#chromatin — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #chromatin, aggregated by home.social.
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RE: https://fediscience.org/@Guillawme/115798148618761432
This article on an ALC1-nucleosome complex with a new conformation was accepted at @ActaCrystD in April and went online today! Check it out!
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#Data-driven techniques enhance understanding of #cell division.
#mitosis #transposons #Telomeres #chromatin
https://phys.org/news/2025-02-driven-techniques-cell-division.html
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#Chromatin fiber's #genomic 'memory' governs the building blocks of life, study reveals.
https://phys.org/news/2025-02-chromatin-fiber-genomic-memory-blocks.html
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Our new article has been published in the Biophysical Journal @BiophysJ: "Nucleosome spacing controls chromatin spatial structure and accessibility". We placed a long #nucleosome chain in a box mimicking natural density conditions. We did not see melting of #chromatin fibers at high densities. Accessibility of #chromatin to diffusive processes increases with higher regularity of nucleosome spacing. https://authors.elsevier.com/a/1ijrB1SPT7sCr. #hochschulestralsund #lmumünchen
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In 2021, we published this paper: Structure and dynamics of the #chromatin remodeler ALC1 bound to a PARylated #nucleosome
https://doi.org/10.7554/eLife.71420It ended with a hypothesis we addressed in a follow-up paper, which will be out soon, hooray! 🥳
I will post a summary thread of this new paper, but in the meantime, I will repost below the summary of the first paper that I posted on Twitter back then (since I no longer have an account on Twitter). -
Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565 -
#GeneRegulation digest week 2:
🧬DNA methylation atlas of human cells
https://www.nature.com/articles/s41586-022-05580-6🧬Evolution of #3Dchromatin organization
https://www.sciencedirect.com/science/article/pii/S0959437X22001344🧬#SMARCA5 (#SNF2H) maintains #nucleosome spacing near CTCF https://www.sciencedirect.com/science/article/pii/S1097276522011753 (in line with our Clarkson et al'2019 https://academic.oup.com/nar/article/47/21/11181/5609524)
🧬Loss of #epigenetic information as a cause of mammalian #aging https://www.sciencedirect.com/science/article/pii/S0092867422015707
🧬#Chromatin assembly of exogenous bacterial #chromosomes in yeast https://www.biorxiv.org/content/10.1101/2022.12.21.520625v2
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Our new preprint! Nucleosome repositioning in chronic lymphocytic leukaemia (CLL) https://www.biorxiv.org/content/10.1101/2022.12.20.518743v1
▶️Nucleosome changes at cancer-sensitive regions allow patient stratification
▶️Nucleosome repeat length (NRL) decreases with #cancer aggressiveness
▶️Interplay with #methylation, #TFbinding and more!