#chromatin — Public Fediverse posts

Obscure X chromosome protein emerges as key driver in several cancers

A little-known protein encoded on the X chromosome is attracting growing attention for its potential role in cancer…
#NewsBeep #News #Health #AU #Australia #Brain #Cancer #carcinoma #Cell #cellbiology #Chromatin #Chromosome #dna #Epigenetics #Gene #GeneSilencing #Genes #Genome #lungcancer #medicine #MerkelCellCarcinoma #oncology #osteosarcoma #protein #research #Sarcoma #Tumor #Xchromosome
https://www.newsbeep.com/au/844523/

Obscure X chromosome protein emerges as key driver in several cancers

A little-known protein encoded on the X chromosome is attracting growing attention for its potential role in cancer…
#NewsBeep #News #Health #AU #Australia #Brain #Cancer #carcinoma #Cell #cellbiology #Chromatin #Chromosome #dna #Epigenetics #Gene #GeneSilencing #Genes #Genome #lungcancer #medicine #MerkelCellCarcinoma #oncology #osteosarcoma #protein #research #Sarcoma #Tumor #Xchromosome
https://www.newsbeep.com/au/844523/

RE: https://fediscience.org/@Guillawme/115798148618761432

This article on an ALC1-nucleosome complex with a new conformation was accepted at @ActaCrystD in April and went online today! Check it out!

https://doi.org/10.1107/S2059798326004158

#CryoEM #StructuralBiology #nucleosome #chromatin

Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target.…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Ageing #Biochemistry #CancerResearch #cellbiology #Chromatin #Developmentalbiology #Genesilencing #general #LifeSciences #Stemcells
https://www.newsbeep.com/us/551744/

Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target.…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Ageing #Biochemistry #CancerResearch #cellbiology #Chromatin #Developmentalbiology #Genesilencing #general #LifeSciences #Stemcells
https://www.newsbeep.com/us/551744/

#Chromatin fiber's #genomic 'memory' governs the building blocks of life, study reveals.

#transcription #nucleosome

https://phys.org/news/2025-02-chromatin-fiber-genomic-memory-blocks.html

#Wolbachia causes embryonic lethality in #FruitFlies by modifying #chromatin integrity in sperm. @KaurTweets @Symbionticism &co show that this occurs in the wMel-transinfected #Aedesaegypti #mosquitoes used to control vector-borne diseases #PLOSBiology https://plos.io/3xgOsBH

Our new article has been published in the Biophysical Journal @BiophysJ: "Nucleosome spacing controls chromatin spatial structure and accessibility". We placed a long #nucleosome chain in a box mimicking natural density conditions. We did not see melting of #chromatin fibers at high densities. Accessibility of #chromatin to diffusive processes increases with higher regularity of nucleosome spacing. https://authors.elsevier.com/a/1ijrB1SPT7sCr. #hochschulestralsund #lmumünchen

In 2021, we published this paper: Structure and dynamics of the #chromatin remodeler ALC1 bound to a PARylated #nucleosome
https://doi.org/10.7554/eLife.71420

It ended with a hypothesis we addressed in a follow-up paper, which will be out soon, hooray! 🥳
I will post a summary thread of this new paper, but in the meantime, I will repost below the summary of the first paper that I posted on Twitter back then (since I no longer have an account on Twitter).

#cryoEM

Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565

A new variation of the #HiC method to study #3Dgenome interactions specifically for open #chromatin. "HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization" https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00098-3?

Anchoring #3Dgenome & #chromatin contacts to #cellnucleus landmarks: Mapping #nucleolus-associated chromatin interactions using nucleolus #HiC reveals pattern of #heterochromatin interactions.
@NatureComms https://doi.org/10.1038/s41467-023-36021-1

#GeneRegulation digest week 2:

🧬DNA methylation atlas of human cells
https://www.nature.com/articles/s41586-022-05580-6

🧬Evolution of #3Dchromatin organization
https://www.sciencedirect.com/science/article/pii/S0959437X22001344

🧬#SMARCA5 (#SNF2H) maintains #nucleosome spacing near CTCF https://www.sciencedirect.com/science/article/pii/S1097276522011753 (in line with our Clarkson et al'2019 https://academic.oup.com/nar/article/47/21/11181/5609524)

🧬Loss of #epigenetic information as a cause of mammalian #aging https://www.sciencedirect.com/science/article/pii/S0092867422015707

🧬#Chromatin assembly of exogenous bacterial #chromosomes in yeast https://www.biorxiv.org/content/10.1101/2022.12.21.520625v2

Our new preprint! Nucleosome repositioning in chronic lymphocytic leukaemia (CLL) https://www.biorxiv.org/content/10.1101/2022.12.20.518743v1
▶️Nucleosome changes at cancer-sensitive regions allow patient stratification
▶️Nucleosome repeat length (NRL) decreases with #cancer aggressiveness
▶️Interplay with #methylation, #TFbinding and more!

#CLL, #nucleosome, #leukaemia, #chromatin