#scatacseq — Public Fediverse posts

We also saw a shift in TF activity.

Footprinting showed increased NFI binding, especially NFIB, in late-born cohorts. These neurons activate maturation modules faster — possibly guided by chromatin remodeling during neurogenesis.
#NewsMayerlab #TFfootprints #TranscriptionFactors #scATACseq
(5/7)

We also saw a shift in TF activity.

Footprinting showed increased NFI binding, especially NFIB, in late-born cohorts. These neurons activate maturation modules faster — possibly guided by chromatin remodeling during neurogenesis.
#NewsMayerlab #TFfootprints #TranscriptionFactors #scATACseq
(5/7)

We also saw a shift in TF activity.

Footprinting showed increased NFI binding, especially NFIB, in late-born cohorts. These neurons activate maturation modules faster — possibly guided by chromatin remodeling during neurogenesis.
#NewsMayerlab #TFfootprints #TranscriptionFactors #scATACseq
(5/7)

This shift was mirrored in chromatin accessibility.

scATAC-seq revealed stage-specific enhancer activation, with late-born cells opening distinct regulatory elements — especially in distal regions. A dynamic change in the regulatory landscape.

#NewsMayerlab #Chromatin #Epigenetics #scATACseq

(4/7)

This shift was mirrored in chromatin accessibility.

scATAC-seq revealed stage-specific enhancer activation, with late-born cells opening distinct regulatory elements — especially in distal regions. A dynamic change in the regulatory landscape.

#NewsMayerlab #Chromatin #Epigenetics #scATACseq

(4/7)

This shift was mirrored in chromatin accessibility.

scATAC-seq revealed stage-specific enhancer activation, with late-born cells opening distinct regulatory elements — especially in distal regions. A dynamic change in the regulatory landscape.

#NewsMayerlab #Chromatin #Epigenetics #scATACseq

(4/7)

@cyrilpedia sadly this is an absolute classic when new technologies emerge, then it turns out they're not as good as each other, and then someone tries to benchmark & rank them! #scatacseq

"NB cells signal to the BM microenvironment, rewiring via macrophage migration inhibitory factor and #midkine signaling specifically #monocytes ..."

#Neuroblastoma paper by Fetahu et al., the latest publication from the Taschner-Mandl lab in Vienna.

Going through this right now - very alike our own work - and talking to a few team members on Wednesday while they visit our center.

#macrophages #scATACseq #scRNAseq #OpenAccess #cancer #immunology

Data available on EGA, behind a DAC.

Anyone know a good review paper / learning resource for building gene regulatory networks #GRN from #scATACseq #ATACseq and/or #scRNAseq data?
Thanks!

Anyone know a good review paper / learning resource for building gene regulatory networks #GRN from #scATACseq #ATACseq and/or #scRNAseq data?
Thanks!

Anyone know a good review paper / learning resource for building gene regulatory networks #GRN from #scATACseq #ATACseq and/or #scRNAseq data?
Thanks!

Anyone know a good review paper / learning resource for building gene regulatory networks #GRN from #scATACseq #ATACseq and/or #scRNAseq data?
Thanks!

Anyone know a good review paper / learning resource for building gene regulatory networks #GRN from #scATACseq #ATACseq and/or #scRNAseq data?
Thanks!

CellOracle builds context-specific #GeneRegulatoryNetworks from combined #scRNAseq #scATACseq data.
Tweetorial from @[email protected] here:
https://twitter.com/morris_lab/status/1623354686630764552?t=EnoMEjFSG-dnY5J_i-NMAg&s=19