#bacteriophage — Public Fediverse posts

Bacteriophages: meet the viruses that hunt superbugs
#Health #Science #Biotechnology #Antibiotics #Superbugs #Microbiome #Innovation #Agriculture #FoodSafety #Viruses #Medical #Environment #Tech #Sustainability #Phages #Bacteriophage #AnimalHealth
https://the-14.com/bacteriophages-meet-the-viruses-that-hunt-superbugs/

Bacteriophages: meet the viruses that hunt superbugs
#Health #Science #Biotechnology #Antibiotics #Superbugs #Microbiome #Innovation #Agriculture #FoodSafety #Viruses #Medical #Environment #Tech #Sustainability #Phages #Bacteriophage #AnimalHealth
https://the-14.com/bacteriophages-meet-the-viruses-that-hunt-superbugs/

Bacteriophages: meet the viruses that hunt superbugs
#Health #Science #Biotechnology #Antibiotics #Superbugs #Microbiome #Innovation #Agriculture #FoodSafety #Viruses #Medical #Environment #Tech #Sustainability #Phages #Bacteriophage #AnimalHealth
https://the-14.com/bacteriophages-meet-the-viruses-that-hunt-superbugs/

Bacteriophages: meet the viruses that hunt superbugs
#Health #Science #Biotechnology #Antibiotics #Superbugs #Microbiome #Innovation #Agriculture #FoodSafety #Viruses #Medical #Environment #Tech #Sustainability #Phages #Bacteriophage #AnimalHealth
https://the-14.com/bacteriophages-meet-the-viruses-that-hunt-superbugs/

Bacteriophages: meet the viruses that hunt superbugs
#Health #Science #Biotechnology #Antibiotics #Superbugs #Microbiome #Innovation #Agriculture #FoodSafety #Viruses #Medical #Environment #Tech #Sustainability #Phages #Bacteriophage #AnimalHealth
https://the-14.com/bacteriophages-meet-the-viruses-that-hunt-superbugs/

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

Not just passengers: Phages as agents of genetic exchange in fecal #microbiota transplantation.

#Phage ‑mediated gene transfer may shape FMT outcomes by altering gut communities and microbial functions.

#bacteriophage #microbiology #virology #virome

https://davidojcius.blogspot.com/2026/04/not-just-passengers-phages-as-agents-of.html

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq

Phage P100 resistance in clinical & foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations & fitness trade-offs.

Study shows diverse P100 resistance mechanisms in #Listeria & significant serovar‑dependent fitness costs.

https://davidojcius.blogspot.com/2026/02/phage-p100-resistance-in-clinical-and.html #OpenAccess #bacteriophage #phage #food

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

🧬 Golden Gate method enables fully-synthetic engineering of therapeutically relevant bacteriophages

https://phys.org/news/2026-01-golden-gate-method-enables-fully.html

#molbio #virus #bacteriophage #bacteria #microbes #biotech #gmo

Show HN: Phage Explorer
https://phage-explorer.org/
#ycombinator #phage #bacteriophage #bioinformatics #genome_visualization #DNA_sequence #amino_acid #lambda_phage #virology #microbiology

Show HN: Phage Explorer
https://phage-explorer.org/
#ycombinator #phage #bacteriophage #bioinformatics #genome_visualization #DNA_sequence #amino_acid #lambda_phage #virology #microbiology

Show HN: Phage Explorer
https://phage-explorer.org/
#ycombinator #phage #bacteriophage #bioinformatics #genome_visualization #DNA_sequence #amino_acid #lambda_phage #virology #microbiology

Show HN: Phage Explorer
https://phage-explorer.org/
#ycombinator #phage #bacteriophage #bioinformatics #genome_visualization #DNA_sequence #amino_acid #lambda_phage #virology #microbiology

Fighting Food Poisoning With A Patch https://hackaday.com/2026/01/09/fighting-food-poisoning-with-a-patch/ #HackadayColumns #bacteriophage #foodpoisoning #bacteria #Science #Ecoli #virus #food

Fighting Food Poisoning With A Patch

https://web.brid.gy/r/https://hackaday.com/2026/01/09/fighting-food-poisoning-with-a-patch/

#biology #medicine #phages #EscherichiaColi

An article published in the journal "Microbiology Spectrum" reports the results of experiments based on the use of genetically modified #bacteriophage #viruses to combat strains of Escherichia coli #bacteria that developed resistance to various antibiotics. These findings offer a way to neutralize these bacteria and new insights into the interactions between bacteriophages and bacteria.

https://english.netmassimo.com/2025/11/12/a-technique-based-on-the-use-of-genetically-modified-bacteriophage-viruses-to-fight-strains-of-bacteria-that-developed-resistance-to-antibiotics/

A precursor procapsid is initially formed during #bacteriophage assembly, but how? The #cryoEM structure of the scaffolding protein complex & portal within #phage P22 procapsid reveals how this complex orchestrates the initiation of procapsid assembly @PLOSBiology https://plos.io/44B71iE

@farbel @Black_Flag A medical example: Phage therapy, pioneered in the USSR.

https://en.wikipedia.org/wiki/Phage_therapy

#socialism #communism #marxism #capitalism #PhageTherapy #bacteriophage

We have a new preprint describing a method for #bacteriophage phylogenetics and comparative genomics.

Maybe useful for those interested in all the amazing #phages out there and their bizarre mosaic genomes

Towards a unifying phylogenomic framework for tailed phages

https://www.biorxiv.org/content/10.1101/2024.10.21.619452v1.abstract

#viruses #microbiology

1915,1917: Frederick Twort & Félix d’Herelle discovered bacteriophages, virus that prey on bacteria. #Poetry #Science #History #Virology #Bacteriophage #Twort #d’Herelle (https://sharpgiving.com/thebookofscience/items/p1915b.html)

'dangerous #Merri lurker' (Merri-merri-uth nyilam marra-natj in #woiwurrung might be useful in treating bacterial infections.

#Bacteriophage
https://www.friendsofmerricreek.org.au/bacteriophage

#AntiMicrobialResistance
https://www.monash.edu/impact-amr

Bacteriophage Virions
https://pmc.ncbi.nlm.nih.gov/articles/PMC8269216/

#firstnations #Wurundjeri
https://www.wurundjeri.com.au/

21y after collecting data during my PhD, we got to publish the structure of RNA-dependent RNA polymerase from #bacteriophage phi8!
Unsolvable in 2003 but #AlphaFold2 model worked!

https://www.nature.com/articles/s41598-024-75213-7

Lesson learned: never discard data!

Great job Kamel El Omari getting it over the line!

"The number of viruses that we found is absolutely wild. We found many viruses that we know very little about and many others that we have never seen before. It's amazing how much untapped biodiversity is all around us. And you don't even have to go far to find it; it's right under our noses," said Dr Erica M. Hartmann.

#microbiology #bacteriophage #biology #research #science #nature

https://www.labroots.com/trending/microbiology/27892/world-mysterious-microbes-on-toothbrush

i did a Summer internship studying homing introns in college. big advance!

"This work demonstrates how a homing endonuclease can be deployed in interference competition among viruses and provide a relative fitness advantage. Given the ubiquity of homing endonucleases, this selective advantage likely has widespread evolutionary implications in diverse plasmid and viral competition as well as virus-host interactions."

#homing #endonuclease #phage #bacteriophage #virus

https://www.science.org/doi/10.1126/science.adl1356

For #ThrowbackThursday , here is the first complete genome sequence: 5375 bp of Phi-X174. Fred Sanger, et al., 1977.

https://www.nature.com/articles/265687a0

#genomics #genetics #bacteriophage

Personalized Phage Therapy Heals Cat With Deadly Bacterial Infection, via Hebrew University, published by #Veterinary🩺 Quarterly

by @GrrlScientist

#Medicine⚕️ #PhageTherapy #Microbiology🔬 #MDRO #bacteria🧫 #bacteriophage🦠 #cats🐈‍⬛ #pets🐾 #SciComm🧪 https://www.forbes.com/sites/grrlscientist/2024/05/30/personalized-phage-therapy-heals-cat-with-deadly-bacterial-infection/

Personalized Phage Therapy Heals Cat With Deadly Bacterial Infection, via Hebrew University, published by #Veterinary🩺 Quarterly

by @grrlscientist

#Medicine⚕️ #PhageTherapy #Microbiology🔬 #MDRO #bacteria🧫 #bacteriophage🦠 #cats🐈‍⬛ #pets🐾 #SciComm🧪 https://www.forbes.com/sites/grrlscientist/2024/05/30/personalized-phage-therapy-heals-cat-with-deadly-bacterial-infection/

'Zombie cells' in the sea: #Viruses keep the most common #marine #bacteria in check.

#SAR11 #bacteriophage #pelagiphage

https://phys.org/news/2024-05-zombie-cells-sea-viruses-common.html

My new story for the Medical Post/Canadian Healthcare Network.
#Doctors and #pharmacists in Canada can log on for free. Here are a few paragraphs.

Could a century old treatment be an answer to antibiotic resistance?
In a first in Canada, a patient with an #antibiotic resistant artificial joint infection has received treatment with phage therapy and is showing promising early responses.

“This is cutting edge stuff, and a potentially new technology,” said Dr. Marisa Azad, the infectious diseases physician who treated the patient. She is also an assistant professor of medicine at the University of Ottawa.

The patient presented with severe periprosthetic joint infection (PJI) in the summer of 2023. She had already undergone multiple surgeries and had experienced several relapses and infections with the same persistent bacteria.

“She’d been on multiple very prolonged courses of antibiotics and had a severe drug allergy to two major drug classes of antibiotics. I was extremely limited in what I could use to treat her,” Dr. Azad told the Medical Post in an interview.

That’s when the idea arose of trying an experimental treatment course with phage therapy. The team got approval for doing the experimental treatment from Health Canada, and worked with Winnipeg-based Cytophage, which supplied the phages.

“We developed a protocol and gave her therapy over two weeks while she was admitted to hospital. She’s completed her therapy. Now we’re monitoring her closely and giving her adjunctive antibiotics,” she said.

The idea didn’t come out of the blue. In the medical literature, a study from just last year in Clinical #Infectious Diseases provided a review of 33 previously published cases of patients with end-stage, refractory bone and joint infections (BJI) who underwent treatment with phage therapy. The authors found that from those case reports, “29 (87%) achieved microbiological or clinical success, two (5.9%) relapsed with the same organisms, and two (5.9%) with a different organism” with no serious adverse events.

The conclusions of that paper stated there were “important advantages, disadvantages, and barriers to the implementation of phage therapy for BJIs.” Yet, at the same time, the authors added they, “believe that if phage therapy were to be used earlier in the clinical course, fewer cumulative antibiotics may be needed in an individual treatment course.”

The word phage is short for #bacteriophage, a word coined in 1917—literally meaning bacteria-eater. They are viruses whose lifecycle depends on certain types of bacteria.

“They latch on to specific types of bacteria and inject their genetic material into the bacterial cell." Dr. Azad explained. "They take over the bacterial cells’ machinery to produce more little viruses inside and explode or burst open the bacteria,” releasing viral particles that can go and infect other cells of the same type of bacteria.

Intriguingly, each #phage targets a specific type of #bacteria...
The story of phages started over 100 years ago. They were independently discovered, first in 1915 by a British pathologist, Frederick Twort, and then again in 1917 by French-Canadian microbiologist Felix d’Herelle. And...

#MedMastodon #IDmastodon #microbiology @medmastodon
https://www.canadianhealthcarenetwork.ca/could-century-old-treatment-be-answer-antibiotic-resistance

First atom-level structure of packaged #viral #genome reveals new properties and dynamics.

#bacteriophage

https://phys.org/news/2024-03-atom-packaged-viral-genome-reveals.html

#bacteriophage #biotechnology #usb #3dprint

Paride: A novel Virus (Bacteriophage) that fights Antibiotic-tolerant Dormant bacteria  
Bacterial dormancy is survival strategy in response to stressful exposure to antibiotics taken by a patient for treatment............
#AntibioticResistance #antibiotictolerant #bacteriophage #Dormantbacteria #ETHZurich #Paride #Phagetherapy #Pseudomonasaeruginosa #viru

https://www.scientificeuropean.co.uk/sciences/biology/paride-a-novel-virus-bacteriophage-that-fights-antibiotic-tolerant-dormant-bacteria/

Nucleotide and force-dependent mechanisms control how the viral genome of lambda #bacteriophage is inserted into capsids. https://elifesciences.org/articles/94128?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

The tail tips, the most diversified region across #bacteriophage lambda & other long-tailed #phages, contain conserved domains which facilitate tail assembly, receptor binding, cell adsorption and DNA retention/release #PLOSBiology https://plos.io/3Rqs6nI

First-ever observation of a #virus #attaching to another virus.

#satellite_virus #bacteriophage

https://phys.org/news/2023-11-first-ever-virus.html