#nmda — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #nmda, aggregated by home.social.
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To pick a few papers on #NMDA in #Drosophila:
"Blockade of the central generator of locomotor rhythm by noncompetitive NMDA receptor antagonists in Drosophila larvae", Cattaert and Birman 2001
https://onlinelibrary.wiley.com/doi/abs/10.1002/neu.1042"Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body", Wu et al. 2007
https://www.nature.com/articles/nn2005"Mg2+ block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression", Miyashita et al. 2012
https://www.cell.com/neuron/fulltext/S0896-6273(12)00379-0"NMDA receptors mediate olfactory learning and memory in Drosophila", Xia et al. 2005
https://www.cell.com/current-biology/fulltext/S0960-9822(05)00232-0 -
Given the amount of papers reporting NMDA receptors in fruit fly neurons, I am left wondering why we all consider glutamatergic synapses as inhibitory – there's only reports of glutamate-gated chloride channels for sensory systems like the olfactory and visual, but I don't know of any in the central brain where there are many glutamatergic neurons, including mushroom body output neurons (MBONs).
Papers on NMDA in Drosophila:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Drosophila+NMDA&btnG= -
🧠 What can a single neuron compute?
A new #bioRxiv #preprint introduces #TwinProp, using a differentiable digital twin to optimize synaptic strengths and locations in a detailed layer 5 #pyramidal #CellModel. One #neuron classified images and speech and even solved 10-bit parity with 91% accuracy. The key: distributed #dendritic nonlinearities, especially #NMDA-dependent integration:
📄 https://doi.org/10.64898/2026.06.08.730984
#CompNeuro #Neuroscience #Dendrites #NeuroAI @albertcardona https://mathstodon.xyz/@albertcardona/116764629463190653
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Researchers at Oregon Health & Science University successfully mapped the precise binding sites where disease-associated #autoantibodies attach to the #NMDA receptor, identifying a novel #therapeutic target for anti-NMDA receptor encephalitis.
#Neuroscience #MolecularNeuroscience #MolecularBiology #sflorg
https://www.sflorg.com/2026/01/ns01142601.html -
Insight Article: A new mode of action for unconventional NMDA receptors
Presynaptic #NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role. #Neuroscience
https://elifesciences.org/articles/107049?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights -
https://ncbi.nlm.nih.gov/pmc/articles/PMC10479373/ Synaptic Plasticity 101: The Story of the AMPA Receptor for the Brain Stimulation Practitioner (Brown, et al, 2022) #brains #Neuroplasticity #ampa #nmda #ketamine #mentalhealth #NeuroScience
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New paper out: Rongkang wondered whether NMDA receptors are required for the development of intracortical circuits. So he deleted them. Turns out that cortical inhibitory but not excitatory synaptic transmission and circuit refinement are altered after the deletion of NMDA receptors during early development.