#newsmayerlab — Public Fediverse posts
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On my way to Otsu, Japan, for the EMBO Workshop “Neurodevelopmental disorders: genes to circuits and behavior.” Looking forward to meeting colleagues, exchanging ideas, and presenting our lab’s latest work on how risk genes affect developmental gene regulation!
https://meetings.embo.org/event/26-neurodev-disorders
#Neurodevelopment #GeneRegulation #EMBO #newsmayerlab -
New preprint from the lab!
How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.
Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.