#gaba — Public Fediverse posts

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

How Your Muscles Really Work 🧠💪 ⁣
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#muscles #neuroscience #movement #physiology #motorneurons #bicep #nervoussystem #GABA #acetylcholine #flexors #extensors

GABA/glutamate imbalance is a core feature of Autism. A new review describes how reduced GABA signaling may lead to excessive excitation in key brain circuits. 🧠✨🔍

Read Full Article

#GABA #Glutamate #AutismResearch #Neuroscience #MentalHealth https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1587432/full
Reenviado desde Science News
(https://t.me/experienciainterdimensional/9489)

[Перевод] То, что должно успокаивать – заставляет бояться. ГАМК, астроциты и ПТСР

Исследование построено вокруг новой и достаточно любопытной теории. В её основе лежит следующий механизм. В нем именно ГАМК, вырабатываемая астроцитами, играет основную роль в развитии ПТСР. По сути, избыточный синтез ГАМК в префронтальной коре нарушает способность мозга избавляться от травматических воспоминаний. Исследователи обнаружили, что этот избыток ГАМК обусловлен ферментом MAOB в астроцитах и нарушает регуляцию страха в медиальной префронтальной коре.

https://habr.com/ru/articles/933468/

#ГАМК #Гаммааминомасляная_кислота #астроциты #ПТСР #посттравматический_стресс #Стресс #тревога #префронтальная_кора #психиатрия #GABA

How Neurotransmitters Shape Your Memory, Mood, and Movement

#BrainScience #Neurotransmitters #Neuroscience #BrainHealth #Memory #Dopamine #Acetylcholine #Glutamate #GABA #BrainCircuits #NeuroscienceEducation #MindAndMemory #BrainFunction #NeuralNetworks #BrainTips

https://youtube.com/shorts/SkXbm5LmCLY?feature=share

"Why Alcohol Hijacks Neurotransmitters & How to Rebalance Them"

by Sarah Rusbatch: https://sarahrusbatch.com/blog/why-alcohol-hijacks-neurotransmitters-how-to-rebalance-them

#serotonin #dopamine #GABA #Glutamate #magnesium #vitamins #neurotransmitters #alcohol #alcoholic #alcoholism #anxiety #balance #sober #sobriety #AA #12steps

Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: https://www.sfari.org/2025/04/08/announcing-the-recipients-of-the-2024-pilot-and-pilot-progression-awards/
NLMFF: https://www.nlmfoundation.org/grant/epigenetic-regulators-ash1l-and-setbp1-in-gabaergic-neuron-development-and-asd/

#newsmayerlab #SFARI #NLMFF #AutismResearch #Neurodevelopment #Epigenetics #GABA #Genomics #Chromatin #Neuroscience

Unraveling the Secrets of Brain Chemistry: The Dance of Serotonin and Beyond!

#BrainChemistry #Serotonin #MentalHealth #Neuroimaging #GABA #BioactivePeptides #Genetics #WellBeing #Neuroscience #MoodBoost #ScienceExplained #SerotoninTransporter #Mindfulness #AnxietyRelief #HealthAndWellness

https://youtube.com/shorts/lnLLsplDNQE?feature=share

Whimsical Wonders of Neurobiology: A Journey Through Our Brain's Symphony

#Neurobiology #Neuroscience #BrainHealth #GABA #Neurotransmitters #MentalHealth #SSRI #Dopamine #Serotonin #Neuroimaging #EntericNervousSystem #PsychotropicAgents #BrainFunction #WhimsicalScience #EmotionalHealth #CognitiveScience

https://youtube.com/shorts/5_sU6CscCnA?feature=share

Amigues que necesitáis una pequeña ayuda para dormir. Tomad una pastilla de Gaba una hora antes de ir a la cama. Aconsejo mínimo 750 mg.

#SuplementosAlimenticios #Insomnio #Dormir #Gaba

Scientists uncover previously unknown target of alcohol in the brain: the TMEM132B-GABAA receptor complex https://www.psypost.org/scientists-uncover-previously-unknown-target-of-alcohol-in-the-brain-the-tmem132b-gabaa-receptor-complex/?utm_source=dlvr.it&utm_medium=mastodon #Neuroscience #AlcoholResearch #BrainHealth #GABA #TMEM132B

GABAARs: not just inhibitory? This study of striatal spiny projection #neurons shows that #GABA is a state-dependent #neurotransmitter, and not simply an inhibitory one, suggesting a revision of the role of intrastriatal #GABAergic signaling #PLOSBiology https://plos.io/3SGKafq

Anyone in science have any experience with SCH-50911 or other GABAᵇ antagonists to undo effects of alcohol or GHB in humans?

Curious to know if it might be possible to effectively turn it into a medication to sober someone up or as response for someone suffering from an overdose.

Would be curious to read studies done on humans or other mammals.Low key tempted to research this and self-administer

#science #gaba #neuroscience

The closer and closer look at #GABA emerald in the glass in the glass-holder.

@tea

"We found that the GABAergic population of association areas is comparable to that of primary sensory areas, and it is enriched of fast-spiking neurons that do not express PV and were not accounted for by previous quantifications."

Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin
Courcelles et al., preprint @ biorxiv 2023
https://doi.org/10.1101/2023.11.02.565290

#neuroscience #gaba #preprint

I take way to many #supplements in general. At night I take #melatonin, #taurine, #stjohnswort, #d3, #theanine, #glucosamine, #gaba and #magnesium. None of those are supposed to interrupt #sleep but here we are; mind's racing, heart rate's up, stomach's a little upset.

Which one do you think it is?

#insomnia #SleepProblems #supplement #nutrition

Cadherins differentiate between two populations of L5 projection neurons, are instrumental in organizing perisomatic inhibition by PV-Basket vs CCK-Basket cells. Fits well with the "cadherins = neuronal barcoding" hypothesis.
Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations
Jezequel et al., #preprint at #biorxiv 2023
https://www.biorxiv.org/content/10.1101/2023.09.28.559922v1

#neuroscience #GABA #cadherins

My paper is out! It's free to access!

https://www.frontiersin.org/articles/10.3389/fnins.2022.1067493/full

We discovered that #marijuana (THC specifically) reduces #GABA #neuron activity. This helps explain some of the rewarding and calming effects of THC because the depression of GABA #neurons means increased dopamine release, which generally makes us feel pretty good.

Don't smoke too young though, we also found #THC is MUCH more influential in adolescents, and sometimes struggles to reverse!

#science #neuroscience #research

Yesterday I tried #GABA Shen puehr, and what I felt was the milder version of the Simao #Shen #puehr #tea I already have. I didn’t feel the bright sweetness which I usually notice in a well-fermented GABA. I have one more portion of the tea, and maybe I’ll feel more the next time.😊

@tea

@wcbdata @itwasntme223

'Among the compounds, many of which have cancer-fighting, contraceptive, and anti-inflammatory properties, is shyobunone, which acts on the brain’s gamma-aminobutiric acid (GABA) receptors and may contribute to the plant’s intoxicating smell. Miski believes that future analyses of the plant will reveal the existence of dozens of yet-to-be-identified compounds of medical interest.

“You find the same chemicals in rosemary, sweet flag, artichoke, sage, and galbanum, another Ferula plant,” the professor marvels. “It’s like you combined half a dozen important medicinal plants in a single species.”'

#NaturalProducts #FunctionalFoods
#GABA

Preparing for the new #tea journey through India and Georgia. Visiting the Dan Cong as well as light #oolong families.🙂

The most unusual thing to taste — #GABA Shen Puehr.

@tea

In response to a few questions people have asked:

We used whole-cell patch-clamp #electrophysiology to record the activity of single #neurons.

The "resist changes" refers to #neuroplasticity. We found a reduction in long-term depression, or #LTD, in adult mice after high frequency stimulus (HFS) compared to adolescent mice.

These cells are specifically #GABA releasing cells in the ventral tegmental area (#VTA ), where GABA can regulate dopamine release throughout the #brain.

#neuro

@P_KA_T It is related in the sense that while frequently used pathways tend to fire more easily, there are controls on those pathways from regulatory inhibition, which is what we studied. So even if a synapse may exhibit relatively high activity from frequent use, they can be told to "slow down' by GABA, which we determined was less adaptive in adults.
#GABA #neuroscience #cellbiology #learning

@DrYohanJohn this is a great reference work I use in class! Does anyone out there have something more recent? That is, are there important revisions to this story that I should be teaching?

Also, should we not just cave and call them #inhibitory cells rather than #interneurons, given the importance of #gaba ergic projection neurons? (Not trolling the developmental people who see gaba excitation).

Bedtime #supplements:

- more #stJohnsWort
- more #krillOil
- #gaba
- #magnesium
- #theanine
- more #taurine
- #elderberry
- more #d3
- #melatonin
- benadryl (during cottonwood season)

GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients https://www.nature.com/articles/s42003-023-04918-8 Perhaps "targeting #GABA could improve the neural specificity in #glaucoma"; #blindness

Cannabis compound rebalances signaling to quell seizures in mice

https://www.spectrumnews.org/news/cannabis-compound-rebalances-signaling-to-quell-seizures-in-mice/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #hippocampus #mousemodels #cannabis #epilepsy #autism #News #GABA

🧠 #Benzodiazepines are positive allosteric modulators and require a γ subunit and the presence of GABA to work! Their effects are mediated by the α subunit.

● Anxiolytics - α2, α3
● Sedatives - α1, α5
● Anticonvulsants - α1, α2, α3, α5
● Anterograde amnesia - α1

α4 and α6 do not bind benzodiazepines
● Possess arginine where other α subunits have histidine

2/2 #PharmPhriday #GABA thread

Retirement announcement for Sol Snyder #JohnsHopkins notes:

His “approach became known as the “grind and bind” technique, and Sol used it to identify… endogenous #opiate receptors in the brain; … the #GABA receptor, to which the drug diazepam attaches; the adenosine receptor, which #caffeine blocks to cause mental stimulation; the #bradykinin receptor, which transmits pain; and the #dopamine receptor, to which antipsychotic drugs attach”

#ohIsThatAll?

Mouse studies cast astrocytes as stars of sensory perception

https://www.spectrumnews.org/news/mouse-studies-cast-astrocytes-as-stars-of-sensory-perception/

#inhibitorysignaling #sensoryperception #fragileXsyndrome #geneexpression #mousemodels #astrocytes #seizures #synapses #hearing #autism #touch #News #FMR1 #GABA

Portrait of a research field: astrocytes in autism

https://www.spectrumnews.org/features/deep-dive/portrait-of-a-research-field-astrocytes-in-autism/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #fragileXsyndrome #postmortembrains #geneexpression #Rettsyndrome #environment #mousemodels #astrocytes #organoids #DeepDive #seizures #synapses #autism #MECP2 #FMR1 #FMRP #GABA

New resource maps gene expression, regulation in neuron subtypes

https://www.spectrumnews.org/news/toolbox/new-resource-maps-gene-expression-regulation-in-neuron-subtypes/

#excitatorysignaling #inhibitorysignaling #bipolardisorder #geneexpression #schizophrenia #chromatin #glutamate #stemcells #Toolbox #autism #ADHD #GABA #SNPs

New resource maps gene expression, regulation in neuron subtypes

https://www.spectrumnews.org/news/toolbox/new-resource-maps-gene-expression-regulation-in-neuron-subtypes/

#excitatorysignaling #inhibitorysignaling #bipolardisorder #geneexpression #schizophrenia #chromatin #glutamate #stemcells #Toolbox #autism #ADHD #GABA #SNPs

Critical time window flagged for autism gene’s influence

https://www.spectrumnews.org/news/critical-time-window-flagged-for-autism-genes-influence/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #socialdeficits #microcephaly #autism #cortex #News #GABA