#foxp3 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #foxp3, aggregated by home.social.
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
⬇️
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
⬇️
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
⬇️
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1/ An elegant study from the Sakaguchi and Hori labs explores the role of Foxp3 in Tregs. Despite extensive work, many aspects of Treg biology remain unresolved. this work uncovers another piece of the puzzle.
⬇️
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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This level of scientific ignorance is unacceptable. You cannot draw conclusions about antigen-specific Treg inhibition from in vitro assays when they do not align with in vivo suppression readouts.
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Why do studies claiming #Treg induction by novel designer drugs test them only when given before or with antigen, rather than in established disease that more closely reflects human cases?
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13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs -
13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs -
13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs -
13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs -
13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs -
Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
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Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
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Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
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Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
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Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3
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6/ 🔬 These inconsistencies raise key questions about how Treg suppression works in different contexts. More research needed! 🏗️📖
What do you think? Drop your thoughts below! ⬇️💬
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6/ 🔬 These inconsistencies raise key questions about how Treg suppression works in different contexts. More research needed! 🏗️📖
What do you think? Drop your thoughts below! ⬇️💬
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1/ 📢 A new study was recently published in Science Translational Medicine investigating antigen specificity in Treg-mediated suppression of effector T cells in a celiac model. 🔬🍞
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1/ 🧵 What is the TCR specificity of Foxp3+ Tregs? They're as diverse as conventional T cells, but very few antigen-specific Tregs have been described. This lack of specificity leads to many unfounded statements. Let's dive in. 🔬
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1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses.
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'We found that up-regulation of a primate-specific short isoform of PRDM1-S induces expression of SGK1 independent from the evolutionarily conserved long PRDM1, which led to destabilization of #FOXP3 & #Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases.'
#Immunology
https://www.science.org/doi/10.1126/scitranslmed.adp1720 -
"Here, by comprehensively mapping 3D #chromatin organization during #Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of #Foxp3, a Treg lineage specifying #transcription factor, were highly enriched at Treg-specific chromatin loop anchors."
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"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183
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#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473