#agingbiology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #agingbiology, aggregated by home.social.
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LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.
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LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.
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LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.
-
LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.
-
LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.
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EZH2 (PRC2) trimethylates H3K27 → PRC1 recruitment → chromatin compaction → transcriptional silencing.
Elegant at the mechanistic level. Consequential at the organismal level — elevated EZH2 activity shortens lifespan in model organisms, likely via progressive silencing of stress-response loci.
The SET domain may be one of the most underrated targets in aging biology.
#EZH2 #PRC2 #Epigenetics #AgingBiology #H3K27me3 #ChromatinRemodeling #Longevity
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Mitochondrial health = longevity foundation 🔋
Healthy mitochondria → efficient energy production + cellular protection
Dysfunction = nearly every age-related disease
Promising interventions: NAD+ precursors, mitophagy enhancers, targeted antioxidants
The question now: how do we translate this into effective therapies?
#Longevity #Mitochondria #AgingBiology #Healthspan #CellularBiology
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https://www.europesays.com/ie/206009/ New sensor captures DNA breaks, repair inside living cells in real time #AgingBiology #CancerResearch #ChromatinRepair #DNADamage #DrugSafetyTesting #Éire #FluorescentSensor #GenomeStability #IE #Ireland #LiveCellImaging #MedicalGoodNews #Research #Science
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New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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I had an amazing chat with Davina McCall (!!!) about ageing, menopause, how we could live to 90 in good health, and how much fun it is to give birth?!? (Her words not mine!)
Check it out her new podcast, Begin Again, for the full conversation :)
#aging #ageing #longevity #menopause #longevityscience #agingbiology
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I had an amazing chat with Davina McCall (!!!) about ageing, menopause, how we could live to 90 in good health, and how much fun it is to give birth?!? (Her words not mine!)
Check it out her new podcast, Begin Again, for the full conversation :)
#aging #ageing #longevity #menopause #longevityscience #agingbiology
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I had an amazing chat with Davina McCall (!!!) about ageing, menopause, how we could live to 90 in good health, and how much fun it is to give birth?!? (Her words not mine!)
Check it out her new podcast, Begin Again, for the full conversation :)
#aging #ageing #longevity #menopause #longevityscience #agingbiology
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I had an amazing chat with Davina McCall (!!!) about ageing, menopause, how we could live to 90 in good health, and how much fun it is to give birth?!? (Her words not mine!)
Check it out her new podcast, Begin Again, for the full conversation :)
#aging #ageing #longevity #menopause #longevityscience #agingbiology
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I had an amazing chat with Davina McCall (!!!) about ageing, menopause, how we could live to 90 in good health, and how much fun it is to give birth?!? (Her words not mine!)
Check it out her new podcast, Begin Again, for the full conversation :)
#aging #ageing #longevity #menopause #longevityscience #agingbiology
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Current lab crew:
The new semester has begun, and we have welcomed a new student to the lab🤩And, we we are already celebrating his birthday during his first week🎉🥳
#GraduateSchool #BiomedicalScience #CellBiology #MolecularBiology #Genetics #Biochemistry #CancerBiology #AgingBiology
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Current lab crew:
The new semester has begun, and we have welcomed a new student to the lab🤩And, we we are already celebrating his birthday during his first week🎉🥳
#GraduateSchool #BiomedicalScience #CellBiology #MolecularBiology #Genetics #Biochemistry #CancerBiology #AgingBiology
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Current lab crew:
The new semester has begun, and we have welcomed a new student to the lab🤩And, we we are already celebrating his birthday during his first week🎉🥳
#GraduateSchool #BiomedicalScience #CellBiology #MolecularBiology #Genetics #Biochemistry #CancerBiology #AgingBiology
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Current lab crew:
The new semester has begun, and we have welcomed a new student to the lab🤩And, we we are already celebrating his birthday during his first week🎉🥳
#GraduateSchool #BiomedicalScience #CellBiology #MolecularBiology #Genetics #Biochemistry #CancerBiology #AgingBiology
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Current lab crew:
The new semester has begun, and we have welcomed a new student to the lab🤩And, we we are already celebrating his birthday during his first week🎉🥳
#GraduateSchool #BiomedicalScience #CellBiology #MolecularBiology #Genetics #Biochemistry #CancerBiology #AgingBiology
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A new paper in Nature Aging suggests age-related changed are nonlinear, and change is most rapid around ages 45 and 60.
As someone rapidly approaching the first, biggest hump: gulp!
They did thousands of measurements, and these graphs show how many change at different ages:
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A new paper in Nature Aging suggests age-related changed are nonlinear, and change is most rapid around ages 45 and 60.
As someone rapidly approaching the first, biggest hump: gulp!
They did thousands of measurements, and these graphs show how many change at different ages:
-
A new paper in Nature Aging suggests age-related changed are nonlinear, and change is most rapid around ages 45 and 60.
As someone rapidly approaching the first, biggest hump: gulp!
They did thousands of measurements, and these graphs show how many change at different ages:
-
A new paper in Nature Aging suggests age-related changed are nonlinear, and change is most rapid around ages 45 and 60.
As someone rapidly approaching the first, biggest hump: gulp!
They did thousands of measurements, and these graphs show how many change at different ages:
-
A new paper in Nature Aging suggests age-related changed are nonlinear, and change is most rapid around ages 45 and 60.
As someone rapidly approaching the first, biggest hump: gulp!
They did thousands of measurements, and these graphs show how many change at different ages:
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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You can check out a video of the session here, and my question around 51 minute sums up my thoughts: https://www.weforum.org/open-forum/event_sessions/turning-back-the-clock-the-science-of-ageing/
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All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
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All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
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All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
-
All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
-
All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
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In a recent podcast, Peter Attia decried some coverage of aging biology as ‘sci-fi’, and said it was impossible to ‘biohack your way to 150’.
I think he’s right.
But I made a video about it because I think he’s missing something very important: https://youtu.be/cCOh8l2NEQg
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In a recent podcast, Peter Attia decried some coverage of aging biology as ‘sci-fi’, and said it was impossible to ‘biohack your way to 150’.
I think he’s right.
But I made a video about it because I think he’s missing something very important: https://youtu.be/cCOh8l2NEQg
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In a recent podcast, Peter Attia decried some coverage of aging biology as ‘sci-fi’, and said it was impossible to ‘biohack your way to 150’.
I think he’s right.
But I made a video about it because I think he’s missing something very important: https://youtu.be/cCOh8l2NEQg
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In a recent podcast, Peter Attia decried some coverage of aging biology as ‘sci-fi’, and said it was impossible to ‘biohack your way to 150’.
I think he’s right.
But I made a video about it because I think he’s missing something very important: https://youtu.be/cCOh8l2NEQg
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In a recent podcast, Peter Attia decried some coverage of aging biology as ‘sci-fi’, and said it was impossible to ‘biohack your way to 150’.
I think he’s right.
But I made a video about it because I think he’s missing something very important: https://youtu.be/cCOh8l2NEQg
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Semaglutide doesn’t just help with weight loss—it also reduces risk of heart attack, and death from any cause!
More work is needed to find out if these effects are ‘just’ the weight loss or some additional effect. So…could this be an anti-aging drug?! https://www.statnews.com/2023/11/11/heart-attack-stroke-obesity-wegovy-novo-nordisk-select/
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Semaglutide doesn’t just help with weight loss—it also reduces risk of heart attack, and death from any cause!
More work is needed to find out if these effects are ‘just’ the weight loss or some additional effect. So…could this be an anti-aging drug?! https://www.statnews.com/2023/11/11/heart-attack-stroke-obesity-wegovy-novo-nordisk-select/
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Semaglutide doesn’t just help with weight loss—it also reduces risk of heart attack, and death from any cause!
More work is needed to find out if these effects are ‘just’ the weight loss or some additional effect. So…could this be an anti-aging drug?! https://www.statnews.com/2023/11/11/heart-attack-stroke-obesity-wegovy-novo-nordisk-select/
-
Semaglutide doesn’t just help with weight loss—it also reduces risk of heart attack, and death from any cause!
More work is needed to find out if these effects are ‘just’ the weight loss or some additional effect. So…could this be an anti-aging drug?! https://www.statnews.com/2023/11/11/heart-attack-stroke-obesity-wegovy-novo-nordisk-select/
-
Semaglutide doesn’t just help with weight loss—it also reduces risk of heart attack, and death from any cause!
More work is needed to find out if these effects are ‘just’ the weight loss or some additional effect. So…could this be an anti-aging drug?! https://www.statnews.com/2023/11/11/heart-attack-stroke-obesity-wegovy-novo-nordisk-select/
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Happy Monday #ScienceMastodon! Check out this #ResearchHighlight from Issue 19 of JCS featuring some gorgeous images of #Drosophila Malpighian tubules. Julian Dow and colleagues at the University of Glasgow and University of Copenhagen show that disrupting septate junctions in fruit fly renal tubules produces cell- and tissue-level dysfunction similar to that seen in aged flies. #agingbiology #CellBiology
Dysfunction at cell junctions ages fruit fly renal tubules
https://journals.biologists.com/jcs/article/136/19/e136_e1901/332754/Dysfunction-at-cell-junctions-ages-fruit-fly-renal -
Happy Monday #ScienceMastodon! Check out this #ResearchHighlight from Issue 19 of JCS featuring some gorgeous images of #Drosophila Malpighian tubules. Julian Dow and colleagues at the University of Glasgow and University of Copenhagen show that disrupting septate junctions in fruit fly renal tubules produces cell- and tissue-level dysfunction similar to that seen in aged flies. #agingbiology #CellBiology
Dysfunction at cell junctions ages fruit fly renal tubules
https://journals.biologists.com/jcs/article/136/19/e136_e1901/332754/Dysfunction-at-cell-junctions-ages-fruit-fly-renal -
Happy Monday #ScienceMastodon! Check out this #ResearchHighlight from Issue 19 of JCS featuring some gorgeous images of #Drosophila Malpighian tubules. Julian Dow and colleagues at the University of Glasgow and University of Copenhagen show that disrupting septate junctions in fruit fly renal tubules produces cell- and tissue-level dysfunction similar to that seen in aged flies. #agingbiology #CellBiology
Dysfunction at cell junctions ages fruit fly renal tubules
https://journals.biologists.com/jcs/article/136/19/e136_e1901/332754/Dysfunction-at-cell-junctions-ages-fruit-fly-renal -
NEW VIDEO: My top five real anti-aging drugs
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NEW VIDEO: My top five real anti-aging drugs
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NEW VIDEO: My top five real anti-aging drugs
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NEW VIDEO: My top five real anti-aging drugs
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NEW VIDEO: My top five real anti-aging drugs
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I’m at #LongevitySummitDublin this weekend and I’ve been live-tweeting (sorry, birdsite, etc…). But for the #aging nerds, here’s what’s been going on:
Yesterday morning: https://twitter.com/statto/status/1692452220996813102
Yesterday afternoon: https://twitter.com/statto/status/1692523075613417788
Today: https://twitter.com/statto/status/1692812476725793084
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I’m at #LongevitySummitDublin this weekend and I’ve been live-tweeting (sorry, birdsite, etc…). But for the #aging nerds, here’s what’s been going on:
Yesterday morning: https://twitter.com/statto/status/1692452220996813102
Yesterday afternoon: https://twitter.com/statto/status/1692523075613417788
Today: https://twitter.com/statto/status/1692812476725793084
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I’m at #LongevitySummitDublin this weekend and I’ve been live-tweeting (sorry, birdsite, etc…). But for the #aging nerds, here’s what’s been going on:
Yesterday morning: https://twitter.com/statto/status/1692452220996813102
Yesterday afternoon: https://twitter.com/statto/status/1692523075613417788
Today: https://twitter.com/statto/status/1692812476725793084
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I’m at #LongevitySummitDublin this weekend and I’ve been live-tweeting (sorry, birdsite, etc…). But for the #aging nerds, here’s what’s been going on:
Yesterday morning: https://twitter.com/statto/status/1692452220996813102
Yesterday afternoon: https://twitter.com/statto/status/1692523075613417788
Today: https://twitter.com/statto/status/1692812476725793084