#h3k27me3 — Public Fediverse posts

Sharing a visualization from ongoing work on chromatin remodeling dynamics in aging hematopoietic stem cells (HSCs).

Figure: "Loss of H3K27me3 repressive domains with age"

#Epigenetics #ChromatinBiology #H3K27me3 #PolycombRepressiveComplex #HematopoieticStemCells #AgingResearch

Sharing a visualization from ongoing methodological work on chromatin domain architecture in aging hematopoiesis.

Figure: Age-Associated Broadening of H3K27me3 Domains Across Chromatin Contexts.

#Epigenetics #ChromatinBiology #PolycombRepressiveComplex #H3K27me3 #Hematopoietic

EZH2 (PRC2) trimethylates H3K27 → PRC1 recruitment → chromatin compaction → transcriptional silencing.

Elegant at the mechanistic level. Consequential at the organismal level — elevated EZH2 activity shortens lifespan in model organisms, likely via progressive silencing of stress-response loci.

The SET domain may be one of the most underrated targets in aging biology.

#EZH2 #PRC2 #Epigenetics #AgingBiology #H3K27me3 #ChromatinRemodeling #Longevity

How #light and #epigenetics cooperate to regulate #plant #growth.

#gene_expression #H3K27me3 #gene_silencing #Arabidopsis #phyB #hypocotyl #elongation

https://phys.org/news/2025-03-epigenetics-cooperate-growth.html

Repressed but ready to go: How #bivalency holds developmental #genes in a poised state for #expression.

#histones #H3K27me3 #H3K4me3 #Nucleosome #KAT6B

https://phys.org/news/2025-02-repressed-ready-bivalency-developmental-genes.html

#Strawberry #ripening revealed: Key #histone modifications uncovered

#genomics #ChIP_seq #H3K9_K14ac #H3K27ac #H3K27me3

https://phys.org/news/2024-09-strawberry-ripening-revealed-key-histone.html

This fascinating study from Gao et al. suggests a new #epigenetic explanation of #heterosis in #Arabidopsis #hybrids--providing new insights into #crop breeding and yield increase.
https://doi.org/10.1111/jipb.13620
@wileyplantsci
#JIPB #PlantSci #CropSci #H3K27me3 #OpenAccess #PlantScience #botany