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#ligase — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #ligase, aggregated by home.social.

  1. The EMBO Journal @[email protected] ·

    How are specific dysfunctional #mitochondria removed under steady-state conditions?

    Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

    embopress.org/doi/10.15252/emb

    #mitochondria #scf #ubiquitin #ligase #fbxl4 #mtdps13
  2. The EMBO Journal @[email protected] ·

    What controls basal, #Parkin-independent #mitophagy?

    E3 #ubiquitin #ligase screen by Sylvie Urbé, Michael Clague and coworkers identifies #VHL and #FBXL4 as negative regulators of mitophagy receptors #NIX and #BNIP3 via transcriptional and direct post-translational mechanisms, respectively

    embopress.org/doi/10.15252/emb

    #parkin #mitophagy #ubiquitin #ligase #vhl #fbxl4