#optogenetics — Public Fediverse posts

Visual perception is the result of orderly, stepwise computations in the mammalian brain, where specific cortical neurons construct complex visual information from broadly tuned neural inputs. This step-by-step processing allows the brain to selectively respond to distinct visual features, such as edges, contrast, and object orientation.
#Neuroscience #Neurobiology #Optogenetics #sflorg
https://www.sflorg.com/2026/04/ns04022601.html

https://www.europesays.com/ie/413594/ New optogenetic method precisely controls marmoset brain communication pathways #Brain #Cell #Cortex #Éire #Health #IE #Ireland #Neurons #Neuroscience #Optogenetics

The tegmentum region in the zebrafish midbrain integrates light signals from both the eyes and the pineal organ (the "third eye") to coordinate spatial orientation. This neural integration allows the fish to adjust its up-and-down swimming behavior based on the specific wavelengths of ambient environmental light.
#Neuroscience #MarineBiology #Photobiology #Optogenetics #sflorg
https://www.sflorg.com/2026/03/ns03302601.html

High spatial resolution artificial vision inferred from the spiking output of retinal ganglion cells stimulated by optogenetic and electrical means (in mice) https://www.frontiersin.org/articles/10.3389/fncel.2022.1033738/full #RGC #optogenetics #AMD #RP #blindness #neuroscience

#KnowledgeByte: #Optogenetics is a biological technique that combines genetics and optics to control the activity of individual, light-sensitive neurons or cells in living tissue with high temporal precision (milliseconds).

https://knowledgezone.co.in/posts/What-Is-Optogenetics-69c75e2bed7bb4a10503e223

Evaluation of lipid nanoparticles as vehicles for optogenetic delivery in primary cortical neurons https://www.mdpi.com/1999-4923/18/1/4 #optogenetics, gene therapy without viruses; #BCI #NeuroTech

#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials https://www.linkedin.com/pulse/zhongmou-wins-us-fda-clearance-chinas-first-optogenetic-k1vte/ using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM

"By bypassing damaged rod and cones, this mutation-agonistic approach is being developed for advanced retinal diseases, including retinitis pigmentosa and geographic atrophy (GA) in age-related macular degeneration."

Advantages of human opsins in optogenetic visual restoration https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1725264/full #optogenetics #BCI #NeuroTech

Adam Claridge-Chang and Shiqiang Gao analyse K+ channelrhodopsins:

"both the absolute K+ to Na+ permeability ratio and its stability over time determine the inhibition to activation transition, which limits their utility for silencing neural circuits."

And they found that a single aminoacid mutant, KCR1-C29D, "shows a relatively high and the most stable K+ to Na+ permeability ratio during illumination", better than heavily protein engineered versions.

"Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins", Duan et al. 2025
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509180

#neuroscience #optogenetics #channelrhodopsin

Bloomberg: Engineered protein that responds to light could help restore sight https://www.bloomberg.com/news/newsletters/2025-10-07/engineered-protein-that-responds-to-light-could-help-restore-sight Archived at https://archive.ph/46Olz #optogenetics

@seeingwithsound

It's interesting that uses of optogenetic therapies work well with goggles that translate RGB video input to "retinal codes" that are projected in the frequency range and amplitudes appropriate for the light sensitive rhodopsins. Fascinating.

#optogenetics #blind #rp #retinituspigmentosa #goggles #vr #ar

The optimism of #optogenetics https://ophthalmologymanagement.com/issues/2025/julyaugust/the-optimism-of-optogenics/ "Vision rehabilitation: Patients receiving optogenetic therapy need training to interpret new visual signals, which requires specialized rehabilitation protocols." #blindness #RP

(YouTube) Engineering ambient light-sensitive opsins for #optogenetics https://www.youtube.com/watch?v=ptPSW4sOnjk

(YouTube, Chinese w/o captions but graphical English subtitles) Blind patient treated with ZM-02 optogenetic gene therapy https://www.youtube.com/watch?v=4kFOhopQZFo Zhongmou Therapeutics; #RP #blindness #optogenetics

Multisensory integration, brain plasticity and optogenetics in visual rehabilitation https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1590305/full

"In the context of visual rehabilitation, combining pharmacological agents with multisensory training paradigms, such as audio-visual integration or tactile-visual substitution, could accelerate recovery by fostering neuroplasticity."

#BCI #optogenetics #multisensory #crossmodal #pharmacology #neuroplasticity #VR

From Stress to Mood: The Neuroendocrine and Immune Interplay in Your Brain

#BrainScience #Neuroscience #SynapticPlasticity #Neurons #BrainChemistry #Optogenetics #Neurotransmitters #BrainHealth #MentalHealth #NeuralNetworks #BrainMetabolism #Neuroimmune #BrainResearch #MindAndBody #BrainInnovation

https://youtube.com/shorts/BJaT-Kjc2QI?feature=share

Researchers used #optogenetics to stimulate epidermal cells in #drosophila larvae, triggering escape behaviours even without injury.

This shows that mechanosensory signals can drive nociceptive responses, linking touch detection to pain responses.
https://elifesciences.org/articles/95379?utm_source=mastodon&utm_medium=social&utm_campaign=organic

🚀 What role does protein design play in advancing next-gen optogenetic tools?

🔗 Protein design accelerates the development and application of optogenetic tools. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.014

📚 CSBJ: https://www.csbj.org/

#Optogenetics #ProteinEngineering #Neuroscience #AlphaFold #ProteinDesign #SyntheticBiology

#Optogenetics is a technique that uses light to control cells, including neurons. It combines genetics and optics to achieve precise control over the activity of specific cells.

https://knowledgezone.co.in/trends/browser?topic=Optogenetics

(09 Apr) Fruit flies can be made to act like miniature robots

Light and smells can turn flies into remote-controlled near-automatons.

https://s.faithcollapsing.com/zt6e9
Archive: ais: https://archive.md/wip/aonCp ia: https://s.faithcollapsing.com/3jisv

#biology #fruit-flies #neurobiology #optogenetics #robotics #science

How do we acquire aversions against flavors of food that causes malaise long after we have experienced the flavors? #Optogenetics in mice reveals a new mechanism for delayed association. https://www.nature.com/articles/s41586-025-08828-z

From Europe, with love for science. #ELEANOR: Studying the brain's complexity with light on a chip https://www.ru.nl/en/donders-institute/news/eleanor-studying-the-brains-complexity-with-light-on-a-chip #BCI #NeuroTech #photonics #optogenetics #neuroscience

Seeing certain things (spiders, ...) leads to instinctive #fear reactions. Animals can learn to overcome such reactions. This study used #optogenetics to identify the relevant brain areas in mice. Could be useful for development of treatments. https://www.science.org/doi/10.1126/science.adr2247

Cortical circuits for cross-modal generalization (in mice) https://www.biorxiv.org/content/10.1101/2023.10.13.562215v4 "Optogenetic sensory substitution for cross-modal generalization"; #optogenetics #crossmodal #neuroscience

Post-doc in network mechanisms of long-term memory and aging

University of Connecticut Health Center

Post-doc in #2p, #electrophysiology and closed-loop #optogenetics of hippocampal network mechanisms of long-term #memory

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-connecticut-health-center-27778-post-doc-in-ne...
https://jobrxiv.org/job/university-of-connecticut-health-center-27778-post-doc-in-network-mechanisms-of-long-term-memory-and-aging/?feed_id=89779

Post-doc in network mechanisms of long-term memory and aging

University of Connecticut Health Center

Post-doc in #2p, #electrophysiology and closed-loop #optogenetics of hippocampal network mechanisms of long-term #memory

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-connecticut-health-center-27778-post-doc-in-ne...
https://jobrxiv.org/job/university-of-connecticut-health-center-27778-post-doc-in-network-mechanisms-of-long-term-memory-and-aging/?feed_id=89408

Postdoctoral Fellow Position_Behavioral Neurobiology

University of Alabama at Birmingham

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=88953

#animal_models #behavioral_neuroscience #cognition #optogenetics #stress_response #ScienceJ...
https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=88953

Seeking Postdocs and Research Assistants

Washington University in St. Louis (WashU)

See the full job description on jobRxiv: https://jobrxiv.org/job/washington-university-in-st-louis-washu-27778-seeking-postdocs-and-research-assistants/?feed_id=88617

#auditory #in_vivo #neural_circuits #optogenetics #sensory #ScienceJobs #hiring #research
https://jobrxiv.org/job/washington-university-in-st-louis-washu-27778-seeking-postdocs-and-research-assistants/?feed_id=88617

Seeking Postdocs and Research Assistants

Washington University in St. Louis (WashU)

See the full job description on jobRxiv: https://jobrxiv.org/job/washington-university-in-st-louis-washu-27778-seeking-postdocs-and-research-assistants/?feed_id=86524

#auditory #in_vivo #neural_circuits #optogenetics #sensory #ScienceJobs #hiring #research
https://jobrxiv.org/job/washington-university-in-st-louis-washu-27778-seeking-postdocs-and-research-assistants/?feed_id=86524

Seeking Postdocs and Research Assistants

Washington University in St. Louis (WashU)

See the full job description on jobRxiv: https://jobrxiv.org/job/washington-university-in-st-louis-washu-27778-seeking-postdocs-and-research-assistants/?feed_id=86309

#auditory #in_vivo #neural_circuits #optogenetics #sensory #ScienceJobs #hiring #research
https://jobrxiv.org/job/washington-university-in-st-louis-washu-27778-seeking-postdocs-and-research-assistants/?feed_id=86309

Hi folks! Here is my #introductionpost. I am a #neuroscientist & #psychiatrist based in NYC. I started a lab at Columbia in 2021 focused on how #stress disrupts the #brain #circuits that govern social, cognitive & reward seeking #behavior. We use #electrophysiology & #optogenetics in freely moving mice to study how dynamic #neural activity, eg, #oscillations yield insight into #susceptibility #resilience #anhedonia & new treatments. I also post about #cooking. #twitterMigration #NeuroMastodons

🚨#Optogenetic preprint alert🚨
Check out PdCO:
Light-controlled inhibition of synaptic transmission via the inhibitory #GPCR pathway. #optogenetics #neuroscience

Link:

Postdoctoral Fellow Position_Behavioral Neurobiology

University of Alabama at Birmingham

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=85614

#animal_models #behavioral_neuroscience #cognition #optogenetics #stress_response #ScienceJ...
https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=85614

#optoPlate-96: An #OpenSource #GUI to design high-throughput #optogenetic experiments with the optoPlate-96:

Paper: https://doi.org/10.1038/s41596-020-0349-x
GitHub: https://github.com/WeberSynBioLab/optoConfig-96
#DIYbio #lab #instruments #Python #Arduino #fluorescence #PlateReader #optogenetics

#optoPlate-96: High-throughput multicolor #OpenSource #optogenetics in #microwell #PlateReader format for $600:

Paper: https://doi.org/10.1038/s41596-019-0178-y
Web: https://www.bugajlab.com/optoplate
GitHub: https://github.com/BugajLab/optoPlate-96
#DIYbio #lab #instruments #optics #3Dprinting #fluorescence #PlateReader

Lab Technician

Cleveland Clinic Lerner Research Institute

We are looking for a lab technician who will responsible for rodent handling and behavioral training.

See the full job description on jobRxiv: https://jobrxiv.org/job/cleveland-clinic-lerner-research-institute-27778-lab-technician/?feed_id=49188

#ScienceJobs #hiring #research #behavior, #imaging, #optogenetics, #multiphoton
Clev...
https://jobrxiv.org/job/cleveland-clinic-lerner-research-institute-27778-lab-technician/?feed_id=49188

Lab Technician

Cleveland Clinic Lerner Research Institute

We are looking for a lab technician who will responsible for rodent handling and behavioral training.

See the full job description on jobRxiv: https://jobrxiv.org/job/cleveland-clinic-lerner-research-institute-27778-lab-technician/?feed_id=48901

#ScienceJobs #hiring #research #behavior, #imaging, #optogenetics, #multiphoton
Clev...
https://jobrxiv.org/job/cleveland-clinic-lerner-research-institute-27778-lab-technician/?feed_id=48901

Usher Syndrome causes varying degrees of progressive deafness and blindness. Many, many advances in diagnosis, remediation, and treatments have improved the outlook for newly diagnosed individuals (including #CochlearImplants for hearing) in recent decades, but there’s no effective treatment for the vision loss yet. Progress with #CRISPR #GeneTherapy #Optogenetics and other areas is impressive and will undoubtedly lead to effective treatments.

2/3

#Optogenetics study detects new #acid #sensor in #plant #cells.

#calcium #channelrhodopsin #KCR2 #guard_cells #endoplasmic_reticulum

https://phys.org/news/2023-12-optogenetics-acid-sensor-cells.html

Postdoctoral Fellow Position_Behavioral Neurobiology

University of Alabama at Birmingham

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=82046

#animal_models #behavioral_neuroscience #cognition #optogenetics #stress_response #system_n...
https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=82046

Postdoctoral Fellow Position_Behavioral Neurobiology

University of Alabama at Birmingham

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=80611

#animal_models #behavioral_neuroscience #cognition #optogenetics #stress_response #system_n...
https://jobrxiv.org/job/university-of-alabama-at-birmingham-27778-postdoctoral-fellow-position_behavioral-neurobiology-3/?feed_id=80611

Above, my #introduction of interests. Here, who I am, what I do: a neuroscientist at the #MRCLMB and University of Cambridge, UK, studying the neural circuit basis of behavior, originally in #Drosophila but now also in #cephalopods (#pygmysquid #Idiosepius), the lancelet #Amphioxus and other animals. Our main approach: whole brain #connectomics with #vEM (volume electron microscopy) as the basis for computational modeling to guide neuronal activity perturbation and monitoring experiments with #optogenetics and #electrophysiology (#ephys for short).
Once upon a time I founded the #ImageJ -based #TrakEM2 software for image registration and neuronal arbor reconstruction and annotation, which spurred founding the #FijiSc (https://fiji.sc) image processing software, and later the #CATMAID web-based software for #connectomics.
Always open to inquires from prospective students and postdocs, and collaborations.

#LITOS: A versatile #OpenSource #LED #illumination tool for #optogenetic stimulation:

-32 × 64 LED matrix
-#ESP32-controlled via #WLAN
-usable with different formats of multi-well plates, petri dishes & flasks.

https://doi.org/10.1038/s41598-022-17312-x
#DIYbio #lab #instruments #optogenetics

Opto-RhoGEFs is an #optogenetic toolbox that can help researchers visualise and manipulate the barrier between endothelial cells like the ones in this clip. #12DaysOfeLife #Optogenetics https://elifesciences.org/articles/84364?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12Days

New #Neuroscience paper, with potential implications for the pyramidal-cell specificity of some #Optogenetic stimulations:

“our results challenge the use of CaMKIIα promoter-driven protein expression as a selective tool in targeting cortical glutamatergic neurons using viral vectors”

CaMKIIα Promoter-Controlled Circuit Manipulations Target Both Pyramidal Cells and Inhibitory Interneurons in Cortical Networks
#NeuroPaper #Optogenetics

Optogenetic activation of visual thalamus generates artificial visual percepts https://www.biorxiv.org/content/10.1101/2022.12.07.519434v1 "Our findings confirm the LGN as a potential target for visual prosthetics"; #LGN #neuroscience #optogenetics #blindness

#introduction toot!! I am a neuroscientist at Instituto Cajal in Madrid, Spain. My lab studies how the 🧠hippocampus generates activity patterns (theta, gamma and ripple oscillations) in service for memory function. We target cell-type specific microcircuits and basic neurophysiological mechs in health & disease (e.g., epilepsy). We use #ephys #neuropixels #miniscopes #uLEDs #optogenetics #computationalneuroscience #machinelearning and love developing new #openscience tools & #neurotechnologies

🚨#Optogenetic preprint alert🚨
Check out PdCO:
Light-controlled inhibition of synaptic transmission via the inhibitory #GPCR pathway. #optogenetics #neuroscience

Link:

🚨#Optogenetic preprint alert🚨
Check out PdCO:
Light-controlled inhibition of synaptic transmission via the inhibitory #GPCR pathway. #optogenetics #neuroscience

Link:

Check out this #NeuroPreprint thread about phase-dependent excitability in the #Striatum! Really exciting (😁) work by my colleague @manishm in the #vanDerMeerLab ⬇️

#Neuroscience #NeuroMouse #Optogenetics

From: @manishm
https://neuromatch.social/@manishm/111865248137896127