#axons — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #axons, aggregated by home.social.
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https://www.europesays.com/ie/415979/ Researchers Unlock the Key to Axon Regeneration #AHRProtein #AxonRegeneration #axons #Éire #IE #Ireland #MountSinai #NerveRepair #neurology #neuroregeneration #Neuroscience #SCI #Science #SpinalCordInjury
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Axons and dendrites are fundamentally different. An example from #Drosophila:
"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."
"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.
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Fully funded 4-Year PhD with Prof. Sanchez Soriano at University of Liverpool, on neurodegeneration, ageing, neurons, and electron microscopy in Drosophila:
"The project will investigate specific structures called axonal varicosities or swellings, that occur on aged axons. These swellings could signal early stages of neuronal decline and are seen in various neurodegenerative diseases. Unfortunately, we currently know little about their role and significance."
Application Deadline: 7th December 2025
#PhDPosition #Drosophila #neuroscience #axons #neurodegeneration
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🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.
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🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.
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🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.
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🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.
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🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.
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Why is neuronal repolarization during #ActionPotentials so uniform despite ~10x range in axonal diameter? Study shows that higher K+ currents in smaller #axons compensate for biophys constraints, resulting in size-independent trigger signals #PLOSBiology https://plos.io/3ZzJvzE
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@SciMag @news-from-science-SciMag
A major criticism is that the technique of high-pressure freezing only handles very small volumes at most 200 micrometers thick, and therefore, the tissue being from a mouse brain, a significant amount of injury to neuronal arbours was caused to generate such small samples.
Three kinds of samples were used:
(1) Cell culture neurons, which have their own problems and can't be considered authoritative on neuronal morphology.
(2) Hippocampal slices, which do recover from sectioning when in the right culture medium but only to some extent. Most neurons exist as fragments in the slice. Artifacts in morphologies are expected.
(3) Acutely extracted brain bits can't be immediately frozen; even a second is enough for neurons to fire and osmolarity to shape neuronal morphologies away from the natural state.In summary: while surely neurons in their natural state don't look like those in textbooks, since all sample preparations suffer from artifacts, I am not convinced that this study resolves the issue. Try to freeze a small animal – like it's been done for C. elegans. Do these peculiar axon morphologies exist in the HFP'ed worm?
The authors themselves admit that:
"treatments that disrupt these parameters like hyper- or hypo-tonic solutions, cholesterol removal, and non-muscle myosin II inhibition all alter the degree of axon pearling" – and all of these come into play during sample preparation.Preprint: https://www.biorxiv.org/content/10.1101/2023.07.20.549958v1.full
As published: https://www.nature.com/articles/s41593-024-01813-1
I wish the reviews were published. Andreas Prokop, a neuroscientist working on microtubules in neurons, was involved, which is reassuring.
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#Nerve #cells (#neurons ) are amongst the most complex cell types in our body. They achieve this complexity during development by extending ramified branches called #dendrites and #axons and establishing thousands of synapses to form intricate networks.
#Neuroscience #sflorg
https://www.sflorg.com/2024/04/ns04082401.html -
"We show that migrating #neurons in mice possess a growth cone at the tip of their leading process, similar to that of #axons, in terms of the #cytoskeletal dynamics and functional responsivity through protein tyrosine #phosphatase receptor type sigma (PTPσ). Migrating-neuron growth cones respond to chondroitin sulfate (CS) through PTPσ and collapse, which leads to inhibition of #neuronal migration."
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Short-term Hebbian learning can implement transformer-like attention
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011843
#ycombinator #Action_potentials #Neuronal_dendrites #Axons #Neurons #Synapses #Machine_learning #Calcium_channels #Ion_channels -
Short-term Hebbian learning can implement transformer-like attention
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011843
#ycombinator #Action_potentials #Neuronal_dendrites #Axons #Neurons #Synapses #Machine_learning #Calcium_channels #Ion_channels -
Short-term Hebbian learning can implement transformer-like attention
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011843
#ycombinator #Action_potentials #Neuronal_dendrites #Axons #Neurons #Synapses #Machine_learning #Calcium_channels #Ion_channels -
`#Oligodendrocytes (from Greek 'cells with a few branches'), also known as oligodendroglia, are a type of #neuroglia whose main functions are to provide support and insulation to #axons within the central nervous system (CNS) of jawed vertebrates. Their function is similar to that of Schwann cells, which perform the same task in the peripheral nervous system`
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`#Oligodendrocytes (from Greek 'cells with a few branches'), also known as oligodendroglia, are a type of #neuroglia whose main functions are to provide support and insulation to #axons within the central nervous system (CNS) of jawed vertebrates. Their function is similar to that of Schwann cells, which perform the same task in the peripheral nervous system`
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`#Oligodendrocytes (from Greek 'cells with a few branches'), also known as oligodendroglia, are a type of #neuroglia whose main functions are to provide support and insulation to #axons within the central nervous system (CNS) of jawed vertebrates. Their function is similar to that of Schwann cells, which perform the same task in the peripheral nervous system`
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`#Oligodendrocytes (from Greek 'cells with a few branches'), also known as oligodendroglia, are a type of #neuroglia whose main functions are to provide support and insulation to #axons within the central nervous system (CNS) of jawed vertebrates. Their function is similar to that of Schwann cells, which perform the same task in the peripheral nervous system`
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`#Oligodendrocytes (from Greek 'cells with a few branches'), also known as oligodendroglia, are a type of #neuroglia whose main functions are to provide support and insulation to #axons within the central nervous system (CNS) of jawed vertebrates. Their function is similar to that of Schwann cells, which perform the same task in the peripheral nervous system`
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Using solely extracellular action potential recordings, researchers provide a noninvasive method for functional imaging of cortical and spinal #axons. #Neuroscience https://elifesciences.org/articles/86512?utm_source=mastodon&utm_medium=social&utm_campaign=organic
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A clinical trial is underway testing a new type of therapy its developer says addresses damage to nerve cells associated with a number of neurological disorders.
https://sciencebusiness.technewslit.com/?p=45143
#News #Press #Science #Business #Neuroscience #Neurons #Axons #ALS #NerveDamage #MultipleSclerosis #TraumaticBrainInjury #ClinicalTrial #Therapy #Biotechnology #Chemistry
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A clinical trial is underway testing a new type of therapy its developer says addresses damage to nerve cells associated with a number of neurological disorders.
https://sciencebusiness.technewslit.com/?p=45143
#News #Press #Science #Business #Neuroscience #Neurons #Axons #ALS #NerveDamage #MultipleSclerosis #TraumaticBrainInjury #ClinicalTrial #Therapy #Biotechnology #Chemistry
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A clinical trial is underway testing a new type of therapy its developer says addresses damage to nerve cells associated with a number of neurological disorders.
https://sciencebusiness.technewslit.com/?p=45143
#News #Press #Science #Business #Neuroscience #Neurons #Axons #ALS #NerveDamage #MultipleSclerosis #TraumaticBrainInjury #ClinicalTrial #Therapy #Biotechnology #Chemistry
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A clinical trial is underway testing a new type of therapy its developer says addresses damage to nerve cells associated with a number of neurological disorders.
https://sciencebusiness.technewslit.com/?p=45143
#News #Press #Science #Business #Neuroscience #Neurons #Axons #ALS #NerveDamage #MultipleSclerosis #TraumaticBrainInjury #ClinicalTrial #Therapy #Biotechnology #Chemistry
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Wiring map reveals how larval fruit fly brain converts sensory signals to movement
https://www.spectrumnews.org/news/wiring-map-reveals-how-larval-fruit-fly-brain-converts-sensory-signals-to-movement/
#neuralcircuits #animalmodels #brainmapping #connectivity #Drosophila #dendrites #circuits #learning #synapses #autism #axons #News -
Protein networks identified in autism-linked genetic deletion
https://www.spectrumnews.org/news/protein-networks-identified-in-autism-linked-genetic-deletion/
#mousemodels #15q11-13 #autism #axons #News -
#Nerve #cells communicate with one another via long processes known as #axons and #dendrites, or, more generally, neurites. During development, these processes first grow and form connections with other cells
#Biology #Neuroscience #sflorg
https://www.sflorg.com/2023/01/bio01262303.html -
@jilleduffy LOL! Just LOL! If it motivates you to learn a new language, your brain will thank you. #brainplasticidity #neurons #pathways #axons #dentrites #intelligence
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Multi-omics study captures CNTNAP2’s far-ranging effects
https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/
#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News -
Multi-omics study captures CNTNAP2’s far-ranging effects
https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/
#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News -
Multi-omics study captures CNTNAP2’s far-ranging effects
https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/
#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News -
#introduction. I am a neuro/cell/dev biologist investigating how the delicate meter-long slender processes of neurons, i.e. the #axons that form the cables wiring our nervous system, can be maintained for a century (or fail in neurodegeneration). As an efficient strategy, I use genetics and neurons of the fruitfly #Drosophila able to deal with the enormous complexity at play (image). For many years I have engaged in #scicomm promoting the importance of fly research (https://poppi62.wordpress.com/publications/)
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Amygdala-linked brain areas grow differently in autism
https://www.spectrumnews.org/news/amygdala-linked-brain-areas-grow-differently-in-autism/
#anteriorcingulategyrus #diagnosticimaging #emotionprocessing #diagnostictests #neuralcircuits #fusiformgyrus #brainimaging #brainmapping #amygdala #anxiety #autism #DSM-IV #gender #axons #DSM-5 #News -
Amygdala-linked brain areas grow differently in autism
https://www.spectrumnews.org/news/amygdala-linked-brain-areas-grow-differently-in-autism/
#anteriorcingulategyrus #diagnosticimaging #emotionprocessing #diagnostictests #neuralcircuits #fusiformgyrus #brainimaging #brainmapping #amygdala #anxiety #autism #DSM-IV #gender #axons #DSM-5 #News