#interneurons — Public Fediverse posts

Molecular Glue of the Brain: Cell Adhesion Molecules and Synaptic Stability

#Neuroscience #BrainScience #Synapses #NeuronalCircuits #Neuroplasticity #ExcitatoryInhibitoryBalance #DendriticSpines #ExtracellularMatrix #Interneurons #CognitiveHealth #Neurobiology #BrainDevelopment #NeuralConnections #Neuropsychiatry #BrainFunction

https://youtube.com/shorts/dz-Wr8VAww0?feature=share

Ascl1 modified at 6 sites to be phosphorylation-resistant leads to in vivo reprogramming of Astrocytes into PV+ fast-spiking neurons. (Also this is enhanced by co-expressing Bcl2).

Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site–deficient Ascl1
Marichal et al., Science Advances 2024
⁠https://doi.org/10.1126/sciadv.adl5935

#neuroscience #interneurons #reprogramming

Psychedelic drug DOI activates specific brain neurons to ease anxiety https://www.psypost.org/psychedelic-drug-doi-activates-specific-brain-neurons-to-ease-anxiety/?utm_source=dlvr.it&utm_medium=mastodon #PsychedelicDrug #DOI #BrainNeurons #EaseAnxiety #Interneurons

Psychedelic drug DOI activates specific brain neurons to ease anxiety https://www.psypost.org/psychedelic-drug-doi-activates-specific-brain-neurons-to-ease-anxiety/?utm_source=dlvr.it&utm_medium=mastodon #PsychedelicDrug #DOI #BrainNeurons #EaseAnxiety #Interneurons

Psychedelic drug DOI activates specific brain neurons to ease anxiety https://www.psypost.org/psychedelic-drug-doi-activates-specific-brain-neurons-to-ease-anxiety/?utm_source=dlvr.it&utm_medium=mastodon #PsychedelicDrug #DOI #BrainNeurons #EaseAnxiety #Interneurons

thinking about making a set of dlx creOFF AAV constructs a la @JDimidschstein and @sohallab. before i do - has anyone got a stash? initially gfp / chr2 but also likely switch gfp/dtomato too. for some 'NOT x' experiments. would be nice if they already existed! #neuroscience #neuromethods #aav #mouse #interneurons HT @elduvelle for the hashtags!

@DrYohanJohn this is a great reference work I use in class! Does anyone out there have something more recent? That is, are there important revisions to this story that I should be teaching?

Also, should we not just cave and call them #inhibitory cells rather than #interneurons, given the importance of #gaba ergic projection neurons? (Not trolling the developmental people who see gaba excitation).

Tweaks to autism-linked pathway tilt circuits’ signaling balance

https://www.spectrumnews.org/news/tweaks-to-autism-linked-pathway-tilt-circuits-signaling-balance/

#inhibitorysignaling #tuberoussclerosis #neuralcircuits #interneurons #circuits #synapses #autism #News #TSC2

Multi-omics study captures CNTNAP2’s far-ranging effects

https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/

#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News