Live and recent posts from across the Fediverse tagged #microtubules, aggregated by home.social.
CELLS DIVIDE, MICROTUBULES ORCHESTRATE
New research shows cell division itself triggers the building of the spindle apparatus, a key structure for passing on genetic material.
#CellDivision, #CellBiology, #SpindleApparatus, #Microtubules, #ScienceNews
https://newsletter.tf/cell-division-starts-spindle-building-study/
Scientists recently found that cell division physically starts the building of the spindle apparatus. This is a new detail about how cells copy themselves.
#CellDivision, #CellBiology, #SpindleApparatus, #Microtubules, #ScienceNews
https://newsletter.tf/cell-division-starts-spindle-building-study/
In situ structural mechanism of epothilone-B-induced CNS axon regeneration
Curcio, M. & Bradke, F. Axon regeneration in the central nervous system: facing the challenges from the inside.…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Cryoelectrontomography #HumanitiesandSocialSciences #Microtubules #multidisciplinary
https://www.newsbeep.com/us/288641/
[フロンティア] 細胞内の運び役キネシン (Kinesin) の働きを超高精細CGで映像化 最新科学が解き明かした命のメカニズムを紹介
https://www.youtube.com/watch?v=yrvf8V_yLGA
#youtube_NHK #キネシン #kinesin #KIF #ダイニン #dynein #vesicles #微小管 #microtubules #cell #science
Mammalian #cilia & #flagella depend on association of A- & B-tubules to form axonemal doublet #microtubules, but how? This study shows that CFAP77 is essential role for #axonemal connection of these tubules and crucial for #sperm motility & #fertility in mice @PLOSBiology plos.io/4ouZ2KJ
The Brain’s Dynamic Highway System: Microtubules, Actin, and Neuroplasticity
#Neuroscience #Neuroplasticity #BrainScience #Microtubules #ActinFilaments #Memory #Learning #BrainHealth #QuantumMind #NeuralNetworks #Cognition #MindMysteries #BrainBiology #Neurodegeneration #Neurophilosophy
Very enjoyable talk from Ron Vale on The Impact of AlphaFold on Cell Biology.
He showcased this recent preprint where AlphaFold was instrumental in formulating testable hypotheses around how mitochondrial transport works in neurons.
"Our findings suggest a pre-eukaryotic origin of microtubules and provide a framework for understanding the fundamental principles of microtubule assembly."
Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
Impressive biochemical work implicates the tRNA modification complex Elongator in microtubule polymerisation.
https://pubmed.ncbi.nlm.nih.gov/39815006/
I was surprised to see that the authors did not cite the seminal paper that established the role of Elongator in tRNA modification, which seems to be its crucial function, at least in yeast (Mol Cell 2006).
But perhaps the most interesting wrinkle in Shadows of the Mind is #Penrose's excursion into microbiology, where he examines cytoskeletons and microtubules, minute substructures lying deep within the brain's neurons. (He argues that #microtubules--not neurons--may indeed be the basic units of the brain, which, if nothing else, would dramatically increase the brain's computational power.)
@PLOSBiology Latest from Melissa Rolls' lab on microtubules in neurons:
"Endocytosis of Wnt ligands from surrounding epithelial cells positions microtubule nucleation sites at dendrite branch points", by Thyagarajan et al. 2024
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002973
To note that "Microtubule nucleation at dendrite branch points can be regulated by clathrin-mediated endocytosis".
This valuable study uses the dendrites of the somatosensory proprioceptive sensory neuron ddaE as a model; ddaE is known to respond to respond specifically to forward peristalsis as per He et al. 2019 https://doi.org/10.1016/j.cub.2019.02.025
Our preprint is up! Take a look if you like kinesin, microtubule transport, single molecule FRET or biophysics. It’s a bit of shift to how we’ve been used to thinking about kinesin-1 regulation as we try to get a handle on its conformational dynamics. Super proud of to have this milestone out in the world and all the hard work it represents from everyone involved.
#kinesin #microtubules #biophys #smFRET #SingleMolecule #AxonalTransport https://biologists.social/@TwelvetreesLab/113691748206473977
#FissionYeast canonically need #microtubules & Tea1-Tea4 complex to establish new growth poles. @Ptcgar &co identify a parallel pathway involving actin & Rgf1-Rho1 that marks the growth poles independently of Tea1-Tea4 #PLOSBiology https://plos.io/3CgOZ9f
#StuartHameroff - Toward a #Science of #Consciousness
https://www.youtube.com/watch?v=mnmpw9nvTl8
#Philosophy #PhilosophyOfScience #PhilosophyOfMind #Mind #PhilosophyOfConsciousness #Qualia #Awareness #Self #Brain #Neuroscience #Neurology #QM #QuantumMechanics #QuantumPhysics #WaveFunction #WaveFunctionCollapse #Decoherence #Penrose #RogerPenrose #Microtubules #HardProblem #Chalmers #DavidChalmers #Computation #Synapse #Panpsychism #Dualism #CloserToTruth #RobertKuhn
Unique characteristics of previously unexplored #protein discovered.
#cell_division #microtubules #cytoskeleton #FAM110A
https://phys.org/news/2024-07-unique-characteristics-previously-unexplored-protein.html
Sabine Hossenfelder changes her mind about Roger Penrose.
Woo-hoo!
https://www.youtube.com/watch?v=R6G1D2UQ3gg
#microtubules #RogerPenrose #brain #consciousness #mind #quantum #physics
#BrianJosephson - Must the #Universe Contain #Consciousness?
https://www.youtube.com/watch?v=kACtzCm9M5w
#Philosophy #PhilosophyOfScience #Science #PhilosophyOfMind #Mind #PhilosophyOfConsciousness #Metaphysics #Physics #Biology #Emergence #UltimateReality #Cosmos #QM #QuantumMechanics #Observation #Observer #Wheeler #Penrose #Microtubules #Neuroscience #God #Creation #ProtoConsciousness #CloserToTruth #RobertKuhn
Sideways stepping of the human #kinesin-5, KIF11, drives right-handed helical motion of anti-parallel #microtubules and orbiting motion of parallel microtubules around each other
Laura Meissner, Stefan Diez et al
https://www.embopress.org/doi/full/10.1038/s44318-024-00048-x
First atomic-scale 'movie' of #microtubules under construction, a key process for #cell #division.
https://phys.org/news/2024-02-atomic-scale-movie-microtubules-key.html
Researchers uncovered surprising findings on the assembly of #microtubules in vitro, illustrating in this animation how holes can appear during polymerisation as subunits don’t perfectly align. #Cytoskeleton #12DaysOfeLife https://elifesciences.org/articles/83021?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days
Optogenetics helped researchers study the role of the microtubule end-binding protein, EB1, in the growth of neurons. Here, the end of a neuron reaches a strip of blue light which optogenetically inactivates EB1 causing the microtubule fibres that usually push and grow the cell to fall apart. #Neuroscience #Optogenetics #Microtubules #12DaysOfeLife https://elifesciences.org/articles/84143?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days
Latest preprint from Mark Dodding's lab on #actin INSIDE #microtubules. A really fascinating observation. This paper shows by cryo-ET that this #cytoskeleton inception occurs in platelets.
#CellBiology
https://www.biorxiv.org/content/10.1101/2023.11.24.568450v1
