#dendrites — Public Fediverse posts

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

I had a friend in the early 2000s who studied dendrites and light and consciousness; it was both fascinating and almost completely incomprehensible to me. I still find it fascinating.

"There is a “zoo” of different events that take place at dendrites, he said. They can fire their own local or global electrical spikes. They can cover a larger or smaller area, and they can surge for longer or shorter periods of time."

"Neuroscientists have found that these events at dendrites can allow even single neurons to perform complex computations — meaning that dendrites are the reason why a single neuron can have the same amount of computational power as a deep artificial neural network."
#neuroscience #dendrites
https://www.quantamagazine.org/a-new-type-of-neuroplasticity-rewires-the-brain-after-a-single-experience-20260424/

https://www.europesays.com/fr/751666/ Les scientifiques découvrent un « nouveau langage » du cerveau humain #cerveau #CortexCérébral #Dendrites #Epilepsie #FR #France #LesTendances #neurone #organe #Science #ScienceAndTechnology #Sciences #SciencesEtTechnologies #SystèmeNerveux #Technologies #Technology #TissuCérébral #TroublesNeurologiques

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Stanford University published a study recently finding that #EV #batteries may see 40% more lifespan than thought.

In a nutshell, the growth of #dendrites on the electrodes is the nail in the coffin for #lithium batteries. Historic testing was to do constant discharge/recharge cycles. But that's not how cars work. Acceleration and regen braking cause huge surges. Turns out, these surges are good and fry the dendrites, making the #battery healthier.

So EV owners, punch it and slam the brakes time to time! (but not with traffic around!!).

https://news.stanford.edu/stories/2024/12/existing-ev-batteries-may-last-up-to-40-longer-than-expected

Chinese study finds hotpot ingredient can boost battery performance in the cold https://www.byteseu.com/665297/ #AdvancedEnergyMaterials #AntifreezeCharacteristics #AqueousZincIonBatteries #BatteryShorts #CellPerformance #ChangshaUniversityOfScienceAndTechnology #dendrites #ElectrochemicalReactions #fibre #glucomannan #HunanProvince #HydrogenBonds #konjac #KonjacGlucomannan #LowTemperatures #MetallicCrystals #polymer #Science #ShiratakiNoodles #WaterBasedElectrolytes #ZincDendriteFormation

A previous study in #plosbiology found that Wnt receptors are housed in early endosomes and required for dendritic #microtubule nucleation. This Update Article shows that microtubule dynamics in #dendrites can be influenced non-autonomously by surrounding epithelial cells plos.io/3DK0M0J

`In this work, we investigated the #dendrites of layer 2 and 3 (L2/3) pyramidal #neurons of the human cerebral cortex ex vivo. In these neurons, we discovered a class of #calcium-mediated dendritic action potentials (dCaAPs) whose waveform and effects on #neuronal output have not been previously described. In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli`

https://www.science.org/doi/10.1126/science.aax6239

Summer vibes! Here researchers have captured dendrite generated on a zinc surface, and added their own seaside-themed flourish.

Photograph: Yutong Zhu

@photography
#nanophotography
#dendrites

#Nerve #cells (#neurons ) are amongst the most complex cell types in our body. They achieve this complexity during development by extending ramified branches called #dendrites and #axons and establishing thousands of synapses to form intricate networks.
#Neuroscience #sflorg
https://www.sflorg.com/2024/04/ns04082401.html

`In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli. These dCaAPs enabled the #dendrites of individual human neocortical pyramidal #neurons to classify linearly nonseparable inputs—a computation conventionally thought to require multilayered #networks.`

https://www.science.org/doi/10.1126/science.aax6239

hat tip @ScienceScholar

"Here we combine cable and renewal theory to describe how input fluctuations shape the response of neuronal ensembles with active #dendrites. We found that dendritic input readily and potently controls interspike interval dispersion. This phenomenon can be understood by considering that #neurons display three fundamental operating regimes: one mean-driven regime and two fluctuation-driven regimes."

https://www.nature.com/articles/s43588-023-00580-6

Dendrite formation is the bane of lithium batteries.

"In the new research, Li and his team stop #dendrites from forming by using micron-sized silicon particles in the anode to constrict the lithiation reaction and facilitate homogeneous plating of a thick layer of #lithium metal."

#batteries
https://www.pv-magazine.com/2024/01/15/new-solid-state-battery-charges-in-minutes-lasts-for-thousands-of-cycles/

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at [email protected].
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at [email protected].
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at [email protected].
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at [email protected].
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at [email protected].
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a postdoctoral researcher who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501741) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501741/postdoctoral-researcher

If you have any questions, please email me at [email protected].

#autism #ASD #therapy #DrugDiscovery #postdoc #PostdocJob #AcademicJob #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Wiring map reveals how larval fruit fly brain converts sensory signals to movement

https://www.spectrumnews.org/news/wiring-map-reveals-how-larval-fruit-fly-brain-converts-sensory-signals-to-movement/

#neuralcircuits #animalmodels #brainmapping #connectivity #Drosophila #dendrites #circuits #learning #synapses #autism #axons #News

Neurons struggle to spike without fragile X gene

https://www.spectrumnews.org/news/neurons-struggle-to-spike-without-fragile-x-gene/

#fragileXsyndrome #prefrontalcortex #dendrites #autism #cortex #News #FMR1 #FMRP

The #INCF #OCNS Software WG software highlight is starting in ~20 minutes (1600UTC) !

Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks

https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html

#OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

The #INCF #OCNS Software WG software highlight is starting in ~20 minutes (1600UTC) !

Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks

https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html

#OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

The #INCF #OCNS Software WG software highlight is starting in ~20 minutes (1600UTC) !

Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks

https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html

#OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

The #INCF #OCNS Software WG software highlight is starting in ~20 minutes (1600UTC) !

Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks

https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html

#OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

The #INCF #OCNS Software WG software highlight is starting in ~20 minutes (1600UTC) !

Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks

https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html

#OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

The problem with consciousness research is that we have Paleolithic emotions, medieval theories, and god-like technology (to paraphrase E.O. Wilson)

Let's use the data provided by this technology to develop new theories of consciousness. Our attempt:

https://psyarxiv.com/vkdt2

#consciousness #dendrites #thalamus #anesthesia

Please join the #INCF #OCNS Software WG at our next software highlight session on Feb 7 at 1600 UTC. Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html #OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

Please join the #INCF #OCNS Software WG at our next software highlight session on Feb 7 at 1600 UTC. Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html #OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

Please join the #INCF #OCNS Software WG at our next software highlight session on Feb 7 at 1600 UTC. Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html #OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

Please join the #INCF #OCNS Software WG at our next software highlight session on Feb 7 at 1600 UTC. Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html #OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

Please join the #INCF #OCNS Software WG at our next software highlight session on Feb 7 at 1600 UTC. Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html #OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

#Nerve #cells communicate with one another via long processes known as #axons and #dendrites, or, more generally, neurites. During development, these processes first grow and form connections with other cells
#Biology #Neuroscience #sflorg
https://www.sflorg.com/2023/01/bio01262303.html

This article [Introducing the Dendrify framework for incorporating dendrites to spiking neural networks | Nature Communications](https://www.nature.com/articles/s41467-022-35747-8)

helps address the criticisms of #neuralnetworks that I presented to Paul Smolensky over 10 years ago regarding lack of realism of connectionist neurons given what we then/now know about real biological computing at the #postSynaptic juncture:

https://www.youtube.com/watch?v=GGuBz63snLU&t=2733s

#connectionism #dendrites

During metamorphosis, fly larval PNS neurons prune their sensory #dendrites by essentially severing them from the cell bodies. This relies on local cytoskeleton disassembly - but how are they severed? (spoiler - they tear mechanically)

An introduction after moving my account to neuromatch.social -

I'm a neuroscientist at #Cornell. My recent research focuses on psychoactive drugs such as #ketamine and #psychedelics. I want to know how these compounds act on #dendrites and cortical microcircuits to mediate behavioral effects.

Outside of the lab, I enjoy drinking a good cup of espresso and rock climbing with my kids.

#introduction #neuroscience #NeuroscienceMigration #ScienceMastodon

Autism subgroups converge on cell growth pathway

https://www.spectrumnews.org/news/autism-subgroups-converge-on-cell-growth-pathway/

#whole-genomesequencing #biomarkers #dendrites #stemcells #16p11.2 #autism #News

as a mastodon newbie, I forgot to add those hashtags to my #introduction

so here we go:
I work on #AI, #vision, #consciousness, #VR, #prediction, #insight, #smartphones, #psychedelics, #intracranial, #computational models, #thalamus, #cortex, #dendrites

My philosophy in science is that you don't have to stick to one topic ... don't be constrained by your past, switch fields if you want to!

I like to visit schools and talk about #neuroscience to #kids

Proud to be from and in #estonia

@ilennaj And you are the author of this most spectacular arXiv paper: "Can single neurons solve MNIST? the computational power of biological dendritic trees" Jones & Kording 2020 https://arxiv.org/abs/2009.01269 Hats off to you & @kordinglab ! And welcome.

#neuroscience #dendrites #MNIST

PS: subsequently published as "Might a Single Neuron Solve Interesting Machine Learning Problems Through Successive Computations on Its Dendritic Tree?" Jones & Kording 2021 https://direct.mit.edu/neco/article/33/6/1554/100576/Might-a-Single-Neuron-Solve-Interesting-Machine

Honda aims for a solid-state-powered EV by the end of the decade - Enlarge / The Honda e is adored by journalists, but it's small and expe... - https://arstechnica.com/?p=1894430 #batteryelectricvehicles #solidstatebatteries #generalmotors #dendrites #ultium #honda #cars

Autism-linked mutation disrupts brain circuit to change social behavior

https://www.spectrumnews.org/news/autism-linked-mutation-disrupts-brain-circuit-to-change-social-behavior/

#excitatorysignaling #inhibitorysignaling #connectivitytheory #prefrontalcortex #neuralcircuits #schizophrenia #connectivity #optogenetics #dendrites #amygdala #synapses #autism #SHANK3 #22q13 #News

Autism-linked mutation disrupts brain circuit to change social behavior

https://www.spectrumnews.org/news/autism-linked-mutation-disrupts-brain-circuit-to-change-social-behavior/

#excitatorysignaling #inhibitorysignaling #connectivitytheory #prefrontalcortex #neuralcircuits #schizophrenia #connectivity #optogenetics #dendrites #amygdala #synapses #autism #SHANK3 #22q13 #News

Two top autism-linked proteins connect to build cell ‘skeleton’

https://www.spectrumnews.org/news/two-top-autism-linked-proteins-connect-to-build-cell-skeleton/

#schizophrenia #genenetworks #mousemodels #treatments #dendrites #synapses #autism #SHANK3 #News #ADNP

Maternal sleep apnea may contribute to autism-like traits in rats

https://www.spectrumnews.org/news/maternal-sleep-apnea-may-contribute-to-autism-like-traits-in-rats/

#dendrites #rapamycin #synapses #autism #sleep #News #rats #sex

Reversing mutations in top autism-linked gene makes adult mice more social

https://www.spectrumnews.org/news/reversing-mutations-in-top-autism-linked-gene-makes-adult-mice-more-social/

#excitatorysignaling #inhibitorysignaling #dendrites #microglia #epilepsy #autism #SCN2A #News