#hippocampal — Public Fediverse posts

Circadian Disruption Alters Rhythmic Gene Expression in the Hippocampus Without Changing Overall Levels

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https://1ban.news/circadian-rhythm-disruption-hippocampal-gene-expression-rats/

#1ban #circadian #rhythm #disruption #hippocampal #sleep

Look what’s now possible: Novel wire-free & waterproof #Miniscope (1P) in the #MorrisWaterMaze 👌

📄 https://www.biorxiv.org/content/10.64898/2026.07.13.734058v1
(#NMDA receptor-dependent #Hebbian #plasticity refines #hippocampal spatial representations during two-dimensional navigation learning, Reshef et al)

Btw they used balloons to keep the mouse‘ head above water level: "3 Mylar spherical helium-filled balloons…were used to reduce the weight load on the animal’s head to avoid sinking." Hackers ✌️

#Neuroscience #Behavior #MWM

🗺️🐀 How does the #brain map uneven terrain? New paper by @rmgrieves, @elduvelle_neuro & Taube suggests that the #hippocampal map is shaped by terrain #geometry itself, not only by where the animal runs. Slopes, ridges & surface contours may act as spatial structure for #PlaceCells. Read more about in the 🧵👇

📄 https://doi.org/10.1126/sciadv.adz9893
"Hippocampal #PlaceCells map terrain geometry independently of #behavior"

#Hippocampus #SpatialNavigation #Neuroscience https://fediscience.org/@rmgrieves/116692850991318267

New paper by Maimon et al (Ulanovsky lab): recordings from #bats flying through tunnels up to 200 m reveal a sparse-to-dense transformation between #hippocampal #CA3 and #CA1.

In small environments, CA3 and CA1 #PlaceCells look similar. At large spatial scales, however, CA3 #neurons mostly show single, ultrasparse #PlaceFields, while CA1 neurons show dense multifield coding.

🌍 https://doi.org/10.1038/s41586-026-10537-0

🧵1/2

#Neuroscience #Hippocampus #SpatialNavigation #NeuralDynamics

🧠 New paper by Aidan J. Horner (2025, Trends in Cognitive Sciences) introduces a 3D neural #StateSpace for #episodic memories. It replaces linear #SystemsConsolidation models with a dynamic framework where #hippocampal, #neocortical, and episodic specificity dimensions evolve independently and non-linearly, allowing memories to shift, reverse, or re-engage hippocampal circuits.

🌍 https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(25)00284-0

#Neuroscience #CognitiveScience #Hippocampus #CogSci #compneuro #memory

🧠 New paper by Pedamonti et al. (2025, Nature Comm.) shows that the #hippocampus supports multi-task #ReinforcementLearning under partial observability. Mice flexibly inferred hidden task states 🐁, and only models with recurrent memory reproduced behavior, linking #hippocampal dynamics to #POMDP (Partially Observable Multi-Task Reinforcement Learning) inference.

🌍 https://doi.org/10.1038/s41467-025-64591-9

#Neuroscience #CompNeuro

How do we balance innate responses & adaptive learning when reacting to threats? @tjryan_77 &co show that repeated exposure to looming stimuli reduces innate defensive responses via #hippocampal modulation, revealing a vCA1 engram needed for learned #fear @PLOSBiology https://plos.io/4pNSnNp

📚 New article by Esparza et al. and @LMPrida : Cell-type-specific #manifold analysis discloses independent parallel #SpatialMaps in #hippocampal #CA1. Using #miniscope imaging, they show deep and superficial CA1 #PyramidalNeurons encode position and running direction via distinct ring manifolds, manipulable via #chemogenetics. Fascinating for revealing parallel, cell-type–specific spatial topologies 👌

🌍 https://doi.org/10.1016/j.neuron.2025.01.022

#Neuroscience #CompNeuro

📖 Vaidya et al. investigate how #hippocampal #CA1 #PlaceCells form expanding #memory representations over days. Using longitudinal in vivo recordings, they show that stable #PlaceFields progressively emerge as active cells increase their likelihood of remaining active across sessions. This gradual stabilization hinges on #behavioral‑timescale #SynapticPlasticity, offering a new model of how CA1 memories solidify w/o #CatastrophicOverwriting.

🌍 https://www.nature.com/articles/s41593-025-01986-3

#Hippocampus #Neuroscience

This paper by Raju et al. proposes a unified model – “clone‑structured causal #graphs” (#CSCG) – for #hippocampal #SpatialCoding. It suggests that #SpatialMaps arise from #learning #latent higher‑order sequences rather than representing #EuclideanSpace directly. The model elegantly explains phenomena like #PlaceFields, #SplitterCells, #contextual #remapping, and predicts when #PlaceFieldMapping may mislead.

🌍 https://www.science.org/doi/10.1126/sciadv.adm8470

#Hippocampus #CognitiveMaps #SequenceLearning #Neuroscience

Does neuronal information storage involve nanoscopic structural changes at #synapses? @olenas_kim &co use nanophysiology & functional EM to reveal structural changes of #hippocampal #ActiveZones during chemical potentiation @ISTAustria #PLOSBiology https://plos.io/3V22v7h

Modeling the #hippocampus: @BlueBrainPjt presents a community-based, full-scale in silico model of the rat #hippocampal CA1 region that integrates diverse experimental data from synapse to network #PLOSBiology https://plos.io/3ApZgzz

I find this article by Ferro just out in nature communication https://rdcu.be/dOzT2 is an interesting intersection between value-based decision-making, embodied cognition/active vision, and memory #reactivation or #reinstatement. Looking is doing some heavy lifting. And lookie there, I didn't even mention the #orbitofrontalcortex recordings they did!

It caught my eye (sorry) b/c some of the scanpath analysis our lab's done in the past suggests that prior to looking at a remembered, rewarded visual target, there's an uptick in #hippocampal #ripples (Leonard et al., Current Biol 2017), which are thought to signal the underlying reactivation of task-relevant activity patterns. And of course, there's work by a number of groups on memory guidance to rewarding/goal targets, that rely on hippocampal function. Ours based on an MTL amnesic: Yoo, et al., (2020). Long-term memory and hippocampal function support predictive gaze control during goal-directed search. Journal of Vision, https://doi.org/10.1167/jov.20.5.10 following from Chau et al., 2011, and the changes in scanpaths and pupil responses of aging adults and people with Alzheimer's disease, too: Dragan, M. C.,et al., (2017). Behavioural Brain Research, https://doi.org/10.1016/j.bbr.2016.09.014

Where we choose to look says so much: see e.g. Kragel/Voss; Castelhano/Henderson, Wynn/Buchsbaum/Olsen/Ryan esp what Jordana Wynn followed up with on the scanpath reinstatements suggests a really intertwined relationship between memory, eye movements, and learning/decisions about goals. (forgive that I'm missing many others and pls add below!)

TL;DR The foraging decision-making folks and the memory-guided vision folks need to be increasingly up in each other's business.

Here's that Ferro link:
https://rdcu.be/dOzT2

@cogneurophys

#CrossFrequencyCoupling (CFC) in cortico-#hippocampal networks enables maintenance of multiple visuo-spatial items in #WorkingMemory. This study shows it also extends to #auditory info, suggesting CFC as a global mechanism for information processing in the human brain #PLOSBiology https://plos.io/3uXjhe6

@thetransmitter
Oh yes - like this (#Hippocampal #ThetaSequences):
https://m.youtube.com/watch?v=IU8wKl5PcLU

Or this (#HippocampalReplay):
https://m.youtube.com/watch?v=q0kD2RSejRo

(source: #vanDerMeerLab)

Fresh new work by Sučević and Schapiro (2023) on A #NeuralNetwork model of #hippocampal contributions to category #learning

🌍 https://doi.org/10.7554/eLife.77185

#CompNeuro #Neuroscience #modelling https://fediscience.org/@ekmiller/111569339907921238

"#Hippocampal neurons reinstate specific episodic memories in humans. These #EpisodeSpecificNeurons are independent of #ConceptNeurons or #TimeCells and code the conjunction of elements that make up the event." according to Luca D. Kolibius (1st author, https://twitter.com/LucaKolibius/status/1709953380779499696)

#Weekendreading #Reviews 2:

Sharpening the blades of the dentate #gyrus:
Federico Calegari and colleagues discuss how adult-born #neurons differentially modulate diverse aspects of #hippocampal learning and memory

https://www.embopress.org/doi/full/10.15252/embj.2023113524

There will be a talk by Peter Jonas (ISTAustria) on "#Synaptic mechanisms of #patterncompletion in the #hippocampal #CA3 region":

⏰ Thu July 27 at 4.15pm CEST
🌎 https://t.co/tlk4CorzwE
📍 University of #Tübingen, Hertie-Institut für klinische Hirnforschung (HIH), Host: Ulrike Hedrich

#neuroscience

Rethinking the #hippocampal #cognitivemap as a #metalearning computational module – New publication by Luca Ambrogioni &
H. Freyja Ólafsdóttir (2023)

📔 https://doi.org/10.1016/j.tics.2023.05.011

#computationalneuroscience #learning

New insights into how hippocampal #MemoryFormation & recall is controlled by a disinhibition-based mechanism, supported by #hippocampal #somatostatin interneurons & their pontine #brainstem inputs from the #NucleusIncertus #PLOSBiology https://plos.io/3NkleaD

#ephys study of monkeys reveals a 2-stage mechanism for recalling #SemanticMemory: 1. retrieve its allocentric representation in #PerirhinalCortex, 2. represent the retrieved information in the 1st-person perspective by #hippocampal neurons #PLOSBiology https://plos.io/3qB4Olx

The transcriptional #coactivator #Yap1 promotes adult #hippocampal neural #stemcell activation
https://www.embopress.org/doi/10.15252/embj.2021110384

#SfN2022 - It doesn't get hotter than adult #neurogenesis! Very excited to be introducing the amazing Alejandro Schinder as Special Lecturer on Saturday, 3pm, covering this, circuit remodelling and all things #hippocampal.