment V-shaped 96-well plates. Then, paraxial #mesodermal differentiation is promoted with #WNT activation, BMP inhibition, and FGF2 signaling. The expression of pluripotency markers OCT4 and NANOG decreases, and the expression of #mesoderm markers Brachyury, T-Box transcription factor 6 (TBX6), and mesogenin 1 (MSGN1) increases. To further characterize paraxial #mesoderm al differentiation, TBX6 is #immunostain ed. After paraxial #mesodermal induction, the #organoid s are embedded with growth factor-reduced Matrigel and transferred to a six-well plate on an orbital shaker. Growth factors are then added to the #myogenic specification media, and #hSkMO s are cultured until the day of analysis. The orbital shaker improves the viability, survival, and differentiation of hSkMOs by increasing the penetration rate of oxygen and nutrients into the core area of hSkMOs. The #hSkMOs gradually grow to more than 1.5 mm in diameter by day 60, appearing round-shaped, uniformly sized, and having relatively homogenous morphology. PAX3 and PAX7 are #myogenic progenitor markers, and their expression is verified by qRT-PCR and #cryo sections. The #myogenic cells appear as clusters, and approximately 9% of PAX7+ cells are double-positive for Ki67 at day 30, demonstrating that proliferating cells are #myogenic #progenitor s in hSkMOs. This indicates that the in vitro #hSkMO #culturesystem is able to recapitulate the features of embryonic skeletal #muscle development.
The different types of #SkeletalMuscle stem/progenitor cells that are involved in myogenesis, the process of muscle formation.
The researchers used qRT-PCR analysis and #immunohistochemistry to identify and characterize the different types of cells. They found that PAX3 and PAX7 (SC markers) were the major population during the early stage of #myogenesis, and that MYOD (proliferating and activated SC marker) and MYOG (differentiated myocyte marker) increased over time. They also observed that MYOD−/PAX7+, MYOD+/PAX7+, and MYOD+/Ki67+ cells accounted for 29%, 6%, and 8% of the putative quiescent, activated, and proliferating #SC s, respectively. MYOD+/PAX7− cells constituted 39% of differentiating myoblasts, and MYOG−/PAX7+ cells constituted 23% of putative quiescent SCs. MYOG+/PAX7− cells accounted for 30% of differentiated #myocyte s, and 8% and 6% of the MYOG+ cells in #hSkMO s co-expressed PAX7 and Ki67, respectively. This data shows that the researchers were able to identify and characterize different types of skeletal muscle stem/progenitor cells during #myogenesis.
The text is discussing the results of a research study that used hSkMOs (human skeletal muscle #organoid s) to study the development of skeletal muscle #tissue. The study found that the #hSkMO s grew exponentially in size within two months, and the growth rate then steadily decreased. The researchers then used scanning electron microscopy (SEM) imaging and confocal microscopy to examine the cytoarchitecture of the hSkMOs. They found that the hSkMOs contained a large population of terminally differentiated #myogenic cells and a small population of preserved myogenic stem/progenitor cells. They also found that the hSkMOs contained a substantial proportion of TITIN+ muscle cells and MAP2-positive #neuron s. To further characterize the presence of sustainable stem cells within the mature hSkMOs, they quantified the amount of dormant stem cells by #confocal #microscopy imaging. The results showed that approximately 56%, 31%, and 5% of PAX7+/Ki67- putative dormant stem cells existed throughout the differentiation of hSkMOs at days 30, 70, and 130, respectively. This indicates that the hSkMOs contained mature skeletal muscle properties and had the potential for #regeneration .
The researchers wanted to see if the #hSkMO s (human #skeletal muscle #organoid s) had the ability to regenerate #muscle #tissue after damage. To test this, they treated the hSkMOs with a cardiotoxin (CTX) which is known to induce muscle inflammation and damage. They then observed a decrease in PAX7+ and MYOD+ cells in the hSkMOs. To further test the #regenerative potential of the #hSkMO s, they added interleukin-4 (IL-4) to the medium to promote #muscleregeneration. After 14 days, they observed a significant increase in MYOG+ myocytes in the CTX-injured hSkMOs with the treatment of IL-4 compared to the CTX-injured hSkMOs without the treatment. This suggests that the hSkMOs have the potential to regenerate muscle tissue after damage.
Generation of Skeletal Muscle Organoids from Human Pluripotent Stem Cells to Model Myogenesis and Muscle Regeneration
Authors :
Min-Kyoung Shin , Jin Seok Bang , Jeoung Eun Lee , Hoang-Dai Tran , Genehong Park , Dong Ryul Lee and Junghyun Jo
