#ribosome — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ribosome, aggregated by home.social.
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How Octopuses Hacked their Ribosome to Become Smart
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As a former #ribosome researcher I completely misunderstood the word #PolyU at the start of this headline and got quite confused. https://www.eurekalert.org/news-releases/1135253
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Researchers try to cut the #genetic code from 20 to 19 #aminoacids
Using #AI tools, the team reworked part of the #ribosome to need one less #aminoacid.
Most hypotheses suggest that earlier forms of life had partial genetic codes and used fewer than 20 amino acids. A team from Columbia and Harvard eliminated one of 20 currently in use. As a first attempt, they engineered a portion of the ribosome that worked without using an otherwise essential amino acid: #isoleucine.
https://arstechnica.com/science/2026/04/researchers-try-to-cut-the-genetic-code-from-20-to-19-amino-acids/ -
Ribosome pausing, ribosome drop-off, an interesting study in the links between codons and translation in S. cerevisiae:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012162
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Pathogenic variants in the #ribosome -associated endoribonuclease SLFN14 cause inherited #thrombocytopenia, but why? This study shows that type II #tRNA cleavage by mutant SLFN14 drives global translational repression and cell death @PLOSBiology https://plos.io/3QegRCk
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Could the #ribosome be a selfish element? @mkrupovic & Eugene Koonin propose that the #evolution of life can viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources.
#OriginsOfLife
https://plos.io/3OPZszf -
How can nature make #peptides covering chemical space beyond the 20 proteinogenic amino acids using the #ribosome?
Wilfred van der Donk talked at #Biochemistry2026 about the power of ribosomally-synthesized and post-translationally modified peptides #RiPPs.
https://pubs.rsc.org/en/content/articlelanding/2021/np/d0np00027b
#Biochemistry #Chemistry #ChemBio -
Structure of an archaeal ribosome reveals a
divergent active site and hibernation factor | Nature Micro"Ribosomes translate mRNA into protein. Despite divergence in ribosome structure over the course of evolution, the catalytic site, known as the peptidyl transferase centre (PTC) is thought to be nearly universally conserved. Here we identify clades of archaea that have highly divergent ribosomal RNA sequences in the PTC."
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I gather this is about reconstructing #ribosome #assembly in the #nucleolus - the PR is a bit wild but may be worth looking at the paper in Nature.
https://www.eurekalert.org/news-releases/1089618 #science #nanoworld #CellBiology #structuralBiology
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New #antibiotic that kills #drugresistant #bacteria discovered in technician’s #garden
It targets bacteria’s protein-making factory, the #ribosome, in a way that other antibiotic drugs don’t. Ribosome is an attractive antibiotic target because bacteria don’t easily develop resistance to #drugs targeting the structure. In studies, #lariocidin slowed the growth of a range of common bacterial #pathogens, including many multidrug-resistant strains.
https://www.nature.com/articles/d41586-025-00945-z
https://archive.ph/NHtJh -
Some new evidence that the functional importance of #ribosome heterogeneity is probably less common than previously believed. From the abstract:
"... This demonstrates that ribosome heterogeneity does not necessarily lead to functional specialization ..."
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An interesting counter-example that puts into perspective the '#ribosome heterogeneity' hypothesis. This hypothesis is that duplicated genes for ribosomal proteins could serve for the formation of functionally specialized ribosomes. At least in D. melanogaster and for a specific example, different levels of expression of ribosomal protein genes led to different global levels of formed ribosomes. So, specialized ribosomes or different levels of them ?
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Interesting paper on the timescale of building the emerging polypeptide chain versus the much faster folding process as it emerges from the #ribosome exit channel
https://www.nature.com/articles/s41467-025-57033-z
They introduce a "Native Fold Delay" metric that indicates how long a particular residue needs to wait until the emergence of its partner residues in the ultimate folded protein state.
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A nice new experimental strategy from the Tanenbaum lab allowed to look at translation on circular #mRNA to understand that elongation short pauses can be relieved by #ribosome collisions.
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No-go-decay (#NGD) is a translational QC pathway that degrades mRNA during #ribosome stalling. @MishimaLab @iwasakilabriken &co characterize NGD substrates during zebrafish development, showing that C2H2-ZF domain mRNAs induce stalling & NGD #PLOSBiology https://plos.io/4g4RESq
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#Cancer is initiated by mutations, but its progression relies on increased #ProteinSynthesis. @Mason_A_McCool @SusanBaserga &co show that #APOBEC3A is not only a source of cancer-initiating mutations, but also promotes #ribosome biogenesis #PLOSBiology https://plos.io/464owGT
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Kinases Rio1, Nob1 & Pno1 cooperate in a checkpoint to prevent escape of immature ribosomes. @KarbsteinL show that Rio1 only releases accurately processed rRNAs; misprocessed #rRNAs are removed via a #ribosome collision-dependent mechanism #PLOSBiology https://plos.io/3UNnn2F
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#Hsp70 chaperones preserve #ProteinSynthesis by promoting folding & preventing aggregation. @microbelab reports a new role of Hsp70 in #Salmonella survival during low Mg2+ conditions by binding to the #ribosome & reducing protein synthesis #PLOSBiology https://plos.io/4431K1j
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It's nice to see, from time to time, a negative result getting published. The title is quite clear (although m6A is not very abundant in 5' untranslated regions):
"N6-methyladenosine in 5′ UTR does not promote translation initiation"
pdf link:
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)01074-2.pdf -
"The mechanism of mRNA activation"
A preprint looking at the role of eIF4F in translation initiation at single molecule resolution.
#mRNA #translation #ribosome #singlemolecule #microscopyhttps://www.biorxiv.org/content/10.1101/2023.11.15.567265v1?rss=1
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.@SarinayElif &co reveal a novel mechanism of growth coordination in #Celegans; inhibition of #ribosome biogenesis in epidermis can trigger organism-wide #GrowthQuiescence, potentially via secreted proteins & the dense-core vesicle pathway #PLOSBiology https://plos.io/3R1jYvq
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🌽 #Kernels are an important focus for improving #yield and quality
🌽 Defective kernel 66 encodes a #GTPase essential for kernel #development in #maize
🌽 Here characterises the candidate gene #DEK66...
