#microtubules — Public Fediverse posts

Mammalian #cilia & #flagella depend on association of A- & B-tubules to form axonemal doublet #microtubules, but how? This study shows that CFAP77 is essential role for #axonemal connection of these tubules and crucial for #sperm motility & #fertility in mice @PLOSBiology plos.io/4ouZ2KJ

#Microtubules in #AsgardArchaea: Maybe we are #archaea after all ...

https://www.cell.com/cell/fulltext/S0092-8674(25)00254-5 #science #evolution

The Brain’s Dynamic Highway System: Microtubules, Actin, and Neuroplasticity

#Neuroscience #Neuroplasticity #BrainScience #Microtubules #ActinFilaments #Memory #Learning #BrainHealth #QuantumMind #NeuralNetworks #Cognition #MindMysteries #BrainBiology #Neurodegeneration #Neurophilosophy

https://youtube.com/shorts/_9HnrDPJM1I?feature=share

Very enjoyable talk from Ron Vale on The Impact of AlphaFold on Cell Biology.

He showcased this recent preprint where AlphaFold was instrumental in formulating testable hypotheses around how mitochondrial transport works in neurons.

https://doi.org/10.1101/2024.09.13.612963

#CellBiology #microtubules

NHKスペシャル「人体」細胞内の運び役キネシン(Kinesin)の働きを超高精細CGで映像化 最新科学が解き明かした命のメカニズムを紹介
https://www.youtube.com/watch?v=SpwaC_gvTV0
#youtube_NHK #NHK #NHKスペシャル #Nスペ #キネシン #kinesin #KIF #ダイニン #dynein #vesicles #微小管 #microtubules #cell #science #biology

"Our findings suggest a pre-eukaryotic origin of microtubules and provide a framework for understanding the fundamental principles of microtubule assembly."

https://www.cell.com/cell/fulltext/S0092-8674(25)00254-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425002545%3Fshowall%3Dtrue

#microtubules #evolution

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Impressive biochemical work implicates the tRNA modification complex Elongator in microtubule polymerisation.

https://pubmed.ncbi.nlm.nih.gov/39815006/

I was surprised to see that the authors did not cite the seminal paper that established the role of Elongator in tRNA modification, which seems to be its crucial function, at least in yeast (Mol Cell 2006).

https://pubmed.ncbi.nlm.nih.gov/17018299/

#RNA #microtubules

@bookstodon

But perhaps the most interesting wrinkle in Shadows of the Mind is #Penrose's excursion into microbiology, where he examines cytoskeletons and microtubules, minute substructures lying deep within the brain's neurons. (He argues that #microtubules--not neurons--may indeed be the basic units of the brain, which, if nothing else, would dramatically increase the brain's computational power.)

@PLOSBiology Latest from Melissa Rolls' lab on microtubules in neurons:

"Endocytosis of Wnt ligands from surrounding epithelial cells positions microtubule nucleation sites at dendrite branch points", by Thyagarajan et al. 2024
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002973

To note that "Microtubule nucleation at dendrite branch points can be regulated by clathrin-mediated endocytosis".

This valuable study uses the dendrites of the somatosensory proprioceptive sensory neuron ddaE as a model; ddaE is known to respond to respond specifically to forward peristalsis as per He et al. 2019 https://doi.org/10.1016/j.cub.2019.02.025

#neuroscience #microtubules #Drosophila

Our preprint is up! Take a look if you like kinesin, microtubule transport, single molecule FRET or biophysics. It’s a bit of shift to how we’ve been used to thinking about kinesin-1 regulation as we try to get a handle on its conformational dynamics. Super proud of to have this milestone out in the world and all the hard work it represents from everyone involved.
#kinesin #microtubules #biophys #smFRET #SingleMolecule #AxonalTransport https://biologists.social/@TwelvetreesLab/113691748206473977

#FissionYeast canonically need #microtubules & Tea1-Tea4 complex to establish new growth poles. @Ptcgar &co identify a parallel pathway involving actin & Rgf1-Rho1 that marks the growth poles independently of Tea1-Tea4 #PLOSBiology https://plos.io/3CgOZ9f

#StuartHameroff - Toward a #Science of #Consciousness

https://www.youtube.com/watch?v=mnmpw9nvTl8

#Philosophy #PhilosophyOfScience #PhilosophyOfMind #Mind #PhilosophyOfConsciousness #Qualia #Awareness #Self #Brain #Neuroscience #Neurology #QM #QuantumMechanics #QuantumPhysics #WaveFunction #WaveFunctionCollapse #Decoherence #Penrose #RogerPenrose #Microtubules #HardProblem #Chalmers #DavidChalmers #Computation #Synapse #Panpsychism #Dualism #CloserToTruth #RobertKuhn

Sabine Hossenfelder changes her mind about Roger Penrose.
Woo-hoo!
https://www.youtube.com/watch?v=R6G1D2UQ3gg
#microtubules #RogerPenrose #brain #consciousness #mind #quantum #physics

#BrianJosephson - Must the #Universe Contain #Consciousness?

https://www.youtube.com/watch?v=kACtzCm9M5w

#Philosophy #PhilosophyOfScience #Science #PhilosophyOfMind #Mind #PhilosophyOfConsciousness #Metaphysics #Physics #Biology #Emergence #UltimateReality #Cosmos #QM #QuantumMechanics #Observation #Observer #Wheeler #Penrose #Microtubules #Neuroscience #God #Creation #ProtoConsciousness #CloserToTruth #RobertKuhn

Sideways stepping of the human #kinesin-5, KIF11, drives right-handed helical motion of anti-parallel #microtubules and orbiting motion of parallel microtubules around each other

Laura Meissner, Stefan Diez et al

https://www.embopress.org/doi/full/10.1038/s44318-024-00048-x

#StuartHameroff - What is #Panpsychism?

https://www.youtube.com/watch?v=i_RXrclM7Bc

#Philosophy #PhilosophyOfConsciousness #Consciousness #PhilosophyOfMind #Mind #Brain #Neuroscience #QM #QuantumMechanics #QuantumPhysics #WaveFunction #Microtubules #CloserToTruth #RobertKuhn

Researchers uncovered surprising findings on the assembly of #microtubules in vitro, illustrating in this animation how holes can appear during polymerisation as subunits don’t perfectly align. #Cytoskeleton #12DaysOfeLife https://elifesciences.org/articles/83021?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days

Optogenetics helped researchers study the role of the microtubule end-binding protein, EB1, in the growth of neurons. Here, the end of a neuron reaches a strip of blue light which optogenetically inactivates EB1 causing the microtubule fibres that usually push and grow the cell to fall apart. #Neuroscience #Optogenetics #Microtubules #12DaysOfeLife https://elifesciences.org/articles/84143?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days

Latest preprint from Mark Dodding's lab on #actin INSIDE #microtubules. A really fascinating observation. This paper shows by cryo-ET that this #cytoskeleton inception occurs in platelets.
#CellBiology
https://www.biorxiv.org/content/10.1101/2023.11.24.568450v1

#Influenza virus infection triggers condensation of host recycling #endosomes next to the ER. @SilviaValeCosta @mjamorim1 &co show that this a regulated process involving ATG9A, which detaches recycling endosomes from #microtubules near the ER #PLOSBiology https://plos.io/3QR78hJ

Please join us for MiQ talks on Wednesday 4th October 2023 at 15:00 UTC (8:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST / 20:30 IST / 23:00 CST).

Speakers:

Alex Fellows (Carter lab) - MRC LMB Cambridge
Visualising endogenous dynein and its regulators reveal neuronal trafficking mechanisms

Shashi Thutupalli - NCBS Bangalore
Two-component molecular motor driven by a GTPase cycle

https://mechanochemistry.org/whatson/MiQ/index.php

#MotorHeads #Cytoskeleton #microtubule #microtubules

New paper from Yean Ming and Rob

“Taxol acts differently on different tubulin isotypes”

http://rdcu.be/dmiem

#cytoskeleton #tubulin #microtubules #CellBiology #Motorheads

Hi #ScienceMastodon! Check out the last Research Highlight from Issue 17 of JCS: Ke Hu and colleagues at Arizona State University mess with microtubule-associated proteins in Toxoplasma gondii to answer whether the distinct helical motility of this apicomplexan parasite arises from the spiral arrangement of its remarkably stable cortical microtubules.
#CellBiology #microtubules #parasitology

Function follows form of cortical microtubules in Toxoplasma gondii
https://journals.biologists.com/jcs/article/136/17/e136_e1702/327904/Function-follows-form-of-cortical-microtubules-in

Happy Monday again, #ScienceMastodon! The first Research Highlight from JCS Issue 16 features a paper from Toshiyuki Oda and colleagues at the Universities of Yamanashi and Tokyo, using the unicellular algae Chlamydomonas reinhardtii to break down roles of tubulin modifications in ciliary/flagellar motility. #CellBiology #microtubules #flagellates

Roles of ciliary tubulin PTMs in Chlamydomonas reinhardtii
https://journals.biologists.com/jcs/article/136/16/e136_e1601/325932/Roles-of-ciliary-tubulin-PTMs-in-Chlamydomonas

#DonaldHoffman - #QuantumPhysics of #Consciousness

https://www.youtube.com/watch?v=tio1vJoTeKY&ab_channel=CloserToTruth

#Philosophy #PhilosophyOfScience #PhilosophyOfMind #Mind #TheMind #Neuroscience #Neurophysiology #QM #QuantumMechanics #Microtubules #QuantumState #Qualia #IdentityTheory #CloserToTruth #RobertKuhn

Hello! A new intro for a new instance.

I lead a research group trying to figure out axonal transport and neurodegeneration. A big emphasis on the microtubules and their motors, but really the transport of anything that doesn't have a membrane around it. For this we use a lot of single molecule methods and live cell imaging. I also post about research culture.

#introduction #kinesin #dynein #microtubules #neurodegeneration #AxonalTransport #neurobiology #SingleMolecule #CellBiology

How does #centrosome #amplification -common in #cancer- promote #cellmigration through confined spaces?
Susana Godinho and colleagues show that it alters intracellular organization via effects on #tubulin #acetylation and #organelle transport along #microtubules
https://www.embopress.org/doi/full/10.15252/embj.2022112812

I was at #EMBL when #TaraOcen project started ... It definitely also was #EricKarsenti wanting some science fun on a boat after years with #microtubules and #microscopes only... #MarineBiology #oceanograpy #TheOtherSideOfTheMoon

The inspiring story of the Tara and its 20-year message from the corals https://www.nature.com/articles/d41586-023-01826-z

The next MiQ talk will be on Wednesday 7th June 2023 at 15:00 UTC (8:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST / 20:30 IST / 23:00 CST).

Speakers:

Beth Lawrence (Zanic lab) - Vanderbilt University
CLASPs stabilize the intermediate state between microtubule growth and catastrophe

Julie Welburn - WTCCB Edinburgh
Predicting pathogenic mutations in tubulin

Details https://mechanochemistry.org/whatson/MiQ/

#CellBiology #MotorHeads #Microtubules #Cytoskeleton

As Stuart Hameroff and Sir Roger Penrose suggest, Tryptophan residues in #microtubules influence #consciousness. In this 3D print of Microtubule 3J2U, we can see how TRP residues (tinted dark) interconnect adjacent #Tubulin molecules. #structuralbiology
https://biologicmodels.com/pdb/3j2u/microtubule-3j2u/?aiEnableCheckShortcode=true

#RogerPenrose - Toward a #Science of #Consciousness

https://www.youtube.com/watch?v=sPd37wfhouo&ab_channel=CloserToTruth

#Philosophy #PhilosophyOfScience #PhilosophyOfConsciousness #Mind #TheMind #NatureOfMind #QM #QuantumMechanics #QuantumPhysics #BiologicalNaturalism #HardProblem #TheHardProblem #Microtubules #CloserToTruth #RobertKuhn

Take a look at our 'First person' interview with Leeba Ann Chacko on her PhD project in the lab of Vaishnavi Ananthanarayanan at the Single Molecule Science initiative, University of New South Wales, Sydney, Australia, investigating how mitochondrial volume homeostasis is maintained during the cell cycle: https://journals.biologists.com/jcs/article/136/1/jcs260895/286575/First-person-Leeba-Ann-Chacko
#cellbiology #research #cellcycle #microtubules #mitochondria

Check out our 'First persons' interview with Kerstin Hinterndorfer and Felix Mikus on their joint project establishing an optimised protocol for expansion microscopy in yeast:
https://journals.biologists.com/jcs/article/135/24/jcs260862/286124/First-person-Kerstin-Hinterndorfer-and-Felix-Mikus
#cellbiology #expansionmicroscopy #U-ExM #S.pombe #S.cerevisiae #microtubules #nuclearporecomplex

#Consciousness and #QuantumMechanics - What's the Link?

https://www.youtube.com/watch?v=v1wqUCATYUA&ab_channel=SabineHossenfelder

#Physics #QM #QuantumPhysics #Philosophy #Mind #Decoherence #WaveFunctionCollapse #Copenhagen #Dualism #MindBodyProblem #Microtubules #IntegratedInformation #SabineHossenfelder

Also looking for a cell biology postdoc for which we have nice toys too: https://atsv7.wcn.co.uk/search_engine/jobs.cgi?owner=5062452&ownertype=fair&jcode=1888948&vt_template=1457&adminview=1 #postdoc #kinesin #dynein #microtubules #latticelightsheet #microscopy

Our new C-Trap is ready to go. Join us and make the most of it: https://www.nature.com/naturecareers/job/research-fellow-in-biochemistry-biophysics-782221122-the-university-of-warwick-warwick-767180 #kinesin #opticaltrap #dynein #microtubules

Hello #ScienceMastodon!

I am a molecular and cellular neurobiologist leading a research group trying to figure out #AxonalTransport & #neurodegeneration. A big emphasis on #microtubules, #kinesin and #dynein, but really the transport of anything that doesn't have a membrane around it. We use a lot of #SingleMolecule methods and #LiveCellImaging.

I also post about #researchculture, particularly how we can better invest in people so they can do great science.

#introduction