#agingbiology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #agingbiology, aggregated by home.social.
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LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.
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https://www.europesays.com/ie/206009/ New sensor captures DNA breaks, repair inside living cells in real time #AgingBiology #CancerResearch #ChromatinRepair #DNADamage #DrugSafetyTesting #Éire #FluorescentSensor #GenomeStability #IE #Ireland #LiveCellImaging #MedicalGoodNews #Research #Science
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New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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I had an amazing chat with Davina McCall (!!!) about ageing, menopause, how we could live to 90 in good health, and how much fun it is to give birth?!? (Her words not mine!)
Check it out her new podcast, Begin Again, for the full conversation :)
#aging #ageing #longevity #menopause #longevityscience #agingbiology
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Current lab crew:
The new semester has begun, and we have welcomed a new student to the lab🤩And, we we are already celebrating his birthday during his first week🎉🥳
#GraduateSchool #BiomedicalScience #CellBiology #MolecularBiology #Genetics #Biochemistry #CancerBiology #AgingBiology
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
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Semaglutide doesn’t just help with weight loss—it also reduces risk of heart attack, and death from any cause!
More work is needed to find out if these effects are ‘just’ the weight loss or some additional effect. So…could this be an anti-aging drug?! https://www.statnews.com/2023/11/11/heart-attack-stroke-obesity-wegovy-novo-nordisk-select/
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Could taurine, amino acid of energy drink fame, be a longevity drug?
A new study has found that it extends life in mice and worms, and seems to improve the health of older monkeys! https://www.science.org/content/article/amino-acid-energy-drinks-makes-mice-live-longer-and-healthier
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New video!
A scientific review of #Limitless, #DisneyPlus and @NatGeo’s epic new series on longevity.
What’s the best thing #chrishemsworth could do for his health? Watch and find out: https://www.youtube.com/watch?v=AfFqxSwEaWs
#aging #ageing #agingbiology #biology #science #apoe #dementia #fasting