#tregs — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tregs, aggregated by home.social.
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Initially, the thymus was believed to be an endocrine organ because its removal in early life caused changes in the ovaries and testes. Now, we understand these changes were linked to autoimmunity. 🤔🔬💡
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9/ If the lost anchor antigen is similar to the target self-antigen, Treg–IL-2+ T cell collaboration stays intact. 🔄 If they’re different, losing the anchor antigen shouldn’t affect other self-antigens. ⚖️ No disruption → No autoimmunity!
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7/ But how could we lose a self-antigen? Not realistic. And if a self-antigen is lost, how can autoimmunity occur? No antigen, no autoimmunity. 🚫
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5/ But what antigens do Tregs and other T cells recognize to collaborate on IL-2 supply? Is it auto-antigen? Unlikely. Why? Because for autoimmunity to happen, Tregs would need to lose their functionality. ⚠️
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“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.
T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.
To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.
They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.
“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/ -
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