#neutrophils — Public Fediverse posts

Scientists discover how neutrophils travel to infection sites without damaging healthy tissue

UMass Chan Medical School scientist Beth McCormick, PhD, and her team collaborated with researchers at the University of…
#NewsBeep #News #Health #Anti-Inflammatory #AU #Australia #Blood #Cell #Chemicals #Chronic #Drugs #Inflammation #inflammatorydisease #MedicalSchool #neutrophils #protein #Receptor #research
https://www.newsbeep.com/au/868146/

Disrupted brain-immune signaling may help drive neurodegeneration

From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
#NewsBeep #News #Health #Antigen #Blood #Brain #CA #Canada #CD4 #Cell #Cytokine #Gene #immunity #Ligand #Microglia #Nerve #nervoussystem #neurodegeneration #Neurons #neutrophils #Pathology #Protein #Synapse #TDP-43 #Vascular
https://www.newsbeep.com/ca/869472/

Cancer cells exploit liver fat to evade immune system destruction

Liver metastases are among the most common and deadly forms of cancer spread. Now, researchers at VIB and…
#NewsBeep #News #Health #AU #Australia #Cancer #Cell #Enzyme #ImmuneSystem #Liver #Metastasis #neutrophils #Nutrients #protein #research #Tumor
https://www.newsbeep.com/au/844431/

https://www.europesays.com/ie/560923/ Smoking reprograms immune cells to accelerate cardiovascular disease #atherosclerosis #blood #CardiovascularDisease #Cell #chemicals #Cholesterol #Chronic #Cigarette #Éire #Health #Heart #IE #ImmuneSystem #Inflammasome #inflammation #Interleukin #Ireland #Lungs #medicine #Neutrophils #Nicotine #pH #Research #smoking #Tobacco #WhiteBloodCell

Nasal viruses may drive allergic rhinitis, and ribavirin shows early promise as a targeted spray treatment

A new study suggests that clearing symptom-driving nasal viruses could calm allergic inflammation and open a fresh treatment…
#NewsBeep #News #Technology #AllergicRhinitis #AU #Australia #Cell #Cytokine #Efficacy #Genes #immunity #Inflammation #Interferon #Knockout #neutrophils #Rhinitis #Ribavirin #RNA #Sleep #Sneezing #therapy #virus
https://www.newsbeep.com/au/766797/

https://www.europesays.com/ie/559168/ Nasal viruses may drive allergic rhinitis, and ribavirin shows early promise as a targeted spray treatment #AllergicRhinitis #Cell #Cytokine #Efficacy #Éire #Genes #IE #immunity #inflammation #Interferon #Ireland #Knockout #Neutrophils #Rhinitis #Ribavirin #RNA #Sleep #Sneezing #Technology #therapy #virus

https://www.europesays.com/ie/506434/ Current-free wireless fields selectively alter immune and cancer cell migration #blood #BreastCancer #cancer #Cell #CellCulture #Éire #IE #imaging #Ireland #Neutrophils #PetriDish #pH #Research #Science #Tumor

A single sauna session boosts immune cells within minutes

New research reveals how a brief Finnish sauna session mobilizes immune defenses within minutes, offering fresh clues into…
#NewsBeep #News #Health #AU #Australia #CardiovascularDisease #Cell #Cytokine #Cytokines #Dementia #Ear #GlobalHealth #heat #heatstress #Hemoglobin #Lymphocyte #neutrophils #Psychosis #research #Respiratory #stress
https://www.newsbeep.com/au/612848/

https://www.europesays.com/ie/322158/ Reprogrammed neutrophils promote tumor growth #Bioinformatics #cancer #CCL3 #Cell #Chemokine #Éire #Evolution #IE #Immunology #Ireland #medicine #Molecule #Neutrophils #oncology #Pathology #Research #Science

Nighttime heart attacks cause less damage due to neutrophil circadian rhythms

Heart attacks that occur at night are less severe than those that strike during the day. A new…
#NewsBeep #News #Health #Anemia #AU #Australia #Blood #BloodVessel #Cell #Heart #heartattack #ImmuneSystem #Inflammation #medicine #neutrophils #RedBloodCells #research #SickleCellAnemia #WhiteBloodCell
https://www.newsbeep.com/au/344322/

https://www.europesays.com/ie/230083/ Nighttime heart attacks cause less damage due to neutrophil circadian rhythms #Anemia #blood #BloodVessel #Cell #Éire #Health #Heart #HeartAttack #IE #ImmuneSystem #inflammation #Ireland #medicine #Neutrophils #RedBloodCells #Research #SickleCellAnemia #WhiteBloodCell

https://www.europesays.com/ie/214384/ NeuMap unveils the hidden architecture and life-long patterns of human neutrophils #cancer #Cell #Covid19 #Éire #IE #inflammation #Ireland #Neutrophils #Research #Science #Translation

https://www.europesays.com/ie/203428/ Hematological and biochemical indicators show growing value in breast cancer management #Anemia #Antioxidant #blood #BreastCancer #cancer #Cell #DDimer #Diagnostic #Éire #GlobalHealth #Health #Hemoglobin #IE #ImmuneResponse #ImmuneSystem #inflammation #Ireland #Lymphocyte #medicine #Metastasis #Mortality #Neutrophils #OxidativeStress #Research #Stress #Tumor #WhiteBloodCell

The heme-binding protein hemopexin promotes functional recovery and tissue protection after spinal cord injury via sex-specific regulation of inflammation and ferroptosis | Journal of Neuroinflammation

Sekhon LH, Fehlings MG. Epidemiology, demographics, and pathophysiology of acute spinal cord injur…
#NewsBeep #News #Health #AU #Australia #Hemopexin #hemorrhage #Immunology #neurobiology #Neurology #Neurosciences #neutrophils #Secondarydamage #SpinalCordInjury
https://www.newsbeep.com/au/299067/

https://www.europesays.com/ie/192371/ The heme-binding protein hemopexin promotes functional recovery and tissue protection after spinal cord injury via sex-specific regulation of inflammation and ferroptosis | Journal of Neuroinflammation #Éire #Health #Hemopexin #hemorrhage #IE #Immunology #Ireland #neurobiology #neurology #Neurosciences #Neutrophils #SecondaryDamage #SpinalCordInjury

https://www.europesays.com/ie/187549/ New light-based technology arranges cellular messengers with unprecedented precision #bacteria #Bacterial #blood #cancer #Cell #Éire #IE #Ireland #Metastasis #Nanoparticles #Neutrophils #Science #Technology #Wound #WoundHealing

A cause for age-related cardiac problems: damage by antimicrobial peptides released by immune cells. #neutrophils #heart #arrhythmia https://www.science.org/doi/abs/10.1126/science.aea6159

Chronic Stress Sends Immune Cells to Brain, Driving Depression

Summary: A new study shows that chronic stress causes immune cells called neutrophils to leave bone marrow in…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #brainresearch #depression #immunecells #Mentalhealth #neurobiology #Neuroscience #neutrophils #Psychology #Science #stress #UniversityofCambridge
https://www.newsbeep.com/us/129170/

New Clozapine Consensus Guidelines Drop ANC Monitoring

Monitoring absolute neutrophil count (ANC) levels be…
#NewsBeep #News #Medication #adverseeffects #antipsychotics #AU #Australia #clinicalguidelines #constipation;costiveness #drooling #guidelines #Health #neurolepticdrugs #neuroleptics #neutropenia #neutrophils #patientsafety #ptyalism #REMS-riskevaluationandmitigationstrategies #RiskEvaluationandMitigationStrategies #Schizophrenia #sialorrhea #sideeffects
https://www.newsbeep.com/au/3420/

#Neutrophils are very abundant and generally helpful #immune cells. However, in tumors they can misfire and form large clumps that block blood vessels. This blockage causes necrosis & metabolic adaptation of #tumor and #metastasis.
https://www.nature.com/articles/s41586-025-09278-3

Obesity Cripples Anti-Bacterial Immunity: It cripples your white blood cells, the neutrophils, that kill bacteria. #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis
https://www.instagram.com/reel/DH9NiUTtOcR/

#neutrophils, one of the most abundant immune cells, have revealed another superpower: they form natural bandages that cover wounds and keep bacteria out. https://www.nature.com/articles/d41586-025-00796-8

Mind blowing #immunology fact!

We now know that the body's first responders (#Neutrophils) have a multi-pronged attack, and when all else fails they turn into little suicide bombers--spewing out their own #DNA as a microscopic #net to catch and kill #bacteria! 🙀

Somebody was cute and named these "Neutrophil Extracellular Traps" or NETs for short. 🙂

https://en.wikipedia.org/wiki/Neutrophil_extracellular_traps

This photo is from a medical journal and is credited to Dr Volker Brinkmann, Max Planck Institute for Infection Biology, Berlin, Germany. Amazing!! 👍 👏

(Neutrophil extracellular trap (NET) formation. Scanning electron microscopy of neutrophil (yellow) casting a net (green) entrapping Helicobacter pylori bacteria (blue))

https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312463

Chronic stress increases #metastasis. Paper describes one mechanism: stress-related glucocorticoids make #neutrophils produce #NETs and thus metastasis-friendly milieu. https://www.cell.com/cancer-cell/fulltext/S1535-6108%2824%2900037-0

Maybe one of the most interesting things to me, as a lay person, in https://www.nature.com/articles/s41390-024-03731-1 is (as I read this) a lab Dx for Long Covid in children can be done right now, and distinguishes cleanly from convalescent children without Long Covid symptoms (Figure 4: D, K, and I).

I read this Nature paper as absolutely putting to rest claims that children aren't getting LC or that it's post-2020 trauma and so on. There's been other evidence before but I don't remember other gaps that were so clean.

h/t a half dozen zeroes.ca and other fedisci folks

#CovidIsNotOver #COVID #COVID19 #SARSCoV2 #neutrophils #LongCovidKids #LongCOVID

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

β-Glucan Reprograms #Neutrophils to Induce Disease #Tolerance Against #Influenza A Virus, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.02.610822v1

Collectively, our data indicate that β-glucan reprograms hematopoietic #stem cells (HSCs) to generate neutrophils with a novel 'regulatory' function, which is required for promoting disease tolerance and maintaining #lung tissue integrity against viral infection.

How water influx and swelling in #neutrophils help them migrate. https://elifesciences.org/reviewed-preprints/90551?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Mechanisms of metastasis.

'Together, our data show that glucocorticoids released during chronic stress cause NET formation and establish a metastasis-promoting microenvironment. Therefore, NETs could be targets for preventing metastatic recurrence in cancer patients, many of whom will experience chronic stress due to their disease.'
#Cancer #Neutrophils #Metastasis #Immunology

https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00037-0?

Postdoctoral Researcher (all genders) Cancer Research

BioMed X Institute

New research team at the #BioMedX Institute: New Strategies to Engage #Neutrophils in Solid #Tumors

See the full job description on jobRxiv: https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-cancer-research-2/?feed_id=70658

#bioinformatics #cancer #cancer_research #...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-cancer-research-2/?feed_id=70658

Research Group Leader (all genders) Cancer Research

BioMed X Institute

New research team at the #BioMedX Institute: New Strategies to Engage #Neutrophils in Solid #Tumors

See the full job description on jobRxiv: https://jobrxiv.org/job/biomed-x-institute-27778-research-group-leader-all-genders-cancer-research/?feed_id=70651

#cancer_immunology #cancer_research #immuno_oncolo #...
https://jobrxiv.org/job/biomed-x-institute-27778-research-group-leader-all-genders-cancer-research/?feed_id=70651

Postdoctoral Researcher (all genders) Cancer Research

BioMed X Institute

New research team at the #BioMedX Institute: New Strategies to Engage #Neutrophils in Solid #Tumors

See the full job description on jobRxiv: https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-cancer-research-2/?feed_id=68674

#bioinformatics #cancer #Cancer_research #...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-cancer-research-2/?feed_id=68674

Research Group Leader (all genders) Cancer Research

BioMed X Institute

New research team at the #BioMedX Institute: New Strategies to Engage #Neutrophils in Solid #Tumors

See the full job description on jobRxiv: https://jobrxiv.org/job/biomed-x-institute-27778-research-group-leader-all-genders-cancer-research/?feed_id=68658

#cancer_immunology #Cancer_research #immuno_oncolo #...
https://jobrxiv.org/job/biomed-x-institute-27778-research-group-leader-all-genders-cancer-research/?feed_id=68658

Postdoctoral Researcher (all genders) Cancer Research

BioMed X Institute

New research team at the #BioMedX Institute: New Strategies to Engage #Neutrophils in Solid #Tumors

See the full job description on jobRxiv: https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-cancer-research-2/?feed_id=68536

#bioinformatics #cancer #Cancer_research #...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-cancer-research-2/?feed_id=68536

Research Group Leader (all genders) Cancer Research

BioMed X Institute

New research team at the #BioMedX Institute: New Strategies to Engage #Neutrophils in Solid #Tumors

See the full job description on jobRxiv: https://jobrxiv.org/job/biomed-x-institute-27778-research-group-leader-all-genders-cancer-research/?feed_id=68520

#cancer_immunology #Cancer_research #immuno_oncolo #...
https://jobrxiv.org/job/biomed-x-institute-27778-research-group-leader-all-genders-cancer-research/?feed_id=68520

#Neutrophils swell to speed up migration. #ReviewedPreprint https://elifesciences.org/reviewed-preprints/90551?utm_source=twitter&utm_medium=social&utm_campaign=organic

Transcriptional profiling of phagocytic leukocytes and microglia reveals a critical role for reactive oxygen species in biofilm containment during Staphylococcus aureus craniotomy infection. https://doi.org/10.4049/jimmunol.2200503 #StaphylococcusAureus #Biofilm #CraniotomyInfection #Microglia #Neutrophils

We're excited that our new study revealing fascinating functions for #neutrophils in #brain #cancers is now online at @cellcellpress

"The local microenvironment drives activation of neutrophils in human brain tumors"

Congrats to all authors in the Joyce lab, in particular Roeltje Maas, Klara Soukup, Nadine Fournier, Matteo Massara, Sabine Galland et al, and our generous collaborators

Our special appreciation to all the patients 🙏

#OpenAccess
Open for all to read 🔗: https://www.cell.com/cell/fulltext/S0092-8674(23)00977-7

Nice papers that #neutrophils can also be epigenetically reprogrammed by infection - stemming from effects on stem cells.

Both use #zebrafish as model

#Shigella: https://www.science.org/doi/full/10.1126/sciadv.adf9706

#Salmonella: https://www.science.org/doi/10.1126/sciadv.adf9904
#trainedimmunity #immunology #epigenetics

Happy Friday in the lab! Great to be back in the lab all week doing experiments 👩🏻‍🔬 Feeling much less like a hassle and incompetent!
I do however feel like I'm spinning a few too many plates at the moment with the masters, exams, applications, clinical work, QIP/portfolio, let alone trying to find time for the classic "New Year New Me" trope... Trying to stay optimistic and realistic!

#WomenInScience #ClinicalResearcher #MedMastodom #Blood #Neutrophils #Monocytes #laboratorylife #SelfDoubt

https://www.researchgate.net/publication/321214290_Immunoglobulin_G_Structure_and_functional_implications_of_different_subclass_modifications_in_initiation_and_resolution_of_allergy/figures?lo=1

Is less neutrophil activation a good or a bad thing for immunity against COVID-19?
Another study shows that the activation of myelopoietic responses #neutrophils is associated with disease severity.
https://pubmed.ncbi.nlm.nih.gov/36208629/

That raises some questions on the role of IgG4 in COVID-19.

The authors note a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis (by neutrophils) and complement deposition. #neutrophils will be less activated by IgG4 antibodies.
IgG4 reduces exacerbations of immune reactions e.g., by IgE, and thus unwanted immune responses. IgG4 might be predicted to have similar effects than dexamethasone that saves lives of patients at the ICU.

#teamMassSpec I've officially joined mastodon. My focus is #proteomics focussed to #immunology particularly working on #tcells and #neutrophils

@shanaqui
There's another talk - I barely remember it - but IIRC it was interesting. Apparently mast cells can also release extracellular traps.

Presented by Imre Varju, MD, PhD
"Immune-derived extracellular traps in COVID-19 and other infections" Sept 2020
https://youtu.be/avFT3ypEBas

#immunology #COVID19 #neutrophils #MastCells #mitochondria #NETosis #ExtracellularTraps #thrombosis #clotting #fibrin
#myeloperoxidase
#histones

@shanaqui

You might enjoy this NIH VideoCast from 2021 on NETs
presented by Marianna Kaplan, MD

'Casting the NET Wide: Neutrophils Shape Chronic Inflammatory Diseases'
https://youtu.be/Kd6FvhvlH3Q

#immunology #autoimmune #autoimmunity #Lupus #inflammation #neutrophils
#SexDifferences

New Open Medicine Foundation study on #neutrophils and #MCFS announced:

https://www.omf.ngo/ron-davis-new-neutrophil-study/

@mecfs

#Intestinal #bacteria composition is crucial to driving the recovery of #neutrophils counts in the blood of mice following treatments such as stem cell #transplants or #chemotherapy.
#Microbiology #Biology #Medical #sflorg
https://www.sflorg.com/2022/11/mcb11212201.html