#chromatin — Public Fediverse posts

The maternal-to-zygotic transition in #zebrafish is activated by TFs that open #chromatin via enhancers lacking H3K4me2. @MTLeeLab &co identify a parallel pathway that is activated by #enhancers that bear H3K4me2, showing that both act in combination @PLOSBiology https://plos.io/3IFqYMc

This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology

PhD in Chromatin Biology

University College Dublin

#PhD position available at University College Dublin to work on the mechanisms of #enhancer dysregulation in acute myeloid #leukemia.

See the full job description on jobRxiv: https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768

#ScienceJobs #hiring #research #chromatin #transcription #enhancers #cance...
https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768

Hallo all - I guess an introduction might be a good idea!

I'm a mid-career (already!?) group leader, trying to unpick how different aspects of the local environment at #enhancers work together to regulate #transcription and #geneexpression.

We especially like non-coding enhancer #RNA, how their structures and dynamic movements make them functional; how disease mutations affect #eRNA activity and how the enhancer environment affects the #chromatin regulator CBP.

Super-excited to land here!

#GeneRegulation digest #4:

🧬 New role of histone tails in nucleosome remodelling https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad079/7034407

🧬 TFBSs under accelerated #evolution in primates https://www.nature.com/articles/s41467-023-36421-3

🧬 Review of IDRs in #transcription regulators https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(23)00008-7

🧬 CpG islands & protection of genes from premature transcription termination https://www.nature.com/articles/s41467-023-36236-2

🧬 Regulation of #enhancers by DNA #methylation https://www.sciencedirect.com/science/article/pii/S1097276523000400

🧬 H2A-H2B & short-term memory of #chromatin states https://www.sciencedirect.com/science/article/pii/S0092867423000077

#paperoftheday

Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)

https://www.science.org/doi/10.1126/science.abn5647

Three autism-linked genes converge on tweaks to cells’ timing

https://www.spectrumnews.org/news/three-autism-linked-genes-converge-on-tweaks-to-cells-timing/

#signalingimbalance #macrocephaly #chromatin #organoids #autism #News #CHD8 #GABA

Disruptions to brain’s ‘thermostat’ may underpin autism traits

https://www.spectrumnews.org/news/disruptions-to-brains-thermostat-may-underpin-autism-traits/

#signalingimbalance #synapticplasticity #neuralcircuits #spokenversion #mousemodels #chromatin #epilepsy #autism #genes #News #CHD8