#innateimmune — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #innateimmune, aggregated by home.social.
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Innate immune signaling and #cancer: This study shows that the tissue-protective functions of Toll-mediated #InnateImmune signaling can be misused by premalignant cells in #Drosophila to induce overgrowth in early stages of #tumor development @PLOSBiology https://plos.io/4jqpmUh
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#ProteinQC pathways play key roles in resistance to #pathogens. @manishgrover_4 @barkoulab &co show that #proteasome regulation keeps #InnateImmune responses against natural pathogens of #Celegans in check in a tissue-specific manner #PLOSBiology https://plos.io/3PhIjLW
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How did our #InnateImmune systems first evolve? Ed Culbertson & @tera_levin reveal origins of three families of #antiviral proteins: CD-NTases (incl #cGAS), STINGs & #Viperins; each reveals a different story connecting animal & bacterial immunity #PLOSBiology https://plos.io/46SfBqM
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The #GPCR CMKLR1 responds to the #adipokine #chemerin and is abundant in #InnateImmune cells. Structure of CMKLR1 in complex with #Gprotein and a peptide agonist (+ mutagenesis & simulations) reveals mechanisms of action #PLOSBiology https://plos.io/4a6Igvd
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Seung Kim, Frederick Dick et al show that resting #Bcells are uniquely sensitive to #EZH2 #polycomb complex inhibition, which activates expression of repetitive genomic elements and subsequent #innateimmune receptor signaling in a form of viral mimicry
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MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to #autoimmunity
Pathology of primary Sjögren's syndrome is known to involve #interferons, but Enrique Martin-Gayo et al @UAM_Medicina show additional roles also for #innateimmune cells like natural killer and #dendritic cells
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The past 20 years have revealed several new #InnateImmune sensing & #CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential #PLOSBiology https://plos.io/40O9xxQ
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The past 20 years have revealed several new #InnateImmune sensing & #CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential #PLOSBiology https://plos.io/40O9xxQ
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The past 20 years have revealed several new #InnateImmune sensing & #CellDeath pathways with disease relevance. @RebeccaTweedell @KannegantiLab look back at the impact of these discoveries & forwards toward their future therapeutic potential #PLOSBiology https://plos.io/40O9xxQ