#sle — Public Fediverse posts

Loss-of-function mutations in PLD4 linked to SLE:

🔬 PLD4 mutations led to high TLR7/9 activation
🔬 5 patients showed reduced exonuclease activity
🔬 Effective baricitinib treatment in mice

#SLE #Genetics #Inflammation #Pub2Post
https://tnyp.me/vwTf6xf5/m

Looking at proteolytis in human plasma, we observed a lot of cleavages in complement C3, with known cleavages for C3a, C3b, and C3(d)g - but also a yet not deeply investigated cleavage at pos. 1514, which represented for us a quite intriguing lupus-enriched cleavage, thus we named it C3-LHF1 for complement "C3 Lupus Human Fragment 1" #C3 #Complement #LHF1 #SLE #Lupus 3/n

Der Mann hat was neues für #Lupus gefunden - oder wie @kabalak selbst sagen würde:

In conclusion, this study uncovers a new dimension of immune crosstalk: a proteolytic plasma network that generates immunoactive fragments with intrinsic self-regulatory capabilities to modulate #inflammation and tissue injury in complex disease contexts. Deciphering these immunoactivities may pave the way for innovative diagnostic and therapeutic strategies in complement-driven pathologies, potentially benefiting a wide range of inflammatory and autoimmune diseases.

#AutoimmuneDiseases #InflammatoryDisease #Science #SLE #proteomics #MassSpec #TeamMassSpec #LupusResearch

https://www.embopress.org/doi/full/10.1038/s44318-025-00598-8

Even Aushra Augustanavichute in her work on the concept of socionics wrote that this is still raw, but they are open to dialogue in the world. Especially if you consider that they had only a few descriptions for SLE.
#socionics #psychosophy #Artist #SLE

https://bsky.app/profile/crijournal.bsky.social/post/3lvoc4wxkpc2k

https://www.dl.begellhouse.com/journals/2ff21abf44b19838,64a172b927050513,5663a19227f6eb0f.html

#Lupus #SLE #LupusResearch #Pathogenesis #PrecisionMedicine

#SUSECON 2025: #SUSE setzt auf #KI und erweiterte #SLE -Unterstützung - #fosstopia

#SUSE hat auf der diesjährigen #SUSECON in Orlando klargestellt, dass es bei der KI-Revolution mitmischen will. Neben einer Reihe von Anwendungsfällen für künstliche Intelligenz gab es auch spannende Neuerungen für Admins im Hinblick auf die verschiedene #Linux-Distributionen.

https://fosstopia.de/susecon-2025-suse-setzt-auf-ki/

🇪🇦 Día tras día

🇬🇧 Day after day

#caturday #CatsOfMastodon #calico #CalicoCat #Lupus #POTS #LES #SLE #EncefalomielitisMialgica #fibromialgia #Sjögren #Sjögrens #fibromyalgia #Autoinmune #Autoimmune

Impressive case at #CharitéBerlin: In a 23-year-old female patient with severe systemic #lupus erythematosus, the #AutoimmuneDisease is no longer detectable after treatment with a cancer medication. Only time will tell if the results will last, but the case marks the starting point for further studies.

👉 https://www.charite.de/en/service/press_reports/artikel/detail/impressive_results_against_autoimmune_disease/

#Medicine #Science #Research #ScienceMastodon #MedMastodon #Medibubble #SLE #CharitéImmunology #autoimmunity

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

Lo prometido es deuda.
Si has visto la serie "Dr House" sabes que cada vez que entraba alguien de urgencias medio muriéndose sin responder a nada, el equipo médico hacía un diagnostico diferencial con el lupus para descartarlo.
Pero seguramente no sepas mucho más. Aprende aquí:

#179 #Lupus 10 preguntas básicas por el #DiaMundialdelLupus 🐺
https://domandoallobo.blogspot.com/2016/05/179-lupus-10-preguntas-basicas-por-el.html #blog #mastoblogs #mastobloggers #LES #SLE #autoinmunes #Autoimmunes #DisOrganic #Discapacidad

Desde el domingo con brote de #EncefalomielitisMiálgica y crisis de dolor neuropático. Al menos hoy duele menos al teclear.

A #MyalgicEncephalomyelitis crash (flare) and neuropathic pain crisis since Sunday. Typing hurts less but still.

#Dolor #DolorNeuropatico #DolorCronico #EMsfc #fibromialgia#Sjögen #Lupus #LES #NeuralgiaDelTrigemino #NdT #Migraña #Pain #ChronicPain #neuropathicPain #ME #MEcfs #fibromyalgia #Sjögrens #SLE #TrigeminalNervePain #TNP #Migraine

'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'

#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity

https://onlinelibrary.wiley.com/doi/10.1002/art.42482