#gaba — Public Fediverse posts

However: The paper/comment does not point to one magic compound, but to a mixture of #caffeine, #catechins, #flavonoids, #theaflavins, #GABA and #tea #polysaccharides. The proposed links are lower oxidative stress and #inflammation, improved endothelial and glucose/insulin function, gut microbiome effects, and possibly reduced #neuroinflammation. …

#Neuroscience

However: The paper/comment does not point to one magic compound, but to a mixture of #caffeine, #catechins, #flavonoids, #theaflavins, #GABA and #tea #polysaccharides. The proposed links are lower oxidative stress and #inflammation, improved endothelial and glucose/insulin function, gut microbiome effects, and possibly reduced #neuroinflammation. …

#Neuroscience

However: The paper/comment does not point to one magic compound, but to a mixture of #caffeine, #catechins, #flavonoids, #theaflavins, #GABA and #tea #polysaccharides. The proposed links are lower oxidative stress and #inflammation, improved endothelial and glucose/insulin function, gut microbiome effects, and possibly reduced #neuroinflammation. …

#Neuroscience

However: The paper/comment does not point to one magic compound, but to a mixture of #caffeine, #catechins, #flavonoids, #theaflavins, #GABA and #tea #polysaccharides. The proposed links are lower oxidative stress and #inflammation, improved endothelial and glucose/insulin function, gut microbiome effects, and possibly reduced #neuroinflammation. …

#Neuroscience

However: The paper/comment does not point to one magic compound, but to a mixture of #caffeine, #catechins, #flavonoids, #theaflavins, #GABA and #tea #polysaccharides. The proposed links are lower oxidative stress and #inflammation, improved endothelial and glucose/insulin function, gut microbiome effects, and possibly reduced #neuroinflammation. …

#Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🤝 Se presentó la nueva Asociación Empresarial en Ereván. 🏗️ Premium Machinery Armenia mostró cómo ser líderes con marcas como JCB y Renault Trucks. 🚛 El director Grigol Bayburt explicó que la clave es el talento local y los altos estándares. #AsociaciónEmpresarialGeorgiaArmenia #cáucaso #ereván #gaba #GrigolBayburt #inversión #jcb #PremiumMachineryArmenia #RenaultTrucks #TegetaHolding https://soyarmenio.com/asociacion-empresarial-georgia-armenia/

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

Getränk ohne Alkohol: Mellow Rush aus Stuttgart soll „kicken ohne Kater“ – was ist dran?

Immer mehr Anbieter bringen Getränke auf den Markt, die angeblich wie Alkohol wirken – aber ohne Nachwehen. Aus…
#Stuttgart #Deutschland #Deutsch #DE #Schlagzeilen #Headlines #Nachrichten #News #Europe #Europa #EU #Alkoholfrei #Ashwagandha #Baden-Württemberg #Funktionsdrink #GABA #Germany #Kater #MellowRush #ohneAlkohol #Stadtkind #WirkungwieAlkohol
https://www.europesays.com/de/669780/

Best Science Stories of 2025 https://www.byteseu.com/1654738/ #2025 #AlcoholFreeBeer #AntiVenom #Antibodies #BestOf #BionicKnee #dogs #GABA #JaneGooddall #labradors #LondonUnderground #Obesity #primatologist #prosthesis #Quantum #QuantumMechanics #Science #snakes #TFl #Transport ForLondon #tube #UterusTransplant

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

GABA/glutamate imbalance is a core feature of Autism. A new review describes how reduced GABA signaling may lead to excessive excitation in key brain circuits. 🧠✨🔍

Read Full Article

#GABA #Glutamate #AutismResearch #Neuroscience #MentalHealth https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1587432/full
Reenviado desde Science News
(https://t.me/experienciainterdimensional/9489)

How Neurotransmitters Shape Your Memory, Mood, and Movement

#BrainScience #Neurotransmitters #Neuroscience #BrainHealth #Memory #Dopamine #Acetylcholine #Glutamate #GABA #BrainCircuits #NeuroscienceEducation #MindAndMemory #BrainFunction #NeuralNetworks #BrainTips

https://youtube.com/shorts/SkXbm5LmCLY?feature=share

I take way to many #supplements in general. At night I take #melatonin, #taurine, #stjohnswort, #d3, #theanine, #glucosamine, #gaba and #magnesium. None of those are supposed to interrupt #sleep but here we are; mind's racing, heart rate's up, stomach's a little upset.

Which one do you think it is?

#insomnia #SleepProblems #supplement #nutrition

New resource maps gene expression, regulation in neuron subtypes

https://www.spectrumnews.org/news/toolbox/new-resource-maps-gene-expression-regulation-in-neuron-subtypes/

#excitatorysignaling #inhibitorysignaling #bipolardisorder #geneexpression #schizophrenia #chromatin #glutamate #stemcells #Toolbox #autism #ADHD #GABA #SNPs

New resource maps gene expression, regulation in neuron subtypes

https://www.spectrumnews.org/news/toolbox/new-resource-maps-gene-expression-regulation-in-neuron-subtypes/

#excitatorysignaling #inhibitorysignaling #bipolardisorder #geneexpression #schizophrenia #chromatin #glutamate #stemcells #Toolbox #autism #ADHD #GABA #SNPs

Cannabis compound rebalances signaling to quell seizures in mice

https://www.spectrumnews.org/news/cannabis-compound-rebalances-signaling-to-quell-seizures-in-mice/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #hippocampus #mousemodels #cannabis #epilepsy #autism #News #GABA

Mouse studies cast astrocytes as stars of sensory perception

https://www.spectrumnews.org/news/mouse-studies-cast-astrocytes-as-stars-of-sensory-perception/

#inhibitorysignaling #sensoryperception #fragileXsyndrome #geneexpression #mousemodels #astrocytes #seizures #synapses #hearing #autism #touch #News #FMR1 #GABA

Whimsical Wonders of Neurobiology: A Journey Through Our Brain's Symphony

#Neurobiology #Neuroscience #BrainHealth #GABA #Neurotransmitters #MentalHealth #SSRI #Dopamine #Serotonin #Neuroimaging #EntericNervousSystem #PsychotropicAgents #BrainFunction #WhimsicalScience #EmotionalHealth #CognitiveScience

https://youtube.com/shorts/5_sU6CscCnA?feature=share

@wcbdata @itwasntme223

'Among the compounds, many of which have cancer-fighting, contraceptive, and anti-inflammatory properties, is shyobunone, which acts on the brain’s gamma-aminobutiric acid (GABA) receptors and may contribute to the plant’s intoxicating smell. Miski believes that future analyses of the plant will reveal the existence of dozens of yet-to-be-identified compounds of medical interest.

“You find the same chemicals in rosemary, sweet flag, artichoke, sage, and galbanum, another Ferula plant,” the professor marvels. “It’s like you combined half a dozen important medicinal plants in a single species.”'

#NaturalProducts #FunctionalFoods
#GABA

🧠 #Benzodiazepines are positive allosteric modulators and require a γ subunit and the presence of GABA to work! Their effects are mediated by the α subunit.

● Anxiolytics - α2, α3
● Sedatives - α1, α5
● Anticonvulsants - α1, α2, α3, α5
● Anterograde amnesia - α1

α4 and α6 do not bind benzodiazepines
● Possess arginine where other α subunits have histidine

2/2 #PharmPhriday #GABA thread

Retirement announcement for Sol Snyder #JohnsHopkins notes:

His “approach became known as the “grind and bind” technique, and Sol used it to identify… endogenous #opiate receptors in the brain; … the #GABA receptor, to which the drug diazepam attaches; the adenosine receptor, which #caffeine blocks to cause mental stimulation; the #bradykinin receptor, which transmits pain; and the #dopamine receptor, to which antipsychotic drugs attach”

#ohIsThatAll?

Portrait of a research field: astrocytes in autism

https://www.spectrumnews.org/features/deep-dive/portrait-of-a-research-field-astrocytes-in-autism/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #fragileXsyndrome #postmortembrains #geneexpression #Rettsyndrome #environment #mousemodels #astrocytes #organoids #DeepDive #seizures #synapses #autism #MECP2 #FMR1 #FMRP #GABA

[Перевод] То, что должно успокаивать – заставляет бояться. ГАМК, астроциты и ПТСР

Исследование построено вокруг новой и достаточно любопытной теории. В её основе лежит следующий механизм. В нем именно ГАМК, вырабатываемая астроцитами, играет основную роль в развитии ПТСР. По сути, избыточный синтез ГАМК в префронтальной коре нарушает способность мозга избавляться от травматических воспоминаний. Исследователи обнаружили, что этот избыток ГАМК обусловлен ферментом MAOB в астроцитах и нарушает регуляцию страха в медиальной префронтальной коре.

https://habr.com/ru/articles/933468/

#ГАМК #Гаммааминомасляная_кислота #астроциты #ПТСР #посттравматический_стресс #Стресс #тревога #префронтальная_кора #психиатрия #GABA

"Why Alcohol Hijacks Neurotransmitters & How to Rebalance Them"

by Sarah Rusbatch: https://sarahrusbatch.com/blog/why-alcohol-hijacks-neurotransmitters-how-to-rebalance-them

#serotonin #dopamine #GABA #Glutamate #magnesium #vitamins #neurotransmitters #alcohol #alcoholic #alcoholism #anxiety #balance #sober #sobriety #AA #12steps

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: https://www.sfari.org/2025/04/08/announcing-the-recipients-of-the-2024-pilot-and-pilot-progression-awards/
NLMFF: https://www.nlmfoundation.org/grant/epigenetic-regulators-ash1l-and-setbp1-in-gabaergic-neuron-development-and-asd/

#newsmayerlab #SFARI #NLMFF #AutismResearch #Neurodevelopment #Epigenetics #GABA #Genomics #Chromatin #Neuroscience

Unraveling the Secrets of Brain Chemistry: The Dance of Serotonin and Beyond!

#BrainChemistry #Serotonin #MentalHealth #Neuroimaging #GABA #BioactivePeptides #Genetics #WellBeing #Neuroscience #MoodBoost #ScienceExplained #SerotoninTransporter #Mindfulness #AnxietyRelief #HealthAndWellness

https://youtube.com/shorts/lnLLsplDNQE?feature=share

Amigues que necesitáis una pequeña ayuda para dormir. Tomad una pastilla de Gaba una hora antes de ir a la cama. Aconsejo mínimo 750 mg.

#SuplementosAlimenticios #Insomnio #Dormir #Gaba

Scientists uncover previously unknown target of alcohol in the brain: the TMEM132B-GABAA receptor complex https://www.psypost.org/scientists-uncover-previously-unknown-target-of-alcohol-in-the-brain-the-tmem132b-gabaa-receptor-complex/?utm_source=dlvr.it&utm_medium=mastodon #Neuroscience #AlcoholResearch #BrainHealth #GABA #TMEM132B

GABAARs: not just inhibitory? This study of striatal spiny projection #neurons shows that #GABA is a state-dependent #neurotransmitter, and not simply an inhibitory one, suggesting a revision of the role of intrastriatal #GABAergic signaling #PLOSBiology https://plos.io/3SGKafq

Anyone in science have any experience with SCH-50911 or other GABAᵇ antagonists to undo effects of alcohol or GHB in humans?

Curious to know if it might be possible to effectively turn it into a medication to sober someone up or as response for someone suffering from an overdose.

Would be curious to read studies done on humans or other mammals.Low key tempted to research this and self-administer

#science #gaba #neuroscience

The closer and closer look at #GABA emerald in the glass in the glass-holder.

@tea