#dendrites — Public Fediverse posts

New paper from the Poirazi lab, together w Losonczy and Polleux labs:

See how much #dendritic geometry matters for #SpatialCoding: Clustered excitatory inputs on #CA1 #dendrites can support stable #PlaceFields with fewer active #synapses, by engaging local dendritic nonlinearities and Ca2+ signaling.

📄 https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00871-5

Nice example of #DendriticComputing: not just which synapses are active, but where they are placed along the dendritic tree, shapes #NeuronalComputation.

#Neuroscience

A recent visit to the #YayoiKusama exhibition at the #MuseumLudwig in #Cologne proved that I’m already very neuro-biased: In many of her paintings, I see nothing but … #dendrites and #spines, #microglia, cell membranes… 🙈😅

Scientists Solve Dendrite-Induced Short Circuits in Solid-State Batteries

📰 Original title: The biggest problem with solid-state batteries may finally be solved

🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️

View full AI summary https://en.killbait.com/scientists-solve-dendrite-induced-short-circuits-in-solid-state-batteries.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait.mastodon_world

#technology #solidstatebatteries #dendrites #batterysafety

🧠 What can a single neuron compute?

A new #bioRxiv #preprint introduces #TwinProp, using a differentiable digital twin to optimize synaptic strengths and locations in a detailed layer 5 #pyramidal #CellModel. One #neuron classified images and speech and even solved 10-bit parity with 91% accuracy. The key: distributed #dendritic nonlinearities, especially #NMDA-dependent integration:

📄 https://doi.org/10.64898/2026.06.08.730984

#CompNeuro #Neuroscience #Dendrites #NeuroAI @albertcardona https://mathstodon.xyz/@albertcardona/116764629463190653

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Stanford University published a study recently finding that #EV #batteries may see 40% more lifespan than thought.

In a nutshell, the growth of #dendrites on the electrodes is the nail in the coffin for #lithium batteries. Historic testing was to do constant discharge/recharge cycles. But that's not how cars work. Acceleration and regen braking cause huge surges. Turns out, these surges are good and fry the dendrites, making the #battery healthier.

So EV owners, punch it and slam the brakes time to time! (but not with traffic around!!).

https://news.stanford.edu/stories/2024/12/existing-ev-batteries-may-last-up-to-40-longer-than-expected

A previous study in #plosbiology found that Wnt receptors are housed in early endosomes and required for dendritic #microtubule nucleation. This Update Article shows that microtubule dynamics in #dendrites can be influenced non-autonomously by surrounding epithelial cells plos.io/3DK0M0J

`In this work, we investigated the #dendrites of layer 2 and 3 (L2/3) pyramidal #neurons of the human cerebral cortex ex vivo. In these neurons, we discovered a class of #calcium-mediated dendritic action potentials (dCaAPs) whose waveform and effects on #neuronal output have not been previously described. In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli`

https://www.science.org/doi/10.1126/science.aax6239

Summer vibes! Here researchers have captured dendrite generated on a zinc surface, and added their own seaside-themed flourish.

Photograph: Yutong Zhu

@photography
#nanophotography
#dendrites

#Nerve #cells (#neurons ) are amongst the most complex cell types in our body. They achieve this complexity during development by extending ramified branches called #dendrites and #axons and establishing thousands of synapses to form intricate networks.
#Neuroscience #sflorg
https://www.sflorg.com/2024/04/ns04082401.html

`In contrast to typical all-or-none action potentials, dCaAPs were graded; their amplitudes were maximal for threshold-level stimuli but dampened for stronger stimuli. These dCaAPs enabled the #dendrites of individual human neocortical pyramidal #neurons to classify linearly nonseparable inputs—a computation conventionally thought to require multilayered #networks.`

https://www.science.org/doi/10.1126/science.aax6239

hat tip @ScienceScholar

"Here we combine cable and renewal theory to describe how input fluctuations shape the response of neuronal ensembles with active #dendrites. We found that dendritic input readily and potently controls interspike interval dispersion. This phenomenon can be understood by considering that #neurons display three fundamental operating regimes: one mean-driven regime and two fluctuation-driven regimes."

https://www.nature.com/articles/s43588-023-00580-6

Dendrite formation is the bane of lithium batteries.

"In the new research, Li and his team stop #dendrites from forming by using micron-sized silicon particles in the anode to constrict the lithiation reaction and facilitate homogeneous plating of a thick layer of #lithium metal."

#batteries
https://www.pv-magazine.com/2024/01/15/new-solid-state-battery-charges-in-minutes-lasts-for-thousands-of-cycles/

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a research assistant who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501807) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501807/research-assistant-i

If you have any questions, please email me at [email protected].
#autism #ASD #therapy #DrugDiscovery #ResearchAssistant #ResearchAssistantJob #AcademicJob #LabTechnician #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Our lab (Toyooka Lab @LabToyooka) at Drexel University in Philadelphia is seeking a postdoctoral researcher who is enthusiastic about autism research. We study the efficacy of peptides on neuronal morphology (neurite/spine/synapse formation), neural circuits and behaviors using autism mouse models (See the details about the project at the lab webpage: https://toyooka-lab.academic.ws/).

Please see the details and apply for this position (Job #: 501741) at the Drexel Human Resources website. https://careers.drexel.edu/en-us/job/501741/postdoctoral-researcher

If you have any questions, please email me at [email protected].

#autism #ASD #therapy #DrugDiscovery #postdoc #PostdocJob #AcademicJob #neuroscience #brain #CellBiology #BrainDevelopment #neurodevelopment #neurodevelopmentalDisorder #Axon #dendrites #Synapse #NeuralCircuit #philadelphia

Wiring map reveals how larval fruit fly brain converts sensory signals to movement

https://www.spectrumnews.org/news/wiring-map-reveals-how-larval-fruit-fly-brain-converts-sensory-signals-to-movement/

#neuralcircuits #animalmodels #brainmapping #connectivity #Drosophila #dendrites #circuits #learning #synapses #autism #axons #News

Neurons struggle to spike without fragile X gene

https://www.spectrumnews.org/news/neurons-struggle-to-spike-without-fragile-x-gene/

#fragileXsyndrome #prefrontalcortex #dendrites #autism #cortex #News #FMR1 #FMRP

The #INCF #OCNS Software WG software highlight is starting in ~20 minutes (1600UTC) !

Michalis Pagkalos will discuss #Dendrify, a framework for incorporating dendrites to spiking neural networks

https://ocns.github.io/SoftwareWG/2023/01/27/dev-session-michalis-pagkalos-dendrify.html

#OpenScience #Neuroscience #ComputationalNeuroscience #Dendrites

The problem with consciousness research is that we have Paleolithic emotions, medieval theories, and god-like technology (to paraphrase E.O. Wilson)

Let's use the data provided by this technology to develop new theories of consciousness. Our attempt:

https://psyarxiv.com/vkdt2

#consciousness #dendrites #thalamus #anesthesia