#calciumsignaling — Public Fediverse posts

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons. 🌍 https://doi.org/10.1016/j.neuron.2026.04.017 #Neuroscience

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

🧠 New paper by Chiu et al: #SST #interneurons do not only suppress #dendritic signaling. Via tonic activation of α5 #GABA receptors, they can paradoxically enhance AP-evoked dendritic #CalciumSignaling in #cortical #pyramidal #neurons.

Mechanistically, tonic #GABA hyperpolarizes #dendrites & deinactivates low-threshold voltage-gated #calcium channels, increasing calcium influx and facilitating calcium-dependent inhibitory #SynapticPlasticity.

🌍 https://doi.org/10.1016/j.neuron.2026.04.017

#Neuroscience #CompNeuro

Japanese Study Uncovers Molecular Mechanism Behind Venus Flytrap’s Rapid Response | Ukraine news

New research from Japan reveals the molecular …
#Japan #JP #JapanNews #bioelectronics #calciumsignaling #Japanese #Japanesenews #japaneseresearch #molecularmechanism #naturecommunications #news #plantelectrophysiology #plantmemory #preydetection #sensorysystem #venusflytrap
https://www.alojapan.com/1381617/japanese-study-uncovers-molecular-mechanism-behind-venus-flytraps-rapid-response-ukraine-news/

Japanese Study Uncovers Molecular Mechanism Behind Venus Flytrap’s Rapid Response | Ukraine news

New research from Japan reveals the molecular …
#Japan #JP #JapanNews #bioelectronics #calciumsignaling #Japanese #Japanesenews #japaneseresearch #molecularmechanism #naturecommunications #news #plantelectrophysiology #plantmemory #preydetection #sensorysystem #venusflytrap
https://www.alojapan.com/1381617/japanese-study-uncovers-molecular-mechanism-behind-venus-flytraps-rapid-response-ukraine-news/

https://www.alojapan.com/1381617/japanese-study-uncovers-molecular-mechanism-behind-venus-flytraps-rapid-response-ukraine-news/ Japanese Study Uncovers Molecular Mechanism Behind Venus Flytrap’s Rapid Response | Ukraine news #bioelectronics #CalciumSignaling #Japan #JapanNews #Japanese #JapaneseNews #JapaneseResearch #MolecularMechanism #NatureCommunications #news #PlantElectrophysiology #PlantMemory #PreyDetection #SensorySystem #VenusFlytrap New research from Japan reveals the molecular mechanism that triggers the Venus flytrap’s immediate response to touch or stres

https://www.alojapan.com/1381617/japanese-study-uncovers-molecular-mechanism-behind-venus-flytraps-rapid-response-ukraine-news/ Japanese Study Uncovers Molecular Mechanism Behind Venus Flytrap’s Rapid Response | Ukraine news #bioelectronics #CalciumSignaling #Japan #JapanNews #Japanese #JapaneseNews #JapaneseResearch #MolecularMechanism #NatureCommunications #news #PlantElectrophysiology #PlantMemory #PreyDetection #SensorySystem #VenusFlytrap New research from Japan reveals the molecular mechanism that triggers the Venus flytrap’s immediate response to touch or stres

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=2573

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=2573

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=2573

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=2573

🔓📄 'Activation of Piezo 1 in the Pathogenesis of Glaucoma' - an article published in 'Neuropharmacology and Therapy' on #ScienceOpen 🔗 https://www.scienceopen.com/hosted-document?doi=10.15212/npt-2024-0013

#GlaucomaResearch #Piezo1 #CalciumSignaling #Cofilin #ActinDynamics

🔓📄 'Activation of Piezo 1 in the Pathogenesis of Glaucoma' - an article published in 'Neuropharmacology and Therapy' on #ScienceOpen 🔗 https://www.scienceopen.com/hosted-document?doi=10.15212/npt-2024-0013

#GlaucomaResearch #Piezo1 #CalciumSignaling #Cofilin #ActinDynamics

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=1271

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=1271

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=1271

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-coll...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=1271

How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function

#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity

https://youtube.com/shorts/fYzKu8dPvi0?feature=share

How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function

#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity

https://youtube.com/shorts/fYzKu8dPvi0?feature=share

How Tiny Ion Channels Power Your Mind: A Deep Dive into Neuronal Function

#Neuroscience #BrainScience #Neurons #IonChannels #CalciumSignaling #NeuralCommunication #BrainHealth #Neurobiology #ElectricalSignals #Neuroplasticity

https://youtube.com/shorts/fYzKu8dPvi0?feature=share

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-colleg...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=12

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-colleg...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=12

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-colleg...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=12

Postdoctoral Scientist - Penn State College of Medicine
Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-colleg...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?fsp_sid=12

From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival

#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine

https://youtube.com/shorts/rHr1BIBV5yg?feature=share

From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival

#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine

https://youtube.com/shorts/rHr1BIBV5yg?feature=share

From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival

#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine

https://youtube.com/shorts/rHr1BIBV5yg?feature=share

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97451

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97451

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97451

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97451

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97346

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97346

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97346

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97346

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97150

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97150

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97150

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97150

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97087

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97087

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97087

Postdoctoral Scientist - Penn State College of Medicine

Penn State College of Medicine

Join us as a #CalciumSignaling #Postdoc at Penn State to explore ion channels and disease mechanisms in a dynamic, multidisciplinary lab!

See the full job description on jobRxiv: https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-co...
https://jobrxiv.org/job/penn-state-college-of-medicine-27778-postdoctoral-scientist-penn-state-college-of-medicine/?feed_id=97087

How Your Brain Forms Memories: The Role of Long-Term Potentiation

#Neuroscience #BrainPlasticity #Neuroplasticity #LongTermPotentiation #SynapticConnections #Glutamate #Neurotransmitters #CalciumSignaling #GlialCells #CircadianRhythms #BrainHealth #MemoryFormation #Learning #NeuroscienceEducation #BrainScience

https://youtube.com/shorts/wO5cQRaE3RE?feature=share

How Your Brain Forms Memories: The Role of Long-Term Potentiation

#Neuroscience #BrainPlasticity #Neuroplasticity #LongTermPotentiation #SynapticConnections #Glutamate #Neurotransmitters #CalciumSignaling #GlialCells #CircadianRhythms #BrainHealth #MemoryFormation #Learning #NeuroscienceEducation #BrainScience

https://youtube.com/shorts/wO5cQRaE3RE?feature=share

How Your Brain Forms Memories: The Role of Long-Term Potentiation

#Neuroscience #BrainPlasticity #Neuroplasticity #LongTermPotentiation #SynapticConnections #Glutamate #Neurotransmitters #CalciumSignaling #GlialCells #CircadianRhythms #BrainHealth #MemoryFormation #Learning #NeuroscienceEducation #BrainScience

https://youtube.com/shorts/wO5cQRaE3RE?feature=share

🛠️ Is it possible to rewire cellular energy control by targeting a single protein domain?

🔗 Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.12.007

📚 CSBJ: https://www.csbj.org/

#Mitochondria #CellBiology #CalciumSignaling #ProteinEngineering #ProteinScience #StructuralBiology #Bioenergetics #MolecularDynamics #Biophysics #MCU #MCUb #NMR

https://www.jbc.org/article/S0021-9258(20)35866-X/fulltext

I know this is social media and you are supposed to post only the latest stuff, but as this is always on my mind, I just stumbled upon another nice mini review on calcium biochemistry.

My PhD advisor loved to say that calcium is the most important metal in your body :)
This review has a nice explanation on how the coordination flexibility of calcium may have made it so.

#biochemistry #calciumsignaling

https://www.jbc.org/article/S0021-9258(20)35866-X/fulltext

I know this is social media and you are supposed to post only the latest stuff, but as this is always on my mind, I just stumbled upon another nice mini review on calcium biochemistry.

My PhD advisor loved to say that calcium is the most important metal in your body :)
This review has a nice explanation on how the coordination flexibility of calcium may have made it so.

#biochemistry #calciumsignaling

https://www.jbc.org/article/S0021-9258(20)35866-X/fulltext

I know this is social media and you are supposed to post only the latest stuff, but as this is always on my mind, I just stumbled upon another nice mini review on calcium biochemistry.

My PhD advisor loved to say that calcium is the most important metal in your body :)
This review has a nice explanation on how the coordination flexibility of calcium may have made it so.

#biochemistry #calciumsignaling

Grateful to the @dfg_public for funding this work at its outset through the TRR186 grant (to Peter Hegemann and me). #HUBerlin #CalciumSignaling #IonChannels

Grateful to the @dfg_public for funding this work at its outset through the TRR186 grant (to Peter Hegemann and me). #HUBerlin #CalciumSignaling #IonChannels

Grateful to the @dfg_public for funding this work at its outset through the TRR186 grant (to Peter Hegemann and me). #HUBerlin #CalciumSignaling #IonChannels

"To understand the basis for Ca2+ transport and signaling in Mtb, we determined Mtb’s transcriptional response to Ca2+. Overall, only few genes changed expression, suggesting a limited role of Ca2+ as a transcriptional regulator. However, 2 of the most strongly down-regulated genes were the pe15 and ppe20 genes that code for members of a large family of proteins that localize to the outer membrane and comprise many intrinsically disordered proteins."

#Tuberculosis #CalciumSignaling #PLOSBiology #Metabolism

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001906

"To understand the basis for Ca2+ transport and signaling in Mtb, we determined Mtb’s transcriptional response to Ca2+. Overall, only few genes changed expression, suggesting a limited role of Ca2+ as a transcriptional regulator. However, 2 of the most strongly down-regulated genes were the pe15 and ppe20 genes that code for members of a large family of proteins that localize to the outer membrane and comprise many intrinsically disordered proteins."

#Tuberculosis #CalciumSignaling #PLOSBiology #Metabolism

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001906