#synapses — Public Fediverse posts

New paper from the Poirazi lab, together w Losonczy and Polleux labs:

See how much #dendritic geometry matters for #SpatialCoding: Clustered excitatory inputs on #CA1 #dendrites can support stable #PlaceFields with fewer active #synapses, by engaging local dendritic nonlinearities and Ca2+ signaling.

📄 https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00871-5

Nice example of #DendriticComputing: not just which synapses are active, but where they are placed along the dendritic tree, shapes #NeuronalComputation.

#Neuroscience

New paper from the Poirazi lab, together w Losonczy and Polleux labs:

See how much #dendritic geometry matters for #SpatialCoding: Clustered excitatory inputs on #CA1 #dendrites can support stable #PlaceFields with fewer active #synapses, by engaging local dendritic nonlinearities and Ca2+ signaling.

📄 https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00871-5

Nice example of #DendriticComputing: not just which synapses are active, but where they are placed along the dendritic tree, shapes #NeuronalComputation.

#Neuroscience

Le corps, un territoire immense

On croit habiter un corps de taille modeste, un mètre soixante-dix, quelques kilos, une silhouette qu’on reconnaît par un simple miroir. Mais dès que l’on se penche sur sa composition et sa complexité, les chiffres font que cette évidence vacille. Le corps n’est pas une forme close. C’est un territoire démesuré, plié dans un espace restreint.

Nous avons 206 os qui soutiennent le corps adulte, contre près de 300 à la naissance, avant que certains ne fusionnent avec la croissance. Le plus petit d’entre eux, l’étrier de l’oreille interne, est plus petit qu’un grain de riz. Le plus grand, le fémur, est capable de porter plusieurs fois le poids du corps.

Autour de cette architecture, entre 600 et 840 muscles, selon la façon dont on les compte, orchestrent chaque geste, du battement de cils au port d’une charge.

Et plus nous entrons dans la composition du corps, une sorte de vertige s’installe.

Mis bout à bout, les vaisseaux sanguins d’un corps humain, les artères, les veines, les capillaires confondus, s’étireraient sur environ 100 000 kilomètres (August Krogh publiés dans son livre The Anatomy and Physiology of Capillaries1922), soit une distance de près de deux fois et demie le tour de la Terre, contenu dans un espace qu’on peut serrer dans ses bras.

Les fibres nerveuses, elles, iraient plus loin encore. On les estime, mise à plat, entre 150 000 et 180 000 kilomètres (Bente Pakkenberg et ses collègues notamment parues dans la revue Ugeskrift for Læger en 1997), de quoi relier la Terre à la Lune, et revenir.

Tout cela replié, enroulé, invisible, sous une peau qui ne mesure qu’environ deux mètres carrés.

Le cerveau, à lui seul, abrite environ 86 milliards de neurones. Chacun peut établir des milliers de connexions avec ses voisins, jusqu’à plusieurs dizaines de milliers pour les plus actifs, pour un total qui se compte en centaines de billions de synapses. Plus de connexions, pourrait-on penser, que d’étoiles dans notre galaxie.

Et ce cerveau, qui ne représente qu’environ 2 % du poids du corps, en consomme à lui seul près de 20 % de l’énergie.

Le corps entier, enfin, serait composé d’environ 37 000 milliards de cellules, un chiffre si grand qu’il cesse d’être intuitif, qu’il devient presque abstrait, comme les distances en années-lumière.

Il y a quelque chose de troublant, et peut-être de juste, dans cette disproportion. Ce que nous appelons « moi », ce point que l’on croit tenir tout entier entre deux mains, est en réalité un déploiement immense, une cartographie que nul œil ne peut embrasser d’un coup.

Peut-être est-ce là une autre forme de seuil : celui qui sépare ce que nous croyons être de ce que nous sommes réellement, un territoire sans commune mesure avec l’idée que nous nous en faisons.

Ces chiffres sont approximatifs, la science elle-même hésitant parfois entre plusieurs estimations, comme si le corps dans l’infini petit devient si grand. Une chose est certaine, nous vivons dans un territoire immense, et, malgré les distances, tout est ressenti de façon instantanée. Une perspective quantique.

Une chanson de Fred Pellerin – C’est un monde

Les paroles sur https://www.boiteachansons.net/partitions/fred-pellerin/c-est-un-monde

https://www.youtube.com/watch?v=9sU8lenjdhM

Par Daniel Jean dans Voies (x) de passage

COPYRIGHT – DROIT DE REPRODUCTION – La reproduction de cet article sur un blogue ou un site est autorisé à condition de respecter :   * L’intégralité du texte — Vous ne devez pas modifier, transformer ou adapter ce texte. * Le droit d’auteur — Vous devez citer le nom de la source (avec un hyperlien vers l’article original de préférence). * La finalité sans but lucratif — Vous n’avez pas le droit d’utiliser cette création à des fins commerciales. Si j’ai utilisé vos textes/photos et que vous souhaitez que je les retire, merci de me contacter en commentaire, ce sera fait rapidement.

Le corps, un territoire immense

On croit habiter un corps de taille modeste, un mètre soixante-dix, quelques kilos, une silhouette qu’on reconnaît par un simple miroir. Mais dès que l’on se penche sur sa composition et sa complexité, les chiffres font que cette évidence vacille. Le corps n’est pas une forme close. C’est un territoire démesuré, plié dans un espace restreint.

Nous avons 206 os qui soutiennent le corps adulte, contre près de 300 à la naissance, avant que certains ne fusionnent avec la croissance. Le plus petit d’entre eux, l’étrier de l’oreille interne, est plus petit qu’un grain de riz. Le plus grand, le fémur, est capable de porter plusieurs fois le poids du corps.

Autour de cette architecture, entre 600 et 840 muscles, selon la façon dont on les compte, orchestrent chaque geste, du battement de cils au port d’une charge.

Et plus nous entrons dans la composition du corps, une sorte de vertige s’installe.

Mis bout à bout, les vaisseaux sanguins d’un corps humain, les artères, les veines, les capillaires confondus, s’étireraient sur environ 100 000 kilomètres (August Krogh publiés dans son livre The Anatomy and Physiology of Capillaries1922), soit une distance de près de deux fois et demie le tour de la Terre, contenu dans un espace qu’on peut serrer dans ses bras.

Les fibres nerveuses, elles, iraient plus loin encore. On les estime, mise à plat, entre 150 000 et 180 000 kilomètres (Bente Pakkenberg et ses collègues notamment parues dans la revue Ugeskrift for Læger en 1997), de quoi relier la Terre à la Lune, et revenir.

Tout cela replié, enroulé, invisible, sous une peau qui ne mesure qu’environ deux mètres carrés.

Le cerveau, à lui seul, abrite environ 86 milliards de neurones. Chacun peut établir des milliers de connexions avec ses voisins, jusqu’à plusieurs dizaines de milliers pour les plus actifs, pour un total qui se compte en centaines de billions de synapses. Plus de connexions, pourrait-on penser, que d’étoiles dans notre galaxie.

Et ce cerveau, qui ne représente qu’environ 2 % du poids du corps, en consomme à lui seul près de 20 % de l’énergie.

Le corps entier, enfin, serait composé d’environ 37 000 milliards de cellules, un chiffre si grand qu’il cesse d’être intuitif, qu’il devient presque abstrait, comme les distances en années-lumière.

Il y a quelque chose de troublant, et peut-être de juste, dans cette disproportion. Ce que nous appelons « moi », ce point que l’on croit tenir tout entier entre deux mains, est en réalité un déploiement immense, une cartographie que nul œil ne peut embrasser d’un coup.

Peut-être est-ce là une autre forme de seuil : celui qui sépare ce que nous croyons être de ce que nous sommes réellement, un territoire sans commune mesure avec l’idée que nous nous en faisons.

Ces chiffres sont approximatifs, la science elle-même hésitant parfois entre plusieurs estimations, comme si le corps dans l’infini petit devient si grand. Une chose est certaine, nous vivons dans un territoire immense, et, malgré les distances, tout est ressenti de façon instantanée. Une perspective quantique.

Une chanson de Fred Pellerin – C’est un monde

Les paroles sur https://www.boiteachansons.net/partitions/fred-pellerin/c-est-un-monde

https://www.youtube.com/watch?v=9sU8lenjdhM

Par Daniel Jean dans Voies (x) de passage

COPYRIGHT – DROIT DE REPRODUCTION – La reproduction de cet article sur un blogue ou un site est autorisé à condition de respecter :   * L’intégralité du texte — Vous ne devez pas modifier, transformer ou adapter ce texte. * Le droit d’auteur — Vous devez citer le nom de la source (avec un hyperlien vers l’article original de préférence). * La finalité sans but lucratif — Vous n’avez pas le droit d’utiliser cette création à des fins commerciales. Si j’ai utilisé vos textes/photos et que vous souhaitez que je les retire, merci de me contacter en commentaire, ce sera fait rapidement.

🧠 New paper from our neighboring Gründemann Lab @dzne 👋

Chloé Maëlle Benoit and colleagues show that #axon initial segments in #mPFC #neurons undergo #learning-dependent #StructuralPlasticity during fear extinction, linking #AIS dynamics to #MemoryFormation in vivo. A very cool study that extends the concept of learning-related #plasticity beyond #synapses to intrinsic neuronal compartments.

🌍 https://doi.org/10.1038/s41593-025-02152-5

#Neuroscience #DZNE

🧠 New paper from our neighboring Gründemann Lab @dzne 👋

Chloé Maëlle Benoit and colleagues show that #axon initial segments in #mPFC #neurons undergo #learning-dependent #StructuralPlasticity during fear extinction, linking #AIS dynamics to #MemoryFormation in vivo. A very cool study that extends the concept of learning-related #plasticity beyond #synapses to intrinsic neuronal compartments.

🌍 https://doi.org/10.1038/s41593-025-02152-5

#Neuroscience #DZNE

La semaine des #dictons :

« Avec 4 tables et une chaise, ça me suffit. », « Tu devrais tourner 4 x autour de ta langue avant de parler ! » et « L’arbre ne tombe jamais loin de la pomme. »

Les #neurones font leur apparition mais il manque encore les #synapses… .

#burnout

🧠 In gaps near a millionth of an inch, consciousness might be dancing. Between trillions of synapses, molecular bridges hold synaptic contacts and slowly remodel with activity, weaving patterns so complex we might wonder if they could experience themselves.

✨ Journey into the neural mystery: https://TPC8.short.gy/JS2DQjc8

🔮 In the space between neurons, a universe of awareness may be unfolding.

#Neuroscience #Consciousness #PhilosophyOfMind #NeuroPhilosophy #CognitiveScience #Synapses #SciComm #TPC8

🧠 In gaps near a millionth of an inch, consciousness might be dancing. Between trillions of synapses, molecular bridges hold synaptic contacts and slowly remodel with activity, weaving patterns so complex we might wonder if they could experience themselves.

✍️ Journey into the neural mystery: https://TPC8.short.gy/JS2DQjc8

🔮 In the space between neurons, a universe of awareness may be unfolding.

#Neuroscience #Consciousness #PhilosophyOfMind #NeuroPhilosophy #CognitiveScience #Synapses #SciComm #TPC8

🧠 #Neurons can communicate via a hidden network of #nanotubes, new study finds. Chang et al. (2025) show that dendritic nanotubes (DNTs) are #actin-based #dendrite-to-dendrite conduits transferring Ca²⁺ and molecular cargo (incl. #Aβ), rising before plaque deposition in mouse #cortex. This overlooked pathway may expand our view of neuronal communication beyond #synapses:

🌍 https://www.science.org/doi/10.1126/science.adr7403

#Neuroscience

🧠Wie Synapsen zusammenhalten 🤝

Diese Entdeckung hat ein Kölner Forschungsteam über die molekulare Architektur von Synapsen gemacht. Die Studie zeigt, dass das Protein Gephyrin im Gehirn flexible Filamente bildet und damit als wichtiger Baustein inhibitorischer Synapsen dient.

Mehr dazu▶️ https://uni.koeln/YAZEK

📰 https://www.nature.com/articles/s41467-025-63748-w

#uniköln #unicologne #Forschung #Synapsen #Gehirn #Neurologie #Research #Synapses #Brain #Neurology

🧠Wie Synapsen zusammenhalten 🤝

Diese Entdeckung hat ein Kölner Forschungsteam über die molekulare Architektur von Synapsen gemacht. Die Studie zeigt, dass das Protein Gephyrin im Gehirn flexible Filamente bildet und damit als wichtiger Baustein inhibitorischer Synapsen dient.

Mehr dazu▶️ https://uni.koeln/YAZEK

📰 https://www.nature.com/articles/s41467-025-63748-w

#uniköln #unicologne #Forschung #Synapsen #Gehirn #Neurologie #Research #Synapses #Brain #Neurology

🧠 How Synapses Hold Together 🤝

This discovery was made by a Cologne-based research team studying the molecular architecture of synapses. The study shows that the protein gephrin forms flexible filaments in the brain, serving as an important building block of inhibitory synapses.

Read more ▶️ https://uni.koeln/PSVRY

📰The study was published in Nature Communications: https://www.nature.com/articles/s41467-025-63748-w

#uniköln #unicologne #Forschung #Synapsen #Gehirn #Neurologie #Research #Synapses #Brain #Neurology

🧠 How Synapses Hold Together 🤝

This discovery was made by a Cologne-based research team studying the molecular architecture of synapses. The study shows that the protein gephrin forms flexible filaments in the brain, serving as an important building block of inhibitory synapses.

Read more ▶️ https://uni.koeln/PSVRY

📰The study was published in Nature Communications: https://www.nature.com/articles/s41467-025-63748-w

#uniköln #unicologne #Forschung #Synapsen #Gehirn #Neurologie #Research #Synapses #Brain #Neurology

🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.

🌍 https://doi.org/10.1101/2025.09.17.676728

#Neuroscience

🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.

🌍 https://doi.org/10.1101/2025.09.17.676728

#Neuroscience

Ah, the riveting tale of psychiatry's #metaphorical #brain babble, where #neurons are poets and #synapses sing 🎤. #Nature.com suggests upgrading your #browser because, apparently, without the latest CSS, you can't truly grasp the profound wisdom of metaphorical mush 💻🔍.
https://www.nature.com/articles/s41380-025-03053-6 #psychiatry #upgrade #HackerNews #ngated

Ah, the riveting tale of psychiatry's #metaphorical #brain babble, where #neurons are poets and #synapses sing 🎤. #Nature.com suggests upgrading your #browser because, apparently, without the latest CSS, you can't truly grasp the profound wisdom of metaphorical mush 💻🔍.
https://www.nature.com/articles/s41380-025-03053-6 #psychiatry #upgrade #HackerNews #ngated

Our new research on cannabinoid signaling in cerebellar development and function is published in eNeuro.
#cannabinoid #cerebellum #Purkinje #DevelopmentalNeuroscience #endocannabinoid #indianauniversity #synapses #braindevelopment

https://www.eneuro.org/content/12/7/ENEURO.0400-24.2025

Molecular Glue of the Brain: Cell Adhesion Molecules and Synaptic Stability

#Neuroscience #BrainScience #Synapses #NeuronalCircuits #Neuroplasticity #ExcitatoryInhibitoryBalance #DendriticSpines #ExtracellularMatrix #Interneurons #CognitiveHealth #Neurobiology #BrainDevelopment #NeuralConnections #Neuropsychiatry #BrainFunction

https://youtube.com/shorts/dz-Wr8VAww0?feature=share

The #Brain stores #Memories primarily by strengthening or weakening the connections between neurons, called #Synapses.

This process, known as synaptic plasticity, allows neural circuits to be physically reshaped, forming robust pathways that encode learned information.

https://knowledgezone.co.in/posts/How-does-the-Brain-Store-Memory-678603b1a7e475eb5e304048

The #Brain stores #Memories primarily by strengthening or weakening the connections between neurons, called #Synapses.

This process, known as synaptic plasticity, allows neural circuits to be physically reshaped, forming robust pathways that encode learned information.

https://knowledgezone.co.in/posts/How-does-the-Brain-Store-Memory-678603b1a7e475eb5e304048

Exploring the Brain: A Journey Through Neuroimaging and Neural Dynamics

#BrainScience #Neuroimaging #Neuroscience #BrainHealth #Microglia #Synapses #Endocannabinoid #Neurochemistry #BrainArchitecture #Memory #Cognition #MoodRegulation #Neurotherapy #BrainConnectivity #MentalHealth #NeuroscienceExplained

https://youtube.com/shorts/JBEXN3VIQ5I?feature=share

Synaptic transmission is modulated by #neuropeptides in sensory systems & interneurons. This study shows that motor #synapses are also modulated by neuropeptidergic signaling, where lower ACh levels are compensated by upregulation of postsynaptic Ca2+ channels @PLOSBiology https://plos.io/4d6Ecgg

Synaptic transmission is modulated by #neuropeptides in sensory systems & interneurons. This study shows that motor #synapses are also modulated by neuropeptidergic signaling, where lower ACh levels are compensated by upregulation of postsynaptic Ca2+ channels @PLOSBiology https://plos.io/4d6Ecgg

How do diverse synapses in the brain organize their nanoarchitecture? This study uses #nanobodies & STED imaging to study the nanoarchitecture of thalamocortical & corticocortical #synapses, revealing distinct principles of synaptic nano-organization in the brain @PLOSBiology https://plos.io/3FY4vcd

How do diverse synapses in the brain organize their nanoarchitecture? This study uses #nanobodies & STED imaging to study the nanoarchitecture of thalamocortical & corticocortical #synapses, revealing distinct principles of synaptic nano-organization in the brain @PLOSBiology https://plos.io/3FY4vcd

Role of axo-axonic synapses among olfactory receptor neurons (ORNs) in odor decorrelation, mediated by metabotropic acetylcholine receptors:

"Nonlinear high-activity neuronal excitation enhances odor discrimination", Julia E. Manoim-Wolkovitz et al. 2025
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00198-8

#neuroscience #Drosophila #AxoAxonicSynapses #synapses #olfaction

Role of axo-axonic synapses among olfactory receptor neurons (ORNs) in odor decorrelation, mediated by metabotropic acetylcholine receptors:

"Nonlinear high-activity neuronal excitation enhances odor discrimination", Julia E. Manoim-Wolkovitz et al. 2025
https://www.cell.com/current-biology/fulltext/S0960-9822(25)00198-8

#neuroscience #Drosophila #AxoAxonicSynapses #synapses #olfaction

#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.

#LLPS #membrane-less_organelles #neurotransmission

https://phys.org/news/2025-03-cellular-membrane-discusses-synapses-liquids.html

#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.

#LLPS #membrane-less_organelles #neurotransmission

https://phys.org/news/2025-03-cellular-membrane-discusses-synapses-liquids.html

"The first synapse was visualized using electron microscopy in the mid–1950s, although parallel work and delicate egos make it difficult to determine with certainty the first researcher to actually see one." – Alexandra Balwit https://www.asimov.press/p/barcoding-brains

Neuroscientists are human after all.

#neuroscience #synapses #ElectronMicroscopy

"The first synapse was visualized using electron microscopy in the mid–1950s, although parallel work and delicate egos make it difficult to determine with certainty the first researcher to actually see one." – Alexandra Balwit https://www.asimov.press/p/barcoding-brains

Neuroscientists are human after all.

#neuroscience #synapses #ElectronMicroscopy

Synapses in the fly brain learning and memory centre, the mushroom body:

"Quantitative characterization of the pattern of Brp clusters across multiple individuals revealed cell-type-dependent synapse heterogeneity and stereotypy. Furthermore, we discovered previously unidentified sub-compartmental synapse configuration and its regulation by cAMP signaling."

From:
"High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain", by Wu et al. (Tanimoto lab) 2025
https://www.biorxiv.org/content/10.1101/2024.12.02.626511v4

#neuroscience #Drosophila #MushroomBody #synapses

Synapses in the fly brain learning and memory centre, the mushroom body:

"Quantitative characterization of the pattern of Brp clusters across multiple individuals revealed cell-type-dependent synapse heterogeneity and stereotypy. Furthermore, we discovered previously unidentified sub-compartmental synapse configuration and its regulation by cAMP signaling."

From:
"High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain", by Wu et al. (Tanimoto lab) 2025
https://www.biorxiv.org/content/10.1101/2024.12.02.626511v4

#neuroscience #Drosophila #MushroomBody #synapses

Digital painting: Ambiguous impulses for your mental cinema!
#kunst #contemporaryArt #mentalCinema #digitalPainting #virtualPainting #aiAssistedArt #saveBioDiversity #climateActionNow #systemChange #endFossilFuels #makeArtNotWar #noAFD #NoRacism #NoFascism #humanrights #humanDignity #Нетвойны #anatomy #brain #neocortex #neurosciences #neurobiology #cognition #perception #emotion #synapses #astronauts #spaceSuit #spaceTravel #tightRopeWalking #balancing #berlin #reichstag #government #capital

Digital painting: Ambiguous impulses for your mental cinema!
#contemporaryArt #mentalCinema #digitalPainting #climateActionNow #systemChange #endFossilFuels #makeArtNotWar #noAFD #NoRacism #NoFascism #humanrights #humanDignity #Нетвойны #appliedSciences #biology #anatomy #architecture #brain #neocortex #neurosciences #neurobiology #cognition #perception #emotion #innerOrgans #crossSection #synapses #connections #bridge #astronautics #astronauts #spaceSuit #spaceTravel #drawing #oldHand

❓ Why do we learn in our #sleep?

❗ A team from #CharitéBerlin finally has a possible explanation: The slow brain waves typical of deep sleep strengthen the connections between human nerve cells, making the #brain especially receptive to information. The details:

👉 https://www.charite.de/en/service/press_reports/artikel/detail/why_deep_sleep_is_helpful_for_memory/

#medicine #research #science #ScienceMastodon #MedMastodon #CharitéNeuro #CharitéPaper #neuroscience #synapses #SlowWaves

❓ Why do we learn in our #sleep?

❗ A team from #CharitéBerlin finally has a possible explanation: The slow brain waves typical of deep sleep strengthen the connections between human nerve cells, making the #brain especially receptive to information. The details:

👉 https://www.charite.de/en/service/press_reports/artikel/detail/why_deep_sleep_is_helpful_for_memory/

#medicine #research #science #ScienceMastodon #MedMastodon #CharitéNeuro #CharitéPaper #neuroscience #synapses #SlowWaves

Does neuronal information storage involve nanoscopic structural changes at #synapses? @olenas_kim &co use nanophysiology & functional EM to reveal structural changes of #hippocampal #ActiveZones during chemical potentiation @ISTAustria #PLOSBiology https://plos.io/3V22v7h

Does neuronal information storage involve nanoscopic structural changes at #synapses? @olenas_kim &co use nanophysiology & functional EM to reveal structural changes of #hippocampal #ActiveZones during chemical potentiation @ISTAustria #PLOSBiology https://plos.io/3V22v7h

Protein translocation at active #synapses. @jaimedejuan & @carlitosroca7 present a method for quantifying translocation of endogenous neuronal proteins to the synaptic surface, visualizing translocation of proteins when #neurons are firing #PLOSBiology https://plos.io/3UsNtqK

Protein translocation at active #synapses. @jaimedejuan & @carlitosroca7 present a method for quantifying translocation of endogenous neuronal proteins to the synaptic surface, visualizing translocation of proteins when #neurons are firing #PLOSBiology https://plos.io/3UsNtqK

Pictures of AMPA receptors at synapses from Axel Brunger's lab. By averaging a lot of tomogram images, they could discern scaffolding molecules bound to the complexes.

These in situ images are lower resolution than purified protein, but retain the native organization and place the receptors somewhat at the side of vesicular docking sites.

https://www.biorxiv.org/content/10.1101/2024.10.19.619226v2

#synapses #neuroscience #CellularStructuralBiology #Receptors

#JosephLeDoux - What is the Nature of the #Self?

https://www.youtube.com/watch?v=NQ0DB0Qn7WQ

#Philosophy #PhilosophyOfMind #Mind #PhilosophyOfConsciousness #Consciousness #Neuron #Neurons #Synapse #Synapses #Psychology #Freud #Person #Personality #Personhood #Identity #PersonalIdentity #CloserToTruth #RobertKuhn

#JosephLeDoux - What is the Nature of the #Self?

https://www.youtube.com/watch?v=NQ0DB0Qn7WQ

#Philosophy #PhilosophyOfMind #Mind #PhilosophyOfConsciousness #Consciousness #Neuron #Neurons #Synapse #Synapses #Psychology #Freud #Person #Personality #Personhood #Identity #PersonalIdentity #CloserToTruth #RobertKuhn

Turns out the postsynaptic densities (PSD) that we use in electron microscopy to identify synapses aren’t made of large protein aggregates but rather of specialised cellular organelles:

“we combined mouse genetics and cryo-electron tomography to determine the 3D molecular architecture of fresh isolated and anatomically intact synapses in the adult forebrain. The native glutamatergic synapse did not consistently show a high density of proteins at the postsynaptic membrane thought to be characteristic of the PSD. Instead, a ‘synaptoplasm’ consisting of cytoskeletal elements, macromolecular complexes and membrane-bound organelles extended throughout the pre- and post-synaptic compartments.”

Excellent work by Julia Peukes et al. 2024 https://elifesciences.org/reviewed-preprints/100335

#neuroscience #synapses #CryoEM #CryoCLEM

Turns out the postsynaptic densities (PSD) that we use in electron microscopy to identify synapses aren’t made of large protein aggregates but rather of specialised cellular organelles:

“we combined mouse genetics and cryo-electron tomography to determine the 3D molecular architecture of fresh isolated and anatomically intact synapses in the adult forebrain. The native glutamatergic synapse did not consistently show a high density of proteins at the postsynaptic membrane thought to be characteristic of the PSD. Instead, a ‘synaptoplasm’ consisting of cytoskeletal elements, macromolecular complexes and membrane-bound organelles extended throughout the pre- and post-synaptic compartments.”

Excellent work by Julia Peukes et al. 2024 https://elifesciences.org/reviewed-preprints/100335

#neuroscience #synapses #CryoEM #CryoCLEM

#KelseyMartin - How do #Human #Brains Function?

https://www.youtube.com/watch?v=n0w3R-aVDdA

#Philosophy #PhilosophyOfCosciousness #Consciousness #Brain #Mind #Thinking #Neuroscience #NeuroPhysiology #Neurons #Neuron #Synapses #Synapse #Plasticity #Memory #Genes #RNA #DNA #CloserToTruth #RobertKuhn

#KelseyMartin - How do #Human #Brains Function?

https://www.youtube.com/watch?v=n0w3R-aVDdA

#Philosophy #PhilosophyOfCosciousness #Consciousness #Brain #Mind #Thinking #Neuroscience #NeuroPhysiology #Neurons #Neuron #Synapses #Synapse #Plasticity #Memory #Genes #RNA #DNA #CloserToTruth #RobertKuhn

Sleep normalizes #synapses in the cortex & hippocampus that have been potentiated during the daytime. This study shows that slow-wave #sleep also down-regulates #AMPAreceptor levels in the #hypothalamus, a brain region that regulates sleep #PLOSBiology https://plos.io/3MdTALe

"Homeostatic synaptic normalization optimizes learning in network models of neural population codes", Mayzel and Schneidman, 2024.
https://elifesciences.org/reviewed-preprints/96566

From the assessment:

"... an important contribution to the development of a biologically plausible theory of statistical modeling of spiking activity. The authors convincingly implemented the statistical inference of input likelihood in a simple neural circuit, demonstrating the relationship between synaptic homeostasis, neural representations, and computational accuracy."

#neuroscience #CompNeurosci #synapses

Hidden #HearingLoss involves loss of #cochlear #InnerHairCell synapses. @CorfasGabriel &co show that this degrades temporal auditory processing; generating extra #synapses results in above-normal processing in mice, with therapeutic potential #PLOSBiology https://plos.io/4eFtLRf

#PeterTse - How #FreeWill Probes #Mind and #Consciousness

https://www.youtube.com/watch?v=rj5Z-vJP5fc

#Philosophy #PhilosophyOfFreeWill #PhilosophyOfConsciousness #PhilosophyOfMind #PhilosophyOfScience #Science #Information #Neuroscience #Neuron #Neurons #Synapse #Synapses #NeuralCode #Determinism #Physics #Biology #CloserToTruth #RobertKuhn

"Long-term microglia depletion using colony-stimulating-factor-1 receptor (CSF1-R) inhibitor PLX5622 resulted in increased overall spine density, especially of mushroom spines, and increased excitatory postsynaptic current amplitudes."
Repopulated microglia after pharmacological depletion decrease dendritic spine density in adult mouse brain
Wickel et al., Glia 2024
https://doi.org/10.1002/glia.24541

#neuroscience #microglia #synapses

"The central-pattern-generating network consists of motoneurons interconnected by electrical synapses that, in contrast to doctrine, produce network activity splayed out in time instead of synchronized across neurons. Experimental and mathematical evidence support a generic mechanism for #network desynchronization that relies on weak electrical #synapses and specific excitability #dynamics of the coupled #neurons."

https://www.nature.com/articles/s41586-023-06099-0

Meta-analysis of postsynaptic proteomes reveals 97 poorly studied proteins; @TakeshiKaizuka @ToruTakumi &co find that FAM81A regulates condensation of #postsynaptic proteins via #LLPS to affect the size & function of #synapses #PLOSBiology https://plos.io/48KDPnO