#ca1 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ca1, aggregated by home.social.
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New paper from the Poirazi lab, together w Losonczy and Polleux labs:
See how much #dendritic geometry matters for #SpatialCoding: Clustered excitatory inputs on #CA1 #dendrites can support stable #PlaceFields with fewer active #synapses, by engaging local dendritic nonlinearities and Ca2+ signaling.
📄 https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00871-5
Nice example of #DendriticComputing: not just which synapses are active, but where they are placed along the dendritic tree, shapes #NeuronalComputation.
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New paper from the Poirazi lab, together w Losonczy and Polleux labs:
See how much #dendritic geometry matters for #SpatialCoding: Clustered excitatory inputs on #CA1 #dendrites can support stable #PlaceFields with fewer active #synapses, by engaging local dendritic nonlinearities and Ca2+ signaling.
📄 https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00871-5
Nice example of #DendriticComputing: not just which synapses are active, but where they are placed along the dendritic tree, shapes #NeuronalComputation.
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Modeling suggests that sparse #CA3 input can speed up #learning of new #SpatialMaps, while dense #CA1 coding provides a more efficient, compressed representation for large-scale #navigation.
🧵2/2
#Neuroscience #Hippocampus #SpatialNavigation #NeuralDynamics
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Modeling suggests that sparse #CA3 input can speed up #learning of new #SpatialMaps, while dense #CA1 coding provides a more efficient, compressed representation for large-scale #navigation.
🧵2/2
#Neuroscience #Hippocampus #SpatialNavigation #NeuralDynamics
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New paper by Maimon et al (Ulanovsky lab): recordings from #bats flying through tunnels up to 200 m reveal a sparse-to-dense transformation between #hippocampal #CA3 and #CA1.
In small environments, CA3 and CA1 #PlaceCells look similar. At large spatial scales, however, CA3 #neurons mostly show single, ultrasparse #PlaceFields, while CA1 neurons show dense multifield coding.
🌍 https://doi.org/10.1038/s41586-026-10537-0
🧵1/2
#Neuroscience #Hippocampus #SpatialNavigation #NeuralDynamics
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New paper by Maimon et al (Ulanovsky lab): recordings from #bats flying through tunnels up to 200 m reveal a sparse-to-dense transformation between #hippocampal #CA3 and #CA1.
In small environments, CA3 and CA1 #PlaceCells look similar. At large spatial scales, however, CA3 #neurons mostly show single, ultrasparse #PlaceFields, while CA1 neurons show dense multifield coding.
🌍 https://doi.org/10.1038/s41586-026-10537-0
🧵1/2
#Neuroscience #Hippocampus #SpatialNavigation #NeuralDynamics
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🧠 New paper by Pachitariu … @computingnature: spontaneous brainwide activity in mice shows macroscopic coordination that resembles linear dynamics driven by a critically normalized random symmetric matrix.
#Cortical and brainwide recordings showed power-law variance spectra, slow global activity modes, and little rotational structure, unlike #CA1, which looked closer to an efficient, less correlated code.
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🧠 New paper by Pachitariu … @computingnature: spontaneous brainwide activity in mice shows macroscopic coordination that resembles linear dynamics driven by a critically normalized random symmetric matrix.
#Cortical and brainwide recordings showed power-law variance spectra, slow global activity modes, and little rotational structure, unlike #CA1, which looked closer to an efficient, less correlated code.
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🧠 New preprint by Lee et al.: Fast dendritic excitations primarily mediate #backpropagation in #CA1 pyramidal #neurons during #behavior
Using kHz #VoltageImaging across the full #dendritic tree, they show that fast dendritic spikes are usually driven by somatic #bAPs, not independently initiated. #bAP propagation into apical dendrites is contin. modulated by pre-spike dendritic voltage & can trigger slower plateau potentials linked to complex spikes.
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🧠 New preprint by Lee et al.: Fast dendritic excitations primarily mediate #backpropagation in #CA1 pyramidal #neurons during #behavior
Using kHz #VoltageImaging across the full #dendritic tree, they show that fast dendritic spikes are usually driven by somatic #bAPs, not independently initiated. #bAP propagation into apical dendrites is contin. modulated by pre-spike dendritic voltage & can trigger slower plateau potentials linked to complex spikes.
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📚 New article by Esparza et al. and @LMPrida : Cell-type-specific #manifold analysis discloses independent parallel #SpatialMaps in #hippocampal #CA1. Using #miniscope imaging, they show deep and superficial CA1 #PyramidalNeurons encode position and running direction via distinct ring manifolds, manipulable via #chemogenetics. Fascinating for revealing parallel, cell-type–specific spatial topologies 👌
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📚 New article by Lopes-dos-Santos, Brizee & Dupret: Spatio-temporal organization of network activity patterns in the #hippocampus. They use a low-dimensional embedding of #CA1–#DG #LFP in behaving mice to reveal layer-specific #GammaRhythms and distinct firing motifs aligned with hippocampal microcircuit architecture – offering a data-driven view of how #oscillations coordinate #InformationFlow across hippocampal layers.
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📖 Vaidya et al. investigate how #hippocampal #CA1 #PlaceCells form expanding #memory representations over days. Using longitudinal in vivo recordings, they show that stable #PlaceFields progressively emerge as active cells increase their likelihood of remaining active across sessions. This gradual stabilization hinges on #behavioral‑timescale #SynapticPlasticity, offering a new model of how CA1 memories solidify w/o #CatastrophicOverwriting.
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If you liked our lab’s SFN poster from @saman, here’s the #preprint, just up! Laminar CA1 recordings in freely moving🐒 🛜 and that buys us some interesting fields in task and overnight #sleep, #inhibitory cell responses, and best of all: superficial/ deep #CA1 #pyramidalneuron #cellassemblies !! @cogneurophys
#hippocampus #neuroscience
https://www.biorxiv.org/content/10.1101/2023.12.06.570369v1.article-metrics -
If you liked our lab’s SFN poster from @saman, here’s the #preprint, just up! Laminar CA1 recordings in freely moving🐒 🛜 and that buys us some interesting fields in task and overnight #sleep, #inhibitory cell responses, and best of all: superficial/ deep #CA1 #pyramidalneuron #cellassemblies !! @cogneurophys
#hippocampus #neuroscience
https://www.biorxiv.org/content/10.1101/2023.12.06.570369v1.article-metrics -
Paper here: https://elifesciences.org/articles/86548
and hopefully we did alright by the 'persuasive communication devices’ on what are some dramatic theta/gamma results from #macaque #hippocampus #CA1 #oscillations @cogneurophys
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Paper here: https://elifesciences.org/articles/86548
and hopefully we did alright by the 'persuasive communication devices’ on what are some dramatic theta/gamma results from #macaque #hippocampus #CA1 #oscillations @cogneurophys
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After years of perfecting my scrambled eggs technique, I am happy to report that our paper on optogenetic scrambling to dissociate spatiotemporal codes and memory is out in Nature Communications: https://doi.org/10.1038/s41467-023-35825-5 #hippocampus #CA1 #CalciumImaging #Miniscope #GCaMP #Optogenetics #Memory #InVivo #Electrophysiology #ThetaOscillations
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After years of perfecting my scrambled eggs technique, I am happy to report that our paper on optogenetic scrambling to dissociate spatiotemporal codes and memory is out in Nature Communications: https://doi.org/10.1038/s41467-023-35825-5 #hippocampus #CA1 #CalciumImaging #Miniscope #GCaMP #Optogenetics #Memory #InVivo #Electrophysiology #ThetaOscillations