#mousemodels — Public Fediverse posts

Research Assistant
Keele University

We are recruiting a Research Assistant to work on an exciting project aimed at defining the role of brown adipose tissue in spinal muscular atrophy.

See the full job description on jobRxiv: https://jobrxiv.org/job/keele-university-27778-research-assistant/

#brownadiposetissue #molecularbiology #mousemodels #Neuromusculardiseases #primarycellculture #spinalmuscularatrophy #Sc...
https://jobrxiv.org/job/keele-university-27778-research-assistant/?fsp_sid=3917

Research Assistant
Keele University

We are recruiting a Research Assistant to work on an exciting project aimed at defining the role of brown adipose tissue in spinal muscular atrophy.

See the full job description on jobRxiv: https://jobrxiv.org/job/keele-university-27778-research-assistant/

#brownadiposetissue #molecularbiology #mousemodels #Neuromusculardiseases #primarycellculture #spinalmuscularatrophy #Sc...
https://jobrxiv.org/job/keele-university-27778-research-assistant/?fsp_sid=3469

Q for my fellow neuroscience peeps. Is there a way to stabilize the expression of cre if its under the control of a promoter that is active only transiently during development?

Is it possible to cross a cre line with a cre-dependent cre-expressing reporter mouse so that cre become permanently expressed in the population of interest, and amenable for e.g. virus injection in the adult?

Are there tried and true solutions?

#AAV #cre #MouseModels #neuroscience

Cannabis compound rebalances signaling to quell seizures in mice

https://www.spectrumnews.org/news/cannabis-compound-rebalances-signaling-to-quell-seizures-in-mice/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #hippocampus #mousemodels #cannabis #epilepsy #autism #News #GABA

‘Splice-switching’ strategy boosts SYNGAP1 expression

https://www.spectrumnews.org/news/splice-switching-strategy-boosts-syngap1-expression/

#mousemodels #treatments #organoids #stemcells #synapses #autism #News

FDA approval of trofinetide may spur further drug development for Rett

https://www.spectrumnews.org/news/fda-approval-of-trofinetide-may-spur-further-drug-development-for-rett/

#Rettsyndrome #mousemodels #treatments #autism #MECP2 #News

Serotonin initiates earliest social bonds

https://www.spectrumnews.org/news/serotonin-initiates-earliest-social-bonds/

#sensoryperception #neuralcircuits #animalmodels #mousemodels #serotonin #oxytocin #News #rats

Going on Trial: Orphan drugs; CBD; bumetanide

https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/

#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1

Protein networks identified in autism-linked genetic deletion

https://www.spectrumnews.org/news/protein-networks-identified-in-autism-linked-genetic-deletion/

#mousemodels #15q11-13 #autism #axons #News

Going on Trial: Orphan drugs; CBD; bumetanide

https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/

#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1

Going on Trial: Orphan drugs; CBD; bumetanide

https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/

#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1

Going on Trial: Orphan drugs; CBD; bumetanide

https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/

#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1

The clinical presentation of #FragileXSyndrome ranges from
#autism and intellectual disability to #neurodegeneration.

A new Review from Rob Willemsen & Frank Kooy at #erasmusmcintl discusses #MouseModels that improve our understanding of this disease to help develop targeted #therapies

📰https://journals.biologists.com/dmm/article/16/2/dmm049485/286737/

Epigenome edits unmute MECP2 in Rett-like neurons

https://www.spectrumnews.org/news/epigenome-edits-unmute-mecp2-in-rett-like-neurons/

#Rettsyndrome #genetherapy #mousemodels #autism #MECP2 #News

Adult Angelman mice get some benefit from boosting UBE3A gene expression

https://www.spectrumnews.org/news/adult-angelman-mice-get-some-benefit-from-boosting-ube3a-gene-expression/

#Angelmansyndrome #clinicaltrials #geneexpression #animalmodels #genetherapy #mousemodels #treatments #autism #sleep #UBE3A #News #EEG

CHD8 mutation in 33 mouse strains yields range of traits

https://www.spectrumnews.org/news/chd8-mutation-in-33-mouse-strains-yields-range-of-traits/

#macrocephaly #mousemodels #anxiety #autism #News #CHD8

Missing mechanism helps solve fragile X protein mystery

https://www.spectrumnews.org/news/missing-mechanism-helps-solve-fragile-x-protein-mystery/

#intellectualdisability #repetitivebehaviors #socialdifficulties #fragileXsyndrome #neuralcircuits #connectivity #hippocampus #mousemodels #treatments #synapses #autism #News #FMR1 #FMRP

Beyond the bench: Finding solitude with Jill Silverman

https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-solitude-with-jill-silverman/

#Angelmansyndrome #mousemodels #autism #UBE3A #QA

Asleep in the Mouse House with Graham Diering

https://www.spectrumnews.org/news/profiles/asleep-in-the-mouse-house-with-graham-diering/

#Phelan-McDermidsyndrome #Rettsyndrome #mousemodels #Profiles #synapses #autism #SHANK3 #sleep

Autism and the cell’s antennae

https://www.spectrumnews.org/news/autism-and-the-cells-antennae/

#intellectualdisability #neurotransmitters #tuberoussclerosis #fragileXsyndrome #geneexpression #schizophrenia #mousemodels #stemcells #epilepsy #synapses #16p11.2 #autism #cortex #DYRK1A #axons #News

Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann

https://www.spectrumnews.org/opinion/q-and-a/calming-neurons-to-quell-seizures-qa-with-gabriele-lignani-and-dimitri-kullmann/

#excitatorysignaling #genetherapy #mousemodels #organoids #epilepsy #autism #QA

Beyond the bench: Finding balance with Gavin Rumbaugh

https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-balance-with-gavin-rumbaugh/

#sensoryperception #neuralcircuits #mousemodels #synapses #autism #QA

The link between maternal infection and autism, explained

https://www.spectrumnews.org/news/the-link-between-maternal-infection-and-autism-explained/

#repetitivebehaviors #maternalinfection #neuralcircuits #neuralnetworks #schizophrenia #animalmodels #epidemiology #immunesystem #environment #mousemodels #microbiome #microglia #pregnancy #COVID-19 #placenta #monkeys #autism #News #ADHD #rats

Multi-omics study captures CNTNAP2’s far-ranging effects

https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/

#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News

Multi-omics study captures CNTNAP2’s far-ranging effects

https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/

#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News

Multi-omics study captures CNTNAP2’s far-ranging effects

https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/

#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News

Shared brain structure, connectivity hint at autism subgroups

https://www.spectrumnews.org/news/shared-brain-structure-connectivity-hint-at-autism-subgroups/

#connectivity #mousemodels #autism #News #fMRI #MRI

New #colitis study from LJI's Kronenberg Lab: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034648/full

The team investigated whether increased expression of two GPRs (GPR183 and GPR18) in the intestine is related to disease severity in colitis models.

#Immunology #Tcells #ImmuneSystem #CellularBiology #MolecularBiology #GPRs #infammation #BowelDisease #Health #MouseModels

Subtyping autism using fMRI: A quick take at SfN with Marco Pagani

https://www.spectrumnews.org/news/subtyping-autism-using-fmri-a-quick-take-at-sfn-with-marco-pagani/

#connectivity #mousemodels #autism #videos #News #fMRI

Autism genes converge on disruptions in social brain circuit

https://www.spectrumnews.org/news/autism-genes-converge-on-disruptions-in-social-brain-circuit/

#excitatorysignaling #inhibitorysignaling #connectivity #mousemodels #autism #News #FMR1 #TSC2

New evidence hints at mechanisms for ‘fever effect’ in autism

https://www.spectrumnews.org/news/new-evidence-hints-at-mechanisms-for-fever-effect-in-autism/

#mousemodels #epilepsy #seizures #autism #SCN2A #News

Autism-linked genes clock daily oscillations

https://www.spectrumnews.org/news/autism-linked-genes-clock-daily-oscillations/

#geneexpression #mousemodels #autism #sleep #News

Mouse studies cast astrocytes as stars of sensory perception

https://www.spectrumnews.org/news/mouse-studies-cast-astrocytes-as-stars-of-sensory-perception/

#inhibitorysignaling #sensoryperception #fragileXsyndrome #geneexpression #mousemodels #astrocytes #seizures #synapses #hearing #autism #touch #News #FMR1 #GABA

Double SHANK knockout highlights brain circuit’s social role

https://www.spectrumnews.org/news/double-shank-knockout-highlights-brain-circuits-social-role/

#repetitivebehaviors #socialdifficulties #mousemodels #striatum #autism #memory #SHANK2 #SHANK3 #News

Double SHANK knockout highlights brain circuit’s social role

https://www.spectrumnews.org/news/double-shank-knockout-highlights-brain-circuits-social-role/

#repetitivebehaviors #socialdifficulties #mousemodels #striatum #autism #memory #SHANK2 #SHANK3 #News

Two-drug combo blunts autism-linked pathway in brain

https://www.spectrumnews.org/news/toolbox/two-drug-combo-blunts-autism-linked-pathway-in-brain/

#tuberoussclerosiscomplex #fragileXsyndrome #mousemodels #Toolbox #autism #PTEN

Gene in autism hotspot regulates neuronal migration

https://www.spectrumnews.org/news/gene-in-autism-hotspot-regulates-neuronal-migration/

#mousemodels #16p11.2 #autism #News

Fragile X neurons develop atypically in chimeric mice

https://www.spectrumnews.org/news/fragile-x-neurons-develop-atypically-in-chimeric-mice/

#fragileXsyndrome #mousemodels #autism #News #FMR1 #FMRP

RNA rewrite improves breathing, survival in Rett mice

https://www.spectrumnews.org/news/rna-rewrite-improves-breathing-survival-in-rett-mice/

#Rettsyndrome #genetherapy #mousemodels #autism #MECP2 #News

Largest-yet fragile X mutation in mice confirms model’s shortcomings

https://www.spectrumnews.org/news/largest-yet-fragile-x-mutation-in-mice-confirms-models-shortcomings/

#fragileXsyndrome #geneexpression #epigenetics #mousemodels #autism #News #FMR1 #FMRP

Lost sleep sparks lasting social problems in SHANK3 mice

https://www.spectrumnews.org/news/lost-sleep-sparks-lasting-social-problems-in-shank3-mice/

#environment #mousemodels #autism #SHANK3 #News

Community Newsletter: Autism gene lists, genetic diversity in mouse models, an autism biomarker

https://www.spectrumnews.org/news/community-newsletter-autism-gene-lists-genetic-diversity-in-mouse-models-an-autism-biomarker/

#faceprocessing #mousemodels #biomarkers #community #autism #News #CHD8 #EEG

In deep water with Gül Dölen

https://www.spectrumnews.org/news/profiles/in-deep-water-with-gul-dolen/

#fragileXsyndrome #mousemodels #evolution #serotonin #Profiles #oxytocin #autism #mGluR5 #FMR1

In deep water with Gül Dölen

https://www.spectrumnews.org/news/profiles/in-deep-water-with-gul-dolen/

#fragileXsyndrome #mousemodels #evolution #serotonin #Profiles #oxytocin #autism #mGluR5 #FMR1

Of mice and human interneurons: A Q&A with Moritz Helmstaedter

https://www.spectrumnews.org/opinion/q-and-a/of-mice-and-human-interneurons-a-qa-with-moritz-helmstaedter/

#inhibitorysignaling #signalingimbalance #neuralcircuits #interneurons #mousemodels #monkeys #autism #cortex #QA

New software flags autism rat model’s telltale squeaks

https://www.spectrumnews.org/news/toolbox/new-software-flags-autism-rat-models-telltale-squeaks/

#vocalization #mousemodels #technology #Toolbox #autism #SHANK3 #rats

Plethora of protein-making machines in neurons may underlie fragile X

https://www.spectrumnews.org/news/plethora-of-protein-making-machines-in-neurons-may-underlie-fragile-x/

#synapticplasticity #fragileXsyndrome #geneexpression #hippocampus #mousemodels #SFARIGene #autism #mGluR5 #News #FMR1 #FMRP

Plethora of protein-making machines in neurons may underlie fragile X

https://www.spectrumnews.org/news/plethora-of-protein-making-machines-in-neurons-may-underlie-fragile-x/

#synapticplasticity #fragileXsyndrome #geneexpression #hippocampus #mousemodels #SFARIGene #autism #mGluR5 #News #FMR1 #FMRP

Portrait of a research field: astrocytes in autism

https://www.spectrumnews.org/features/deep-dive/portrait-of-a-research-field-astrocytes-in-autism/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #fragileXsyndrome #postmortembrains #geneexpression #Rettsyndrome #environment #mousemodels #astrocytes #organoids #DeepDive #seizures #synapses #autism #MECP2 #FMR1 #FMRP #GABA

Mouse study links dopamine in cerebellum to social behavior

https://www.spectrumnews.org/news/mouse-study-links-dopamine-in-cerebellum-to-social-behavior/

#socialdeficits #Purkinjecells #mousemodels #cerebellum #dopamine #autism #News