#prc2 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #prc2, aggregated by home.social.
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EZH2 (PRC2) trimethylates H3K27 → PRC1 recruitment → chromatin compaction → transcriptional silencing.
Elegant at the mechanistic level. Consequential at the organismal level — elevated EZH2 activity shortens lifespan in model organisms, likely via progressive silencing of stress-response loci.
The SET domain may be one of the most underrated targets in aging biology.
#EZH2 #PRC2 #Epigenetics #AgingBiology #H3K27me3 #ChromatinRemodeling #Longevity
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The intricate mechanisms of #epigenetic silencing.
#PRC2 #Arabidopsis #VIN3 #VRN5
https://phys.org/news/2023-10-intricate-mechanisms-epigenetic-silencing.html
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The intricate mechanisms of #epigenetic silencing.
#PRC2 #Arabidopsis #VIN3 #VRN5
https://phys.org/news/2023-10-intricate-mechanisms-epigenetic-silencing.html
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Development of a potent EED-targeted #PRC2 degrader, UNC7700, highly effective after 24 h in a diffuse large B-cell lymphoma DB cell line:
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components https://pubs.acs.org/doi/10.1021/acschembio.2c00804
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Development of a potent EED-targeted #PRC2 degrader, UNC7700, highly effective after 24 h in a diffuse large B-cell lymphoma DB cell line:
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components https://pubs.acs.org/doi/10.1021/acschembio.2c00804
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Development of a potent EED-targeted #PRC2 degrader, UNC7700, highly effective after 24 h in a diffuse large B-cell lymphoma DB cell line:
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components https://pubs.acs.org/doi/10.1021/acschembio.2c00804
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Development of a potent EED-targeted #PRC2 degrader, UNC7700, highly effective after 24 h in a diffuse large B-cell lymphoma DB cell line:
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components https://pubs.acs.org/doi/10.1021/acschembio.2c00804
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#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473 -
#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296
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#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296
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#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296
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#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296