#newsmayerlab — Public Fediverse posts

🎉 Big congratulations to Yana Kotlyarenko for successfully defending her PhD!
She carried out her research project in our lab, and it’s been a joy to see her science and ideas grow. Wishing her all the best for the next steps! 🌟

#PhDDefense #NewsMayerlab

Explore the data — single-cell RNA, ATAC, and eGRNs — in our interactive app:
https://mayerlab.net/mouse-inhibitory-neuron-development/

Join the discussion in our Matrix room: #Mouse.Inhibitory.Neuron.Development:mpg.de

#NewsMayerlab #ShinyApp #OpenScience

(7/7)

Gene regulatory network analysis pointed to NFIB as a central hub. It interacts with MEIS2 and TCF4, and drives late-stage enhancer activation. Heterochronic transplants confirmed: maturation competence is sensitive to environmental timing.

#NewsMayerlab #GRN #GeneRegulation #GeneRegulatoryNetwork #Scenic+ #NFIB #Transplantation

(6/7)

We also saw a shift in TF activity.

Footprinting showed increased NFI binding, especially NFIB, in late-born cohorts. These neurons activate maturation modules faster — possibly guided by chromatin remodeling during neurogenesis.
#NewsMayerlab #TFfootprints #TranscriptionFactors #scATACseq
(5/7)

This shift was mirrored in chromatin accessibility.

scATAC-seq revealed stage-specific enhancer activation, with late-born cells opening distinct regulatory elements — especially in distal regions. A dynamic change in the regulatory landscape.

#NewsMayerlab #Chromatin #Epigenetics #scATACseq

(4/7)

During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.

But it turns out that in inhibitory lineages, progenitors retain stable differentiation competence. Instead, temporal progression alters maturation dynamics.

#NewsMayerlab #Corticogenesis #PatchClamp

(2/7)

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: https://www.sfari.org/2025/04/08/announcing-the-recipients-of-the-2024-pilot-and-pilot-progression-awards/
NLMFF: https://www.nlmfoundation.org/grant/epigenetic-regulators-ash1l-and-setbp1-in-gabaergic-neuron-development-and-asd/

#newsmayerlab #SFARI #NLMFF #AutismResearch #Neurodevelopment #Epigenetics #GABA #Genomics #Chromatin #Neuroscience

Our lab at the Max Planck Institute for Biological Intelligence (Campus Martinsried) is hiring a Student Assistant (HiWi). The position can be filled as soon as possible and is open only to students enrolled at a university in Munich. All details here:All details here: https://keeper.mpdl.mpg.de/f/92efd20d4e5948fa955e/

#Hiring #LabTechnician #BiologyJobs #Neuroscience #MolecularBiology #CellBiology #ResearchJobs #ScienceJobs #AcademicJobs #NewsMayerlab #MPI

Our lab at the Max Planck Institute for Biological Intelligence (Campus Martinsried) is hiring a lab technician. The position can be filled as soon as possible. All details here: https://keeper.mpdl.mpg.de/f/047f7d13e1a54a26b1ae/

#Hiring #LabTechnician #BiologyJobs #Neuroscience #MolecularBiology #CellBiology #ResearchJobs #ScienceJobs #AcademicJobs #NewsMayerlab #MPI

We’re hiring!

Join our lab at the Max Planck Institute for Biological Intelligence in Munich. Open positions for Postdocs, PhD students, Master’s students, and Technicians to work on wet lab molecular biology projects exploring gene regulation and neuronal diversity.

More information here: https://mayerlab.net/join-us/

#Neuroscience #MolecularBiology #AcademicJobs #WetLab #GeneRegulation #PostdocJobs #PhDPositions #NewsMayerLab