@PsychedelicInstitute I presume if this stands it will raise the cost of #ketamine therapy for everyone. That would suck.
#ketamine — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ketamine, aggregated by home.social.
-
I mean, it is diplomatic spech but what I got from the #Selenskyj Interview @janboehm @ZDF is:
The thing with Elon #Musk is rather #ketamine … -
i picked a hell of a day for my first session of #ketamine therapy, eh folks?
the medicine is STRONG
the news is to my surprise and delight not a come down
i feel HOPE
-
"Doomsday-Prepping for Trump’s Third Term
Dmitri Mehlhorn has created a fictional world to game out constitutional collapse.
Betting money puts the odds of constitutional collapse in the United States at about one in 25. Anyone can wager three or four cents on Polymarket, Kalshi, or PredictIt that will pay out $1 if Donald Trump wins a third term in the 2028 election—an impossibility, according to the plain text of the Twenty-Second Amendment: 'No person shall be elected to the office of the President more than twice.'
Dmitri Mehlhorn, a former Democratic strategist, thinks that the chance of political apocalypse is about 20 times higher—and that Americans need to start preparing now. He recently secured dual citizenship for his family on the Caribbean island of St. Kitts and is obsessively thinking through how people should respond if Trump tries to maintain power with the threat of force. He styles himself a doomsday philosopher of this worst-case scenario.
On a Tuesday last month, this effort brought him to a co-working space in Manhattan’s SoHo neighborhood to play a war game of sorts with about 15 finance professionals, nonprofit leaders, technology executives, and former Democratic-campaign advisers—and me."
"Ketamine and MDMA treatments are linked to epigenetic changes in genes tied to brain plasticity
Ketamine and MDMA treatment were associated with changes in DNA methylation, a chemical modification that can influence gene activity, at genes linked to neuroplasticity and immune processes, according to a study published in Translational Psychiatry. The changes were measured in blood and saliva samples from people treated for depression or post-traumatic stress disorder.
DNA methylation is a chemical mark that can influence how easily a cell reads certain genes. It does not alter the DNA code itself. Researchers often measure methylation in blood or saliva because those samples are easier to collect than brain tissue. However, a change in blood or saliva does not necessarily mean the same change has occurred in the brain.
Ketamine and MDMA are being studied for mental health conditions, including depression and post-traumatic stress disorder (PTSD). Both are sometimes called psychoplastogens, compounds thought to promote neuroplasticity, the brain’s ability to form and reorganize connections. They act through different mechanisms, and researchers do not yet fully understand how their effects may last beyond the treatment sessions."
"Paramilitary Forces, Concentration Camps, and the Midterms: Timothy Snyder on Fighting Fascism
We are days away from what many consider a very consequential US midterm election in terms of whether the country continues to flirt with fascism. One such person is historian Timothy Snyder, author of many books including *On Freedom*, and *On Tyranny: Twenty Lessons from the Twentieth Century*.
'The role of the people is what’s gonna be decisive,' said historian Timothy Snyder. 'The opposition party has a chance to win a decisive victory in both chambers, and thereby begin systematic changes which could drastically improve the lives of Americans.'
Host Maria Hinojosa speaks with Snyder about the significance of this historic moment, the best and worst case scenarios, and whether it is accurate to call what is happening fascism.
'What we’re doing definitely involves concentration camps. We deport people off the street violently,' said Snyder. 'We have even greater concentration of wealth than we did 10 years ago, and we have a president who runs foreign policy essentially as a matter of who can bribe him the most.'"
-
-
-
DATE: October 29, 2026 at 08:00AM
SOURCE: PSYPOST.ORG** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
-------------------------------------------------TITLE: Ketamine and MDMA treatments are linked to epigenetic changes in genes tied to brain plasticity
Ketamine and MDMA treatment were associated with changes in DNA methylation, a chemical modification that can influence gene activity, at genes linked to neuroplasticity and immune processes, according to a study published in Translational Psychiatry. The changes were measured in blood and saliva samples from people treated for depression or post-traumatic stress disorder.
DNA methylation is a chemical mark that can influence how easily a cell reads certain genes. It does not alter the DNA code itself. Researchers often measure methylation in blood or saliva because those samples are easier to collect than brain tissue. However, a change in blood or saliva does not necessarily mean the same change has occurred in the brain.
Ketamine and MDMA are being studied for mental health conditions, including depression and post-traumatic stress disorder (PTSD). Both are sometimes called psychoplastogens, compounds thought to promote neuroplasticity, the brain’s ability to form and reorganize connections. They act through different mechanisms, and researchers do not yet fully understand how their effects may last beyond the treatment sessions.
Led by Moira G. Semple of Arizona State University, the researchers investigated whether either treatment was associated with methylation changes in genes considered relevant to brain health. Rather than examining the entire genome, they focused on about 2,900 genes that are particularly active in the brain or involved in signaling between nerve cells, an approach intended to make the analysis more manageable in small samples.
The researchers analyzed samples from two separate studies. The ketamine group included 20 people (average age about 40; 15 women) with moderate-to-severe depression, PTSD, or both. They received six ketamine infusions over two to three weeks, with blood samples collected before treatment and 10 days after it ended.
The MDMA group included 16 people (average age about 43; seven women) with severe PTSD who took part in a Phase 3 clinical trial of MDMA-assisted therapy. They received three MDMA doses about four weeks apart alongside psychotherapy, with saliva collected before treatment and six to eight weeks after the final session. Neither analysis included a comparison group that did not receive the drug.
In each group, no individual methylation site changed enough to remain statistically significant after correcting for the large number of sites tested. When the researchers combined results across all the sites within each gene, they identified 405 genes with statistically significant methylation changes after ketamine and 346 after MDMA.
In both groups, the changes clustered in biological pathways related to neuroplasticity, such as the structure and organization of synapses, the points where nerve cells communicate. Some pathways related to immune and stress-response signaling also emerged. Ketamine was associated with changes in genes involved in glutamate signaling, while MDMA was associated with changes in genes such as BDNF, which supports the growth and survival of nerve cells, and a dopamine transporter gene.
The two treatments overlapped only partly at the level of individual genes. Forty-seven genes changed in both groups, but only about a quarter changed in the same direction, and the sizes of the changes were not correlated. The overlap was greater at the level of broader biological pathways, and both treatments were associated with increased methylation of EFNA5, a gene that has been linked to PTSD in large genetic studies.
Some of the patterns also differed. Ketamine changes were more strongly linked to synapse-related pathways, while MDMA changes were associated with a wider range of processes, including the movement of substances across cell membranes and electrical signaling. The authors noted that these differences could reflect the treatments’ distinct effects, but could also be due to differences between the studies, such as the use of psychotherapy with MDMA, the mix of diagnoses in the ketamine group, and the different sample types and collection times.
The authors summarized the shared pattern: “Across both compounds, altered loci [locations in the genome] converged on pathways related to neuroplasticity and neuroimmune regulation.” This is evidence of treatment-associated molecular changes, not proof that these changes explain why either treatment may help patients.
Some limitations should be noted. The groups were small, neither included a comparison group, and the study did not examine whether the methylation changes were related to symptom improvement. The ketamine and MDMA participants were not compared within one trial and differed in diagnosis, treatment context, and whether blood or saliva was tested.
The study also could not show whether the methylation changes affected gene activity, and participants receiving ketamine were allowed to continue most of their medications. Smoking and ethnicity, both of which can affect methylation, were not included in the analysis. Two of the authors are employees of TruDiagnostic, an epigenetic testing company, and nonprofits led by two other authors helped fund the MDMA analyses.
The study, “Brain-targeted epigenetic effects of two emerging psychoplastogens: ketamine & MDMA,” was authored by Moira G. Semple, Sarah E. Mennenga, Ryan Smith, Varun B. Dwaraka, Baruch Rael Cahn, Joseph Tafur, David M. Rabin, Berra Yazar-Klosinski and Candace R. Lewis.
-------------------------------------------------
Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
-------------------------------------------------
#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #Ketamine #MDMA #MentalHealth #Neuroplasticity #Epigenetics #DNA Methylation #Depression #PTSD #PsychedelicTherapy #Psychiatry
-
To me it did seem the scene until early 2000s was slightly more sustainable and Police (at least in the middle class area of SE England I then lived in) weren't even bothering that hard to stop it - they did bust some illegal raves heavily every so often a lot more were allowed to happen, and weren't able to put a lid on the rampant use of #ketamine and other substances nor the entire alternative economy that revolved around those substances (there was relatively little violence or gang activity).
There was also a lot less bigotry and racism until early 2000s (when the paranoia started about Islam), folk genuinely did seem to party together but also knew when to calm down (but maybe there is some survivorship bias, as those who didn't are dead/locked up?)
-
The Pentagon wants ketamine wafers as a battlefield medicine option
The Pentagon wants ketamine wafers. And it seems to want th…
#NewsBeep #News #Medication #AU #ausa-2026 #Australia #circulated-air-force-times #circulated-army-times #circulated-defense-news #circulated-marine-corps-times #circulated-military-times #circulated-navy-times #defense-news #DepartmentofDefense #departmentofhealthandhumanservices #dn-dnr #Drugs #FDA #Health #ketamine #Pentagon #rfk
https://www.newsbeep.com/au/937106/
