#gabaergic — Public Fediverse posts

Diversity of somatostatin #GABAergic inhibitory interneurons. Study compares anatomical & physiological properties of 2 subtypes of #somatostatin #interneuron, finding key differences that may underlie their functionalities #PLOSBiology https://plos.io/3wRTXXD

Diversity of somatostatin #GABAergic inhibitory interneurons. Study compares anatomical & physiological properties of 2 subtypes of #somatostatin #interneuron, finding key differences that may underlie their functionalities #PLOSBiology https://plos.io/3wRTXXD

Diversity of somatostatin #GABAergic inhibitory interneurons. Study compares anatomical & physiological properties of 2 subtypes of #somatostatin #interneuron, finding key differences that may underlie their functionalities #PLOSBiology https://plos.io/3wRTXXD

Diversity of somatostatin #GABAergic inhibitory interneurons. Study compares anatomical & physiological properties of 2 subtypes of #somatostatin #interneuron, finding key differences that may underlie their functionalities #PLOSBiology https://plos.io/3wRTXXD

Diversity of somatostatin #GABAergic inhibitory interneurons. Study compares anatomical & physiological properties of 2 subtypes of #somatostatin #interneuron, finding key differences that may underlie their functionalities #PLOSBiology https://plos.io/3wRTXXD

Cool new #PNN paper: PNNs regulate excitatory input on PV+ cells (in NAc at least):

The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors
Hazlett et al., Biological Psychiatry 2024
https://doi.org/10.1016/j.biopsych.2024.02.003

#neuroscience #parvalbumin #GABAergic

GABAARs: not just inhibitory? This study of striatal spiny projection #neurons shows that #GABA is a state-dependent #neurotransmitter, and not simply an inhibitory one, suggesting a revision of the role of intrastriatal #GABAergic signaling #PLOSBiology https://plos.io/3SGKafq

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

A network of #plasticity mechanisms: subcortical microstructural (#myelination) plasticity & cortical neurochemical (#GABAergic) plasticity interact via #thalamocortical connectivity to support optimized perceptual decisions @CambridgeABL #PLOSBiology https://plos.io/3YHNvdR

A network of #plasticity mechanisms: subcortical microstructural (#myelination) plasticity & cortical neurochemical (#GABAergic) plasticity interact via #thalamocortical connectivity to support optimized perceptual decisions @CambridgeABL #PLOSBiology https://plos.io/3YHNvdR

A network of #plasticity mechanisms: subcortical microstructural (#myelination) plasticity & cortical neurochemical (#GABAergic) plasticity interact via #thalamocortical connectivity to support optimized perceptual decisions @CambridgeABL #PLOSBiology https://plos.io/3YHNvdR

Info from #somatosensory nerves can be actively modified at the #DorsalRootGanglion. This study reveals the existence of tonic & dynamic #GABAergic filtering of action potentials traveling through the #DRG; implications for #PainRelief #PLOSBiology https://plos.io/3VSJFNo

Info from #somatosensory nerves can be actively modified at the #DorsalRootGanglion. This study reveals the existence of tonic & dynamic #GABAergic filtering of action potentials traveling through the #DRG; implications for #PainRelief #PLOSBiology https://plos.io/3VSJFNo

Info from #somatosensory nerves can be actively modified at the #DorsalRootGanglion. This study reveals the existence of tonic & dynamic #GABAergic filtering of action potentials traveling through the #DRG; implications for #PainRelief #PLOSBiology https://plos.io/3VSJFNo

#introduction
I'm a #neuroscientist at #Oxford and my group investigates neural circuits relating to spatial #memory, especially in the #thalamus.
Previous research includes defining #GABAergic #neurons in the #hippocampus and medial septum by recording and labelling them in vivo.
We also want to understand the earliest changes in the human #brain that lead to the build up of pathological #Tau proteins, which correlate with #cognitive decline.
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