#ribosome — Public Fediverse posts

SNOR promotes translation restart after dormancy

Sample preparation for cryo-ET Cryo-ET samples were prepared using 200-mesh R2/2 copper grids (Quantifoil) plasma-cleaned for 30 s in…
#NewsBeep #News #Science #Cryoelectronmicroscopy #Cryoelectrontomography #GB #HumanitiesandSocialSciences #multidisciplinary #Ribosome #UK #UnitedKingdom
https://www.newsbeep.com/uk/582576/

https://www.europesays.com/uk/958051/ SNOR promotes translation restart after dormancy #CryoelectronMicroscopy #CryoelectronTomography #HumanitiesAndSocialSciences #multidisciplinary #Ribosome #Science #UK #UnitedKingdom

Could the #ribosome be a selfish element? @mkrupovic & Eugene Koonin propose that the #evolution of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources.
#OriginsOfLife
https://plos.io/3OPZszf

Could the #ribosome be a selfish element? @mkrupovic & Eugene Koonin propose that the #evolution of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources.
#OriginsOfLife
https://plos.io/3OPZszf

Could the #ribosome be a selfish element? @mkrupovic & Eugene Koonin propose that the #evolution of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources.
#OriginsOfLife
https://plos.io/3OPZszf

Could the #ribosome be a selfish element? @mkrupovic & Eugene Koonin propose that the #evolution of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources.
#OriginsOfLife
https://plos.io/3OPZszf

Could the #ribosome be a selfish element? @mkrupovic & Eugene Koonin propose that the #evolution of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources.
#OriginsOfLife
https://plos.io/3OPZszf

How can nature make #peptides covering chemical space beyond the 20 proteinogenic amino acids using the #ribosome?

Wilfred van der Donk talked at #Biochemistry2026 about the power of ribosomally-synthesized and post-translationally modified peptides #RiPPs.

https://pubs.rsc.org/en/content/articlelanding/2021/np/d0np00027b
#Biochemistry #Chemistry #ChemBio

Structure of an archaeal ribosome reveals a
divergent active site and hibernation factor | Nature Micro

https://rdcu.be/ewZ3S

"Ribosomes translate mRNA into protein. Despite divergence in ribosome structure over the course of evolution, the catalytic site, known as the peptidyl transferase centre (PTC) is thought to be nearly universally conserved. Here we identify clades of archaea that have highly divergent ribosomal RNA sequences in the PTC."

#archea #structuralbiology #ribosome #cryoEM

I gather this is about reconstructing #ribosome #assembly in the #nucleolus - the PR is a bit wild but may be worth looking at the paper in Nature.

https://www.eurekalert.org/news-releases/1089618 #science #nanoworld #CellBiology #structuralBiology

New #antibiotic that kills #drugresistant #bacteria discovered in technician’s #garden
It targets bacteria’s protein-making factory, the #ribosome, in a way that other antibiotic drugs don’t. Ribosome is an attractive antibiotic target because bacteria don’t easily develop resistance to #drugs targeting the structure. In studies, #lariocidin slowed the growth of a range of common bacterial #pathogens, including many multidrug-resistant strains.
https://www.nature.com/articles/d41586-025-00945-z
https://archive.ph/NHtJh

Some new evidence that the functional importance of #ribosome heterogeneity is probably less common than previously believed. From the abstract:

"... This demonstrates that ribosome heterogeneity does not necessarily lead to functional specialization ..."

https://pubmed.ncbi.nlm.nih.gov/40113756/

#science #research

An interesting counter-example that puts into perspective the '#ribosome heterogeneity' hypothesis. This hypothesis is that duplicated genes for ribosomal proteins could serve for the formation of functionally specialized ribosomes. At least in D. melanogaster and for a specific example, different levels of expression of ribosomal protein genes led to different global levels of formed ribosomes. So, specialized ribosomes or different levels of them ?

https://www.biorxiv.org/content/10.1101/2024.11.14.623487v3

#rnascience #rna

Interesting paper on the timescale of building the emerging polypeptide chain versus the much faster folding process as it emerges from the #ribosome exit channel

https://www.nature.com/articles/s41467-025-57033-z

They introduce a "Native Fold Delay" metric that indicates how long a particular residue needs to wait until the emergence of its partner residues in the ultimate folded protein state.

A nice new experimental strategy from the Tanenbaum lab allowed to look at translation on circular #mRNA to understand that elongation short pauses can be relieved by #ribosome collisions.

https://www.cell.com/cell/fulltext/S0092-8674(25)00045-5

#science #research #rna

No-go-decay (#NGD) is a translational QC pathway that degrades mRNA during #ribosome stalling. @MishimaLab @iwasakilabriken &co characterize NGD substrates during zebrafish development, showing that C2H2-ZF domain mRNAs induce stalling & NGD #PLOSBiology https://plos.io/4g4RESq

Think you know the ribosome? Think again....

"Despite its fundamental biological importance and intense study, scientists haven't been able to pinpoint how angiogenin was turned on, until now," said Anna Loveland, PhD.

#CellBiology #biology #research #nature #ribosome #health #genetics #science

https://www.labroots.com/trending/cell-and-molecular-biology/27408/surprising-roles-ribosome-finally-revealed

#Cancer is initiated by mutations, but its progression relies on increased #ProteinSynthesis. @Mason_A_McCool @SusanBaserga &co show that #APOBEC3A is not only a source of cancer-initiating mutations, but also promotes #ribosome biogenesis #PLOSBiology https://plos.io/464owGT

Kinases Rio1, Nob1 & Pno1 cooperate in a checkpoint to prevent escape of immature ribosomes. @KarbsteinL show that Rio1 only releases accurately processed rRNAs; misprocessed #rRNAs are removed via a #ribosome collision-dependent mechanism #PLOSBiology https://plos.io/3UNnn2F

#Hsp70 chaperones preserve #ProteinSynthesis by promoting folding & preventing aggregation. @microbelab reports a new role of Hsp70 in #Salmonella survival during low Mg2+ conditions by binding to the #ribosome & reducing protein synthesis #PLOSBiology https://plos.io/4431K1j

It is important to understand how the #ribosome is built and how it works, because it is the only #cell particle that produces #proteins in humans and all other living organisms. And without proteins, life would cease to exist
#Biology #sflorg
https://www.sflorg.com/2024/02/bio02232401.html

It's nice to see, from time to time, a negative result getting published. The title is quite clear (although m6A is not very abundant in 5' untranslated regions):

"N6-methyladenosine in 5′ UTR does not promote translation initiation"

pdf link:
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)01074-2.pdf

#ribosome #rnamodification

"The mechanism of mRNA activation"
A preprint looking at the role of eIF4F in translation initiation at single molecule resolution.
#mRNA #translation #ribosome #singlemolecule #microscopy

https://www.biorxiv.org/content/10.1101/2023.11.15.567265v1?rss=1

.@SarinayElif &co reveal a novel mechanism of growth coordination in #Celegans; inhibition of #ribosome biogenesis in epidermis can trigger organism-wide #GrowthQuiescence, potentially via secreted proteins & the dense-core vesicle pathway #PLOSBiology https://plos.io/3R1jYvq

🌽 #Kernels are an important focus for improving #yield and quality
🌽 Defective kernel 66 encodes a #GTPase essential for kernel #development in #maize
🌽 Here characterises the candidate gene #DEK66...

📖 https://doi.org/10.1093/jxb/erad289

#Endosperm #mitochondria #ribosome #mutant

@JoachimFrank

Wow: “In an operating range from 10 to 1000 ms, the device allows us to follow in vitro reactions of biological molecules at resolution levels in the range of 3 Å. By employing this method, we show for the first time the mechanism of progressive HlfX-mediated splitting of the 70S E. coli ribosome in the presence of the GTP, via capture of three high-resolution reaction intermediates within 140 ms.” —Bhattacharjee et al. 2023 https://www.biorxiv.org/content/10.1101/2023.01.25.525430v2.full

#StructuralBiology #CryoEM #ribosome

Protein Synthesis – A Molecular Happening
by Roberto
More than fifty years ago, towards the end of Spring term in May 1971, university campuses across the U.S. were rife with protests over the Vietnam war. Students skipped classes and left labs to participate in marches and sit-ins. In addition, the memory of Woodstock (August 1969) was still fresh in everyone's mind.

Read more → https://schaechter.asmblog.org/schaechter/2023/08/protein-synthesis-a-molecular-happening.html

#microbiology #translation #ribosome

Are there mRNA-selective functions of individual #eIF3 subunits?
Dieter Wolf and coworkers (Xiamen University) reveal eIF3k-l as an #mRNA-specific module serving as a rheostat of #ribosome content, to secure spare translational capacity that can be mobilized during stress

https://www.embopress.org/doi/10.15252/embj.2022112362

Biotech to Design Disease-Blocking Drugs, Gains $75M

A new company that says it can stop disease-causing #proteins from forming in #cells began public operations today, and is raising $75 million in its first venture round.

https://sciencebusiness.technewslit.com/?p=44745

#News #Science #Business #Biotechnology #Biochemistry #ProteinSynthesis #Ribosome #Microfluidics #Engineering #Finance #VentureCapital

An #ERK1/2-driven RNA-binding switch in #nucleolin drives #ribosome #biogenesis and #pancreatic #tumorigenesis downstream of RAS #oncogene
Faraz K Mardakheh and collaborators
https://www.embopress.org/doi/10.15252/embj.2022110902

Relationship status: *It's complicated*🤷

Lee et al. work on untangling how the targeting specificity of signal-anchored #proteins is determined for specific targeting to #mitochondria and #chloroplasts.
https://doi.org/10.1111/jipb.13475
@wileyplantsci
#PlantScience #JIPB #ribosome #mRNA

Translation of viral #RNAs is often driven by non-canonical events, which are encoded in the viral genome to hijack the cellular translation machinery. One such event is programmed ribosomal #frameshifting. It prompts the translating #ribosome to slip one nucleotide back or forth into a different reading frame, enabling viral replication. Researchers from the Helmholtz Institute Würzburg unveiled the structural transitions in the #SARSCoV2 frameshifting process. 🧬 👩‍🔬 🦠
➡️ https://www.helmholtz-hiri.de/en/newsroom/news/detail/news/decoding-sars-cov-2/

Online now - our 2023 issue 5:
Activation of #plant #NLR #immune receptors
#Stereoisomer specificity in #flagellin #sialylation
Dormant #ribosome activation by #TORC1
#Cytomegaloviral #DCAF for #cullin-mediated #STAT2 degradation
Cover: Korolchuk lab
https://www.embopress.org/toc/14602075/2023/42/5

Online now - our 2023 issue 5:
Activation of #plant #NLR #immune receptors
#Stereoisomer specificity in #flagellin #sialylation
Dormant #ribosome activation by #TORC1
#Cytomegaloviral #DCAF for #cullin-mediated #STAT2 degradation
Cover: Korolchuk lab
https://www.embopress.org/toc/14602075/2023/42/5

Online now - our 2023 issue 5:
Activation of #plant #NLR #immune receptors
#Stereoisomer specificity in #flagellin #sialylation
Dormant #ribosome activation by #TORC1
#Cytomegaloviral #DCAF for #cullin-mediated #STAT2 degradation
Cover: Korolchuk lab
https://www.embopress.org/toc/14602075/2023/42/5

Online now - our 2023 issue 5:
Activation of #plant #NLR #immune receptors
#Stereoisomer specificity in #flagellin #sialylation
Dormant #ribosome activation by #TORC1
#Cytomegaloviral #DCAF for #cullin-mediated #STAT2 degradation
Cover: Korolchuk lab
https://www.embopress.org/toc/14602075/2023/42/5

Physically separating early steps in #ribosome assembly in the #Ecoli nucleoid from the RNA #degradosome attached to the inner cytoplasmic membrane protects precursor #ribosomal RNA in immature particles from degradation @Lydia_LH17 &co #PLOSBiology https://plos.io/3Qj1x2O

Physically separating early steps in #ribosome assembly in the #Ecoli nucleoid from the RNA #degradosome attached to the inner cytoplasmic membrane protects precursor #ribosomal RNA in immature particles from degradation @Lydia_LH17 &co #PLOSBiology https://plos.io/3Qj1x2O

Physically separating early steps in #ribosome assembly in the #Ecoli nucleoid from the RNA #degradosome attached to the inner cytoplasmic membrane protects precursor #ribosomal RNA in immature particles from degradation @Lydia_LH17 &co #PLOSBiology https://plos.io/3Qj1x2O

Having an out of frame AUG downstream and close to the annotated AUG can have deleterious effects on protein synthesis through a competition effect on translation initiation.

https://pubmed.ncbi.nlm.nih.gov/36510274/

#ribosome #proteinsynthesis #mrna

@kurianlab

Welcome, Leo and Team !!! :beamingFace: Great that you are here now!

#ScienceMastodon #NewHere
#RNA #RBP #ribosome #cellbiology #devbiol #UniklinikKöln #CMMC

So, after lurking here for a couple of days, I realized that hashtags are important here. So here are a few of my interests:
#RNA
#mRNA
#mRNALocalization
#ribosome #P_bodies #StressGranules
#Transcription #Translation #mRNADegradation
#CellBiology #MolecularBiology
#TunnelingNanotubes
#EndoplasmicReticulum #mitochondria #Peroxisome
#Microscopy #fluorescent #FluorescentProteins
#PeerReview #StaffScientist
#Reproducibility
#LabLife

Hi all, this is my #introduction.
I am a postdoc working in the #biology department at #Stanford University; research in #cellbiology & #biochemistry. Interests: #ribosome #RQC #ubiquitin #UBLs #proteinqualitycontrol #proteinfolding #endoplasmicreticulum.
I hope to connect with other researchers here!

Retrotechtacular: Understanding Protein Synthesis Through Interpretive Dance - With the principles of molecular biology very much in the zeitgeist these days, we... - https://hackaday.com/2021/08/01/retrotechtacular-understanding-protein-synthesis-through-interpretive-dance/ #retrotechtacular #molecularbiology #proteinsynthesis #translation #aminoacid #ribosome #dance #mrna #trna #art