#tregs — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tregs, aggregated by home.social.
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The results appear contradictory. If the CD5-high population produces more IL-2, it should be less, not more, dependent on exogenous IL-2 for Foxp3+ Treg conversion.
#science
#immunology
#Foxp3
#Tregshttps://www.biorxiv.org/content/10.64898/2026.06.16.732736v1
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The results appear contradictory. If the CD5-high population produces more IL-2, it should be less, not more, dependent on exogenous IL-2 for Foxp3+ Treg conversion.
#science
#immunology
#Foxp3
#Tregshttps://www.biorxiv.org/content/10.64898/2026.06.16.732736v1
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#Sangamo had one of the most advanced CAR-Treg programs in the field, the HLA-A2–directed TX200 (STEADFAST) kidney transplant tolerance program.
Is it going to be discontinued?
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#Sangamo had one of the most advanced CAR-Treg programs in the field, the HLA-A2–directed TX200 (STEADFAST) kidney transplant tolerance program.
Is it going to be discontinued?
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These results are difficult to explain. How can a malaria-primed memory T-cell pool depleted of Tregs be less effective upon recall than either the same pool containing Tregs or even purified memory Tregs alone?
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These results are difficult to explain. How can a malaria-primed memory T-cell pool depleted of Tregs be less effective upon recall than either the same pool containing Tregs or even purified memory Tregs alone?
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
⬇️
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
⬇️
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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Für die Entdeckung der regulatorischen T-Zellen #Tregs wurden drei Forscher:innen 2025 mit dem Medizin-Nobelpreis ausgezeichnet. HZI-Immunologe Jochen Hühn erklärt im @NDR, wie Tregs als "Dirigenten" des Immunsystems für eine ausbalancierte Immunantwort sorgen.
https://www.ndr.de/ndr-text/fernsehen/visite/regulatorische-t-zellen-hilfe-bei-allergie-entzuendung-und-organabstossung,visite-692.html -
Für die Entdeckung der regulatorischen T-Zellen #Tregs wurden drei Forscher:innen 2025 mit dem Medizin-Nobelpreis ausgezeichnet. HZI-Immunologe Jochen Hühn erklärt im @NDR, wie Tregs als "Dirigenten" des Immunsystems für eine ausbalancierte Immunantwort sorgen.
https://www.ndr.de/ndr-text/fernsehen/visite/regulatorische-t-zellen-hilfe-bei-allergie-entzuendung-und-organabstossung,visite-692.html -
"microbiota-dependent immune tolerance mechanisms that promote fetal development."
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"microbiota-dependent immune tolerance mechanisms that promote fetal development."
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Why do Tregs accumulate within tumors? What antigen do they recognize, is it a self antigen, a neoantigen, or a cryptic antigen? Without determining the antigen specificity of these Tregs, we are basically going in circles without advancing.
#science
#immunology
#tumor
#Tregshttps://www.preprintclub.com/preprint-reviews/2025-nov-chaib
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**Công thức mới giúp tạo tế bàoGuardian vor すべて sièges tự nhiễmquen - Tăng cơ hội th edo hiệu trị bệnh tự cảm**
Công学家 Sakaguchi dẫn công thức mới tạo tế bào Treg (tractor düzen) nhiều hơn và bền vững để điều gián hệ miễn dịch. Nghiên cứu trên chuột và tế bào từ người đã cónhuفية. Có tiềm năng thílioсут đặc bản cho scheme điều trị. #Autoimmune #Tregs #Health #CôngThứcMới #BệnhTựCực #Y học }) -
The Treg story continues! 🔬 Nicole Joller – Tregs & Th1 Steve Ziegler – regulating Tregs Fabio Canto – Gut Tregs & B cells Luciana Berod – linking Metabolism & T cell fate via post-translational protein modifications #Tregs #Immunology #Science #Metabolism #Nobel #SBI #ImmunoBuzios2025
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13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs -
Why T Cell Tolerance Is Fixed from Birth
1. Unlike the innate immune system, which uses receptors to discriminate self from nonself based on biochemical features of the ligand (like LPS, foreign DNA, or foreign RNA)
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Why T Cell Tolerance Is Fixed from Birth
1. Unlike the innate immune system, which uses receptors to discriminate self from nonself based on biochemical features of the ligand (like LPS, foreign DNA, or foreign RNA)
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Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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Initially, the thymus was believed to be an endocrine organ because its removal in early life caused changes in the ovaries and testes. Now, we understand these changes were linked to autoimmunity. 🤔🔬💡
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6/ 🔬 These inconsistencies raise key questions about how Treg suppression works in different contexts. More research needed! 🏗️📖
What do you think? Drop your thoughts below! ⬇️💬
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6/ 🔬 These inconsistencies raise key questions about how Treg suppression works in different contexts. More research needed! 🏗️📖
What do you think? Drop your thoughts below! ⬇️💬
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1/ 📢 A new study was recently published in Science Translational Medicine investigating antigen specificity in Treg-mediated suppression of effector T cells in a celiac model. 🔬🍞
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1/ 📢 A new study was recently published in Science Translational Medicine investigating antigen specificity in Treg-mediated suppression of effector T cells in a celiac model. 🔬🍞
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6/ How can antigen-specific Tregs lose their functionality? By losing the antigen. Without the anchor antigen to engage the Treg TCR and collaborate with other T cells for IL-2, the process breaks down. 🔓
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9/ If the lost anchor antigen is similar to the target self-antigen, Treg–IL-2+ T cell collaboration stays intact. 🔄 If they’re different, losing the anchor antigen shouldn’t affect other self-antigens. ⚖️ No disruption → No autoimmunity!
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7/ But how could we lose a self-antigen? Not realistic. And if a self-antigen is lost, how can autoimmunity occur? No antigen, no autoimmunity. 🚫
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6/ How can antigen-specific Tregs lose their functionality? By losing the antigen. Without the anchor antigen to engage the Treg TCR and collaborate with other T cells for IL-2, the process breaks down. 🔓
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7/ But how could we lose a self-antigen? Not realistic. And if a self-antigen is lost, how can autoimmunity occur? No antigen, no autoimmunity. 🚫
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4/ Based on this evidence, if Tregs inhibit other T cells in an antigen-specific manner, they must recognize similar antigens. Likewise, IL-2 supply from other T cells is also likely antigen-specific. 🔑
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4/ Based on this evidence, if Tregs inhibit other T cells in an antigen-specific manner, they must recognize similar antigens. Likewise, IL-2 supply from other T cells is also likely antigen-specific. 🔑
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1/ 🧵 What is the TCR specificity of Foxp3+ Tregs? They're as diverse as conventional T cells, but very few antigen-specific Tregs have been described. This lack of specificity leads to many unfounded statements. Let's dive in. 🔬
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5/ But what antigens do Tregs and other T cells recognize to collaborate on IL-2 supply? Is it auto-antigen? Unlikely. Why? Because for autoimmunity to happen, Tregs would need to lose their functionality. ⚠️
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2/ A common claim: Tregs are autoreactive, meaning they recognize self-antigens. Since Tregs protect against autoimmunity, this seems logical. But does it really hold up? 🤔 Let's run a thought experiment. 💭
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2/ A common claim: Tregs are autoreactive, meaning they recognize self-antigens. Since Tregs protect against autoimmunity, this seems logical. But does it really hold up? 🤔 Let's run a thought experiment. 💭
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1/ 🧵 What is the TCR specificity of Foxp3+ Tregs? They're as diverse as conventional T cells, but very few antigen-specific Tregs have been described. This lack of specificity leads to many unfounded statements. Let's dive in. 🔬
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5/ But what antigens do Tregs and other T cells recognize to collaborate on IL-2 supply? Is it auto-antigen? Unlikely. Why? Because for autoimmunity to happen, Tregs would need to lose their functionality. ⚠️
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SciTech Chronicles. . . . . . . . .Mar 14th, 2025
#singularity #black #white #planar #Additive #spares #MMPACT #Regolith #gluconolactone #regulation #inflammation #Tregs #Serpentinization #olivine #magnetite #magnetizations #silicon #biomolecules #autotrophs #aquaporins
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Scientists at Harvard Medical School have discovered a distinct population of #Tregs dwelling in the protective layers of the #brains of healthy mice with a repertoire much broader than inflammation control.
#Biology #Biomedical #Neuroscience #sflorg
https://www.sflorg.com/2025/01/bio01282501.html -
Scientists at Harvard Medical School have discovered a distinct population of #Tregs dwelling in the protective layers of the #brains of healthy mice with a repertoire much broader than inflammation control.
#Biology #Biomedical #Neuroscience #sflorg
https://www.sflorg.com/2025/01/bio01282501.html -
1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses.
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1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses.
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'We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (Klf2) within the T cell lineage blocks the generation of peripheral-derived Tregs (pTregs) without impairing production of thymic-derived Tregs. Using this mouse model, we have now demonstrated that eliminating pTregs is sufficient to delay/prevent tumor malignancy without causing autoimmunity.'
#Immunology #TumorImmunology #Tregs #Immunotherapy -
'We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (Klf2) within the T cell lineage blocks the generation of peripheral-derived Tregs (pTregs) without impairing production of thymic-derived Tregs. Using this mouse model, we have now demonstrated that eliminating pTregs is sufficient to delay/prevent tumor malignancy without causing autoimmunity.'
#Immunology #TumorImmunology #Tregs #Immunotherapy -
“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.
T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.
To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.
They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.
“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/ -
“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.
T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.
To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.
They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.
“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/