#ionchannels — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ionchannels, aggregated by home.social.
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Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of MedicineSee the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/
#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=13689 -
Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of MedicineSee the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/
#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=12185 -
P2X receptors are ATP-gated #IonChannels that are targets for treating #ChronicPain & #cough. The #cryoEM structure of the human #P2X3 receptor in complex with the negative allosteric modulator sivopixant reveals how it stabilizes inhibitory conformations of P2X3 @PLOSBiology https://plos.io/4vMWCvy
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Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of MedicineSee the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/
#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=10553 -
Postdoctoral Associate in Membrane Protein Structural Biology & Biophysics
Duke University School of MedicineSee the full job description on jobRxiv: https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/
#cellularbiophysics #cryoEM #ionchannels #membranep...
https://jobrxiv.org/job/duke-university-school-of-medicine-27778-postdoctoral-associate-in-membrane-protein-structural-biology-biophysics/?fsp_sid=10297 -
⚡️ How does the Hv1 proton channel conduct protons faster than diffusion should allow?
🔗 Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.021
📚 CSBJ: https://www.csbj.org/
#Biophysics #ProtonChannel #MolecularDynamics #StructuralBiology #HydrogenBonding #IonChannels #ProtonTransport #Hv1
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Postdoctoral Research Fellow
The Ohio State UniversitySee the full job description on jobRxiv: https://jobrxiv.org/job/the-ohio-state-university-27778-postdoctoral-research-fellow/
#cellbiology #electrophysiology #ionchannels #lipidscramblases #pathology #ScienceJobs #hiring #research
https://jobrxiv.org/job/the-ohio-state-university-27778-postdoctoral-research-fellow/?fsp_sid=4820 -
Postdoc in ion channel structure–work in Milan!
Universita delgi Studi di MilanoCome and work with us in Milan on the structure of natural and engineered ion channels.
See the full job description on jobRxiv: https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/
#cryoelectronmicroscopy #ionchannels #membranepr...
https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/?fsp_sid=1187 -
'Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function' - an article in the Journal of #Physiology on #ScienceOpen:
🔗 https://www.scienceopen.com/document?vid=ca9adf46-7161-460f-acd6-140774e62eb4
#Pathophysiology #ParkinsonsDisease #Kir4_2 #IonChannels #IonChannelopathy #GeneticMutation #MolecularNeuroscience
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Postdoc in ion channel structure–work in Milan!
Universita delgi Studi di MilanoCome and work with us in Milan on the structure of natural and engineered ion channels.
See the full job description on jobRxiv: https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/
#cryoelectronmicroscopy #ionchannels #membranepro...
https://jobrxiv.org/job/universita-delgi-studi-di-milano-27778-postdoc-in-ion-channel-structure-work-in-milan/?fsp_sid=473 -
How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function
#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity
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Ion Channels and Neurotransmitters: The Building Blocks of Brain Activity
#Neuroscience #BrainScience #Neurobiology #SynapticTransmission #Neurogenetics #BrainHealth #Neuroplasticity #IonChannels #MentalHealth #Neurodegeneration
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Sounds are amplified in the ear by hair cell motility. The signal for this comes from the brain. But what if the sounds are loud enough to cause damage? Then the brain must protect the cochlea. This important work shows the major involvement of an ATP gated ion channel in this damage limitation process, P2X7. P2X channels are somewhat neglected in their physiological roles, so this role in hearing is quite fascinating!
https://www.biorxiv.org/content/10.1101/2024.10.14.618333v1?med=mas
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Humans are #bioelectrical beings. The collections of #cells that make up tissues and organs #communicate using the #language of voltages and #electricfields. This electrical #code is produced by specialized #ionchannels and #proteins imbedded in cell membranes.
https://www.the-scientist.com/shaping-brain-recovery-using-bioelectricity-71252?t
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Fred Sigworth has recorded the beautiful talk that he gave at the GRC Ion Channels and posted it on YouTube. Fred is not only a scientist of abundant experimental and theoretical gifts, but an incredibly gracious and generous speaker. He is an inspiration to us all. Thank you, Fred!
#ionchannels #biophysics #physiology
https://www.youtube.com/watch?v=db1afWzokOU -
🚨 Just a few days to go - the course is filling up, please send in your application before 30th June for full consideration!🚨
The 2nd edition of the Berlin Single Molecule Biophysics Course will be held this September 9 - 13th. We will charge a fee for external participants but waivers and bursaries should be available if needed. Please retoot!
More details:
https://www.biologie.hu-berlin.de/en/groupsites/cellbp/berlin-smb-course -
The 2nd edition of the Berlin Single Molecule Biophysics Course will be held this september. We will charge a fee for external participants but waivers and bursaries should be available if needed. Please retoot!
#biophysics #ionchannels #physiology #TIRF
https://www.biologie.hu-berlin.de/en/groupsites/cellbp/berlin-smb-course
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Nice work from the team at Van Andel Institute (including my former colleague Ian Orozco) to show the temperature dependence of ligand action - a concept new to me - for TRPM4 ion channel. The binding sites for activators are temperature dependent. Very interesting. We will put it on the list for our Master student Oberseminar in NeuroBiophysics.
#IonChannels #Thermosensation #physiology #neuroscience #biophysics
https://www.nature.com/articles/s41586-024-07436-7 -
Just Published!
Mechanobiology
https://link.springer.com/book/10.1007/978-3-031-45379-3
This conference proceedings includes a selection of the science discussed at the 4th International Symposium on Mechanobiology.
This collection reflects the diverse and multidisciplinary nature of mechanobiology research spanning length scales and organ systems.
Enjoy!
Chapter 4 is available as open access.
#Biophysics #Mechanotransduction #TissueMechanics #Bioengineering #IonChannels #Books
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29-FEB-2024
A new channel for #touch -
GYKI inhibition "desensitises" AMPA receptors. Elegant set of structural, functional and computational experiments to investigate a new "state" of #glutamate receptors from Ed Twomey and featuring our collaborator, Albert Lau. #biophysics #IonChannels
https://www.biorxiv.org/content/10.1101/2023.11.28.569057v1.abstract
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Now out in Current Biology - our attempt at detecting protein homologs in the post-protein folding age.
Insect ORs and GRs are particularly difficult to work with because of rapid evolution and huge sequence divergence. By combining structure and sequence based searches, we surprisingly found homologs across the tree of life. Cryptic proteins as old as LUCA?
https://doi.org/10.1016/j.cub.2023.10.008
#phylogenetics #alphafold #evolution #ionchannels #olfaction #smell #gustation #taste #drosophila #asgard #LUCA
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Photoswitchable NMDA inhibition - from recombinant receptors to blocking tadpole locomotion. Nice work from Laetitia Mony and Pierre Paoletti.
#neuroscience #ionchannels #receptors
https://www.biorxiv.org/content/10.1101/2023.10.16.562518v2.abstract
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#Ketamine binding to NMDAR is tight enough to dominate the pharmacokinetics- and effect can be reversed by voltage (activity).
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Sad to hear that the almighty David A. Brown has passed away. A legend of #UCL #pharmacology discoverer of the M-current and just such a friendly and funny person. He was razor sharp but ever so kind.
You can watch a video interview with DAB about the M-current here:
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An ion transporter with voltage-sensing domains - confirmed! Nature is the best designer... this transporter is essential for sperm motility, and so could be a new target for male contraceptive.
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Beautiful study from my colleagues in the #dynion consortium about potassium #IonChannels gating by the ion selectivity filter. The connection of the membrane interaction, phosphorylation and conduction is very elegant.
From: @bioRxiv_biophys
https://botsin.space/@bioRxiv_biophys/111203076129003019