#chromatin — Public Fediverse posts

In the most recent episode we speak with Alon Goren from UC San Diego about his work at the intersection of genomic technology development and chromatin biology. We discuss how his lab studies how the epigenome is regulated, how disruption of that regulation contributes to disease, and how technology can be improved to make results more robust and reproducible. #epigenetics #podcast #chromatin

Listen here: https://activemotif.com/podcasts-alon-goren

In this episode we speak with Alon Goran from UC San Diego about his work at the intersection of genomic technology development and chromatin biology. We discuss how his lab studies how the epigenome is regulated, how disruption of that regulation contributes to disease, and how technology can be improved to make results more robust and reproducible. #epigenetics #podcast #chromatin

Listen here: https://activemotif.com/podcasts-alon-goren

In the most recent episode of the Epigenetics Podcast, we talked with Peter Becker from the Biomedical Center Munich about his successful career in Epigenetics, where he discovered the chromatin remodeler ISWI and dosage compensation complex MOF. #podcast #epigenetics #chromatin

Listen here: https://www.activemotif.com/podcasts-peter-becker

In this episode of the Epigenetics Podcast, we talked with Peter Becker from the Biomedical Center Munich about his successful career in Epigenetics, where he discovered the chromatin remodeler ISWI and dosage compensation complex MOF. #podcast #epigenetics #chromatin

Listen here: https://www.activemotif.com/podcasts-peter-becker

In the most recent episode we talked with Filippo Rijli from the Friedrich Miescher Institute about his work on transcriptional and epigenetic regulation of craniofacial and neuronal development. #podcast #epigenetics #chromatin

Listen here: https://www.activemotif.com/podcasts-filippo-rijli

In this episode we talked with Filippo Rijli from the Friedrich Miescher Institute about his work on transcriptional and epigenetic regulation of craniofacial and neuronal development. #podcast #epigenetics #chromatin

Listen here: https://www.activemotif.com/podcasts-filippo-rijli

RE: https://fediscience.org/@Guillawme/115798148618761432

This article on an ALC1-nucleosome complex with a new conformation was accepted at @ActaCrystD in April and went online today! Check it out!

https://doi.org/10.1107/S2059798326004158

#CryoEM #StructuralBiology #nucleosome #chromatin

RE: https://fediscience.org/@Guillawme/115798148618761432

This article on an ALC1-nucleosome complex with a new conformation was accepted at @ActaCrystD in April and went online today! Check it out!

https://doi.org/10.1107/S2059798326004158

#CryoEM #StructuralBiology #nucleosome #chromatin

creates semantic nodes and clusters #ACTIVE #CHROMATIN #SEQUENCE search.brave.com/ask?q=Analyz... Do you like aéPiot semantics? Donate to the aéPiot semantic platform: www.paypal.com/donate?busin...

Brave Search

In the most recent episode we talked with Alena van Bömmel from the Biomedical Center (BMC) in Munich about her work on the development of interpretable epigenetic clocks and statistical models of epigenetic dynamics during aging. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-alena-van-bommel

In the most recent episode we talked with Alena van Bömmel from the Biomedical Center (BMC) in Munich about her work on the development of interpretable epigenetic clocks and statistical models of epigenetic dynamics during aging. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-alena-van-bommel

In this episode we talked with Alena van Bömmel from the Biomedical Center (BMC) in Munich about her work on the development of interpretable epigenetic clocks and statistical models of epigenetic dynamics during aging. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-alena-van-bommel

In the most recent episode we talked with Iva Tchasovnikarova from the Wellcome Trust Cancer Research UK Gurdon Institute about her work on heterochromatin formation and epigenetic control. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-iva-tchasovnikarova

In the most recent episode we talked with Iva Tchasovnikarova from the Wellcome Trust Cancer Research UK Gurdon Institute about her work on heterochromatin formation and epigenetic control. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-iva-tchasovnikarova

In this episode we talked with Iva Tchasovnikarova from the Wellcome Trust Cancer Research UK Gurdon Institute about her work on heterochromatin formation and epigenetic control. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-iva-tchasovnikarova

In the most recent episode we talked with Eva Nogales from UC Berkeley about her work on Cryo-EM and the Dynamics of TFIID and PRC2. #epigenetics #podcast #chromatin

Listen here: https://www.activemotif.com/podcasts-eva-nogales

In this episode we talked with Eva Nogales from UC Berkeley about her work on Cryo-EM and the Dynamics of TFIID and PRC2. #epigenetics #podcast #chromatin

Listen here: https://www.activemotif.com/podcasts-eva-nogales

In the most recent episode of the Epigenetics Podcast, we talked with Michaela Frye from the German Cancer Research Center (DKFZ) in Heidelberg about her work on the role of RNA modifications and RNA binding proteins in gene expression and cancer development. #podcast #chromatin #epigenetics

Listen here: https://activemotif.com/podcasts-michaela-frye

In this episode of the Epigenetics Podcast, we talked with Michaela Frye from the German Cancer Research Center (DKFZ) in Heidelberg about her work on the role of RNA modifications and RNA binding proteins in gene expression and cancer development. #podcast #chromatin #epigenetics

Listen here: https://activemotif.com/podcasts-michaela-frye

In the most recent episode of the Epigenetics Podcast, we talked with Oliver Bell from the University of Southern California in Los Angeles about his work on chromatin-based regulatory systems that encode cellular memory and their implications for development and disease. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-oliver-bell

In this episode of the Epigenetics Podcast, we talked with Oliver Bell from the University of Southern California in Los Angeles about his work on chromatin-based regulatory systems that encode cellular memory and their implications for development and disease. #epigenetics #podcast #chromatin

In the most recent episode we talked with Patrick Murphy from Cornell University about his work on Placeholder Nucleosomes to zygotic genome activation and cellular identity. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-patrick-murphy

In this episode we talked with Patrick Murphy from Cornell University about his work on Placeholder Nucleosomes to zygotic genome activation and cellular identity. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-patrick-murphy

❓How does the 3D architecture of #chromatin—especially the formation of chromatin loops—regulate spatial #gene expression?
❗️A new #JIPB commentary explores this central question in molecular #biology.
🔗https://doi.org/10.1111/jipb.70108
📿
@WileyLifeSci
#PlantSci #JIPB #Agriculture #crop #botany

❓How does the 3D architecture of #chromatin—especially the formation of chromatin loops—regulate spatial #gene expression?
❗️A new #JIPB commentary explores this central question in molecular #biology.
🔗https://doi.org/10.1111/jipb.70108
📿
@WileyLifeSci
#PlantSci #JIPB #Agriculture #crop #botany

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9755

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9755

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9741

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9741

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9580

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9580

In the most recent episode we talked with Srinjan Basu from Imperial College London to talk about his work on how chromatin architecture and epigenetic mechanisms orchestrate developmental gene expression programs. #chromatin #epigenetics #podcast

Listen here: https://activemotif.com/podcasts-srinjan-basu

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9426

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9426

In this episode we talked with Srinjan Basu from Imperial College London to talk about his work on how chromatin architecture and epigenetic mechanisms orchestrate developmental gene expression programs. #chromatin #epigenetics #podcast

Listen here: https://activemotif.com/podcasts-srinjan-basu

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9321

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9321

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9286

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9286

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9160

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9160

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9027

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=9027

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=8936

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=8642

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=8565

Histone variant H3.14 responds to abiotic stress in Arabidopsis:
🌱 H3.14 expressed in root transition zone
🔬 Dual role: activates stress genes, represses
More at https://tnyp.me/S0eSd1Ut/m
#Arabidopsis #StressResponse #Chromatin #H3Variant #Pub2Post

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=8362

H3.14's key role in Arabidopsis stress response:
🌱 H3.14 facilitates chromatin remodeling under stress
🌿 Exhibits unique binding in root transition zone
🧬 Initiates stress gene activation & growth gene repression
#Arabidopsis #StressResponse #Chromatin #H3.14 #Pub2Post https://tnyp.me/S0eSd1Ut/m

H3.14's key role in Arabidopsis stress response:
🌱 H3.14 facilitates chromatin remodeling under stress
🌿 Exhibits unique binding in root transition zone
🧬 Initiates stress gene activation & growth gene repression
#Arabidopsis #StressResponse #Chromatin #H3.14 #Pub2Post https://tnyp.me/S0eSd1Ut/m

H3.14's key role in Arabidopsis stress response:
🌱 H3.14 facilitates chromatin remodeling under stress
🌿 Exhibits unique binding in root transition zone
🧬 Initiates stress gene activation & growth gene repression
#Arabidopsis #StressResponse #Chromatin #H3.14 #Pub2Post https://tnyp.me/S0eSd1Ut/m

H3.14's key role in Arabidopsis stress response:
🌱 H3.14 facilitates chromatin remodeling under stress
🌿 Exhibits unique binding in root transition zone
🧬 Initiates stress gene activation & growth gene repression
#Arabidopsis #StressResponse #Chromatin #H3.14 #Pub2Post https://tnyp.me/S0eSd1Ut/m

H3.14's key role in Arabidopsis stress response:
🌱 H3.14 facilitates chromatin remodeling under stress
🌿 Exhibits unique binding in root transition zone
🧬 Initiates stress gene activation & growth gene repression
#Arabidopsis #StressResponse #Chromatin #H3.14 #Pub2Post https://tnyp.me/S0eSd1Ut/m

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=8005

The study outlines a new scenario for understanding how #genome regulation and #chromatin organization influence the #evolution of #animal body plans.
#EvolutionaryBiology #sflorg
https://www.sflorg.com/2026/01/ebio01082602.html

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=7802

In 2021, I was involved in a study of the #chromatin remodeler ALC1, a protein involved in the early events of the DNA damage response. This led to a paper summarized in a previous thread: https://fediscience.org/@Guillawme/111534984107819771

We had deposited the raw #cryoEM data to #EMPIAR (dataset EMPIAR-10739), which is the primary reason this new preprint could come to exist at all.

This figure shows the structural knowledge available on ALC1 up to the point of the new structure we report in the preprint. An AlphaFold2 prediction, a structure of the auto-inhibited conformation, and a few structures of ALC1-nucleosome complexes. Notably, none of the structures of nucleosome complexes resolved the macro domain. This is a significant gap, because the macro domain is key in regulating ALC1: it is responsible for auto-inhibition and recruitment to PARylated nucleosomes, and these two things are exclusive, which is why recruitment also causes release of the auto-inhibition. So at this point we know what the protein looks like when auto-inhibited and when active, but how it transitions from the former to the latter is unclear.

2/5

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=7452

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=7298

Postdoctoral Fellow in Chromatin Biology and Genomics
National Cancer Institute, National Institutes of Health

Come join us at the NIH as a #chromatin biology and #genomics postdoc to elucidate topoisomerase and DNA supercoiling in biology and in disease!

See the full job description on jobRxiv: https://jobrxiv.org/job/national-cancer-ins...
https://jobrxiv.org/job/national-cancer-institute-national-institutes-of-health-27778-postdoctoral-fellow-in-chromatin-biology-and-genomics/?fsp_sid=6493