#ionchannels — Public Fediverse posts

P2X receptors are ATP-gated #IonChannels that are targets for treating #ChronicPain & #cough. The #cryoEM structure of the human #P2X3 receptor in complex with the negative allosteric modulator sivopixant reveals how it stabilizes inhibitory conformations of P2X3 @PLOSBiology https://plos.io/4vMWCvy

Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of Medicine

See the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/

#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=10553

Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of Medicine

See the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/

#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=10297

⚡️ How does the Hv1 proton channel conduct protons faster than diffusion should allow?

🔗 Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.021

📚 CSBJ: https://www.csbj.org/

#Biophysics #ProtonChannel #MolecularDynamics #StructuralBiology #HydrogenBonding #IonChannels #ProtonTransport #Hv1

Postdoctoral Research Fellow
The Ohio State University

See the full job description on jobRxiv: https://jobrxiv.org/job/the-ohio-state-university-27778-postdoctoral-research-fellow/

#cellbiology #electrophysiology #ionchannels #lipidscramblases #pathology #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-ohio-state-university-27778-postdoctoral-research-fellow/?fsp_sid=4820

Postdoc in ion channel structure–work in Milan!
Universita delgi Studi di Milano

Come and work with us in Milan on the structure of natural and engineered ion channels.

See the full job description on jobRxiv: https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/

#cryoelectronmicroscopy #ionchannels #membranepr...
https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/?fsp_sid=1187

'Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function' - an article in the Journal of #Physiology on #ScienceOpen:

🔗 https://www.scienceopen.com/document?vid=ca9adf46-7161-460f-acd6-140774e62eb4

#Pathophysiology #ParkinsonsDisease #Kir4_2 #IonChannels #IonChannelopathy #GeneticMutation #MolecularNeuroscience

Postdoc in ion channel structure–work in Milan!
Universita delgi Studi di Milano

Come and work with us in Milan on the structure of natural and engineered ion channels.

See the full job description on jobRxiv: https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/

#cryoelectronmicroscopy #ionchannels #membranepro...
https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/?fsp_sid=473

How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function

#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity

https://youtube.com/shorts/fYzKu8dPvi0?feature=share

Ion Channels and Neurotransmitters: The Building Blocks of Brain Activity

#Neuroscience #BrainScience #Neurobiology #SynapticTransmission #Neurogenetics #BrainHealth #Neuroplasticity #IonChannels #MentalHealth #Neurodegeneration

https://youtube.com/shorts/YwcRMWCVvyE?feature=share

Sounds are amplified in the ear by hair cell motility. The signal for this comes from the brain. But what if the sounds are loud enough to cause damage? Then the brain must protect the cochlea. This important work shows the major involvement of an ATP gated ion channel in this damage limitation process, P2X7. P2X channels are somewhat neglected in their physiological roles, so this role in hearing is quite fascinating!

https://www.biorxiv.org/content/10.1101/2024.10.14.618333v1?med=mas

#ionchannels #physiology #hearing #electromotility

Humans are #bioelectrical beings. The collections of #cells that make up tissues and organs #communicate using the #language of voltages and #electricfields. This electrical #code is produced by specialized #ionchannels and #proteins imbedded in cell membranes.

#Brain #Science #Technology

https://www.the-scientist.com/shaping-brain-recovery-using-bioelectricity-71252?t

Fred Sigworth has recorded the beautiful talk that he gave at the GRC Ion Channels and posted it on YouTube. Fred is not only a scientist of abundant experimental and theoretical gifts, but an incredibly gracious and generous speaker. He is an inspiration to us all. Thank you, Fred!

#ionchannels #biophysics #physiology
https://www.youtube.com/watch?v=db1afWzokOU

🚨 Just a few days to go - the course is filling up, please send in your application before 30th June for full consideration!🚨

The 2nd edition of the Berlin Single Molecule Biophysics Course will be held this September 9 - 13th. We will charge a fee for external participants but waivers and bursaries should be available if needed. Please retoot!

More details:
https://www.biologie.hu-berlin.de/en/groupsites/cellbp/berlin-smb-course

#biophysics #ionchannels #physiology #TIRF

The 2nd edition of the Berlin Single Molecule Biophysics Course will be held this september. We will charge a fee for external participants but waivers and bursaries should be available if needed. Please retoot!

#biophysics #ionchannels #physiology #TIRF

https://www.biologie.hu-berlin.de/en/groupsites/cellbp/berlin-smb-course

Nice work from the team at Van Andel Institute (including my former colleague Ian Orozco) to show the temperature dependence of ligand action - a concept new to me - for TRPM4 ion channel. The binding sites for activators are temperature dependent. Very interesting. We will put it on the list for our Master student Oberseminar in NeuroBiophysics.
#IonChannels #Thermosensation #physiology #neuroscience #biophysics
https://www.nature.com/articles/s41586-024-07436-7

Just Published!

Mechanobiology

https://link.springer.com/book/10.1007/978-3-031-45379-3

This conference proceedings includes a selection of the science discussed at the 4th International Symposium on Mechanobiology.

This collection reflects the diverse and multidisciplinary nature of mechanobiology research spanning length scales and organ systems.

Enjoy!

Chapter 4 is available as open access.

#Biophysics #Mechanotransduction #TissueMechanics #Bioengineering #IonChannels #Books

29-FEB-2024
A new channel for #touch

https://www.eurekalert.org/news-releases/1035440

#science #sensory #perception #IonChannels

GYKI inhibition "desensitises" AMPA receptors. Elegant set of structural, functional and computational experiments to investigate a new "state" of #glutamate receptors from Ed Twomey and featuring our collaborator, Albert Lau. #biophysics #IonChannels

https://www.biorxiv.org/content/10.1101/2023.11.28.569057v1.abstract

Now out in Current Biology - our attempt at detecting protein homologs in the post-protein folding age.

Insect ORs and GRs are particularly difficult to work with because of rapid evolution and huge sequence divergence. By combining structure and sequence based searches, we surprisingly found homologs across the tree of life. Cryptic proteins as old as LUCA?

https://doi.org/10.1016/j.cub.2023.10.008

#phylogenetics #alphafold #evolution #ionchannels #olfaction #smell #gustation #taste #drosophila #asgard #LUCA

Photoswitchable NMDA inhibition - from recombinant receptors to blocking tadpole locomotion. Nice work from Laetitia Mony and Pierre Paoletti.

#neuroscience #ionchannels #receptors

https://www.biorxiv.org/content/10.1101/2023.10.16.562518v2.abstract

#Ketamine binding to NMDAR is tight enough to dominate the pharmacokinetics- and effect can be reversed by voltage (activity).

#neuroscience #depression #ionchannels

https://www.nature.com/articles/s41586-023-06624-1

Sad to hear that the almighty David A. Brown has passed away. A legend of #UCL #pharmacology discoverer of the M-current and just such a friendly and funny person. He was razor sharp but ever so kind.

You can watch a video interview with DAB about the M-current here:

https://www.cambridge.org/download_file/1030688

#ionchannels #neuroscience #epilepsy

An ion transporter with voltage-sensing domains - confirmed! Nature is the best designer... this transporter is essential for sperm motility, and so could be a new target for male contraceptive.

#ionchannels #physiology #sperm

https://www.nature.com/articles/d41586-023-03154-8

Beautiful study from my colleagues in the #dynion consortium about potassium #IonChannels gating by the ion selectivity filter. The connection of the membrane interaction, phosphorylation and conduction is very elegant.

From: @bioRxiv_biophys
https://botsin.space/@bioRxiv_biophys/111203076129003019

Structures of native GABA receptor #ionchannels from mouse brain reveal well-bound neurosteroid and subunit composition. From Eric Gouaux and colleagues.

#synapses #neuroscience

https://www.nature.com/articles/s41586-023-06556-w

Helge Ewers and Purba Kashyap developed an elegant way to trap proteins in the Golgi and uncage them with light. Sara Bertelli from our lab showed that it works well for BK #ionchannels , amongst other targets.

From: @bioRxiv_biophys
https://botsin.space/@bioRxiv_biophys/111081808482056212

Our projects on cardiac #IonChannels & #Channelopathies have received funding from the @snsf_ch. We are seeking two PhD candidates to join our team. Do you know someone interested?
Learn more: https://abriellab.org/
RTs are greatly appreciated!
#PhDpositions #CardiacResearch

Free link (50 days) to the final version of our paper about monovalent ion permeation in NaK mutants emulating glutamate receptor selectivity filters https://authors.elsevier.com/a/1gYpQ54HFRkZC

The preprint is free for the long term (and it's quite similar):

https://www.biorxiv.org/content/10.1101/2022.08.08.502946v2

#biophysics #ionchannels #selectivity #Crystallography #MolecularDynamics #Electrophysiology

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

Nice to see my friends Lilia Leisle, Alessio Accardi, Chris Ahern and more teaming up! Here, CLC-type ion channels, widely responsible for #chloride balance, were subjected to unnatural amino acid #mutagenesis. In a subtle example of the genre, the peptide backbone was changed at individual sites by introducing alpha-hydroxy amino acids.This showed that backbone amides coordinate permeating chloride ions.

#biophysics #IonChannels #physiology #GeneticCodeExpansion

https://www.nature.com/articles/s41467-022-35279-1

One more test with #Galactica @paperswithcode: Generate a #ReviewArticle on "Literature review on the challenges of cystic fibrosis on the African continent" - Last sentence of the #AI generated abstract: "The challenges of #CysticFibrosis (CF) on the African Continent are enormous and need to be addressed urgently."

#AIIsAmazing
#Channelopathies
#IonChannels
#ScienceInAfrica

#ionchannels #physiology #pacemaking #patchclamp #biophysics

Mini biopsies point to source of lethal seizures in model mice

https://www.spectrumnews.org/news/mini-biopsies-point-to-source-of-lethal-seizures-in-model-mice/

#interneurons #ionchannels #mousemodels #seizures #synapses #autism #News