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#chromatin — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #chromatin, aggregated by home.social.

  1. Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

    Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target.…
    #NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Ageing #Biochemistry #CancerResearch #cellbiology #Chromatin #Developmentalbiology #Genesilencing #general #LifeSciences #Stemcells
    newsbeep.com/us/551744/

  2. Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

    Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target.…
    #NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Ageing #Biochemistry #CancerResearch #cellbiology #Chromatin #Developmentalbiology #Genesilencing #general #LifeSciences #Stemcells
    newsbeep.com/us/551744/

  3. #Wolbachia causes embryonic lethality in #FruitFlies by modifying #chromatin integrity in sperm. @KaurTweets @Symbionticism &co show that this occurs in the wMel-transinfected #Aedesaegypti #mosquitoes used to control vector-borne diseases #PLOSBiology plos.io/3xgOsBH

  4. Our new article has been published in the Biophysical Journal @BiophysJ: "Nucleosome spacing controls chromatin spatial structure and accessibility". We placed a long #nucleosome chain in a box mimicking natural density conditions. We did not see melting of #chromatin fibers at high densities. Accessibility of #chromatin to diffusive processes increases with higher regularity of nucleosome spacing. authors.elsevier.com/a/1ijrB1S. #hochschulestralsund #lmumünchen

  5. In 2021, we published this paper: Structure and dynamics of the #chromatin remodeler ALC1 bound to a PARylated #nucleosome
    doi.org/10.7554/eLife.71420

    It ended with a hypothesis we addressed in a follow-up paper, which will be out soon, hooray! 🥳
    I will post a summary thread of this new paper, but in the meantime, I will repost below the summary of the first paper that I posted on Twitter back then (since I no longer have an account on Twitter).

    #cryoEM

  6. Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
    Sam Witus, Rachel Klevit, Weixing Zhao et al
    embopress.org/doi/10.15252/emb

  7. A new variation of the #HiC method to study #3Dgenome interactions specifically for open #chromatin. "HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization" cell.com/molecular-cell/fullte?

  8. Anchoring #3Dgenome & #chromatin contacts to #cellnucleus landmarks: Mapping #nucleolus-associated chromatin interactions using nucleolus #HiC reveals pattern of #heterochromatin interactions.
    @NatureComms doi.org/10.1038/s41467-023-360

  9. Our new preprint! Nucleosome repositioning in chronic lymphocytic leukaemia (CLL) biorxiv.org/content/10.1101/20
    ▶️Nucleosome changes at cancer-sensitive regions allow patient stratification
    ▶️Nucleosome repeat length (NRL) decreases with #cancer aggressiveness
    ▶️Interplay with #methylation, #TFbinding and more!

    #CLL, #nucleosome, #leukaemia, #chromatin