#chromatinremodeling — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #chromatinremodeling, aggregated by home.social.
-
EZH2 (PRC2) trimethylates H3K27 → PRC1 recruitment → chromatin compaction → transcriptional silencing.
Elegant at the mechanistic level. Consequential at the organismal level — elevated EZH2 activity shortens lifespan in model organisms, likely via progressive silencing of stress-response loci.
The SET domain may be one of the most underrated targets in aging biology.
#EZH2 #PRC2 #Epigenetics #AgingBiology #H3K27me3 #ChromatinRemodeling #Longevity
-
A #cryoem model of the RSF–NCP complex reveals distinct binding characteristics compared with the SNF2h–NCP complex and biochemical analyses indicate that RSF possesses unique chromatin-remodeling properties #ChromatinRemodeling #RSF #Nucleosome https://t.co/ZP6ZglquKq