#chemotherapy — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #chemotherapy, aggregated by home.social.
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https://www.europesays.com/ie/681790/ Anti-cancer drugs may help treat MRSA – Irish study #cancer #chemotherapy #Éire #Health #IE #Ireland #Microbiology #StaphylococcalBacteria #UniversityOfGalway
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A mouse study found that two doses of psilocybin prior to cancer chemotherapy reduced peripheral neuropathy (pain or loss of sensation). The protection persisted through six rounds of chemotherapy.
Original paper: https://www.science.org/doi/10.1126/science.aec6116
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Volunteers maintain historic cactus garden https://www.allforgardening.com/1938359/volunteers-maintain-historic-cactus-garden/ #arizona #ArizonaCactusGarden #beauty #cacti #california #Cancer #chemotherapy #ChristySmith #Colours #community #connection #design #enjoyment #garden #GardeningArizona #Hospital #JaneStanford #JohnPriola #LelandStanford #meaningful #NaomiMier #nature #plants #preservation #public #restoration #Stanford #style #succulents #survivor #victorian #Volunteering
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#Psilocybin May Prevent Nerve Damage Caused by #Chemotherapy, Study Finds
The preliminary research was conducted in mice, but scientists were optimistic the results would apply to humans. A #clinicaltrial begins this month.
There are no effective treatments for #neuropathy, which causes pain, tingling and numbness in the hands and feet, and can force patients to scale back or halt chemotherapy when the discomfort becomes too much to bear.
https://www.nytimes.com/2026/09/03/health/psilocybin-cancer-nerve-damage.html
https://archive.ph/laY4A -
Chef Grant Achatz’s Battle with Cancer of the Tongue https://www.diningandcooking.com/chefs/4586/ #bruni #Chefs #chemotherapy #Chicago #food #Frank #grant #GrantAchatz #illinois #MolecularGastronomy #nick #restaurants #ruth #taste #thomas #trio
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USP22 Loss Drives Chemotherapy Resistance in Small Cell Lung Cancer — But Creates a Metabolic Vulnerability
If this matters to you, share it.
https://1ban.news/usp22-chemotherapy-resistance-small-cell-lung-cancer/
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Arrived at hospital for (hopefully) the final chemo (plus a few weeks more of the horrible toxic pills).
Last session left me in a mess for ages, so really not looking forward to more of it. And dear chum sends me funny little poem about me, to cheer me up...
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USP22 Loss Drives Chemotherapy Resistance in Small Cell Lung Cancer — But Creates a Metabolic Vulnerability
https://1ban.news/usp22-chemotherapy-resistance-small-cell-lung-cancer/
#1ban #usp22 #chemotherapy #resistance #small #science -
I just finished with nine months of treatment for cancer. First they poison you, then they mutilate you, then they burn you. I’ve had more fun. And when it’s over, you’re so glad that you’re grateful to absolutely everyone. And I am. The trouble is, I’m not a better person. I was in great hopes that confronting my own mortality would make me deeper, more thoughtful. Many lovely people sent books on how to find a more spiritual meaning in life. My response was, “Oh, hell, I can’t go on a spiritual journey — I’m constipated.”
Molly Ivins (1944-2007) American writer, political columnist [Mary Tyler Ivins]
Essay (2000-10), “Cancer, II,” The Progressive magazineMore about this quote: wist.info/ivins-molly/15925/
#quote #quotes #quotation #qotd #mollyivins #breastcancer #cancer #chemotherapy #gratitude #medicaltreatment #mortality #radiation #selfimprovement #spirituality
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I 100% guarantee the #rich #wealthy #millionaires #billionaires are getting the drugs before we plebs.
Shortage of #Chemotherapy #Drugs Brings #Rationing Fears
Doctors are contending with low supplies & unfilled orders of generic chemotherapy infusions that are crucial to the treatment of a long list of #cancers.
#FDT #Trump #tariffs #sanctions #law #healthcare #medicine #cancer #BigC
https://www.nytimes.com/2026/06/24/health/chemotherapy-drug-shortage.html?smid=nytcore-ios-share -
Ivermectin Tested against 28 types of Cancer: Most Sensitive vs Least Sensitive A research group from Mexico investigated Ivermectin in Cancer. This is the first study that has tested as many as 28...
#cancer #chemotherapy #ivermectin #repurposed #drugs
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On Assurances Given By Medical Practitioners To A PatientMy still swollen face lathered with moisturiser & splashed with decades-old aftershave at 2am to stop disquieting sensations, after I applied Efudix as per my doctors instructions, has me considering what is a reasonable degree of confidence for a patient to have in assurances about short, medium and long term outcomes from their doctor.
The topic is complex. And emotional for some patients etc
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“The company developing the drug, #RevolutionMedicines, presented results on May 31, 2026, from its Phase 3 clinical trial of 500 patients with metastatic #PancreaticCancer who had received prior treatment.
Compared to standard #chemotherapy, #daraxonrasib nearly doubled overall survival from 6.7 months to 13.2 months after diagnosis. Overall, daraxonrasib reduced the risk of death for metastatic pancreatic cancer patients by 60%.”https://www.sciencealert.com/a-breakthrough-drug-just-achieved-the-impossible-for-pancreatic-cancer
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Ivermectin Tested against 28 types of Cancer: Most Sensitive vs Least Sensitive A research group from Mexico investigated Ivermectin in Cancer. This is the first study that has tested as many as 28...
#cancer #chemotherapy #ivermectin #repurposed #drugs
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And so it begins... Off to hospital again, first four hour chemotherapy session. Just as I'm starting to feel stronger, this will kick the hell out of me again. Has to be done, but highly unpleasant.
At least I can read during it.
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Immunotherapy vs. Chemotherapy vs Targeted Therapy: What's the Difference? Cancer treatment is no longer one-dimensional. For decades, chemotherapy dominated oncology. Today, treatment may in...
#cancer #chemotherapy #immunotherapy #targeted #therapy
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Revolution Medicines' pancreatic cancer therapy daraxonrasib has delivered stunning results in clinical trials, offering patients significantly more time to live and laying the groundwork for future advancements. https://www.japantimes.co.jp/commentary/2026/04/24/world/progress-against-pancreatic-cancer/?utm_medium=Social&utm_source=mastodon #commentary #worldnews #daraxonrasib #revolutionmedicine #pancreaticcancer #cancer #health #medicine #chemotherapy
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Immunotherapy vs. Chemotherapy vs Targeted Therapy: What's the Difference? Cancer treatment is no longer one-dimensional. For decades, chemotherapy dominated oncology. Today, treatment may in...
#cancer #chemotherapy #immunotherapy #targeted #therapy
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#OnThisDay Birth Anniversary of George H. Hitchings (1905). He received 1988 Nobel Prize in Physiology or Medicine for his work on #Chemotherapy and development of the two first successful chemotherapy drugs for the treatment of children with #Leukemia.
Today is International Day For #Monuments and Sites.
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I'm reminded when I see the Common Periwinkle - Vinca Major of a related plant, the Madagascar Periwinkle - Vinca Rosea. It's the source of Vincristine, a #chemotherapy drug that those of us who have #Lymphoma behind us are grateful for.
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A 13-year-old boy has become the first person to be cured of this deadly brain cancer
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Breakthrough chemotherapy treatment eliminates side effects and is 20,000 times stronger
https://web.brid.gy/r/https://www.upworthy.com/chemotherapy-treatment-eliminates-side-effects
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ENG: "Over 70% Of Studies Back Medical Cannabis In Cancer Treatment, Meta-Analysis Finds." They searched 10.000 published papers. Keep that in mind, next time you read the old " more reasearch is needed".
Here is a modern proven anti-cancer protocol. Nothing for sale. Strictly educational: https://jorge--alban--dobles-blogspot-com.translate.goog/2025/06/flores-cancer-y-salon-nacional.html?m=1&_x_tr_sl=es&_x_tr_tl=en&_x_tr_hl=es&_x_tr_pto=wapp
ESP: "Meta análisis de 10.000 estudios científicos publicados reveló una tendencia significativa ( 71.4%) que apoya el potencial terapéutico del cannabis, en particular para el manejo de los síntomas relacionados con el cáncer y efectos anticancerígenos directos."
Aqui tienen un artículo entero con un protocolo anticancerígena actual. Nada a la venta. Fin exclusivamente educativo: https://jorge-alban-dobles.blogspot.com/2025/06/flores-cancer-y-salon-nacional.html?m=1
#cancer #Cannabinoids #medicine
#marijuana #cannabismedicinal
#medicalcannabis #healing #cbda #chemotherapy #cbd #quimioterapia
#thc #thca #regenerativemedicine
#herbalist #healthare #healthscience
#medical #marijuananews #cbn #homeostasis #chemo #pharmagreed
#endocannabinoidsystem #weed
#endocannabinoide #marihuana
#pharma #pharmaceuticals #healthcare #HealthCrisis #healthEdited for for links to new cancer article on my blog
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Chemotherapy awakens dormant #cancer. #Tumor stromal organoid & murine #BreastCancer model show that #chemotherapy injures stromal cells; this injury in turn invokes proinflammatory #cytokine signaling and can awaken dormant cancer cells #PLOSBiology https://plos.io/3RjsGoQ
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Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients
Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk JaegerTargeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases
#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.
the microenvironment of #liver metastases of #colorectal cancer (#CRC).
the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.
the effects of CCR5 blockade on the #tissue level.
Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.
The microenvironment of the invasive margin of #liver metastases.
There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.
#CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).
The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.
A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.
CCR5 blockade, is a type of #therapy used to treat #cancer.
The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.
