#calciumsignaling — Public Fediverse posts

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=2573

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=1271

How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function

#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity

https://youtube.com/shorts/fYzKu8dPvi0?feature=share

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-colleg...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=12

From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival

#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine

https://youtube.com/shorts/rHr1BIBV5yg?feature=share

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97451

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97346

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97150

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97087

How Your Brain Forms Memories: The Role of Long-Term Potentiation

#Neuroscience #BrainPlasticity #Neuroplasticity #LongTermPotentiation #SynapticConnections #Glutamate #Neurotransmitters #CalciumSignaling #GlialCells #CircadianRhythms #BrainHealth #MemoryFormation #Learning #NeuroscienceEducation #BrainScience

https://youtube.com/shorts/wO5cQRaE3RE?feature=share

https://www.jbc.org/article/S0021-9258(20)35866-X/fulltext

I know this is social media and you are supposed to post only the latest stuff, but as this is always on my mind, I just stumbled upon another nice mini review on calcium biochemistry.

My PhD advisor loved to say that calcium is the most important metal in your body :)
This review has a nice explanation on how the coordination flexibility of calcium may have made it so.

#biochemistry #calciumsignaling

Grateful to the @dfg_public for funding this work at its outset through the TRR186 grant (to Peter Hegemann and me). #HUBerlin #CalciumSignaling #IonChannels

"To understand the basis for Ca2+ transport and signaling in Mtb, we determined Mtb’s transcriptional response to Ca2+. Overall, only few genes changed expression, suggesting a limited role of Ca2+ as a transcriptional regulator. However, 2 of the most strongly down-regulated genes were the pe15 and ppe20 genes that code for members of a large family of proteins that localize to the outer membrane and comprise many intrinsically disordered proteins."

#Tuberculosis #CalciumSignaling #PLOSBiology #Metabolism

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001906

Woohoo #AllThingsBrightAndCilia :blobcatwave: - we have the kick-ass Dagmar in the #Fediverse- @Wachtenlab huge welcome! Dagmar is queen of #Optigenetics #Biosensors #CalciumSignaling #Cilia #LiveImaging and well-worth having in your timeline!