#chromatin — Public Fediverse posts

In the most recent episode we talked with Alena van Bömmel from the Biomedical Center (BMC) in Munich about her work on the development of interpretable epigenetic clocks and statistical models of epigenetic dynamics during aging. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-alena-van-bommel

In this episode we talked with Alena van Bömmel from the Biomedical Center (BMC) in Munich about her work on the development of interpretable epigenetic clocks and statistical models of epigenetic dynamics during aging. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-alena-van-bommel

https://www.europesays.com/ie/466053/ Penn engineers use AI to solve some of science’s most difficult math problems #AI #ArtificialIntelligence #Chromatin #Éire #Epigenetics #IE #InversePDEs #Ireland #MollifierLayers #NeuralNetworks #PennEngineering #PhysicsInformedMachineLearning #Research #Science #ScientificComputing #WeatherForecasting

Penn engineers use AI to solve some of science’s most difficult math problems

A ripple tells you something happened, but not exactly what. That is the core problem behind a hard…
#NewsBeep #News #Science #AI #Artificialintelligence #AU #Australia #Chromatin #Epigenetics #inversePDEs #mollifierlayers #neuralnetworks #PennEngineering #physics-informedmachinelearning #research #scientificcomputing #weatherforecasting
https://www.newsbeep.com/au/645663/

Penn engineers use AI to solve some of science’s most difficult math problems

A ripple tells you something happened, but not exactly what. That is the core problem behind a hard…
#NewsBeep #News #Science #AI #Artificialintelligence #AU #Australia #Chromatin #Epigenetics #inversePDEs #mollifierlayers #neuralnetworks #PennEngineering #physics-informedmachinelearning #research #scientificcomputing #weatherforecasting
https://www.newsbeep.com/au/645663/

In the most recent episode we talked with Iva Tchasovnikarova from the Wellcome Trust Cancer Research UK Gurdon Institute about her work on heterochromatin formation and epigenetic control. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-iva-tchasovnikarova

https://www.europesays.com/ie/453533/ Molecular map reveals how Down syndrome alters brain development #Alzheimer'sDisease #Brain #Cell #Chromatin #Cortex #CT #DownSyndrome #Éire #Gene #GeneExpression #Health #IE #InVitro #Ireland #medicine #neocortex #Neurodegeneration #Neuron #Neurons #Prenatal #ProgenitorCells #Research #Syndrome

In this episode we talked with Iva Tchasovnikarova from the Wellcome Trust Cancer Research UK Gurdon Institute about her work on heterochromatin formation and epigenetic control. #podcast #epigenetics #chromatin

Listen here: https://activemotif.com/podcasts-iva-tchasovnikarova

https://www.europesays.com/ie/441544/ Key gene variants tied to developmental dysplasia of the hip and osteoarthritis #Bone #Calcium #Chromatin #Collagen #DNA #Dysplasia #education #Éire #Genes #Genetic #Health #HipDysplasia #hospital #IE #Ireland #Orthopaedic #Osteoarthritis #posture #Protein #Research #rheumatology #website

In the most recent episode we talked with Eva Nogales from UC Berkeley about her work on Cryo-EM and the Dynamics of TFIID and PRC2. #epigenetics #podcast #chromatin

Listen here: https://www.activemotif.com/podcasts-eva-nogales

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of…
#NewsBeep #News #Health #Assay #AU #Australia #Cancer #Cell #Chromatin #Chronic #Colon #Colorectal #dna #Inflammation #InflammatoryBowelDisease #inflammatorydisease #MouseModel #Mutation #protein #StemCells #Transcription #Tumor
https://www.newsbeep.com/au/573305/

Chronic colitis reshapes colon stem cells in ways that can accelerate tumour growth

Even after inflammation resolves, colonic stem cells can retain a hidden molecular memory that increases the likelihood of…
#NewsBeep #News #Health #Assay #AU #Australia #Cancer #Cell #Chromatin #Chronic #Colon #Colorectal #dna #Inflammation #InflammatoryBowelDisease #inflammatorydisease #MouseModel #Mutation #protein #StemCells #Transcription #Tumor
https://www.newsbeep.com/au/573305/

Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target.…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Ageing #Biochemistry #CancerResearch #cellbiology #Chromatin #Developmentalbiology #Genesilencing #general #LifeSciences #Stemcells
https://www.newsbeep.com/us/551744/

Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target.…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Ageing #Biochemistry #CancerResearch #cellbiology #Chromatin #Developmentalbiology #Genesilencing #general #LifeSciences #Stemcells
https://www.newsbeep.com/us/551744/

https://www.europesays.com/ie/376820/ Enzyme helps maintain retinal progenitor cells during eye development #Apoptosis #Brain #Cell #Chromatin #DNA #DNADamage #Éire #Enzyme #eye #Gene #Genes #IE #Ireland #Laboratory #Neurons #ProgenitorCells #Proliferation #Protein #Research #Science #Technology

❓How does the 3D architecture of #chromatin—especially the formation of chromatin loops—regulate spatial #gene expression?
❗️A new #JIPB commentary explores this central question in molecular #biology.
🔗https://doi.org/10.1111/jipb.70108
📿
@WileyLifeSci
#PlantSci #JIPB #Agriculture #crop #botany

https://www.europesays.com/ie/348202/ Embryonic reproductive cells reveal striking genomic architecture before development #Cell #CellDivision #Chromatin #Chromosome #DNA #Éire #Genes #Genetic #Genome #IE #InVitro #infertility #Ireland #Laboratory #MedicalResearch #Meiosis #Research #Science #Sperm

Epigenetic plasticity in germinal center B cells may help explain lymphoma origins

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During…
#NewsBeep #News #Health #Antibodies #Antibody #Antigen #AU #Australia #BCell #Bacteria #Cancer #Cell #cellbiology #Chromatin #Genetic #ImmuneResponse #LymphNodes #lymphoma #medicine #molecularbiology #Preclinical #research #StemCells
https://www.newsbeep.com/au/380051/

https://www.europesays.com/ie/257722/ Epigenetic plasticity in germinal center B cells may help explain lymphoma origins #Antibodies #Antibody #Antigen #BCell #bacteria #cancer #Cell #CellBiology #Chromatin #Éire #Genetic #Health #IE #ImmuneResponse #Ireland #LymphNodes #Lymphoma #medicine #MolecularBiology #Preclinical #Research #StemCells

🧬 Can cells “remember” their identity without changing their DNA?

🔗 Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.08.034

📚 CSBJ: https://www.csbj.org/

#Epigenetics #Chromatin #GeneRegulation #DNA #MolecularBiology #SyntheticBiology #CellEngineering #Genomics #SystemsBiology #DNAmethylation

What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @PLOSBiology https://plos.io/46cBaE4

Next-gen sequencing reveals the regulatory potential of the non-coding genome

The non-coding genome, once dismissed as “junk DNA”, is now recognized as a fundamental regulator of gene expression…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #cancer #Cell #cellbiology #Chromatin #DNA #Gene #GeneExpression #Genes #Genetic #Genome #Genomic #JunkDNA #medicine #precisionmedicine #Promoter #protein #RNA #Science
https://www.newsbeep.com/us/106986/

Next-gen sequencing reveals the regulatory potential of the non-coding genome

The non-coding genome, once dismissed as “junk DNA”, is now recognized as a fundamental regulator of gene expression…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #cancer #Cell #cellbiology #Chromatin #DNA #Gene #GeneExpression #Genes #Genetic #Genome #Genomic #JunkDNA #medicine #precisionmedicine #Promoter #protein #RNA #Science
https://www.newsbeep.com/us/106986/

Epigenetic regulators like EZH2 are mutated in #Bcell #lymphoma, but what is their effect? This study reveals a role for mutant EZH2 in lymphomagenesis, using a new method for measuring #epigenetic heterogeneity & intra- #chromatin connectivity in #cancer @PLOSBiology https://plos.io/4mZcS8n

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: https://www.sfari.org/2025/04/08/announcing-the-recipients-of-the-2024-pilot-and-pilot-progression-awards/
NLMFF: https://www.nlmfoundation.org/grant/epigenetic-regulators-ash1l-and-setbp1-in-gabaergic-neuron-development-and-asd/

#newsmayerlab #SFARI #NLMFF #AutismResearch #Neurodevelopment #Epigenetics #GABA #Genomics #Chromatin #Neuroscience

#Data-driven techniques enhance understanding of #cell division.

#mitosis #transposons #Telomeres #chromatin

https://phys.org/news/2025-02-driven-techniques-cell-division.html

#job alert: junior/mid-career PI opportunities in cancer research @ Oxford university: https://www.ludwig.ox.ac.uk/news/vacancies-assistant-or-associate-professor-level-cancer-researchers

Areas we're looking for:
#epigenetics #chromatin #epitranscriptomics #RNA #myeloidCells #spatialTranscriptomics

Please boost for visibility! @academicchatter #hiring

How #aging affects #stem_cells: A #fly's tale.

#drosophila #chromatin #ced_6

https://medicalxpress.com/news/2024-09-aging-affects-stem-cells-fly.html

This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology

CFDP1 regulates cell proliferation & higher-order #chromatin structure. This study shows that CFDP1 is essential for structural stability of centromeric #heterochromatin, so influencing #microtubule nucleation during #MitoticSpindle formation #PLOSBiology https://plos.io/3W5eFhc

The shelterin component #TRF2 mediates columnar stacking of human telomeric #chromatin
–find Lars Nordenskiold and colleagues using biophysical and electron-microscopy in vitro analyses
https://www.embopress.org/doi/full/10.1038/s44318-023-00002-3

"Here, by comprehensively mapping 3D #chromatin organization during #Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of #Foxp3, a Treg lineage specifying #transcription factor, were highly enriched at Treg-specific chromatin loop anchors."

https://www.nature.com/articles/s41467-023-42647-y

Nice work on #chromatin and #splicing by the lab of Gil Ast:

Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation

Mol Cell,
https://doi.org/10.1016/j.molcel.2023.10.003

#DELLA-mediated #repression of #gibberellin signaling is maintained by #chromatin modification in #rice
Dao-Xiu Zhou and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2023114220

Lineage commitment of #dermal #fibroblast #progenitors is controlled by #Kdm6b-mediated #chromatin #demethylation
Ryan Driskell and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2023113880

Lineage commitment of #dermal #fibroblast #progenitors is controlled by #Kdm6b-mediated #chromatin #demethylation
Ryan Driskell and coworkers @DriskellLab
https://www.embopress.org/doi/full/10.15252/embj.2023113880

Lineage commitment of #dermal #fibroblast #progenitors is controlled by #Kdm6b-mediated #chromatin #demethylation
Ryan Driskell and coworkers @DriskellLab
https://www.embopress.org/doi/full/10.15252/embj.2023113880

Postdoc at Lund Stem Cell Center: epigenetic control of genomic repeats

Lund Stem Cell Center

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-stem-cell-center-27778-postdoc-at-lund-stem-cell-center-epigenetic-control-of-genomic-repeats/?feed_id=55549

#ScienceJobs #hiring #research #transposons #epigenetics #chromatin
Lund #Swede...
https://jobrxiv.org/job/lund-stem-cell-center-27778-postdoc-at-lund-stem-cell-center-epigenetic-control-of-genomic-repeats/?feed_id=55549

A new study from Yuri Schwartz's lab:

#Polycomb proteins translate #histone #methylation to #chromatin
folding

DOI: 10.1016/j.jbc.2023.105080

A new study from Yuri Schwartz's lab:

#Polycomb proteins translate #histone #methylation to #chromatin
folding

DOI: 10.1016/j.jbc.2023.105080

A new study from Yuri Schwartz's lab:

#Polycomb proteins translate #histone #methylation to #chromatin
folding

DOI: 10.1016/j.jbc.2023.105080

See chromatin magnified by reading here:

#Chromatin expansion microscopy reveals #nanoscale organization of #transcription and chromatin

DOI: 10.1126/science.ade53

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

Excellent review on NIPBL function and the different roles of STAG1 and STAG2 by Dácil Alonso-Gil and Ana Losada https://doi.org/10.1016/j.tcb.2023.03.006 lots to think about in here #chromatin #cdls #chromatindisorders
#cohesin #genetics

Excellent review on NIPBL function and the different roles of STAG1 and STAG2 by Dácil Alonso-Gil and Ana Losada https://doi.org/10.1016/j.tcb.2023.03.006 lots to think about in here #chromatin #cdls #chromatindisorders
#cohesin #genetics

Surprises from #FLIM-#FRET studies of nanometer-range distances between #nucleosomes in living, non-fixed cells:

Claire Dupont, Robert Feil, David Lleres et al show that constitutive #heterochromatin is in fact less compacted than bulk #chromatin

https://www.embopress.org/doi/10.15252/embj.2021110286

Check out our new paper in which we explored what happens when the boundaries between topologically associating chromatin domains ("TADs") get deleted - in this case in mice using CRISPR.

Spoiler alert: Some TAD boundaries are quite important!

https://www.nature.com/articles/s42003-023-04819-w

@LBNLBioSci @berkeleylab #TAD #TADBoundary #chromatin #knockout

Another fruitful @viennabiocenter collaboration, in this case with @golobor @IMBA_Vienna. #cohesin #immunoglobolin #DNA #chromatin #antibody

Another fruitful @viennabiocenter collaboration, in this case with @golobor @IMBA_Vienna. #cohesin #immunoglobolin #DNA #chromatin #antibody

Another fruitful @viennabiocenter collaboration, in this case with @golobor @IMBA_Vienna. #cohesin #immunoglobolin #DNA #chromatin #antibody