#dendritic — Public Fediverse posts

New paper from the Poirazi lab, together w Losonczy and Polleux labs:

See how much #dendritic geometry matters for #SpatialCoding: Clustered excitatory inputs on #CA1 #dendrites can support stable #PlaceFields with fewer active #synapses, by engaging local dendritic nonlinearities and Ca2+ signaling.

📄 https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00871-5

Nice example of #DendriticComputing: not just which synapses are active, but where they are placed along the dendritic tree, shapes #NeuronalComputation.

#Neuroscience

Moved my #nix flake (#nixos) over to a #dendritic setup. So far I like it, but I don't know if it was worth the effort :D

Take a look and tell me what you think over on #codeberg: https://codeberg.org/DontBlameMe/nix_dotfiles

@yisraeldov
Now if we make the flake.nixosModules.somename : {arg1, arg2} = {}
Then we can start composing too.

In short: it's a very neat approach to modularize the options which scales better.

Those who are using nix flake-parts and dendritic pattern, feel free to correct me or simplify this please.

#nix #flakes #nixos #homemanager #nixhomemanager #flake-parts #dendritic #dendriticpattern

@yisraeldov
But in dendritic pattern we wrap option A to F under common top level attribute in same file:
flake.nixosModules.somename = {option A to C here}
flake.homeModules.somerelatedname = {option D to F here}

And then we can do like
In nixos:-
imports =
[ self.flake.nixosModules.somename ]
In hm:-
imports = [self.flake.nixosModules.someothername]

This way we can declare options of same aspects in same file and the import them later respectively.

#nix #dendritic #flake #flake-parts

@yisraeldov
(Follow this thread)
#dendritic nix is the idea of modularising in a very top level option. And #flake-parts is just one tool to achieve that, there are many custom functions that many use personally on their config too.
Eg:
optionA, optionB, optionC are nixos options
optionD, optionE, optionF are home-manager options

We use A to C in a nixos module file and D to F in hm module file and we can use both in same file, coz we typically import the whole file as module.
#nix #flake

@vivekanandanks @arichtman Thanks for posting this example. I have been meaning to refactor my flake for ages. The #dendritic #dendriticpattern part looks like it is in flake.nix

outputs = inputs @ { flake-parts, ... }:
flake-parts.lib.mkFlake { inherit inputs; } (
top @ { config, withSystem, moduleWithSystem, lib, ... }: {
imports = [
...
(inputs.import-tree ./flakepartsModules)
];

#nixos
and it is great to see this example.

@arichtman
Recently started using #dendritic pattern using #flake parts it's really helpful.

Earlier: A new module file means I add it to a folder, then import them in my configuration.nix home.nix accordingly.

Now: a module file added to a folder. That's it.

And more awesome is that I can place both a nixos module and home module in the same file to have aspects together🔥 much more benefits

It's worth doing things this way

#nix #nixos #dendriticpattern #config #management #flakeparts

🧠 What can a single neuron compute?

A new #bioRxiv #preprint introduces #TwinProp, using a differentiable digital twin to optimize synaptic strengths and locations in a detailed layer 5 #pyramidal #CellModel. One #neuron classified images and speech and even solved 10-bit parity with 91% accuracy. The key: distributed #dendritic nonlinearities, especially #NMDA-dependent integration:

📄 https://doi.org/10.64898/2026.06.08.730984

#CompNeuro #Neuroscience #Dendrites #NeuroAI @albertcardona https://mathstodon.xyz/@albertcardona/116764629463190653

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

https://krutonium.ca/posts/im-using-flake-parts-now/

New #Blog about #NixOS and #FlakeParts and honestly how good the #dendritic pattern is for Nix.

(2/2)

For example, u might have to enable a service in both nixos option and home manager option for something. Like enabling KDE in nixos and then customising the options via home manager.

Usually one will write those in separate files. But in dendritic pattern u can actually make those in same file so that configs of same feature stays together to organise configs in better way.

I'm still figuring out too, so this is just my basic understanding so far 😅
#nix #nixos #dendritic #pattern

@innocentzero
(1/2)
I'm a noob in that area. But here's my understanding:
It's a way in which evrything is a flake_parts module. That's all. It's not even a new tool or framework. It's just a practice.

This way of structuring paves a lot of benefits when managing the systems.
The first steps would be to make everything as a flake_parts module and then start clubbing the configs based on feature.
#nix #nixos #dendritic #pattern

🧠 New preprint by Lee et al.: Fast dendritic excitations primarily mediate #backpropagation in #CA1 pyramidal #neurons during #behavior

Using kHz #VoltageImaging across the full #dendritic tree, they show that fast dendritic spikes are usually driven by somatic #bAPs, not independently initiated. #bAP propagation into apical dendrites is contin. modulated by pre-spike dendritic voltage & can trigger slower plateau potentials linked to complex spikes.

🌍https://doi.org/10.64898/2026.01.03.696606

#NeuralDynamics

🧠 Pastorelli et al. (2025) present a "simplified two-compartment #neuron with #CalciumDynamics capturing #brain-state-specific apical-amplification, -isolation and -drive". This Ca-#AdEx model replicates distinct #dendritic mechanisms across wakefulness, #NREM & #REM sleep using a compact ThetaPlanes transfer function. Cool implementation using the #NESTsimulator 💻!

🌍 https://doi.org/10.3389/fncom.2025.1566196

#Neuroscience #CompNeuro

Dendritic patterns along the shore of Cobequid Bay in Nova Scotia. #photography #aerial #drone #novascotia #dronephotography #river #cobequidbay #dendritic #patterns #shore #landscape #shoreline #EastCoastKin

Dendritic patterns on the mud flats of the Avon River at Windsor, Nova Scotia. #photography #dronephotography #aerialphotography #dendritic #patterns #geography #nature #windsor #novascotia #BayOfFundy #EastCoastKin

#OpenSLS update: Generation of model #tissues with #dendritic #vascular networks via sacrificial #laser-sintered #carbohydrate templates: https://rdcu.be/b5tHy

Hardware designs: https://github.com/MillerLabFTW/OpenSLS
-R4: specialty powders for biomaterials research
-R3: nylon & wax #SLS

-#Python add-on for #Blender to generate bifurcating vascular structures
#DIYbio #OpenSource #lab #3Dprinting #bioprinter #laser #hydrogel #instruments

glass with inclusions

#GlassLike #Inclusions #Purple #Blue #Teal #Green #Dendritic #Copper #Reflective #Shiny #Futuristic
#Img2Img #AIArt #AIArtists #AIArtCommunity #StableDiffusion

in real life: https://aieris.art/featured/glass-with-inclusions-eris-and-ai.html

How can coronavirus infection cause uncontrolled, excessive inflammation?
Marta Bermejo-Jambrina, Teunis Geijtenbeek et al show that #SarsCoV2 opsonization by the complement system induces interferon responses from #dendritic cells, which require control by antiviral antibodies

https://www.embopress.org/doi/full/10.1038/s44318-024-00061-0

MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to #autoimmunity

Pathology of primary Sjögren's syndrome is known to involve #interferons, but Enrique Martin-Gayo et al @UAM_Medicina show additional roles also for #innateimmune cells like natural killer and #dendritic cells

https://www.embopress.org/doi/full/10.15252/embj.2023113714

What is going on with our immune cells after COVID-19 infection?

This thread will explore some of the impacts of #COVID #infection on our #immune system even after people are recovered including:
- Missing naive #T-cells
- Exhausted T-cells
- Loss of #B-cell maturation
- Hyper-activated #inflammatory response
- Immune system is impeded post-infection
- #Immunological #dysfunction persists 8+ months
- #Depletion and dysfunction of #dendritic cells

🧵 1/