#glutamate — Public Fediverse posts

Given the amount of papers reporting NMDA receptors in fruit fly neurons, I am left wondering why we all consider glutamatergic synapses as inhibitory – there's only reports of glutamate-gated chloride channels for sensory systems like the olfactory and visual, but I don't know of any in the central brain where there are many glutamatergic neurons, including mushroom body output neurons (MBONs).

Papers on NMDA in Drosophila:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Drosophila+NMDA&btnG=

#neuroscience #NMDA #Drosophila #glutamate

Given the amount of papers reporting NMDA receptors in fruit fly neurons, I am left wondering why we all consider glutamatergic synapses as inhibitory – there's only reports of glutamate-gated chloride channels for sensory systems like the olfactory and visual, but I don't know of any in the central brain where there are many glutamatergic neurons, including mushroom body output neurons (MBONs).

Papers on NMDA in Drosophila:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Drosophila+NMDA&btnG=

#neuroscience #NMDA #Drosophila #glutamate

To capture this local heterogeneity, the authors developed a #multiphoton #FLIM approach with the Na⁺ indicator ING-2 and #astrocyte labeling, enabling quantitative Na⁺ measurements in individual #astrocytes and their processes. This is important because astrocytic Na⁺ is not just a bulk somatic variable. It varies locally across branches and subdomains, where K⁺ uptake and #glutamate-linked Na⁺ influx are regulated.

#Neuroscience #Imaging

To capture this local heterogeneity, the authors developed a #multiphoton #FLIM approach with the Na⁺ indicator ING-2 and #astrocyte labeling, enabling quantitative Na⁺ measurements in individual #astrocytes and their processes. This is important because astrocytic Na⁺ is not just a bulk somatic variable. It varies locally across branches and subdomains, where K⁺ uptake and #glutamate-linked Na⁺ influx are regulated.

#Neuroscience #Imaging

🧠🎨 New paper by Meyer et al: #astrocytic #sodium #homeostasis is not uniform. Using multiphoton #FLIM in #mouse #brain slices and #invivo, they show strong #cellular and #subcellular heterogeneity in astrocytic Na⁺ levels.

Processes contain more Na⁺ than somata, Na⁺ varies between #astrocyte branches, and distinct Na⁺/K⁺-ATPase subunit patterns help tune local K⁺ uptake and #glutamate-linked Na⁺ influx.

🌍 https://doi.org/10.1038/s41467-026-73435-z

#Neuroscience #Astrocytes #Neurobiology #NeuralDynamics

🧠🎨 New paper by Meyer et al: #astrocytic #sodium #homeostasis is not uniform. Using multiphoton #FLIM in #mouse #brain slices and #invivo, they show strong #cellular and #subcellular heterogeneity in astrocytic Na⁺ levels.

Processes contain more Na⁺ than somata, Na⁺ varies between #astrocyte branches, and distinct Na⁺/K⁺-ATPase subunit patterns help tune local K⁺ uptake and #glutamate-linked Na⁺ influx.

🌍 https://doi.org/10.1038/s41467-026-73435-z

#Neuroscience #Astrocytes #Neurobiology #NeuralDynamics

Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation [2019]
https://pubmed.ncbi.nlm.nih.gov/31733014/

link to full text:
https://repositorio.udd.cl/server/api/core/bitstreams/19b18abc-323a-4be6-9fa9-b084fa5ec1ab/content

~
Female only study ('Adult female rats, Wistar-derived, bred for over 90 generations as alcohol consumers').

#neuroinflammation #glutamate #AlcoholUseDisorder #NAC #aspirin

Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation [2019]
https://pubmed.ncbi.nlm.nih.gov/31733014/

link to full text:
https://repositorio.udd.cl/server/api/core/bitstreams/19b18abc-323a-4be6-9fa9-b084fa5ec1ab/content

~
Female only study ('Adult female rats, Wistar-derived, bred for over 90 generations as alcohol consumers').

#neuroinflammation #glutamate #AlcoholUseDisorder #NAC #aspirin

New findings show that #pancreatictumors form nerve-like “pseudosynapses” where #neurotransmitter #glutamate binds to receptors, triggering calcium waves. The findings reveal a link between neural communication processes and #tumor progression: http://go.tum.de/285549

📷E. Demir

New findings show that #pancreatictumors form nerve-like “pseudosynapses” where #neurotransmitter #glutamate binds to receptors, triggering calcium waves. The findings reveal a link between neural communication processes and #tumor progression: http://go.tum.de/285549

📷E. Demir

GABA/glutamate imbalance is a core feature of Autism. A new review describes how reduced GABA signaling may lead to excessive excitation in key brain circuits. 🧠✨🔍

Read Full Article

#GABA #Glutamate #AutismResearch #Neuroscience #MentalHealth https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1587432/full
Reenviado desde Science News
(https://t.me/experienciainterdimensional/9489)

Overactive Anterior Insula May Fuel Anxiety and Depression

Summary: New research shows that elevated glutamate-glutamine (Glx) levels in the anterior insular cortex (AIC) make people more…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #anteriorinsula #anxiety #brainresearch #depression #glutamate-glutamine #Mentalhealth #neurobiology #Neuroscience #NeuroscienceNews #Psychology
https://www.newsbeep.com/us/17476/

Neurotransmitters and Brain Health: The Science Behind Memory and Mood

#BrainChemistry #Neurotransmitters #Neuroscience #BrainHealth #MentalHealth #Glutamate #Serotonin #Dopamine #BloodBrainBarrier #NeuralCommunication #Neuroplasticity #BrainFunction #Neurobiology #CognitiveScience #MentalWellness

https://youtube.com/shorts/oM4FjZm4FEg?feature=share

"Why Alcohol Hijacks Neurotransmitters & How to Rebalance Them"

by Sarah Rusbatch: https://sarahrusbatch.com/blog/why-alcohol-hijacks-neurotransmitters-how-to-rebalance-them

#serotonin #dopamine #GABA #Glutamate #magnesium #vitamins #neurotransmitters #alcohol #alcoholic #alcoholism #anxiety #balance #sober #sobriety #AA #12steps

"Why Alcohol Hijacks Neurotransmitters & How to Rebalance Them"

by Sarah Rusbatch: https://sarahrusbatch.com/blog/why-alcohol-hijacks-neurotransmitters-how-to-rebalance-them

#serotonin #dopamine #GABA #Glutamate #magnesium #vitamins #neurotransmitters #alcohol #alcoholic #alcoholism #anxiety #balance #sober #sobriety #AA #12steps

How Your Brain Forms Memories: The Role of Long-Term Potentiation

#Neuroscience #BrainPlasticity #Neuroplasticity #LongTermPotentiation #SynapticConnections #Glutamate #Neurotransmitters #CalciumSignaling #GlialCells #CircadianRhythms #BrainHealth #MemoryFormation #Learning #NeuroscienceEducation #BrainScience

https://youtube.com/shorts/wO5cQRaE3RE?feature=share

This is the good stuff!

#cooking #spice #glutamate

Unlocking the Secrets of Brain Chemistry: Glutamate, NAC, and the Power of Our Inner Defenses

#BrainHealth #Neuroscience #MentalHealth #Glutamate #NAC #Glutathione #OxidativeStress #MentalWellness #BrainChemistry #InnerDefense #Neurobiology #HealthInnovation #SelfCare #BiologyIsAmazing

https://youtube.com/shorts/4Rw-owQHqBc?feature=share

Glutamate as an inhibitory neurotransmitter in zebrafish – the insect research community welcomes vertebrates into this mess.

"Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors", Anna Ostenrath et al 2024, from Emre Yaksi's lab.

https://www.biorxiv.org/content/10.1101/2024.09.11.612421v1

#neuroscience #glutamate #zebrafish

Glutamate as an inhibitory neurotransmitter in zebrafish – the insect research community welcomes vertebrates into this mess.

"Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors", Anna Ostenrath et al 2024, from Emre Yaksi's lab.

https://www.biorxiv.org/content/10.1101/2024.09.11.612421v1

#neuroscience #glutamate #zebrafish

Psilocybin desynchronizes the human brain

https://www.nature.com/articles/s41586-024-07624-5

#Psilocybin #Neuroplasticity #BrainConnectivity #Psychedelics #Serotonin #MentalHealth #Therapeutics #fMRI #Neuroscience #FunctionalMapping #Hippocampus #ClinicalTrials #Depression #Addiction #Anxiety #Synaptogenesis #Glutamate #BrainResearch #Cortex #Subcortex #EgoDissolution #SpaceTimePerception #Neurobiology #TherapeuticMechanisms #BrainNetworks #PrecisionMapping #BrainChanges #PsychedelicResearch #BrainFunction

Psilocybin desynchronizes the human brain

https://www.nature.com/articles/s41586-024-07624-5

#Psilocybin #Neuroplasticity #BrainConnectivity #Psychedelics #Serotonin #MentalHealth #Therapeutics #fMRI #Neuroscience #FunctionalMapping #Hippocampus #ClinicalTrials #Depression #Addiction #Anxiety #Synaptogenesis #Glutamate #BrainResearch #Cortex #Subcortex #EgoDissolution #SpaceTimePerception #Neurobiology #TherapeuticMechanisms #BrainNetworks #PrecisionMapping #BrainChanges #PsychedelicResearch #BrainFunction

Caroline Berlage and Benjamin Judkewitz made a very clever multiphoton scanning microscope, SPARCLS. Very excited to be part of this cool project, along with DAAD student Ana Sanchez Moreno and more. #biophysics #microscopy #glutamate

https://www.biorxiv.org/content/10.1101/2024.07.08.602445v1

@kofanchen that's a great idea to teach that the one rule in neuroscience is that all rules get broken sooner or later 😅​

love your masto bio @andrewplested! 😄​ followed for all things #glutamate

More weird stuff with Delta type #glutamate #receptors - GABA binding and a non-iontropic plasticity at inhibitory #synapses from the GluD1 subtype.

https://www.science.org/doi/10.1126/science.adf3406

GYKI inhibition "desensitises" AMPA receptors. Elegant set of structural, functional and computational experiments to investigate a new "state" of #glutamate receptors from Ed Twomey and featuring our collaborator, Albert Lau. #biophysics #IonChannels

https://www.biorxiv.org/content/10.1101/2023.11.28.569057v1.abstract

I wonder if there is a link between my childhood epilepsy and the intrusive thoughts that emerged around the same time. Not necessarily in a brain damage sort of way, but in a neurotransmitter kinda way.

#epilepsy #seizures #glutamate #gaba #dangercardio

Little vesicle animation. No receptors yet.

#synapses #glutamate

In case you are in Paris at the end of the month and interested in #synapses, I shall give a talk about tools and methods for #glutamate imaging at the Vision Institute on 30th June. #neuroscience #optobiology

https://www.institut-vision.org/en/our-seminars/815-seeing-glutamate-at-central-synapses.html

"In light of the known deficiencies in #glutamate and potassium uptake by HD astrocytes, these findings suggest the potential for leakage of excitatory #synaptic contents during neurotransmission, and hence a structural basis for neuronal hyperexcitability in HD. More broadly, our data suggest that astrocytic structural #pathology may causally contribute to those #neurodegenerative disorders associated with central #hyperexcitability."

#asyrocyte #neurodegeneration

https://www.pnas.org/doi/10.1073/pnas.2210719120

@cian I saw that! Thank you! I am glad if that review on #glutamate sensing is useful. As usual, it was a lot of work and nice to know that it's not in vain.

@cian I saw that! Thank you! I am glad if that review on #glutamate sensing is useful. As usual, it was a lot of work and nice to know that it's not in vain.

#Glutamate dehydrogenase1 supports #HIF1α stability to promote #colorectal #tumorigenesis under #hypoxia

An siRNA screen identifies αKG metabolic enzyme #GDH1 as acetylation-dependent control factor for intestinal cancer progression

https://www.embopress.org/doi/10.15252/embj.2022112675

#Glutaminsäure und #Glutamate (E 620–E 625): Gesundheitliche Bewertung der Verwendung als #Lebensmittelzusatzstoffe

➡️ https://www.bfr.bund.de/cm/343/glutaminsaeure-und-glutamate-gesundheitliche-bewertung-der-verwendung-als-lebensmittelzusatzstoffe.pdf

#Glutamat

#Plants #ommunicate #distress using their own kind of #nervoussystem. Model mustard plant uses the same signals as animals to relay distress. Although plant biologists already know that changes to one part of a plant are sensed by the others, they had no idea how that information was transmitted. Now that they have seen the #calcium wave and the role of #glutamate, researchers can better monitor and—perhaps one day even manipulate—the plant's #internalcommunications.https://www.science.org/content/article/plants-communicate-distress-using-their-own-kind-nervous-system