#dnarepair — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #dnarepair, aggregated by home.social.
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FANCM (PDB: 5V5X) — DEAD-box ATPase geometry (K1175/Mg²⁺) drives replication fork reversal at interstrand crosslinks, not classical duplex unwinding. Helicase–DNA interface: residues 1290–1297.
Fork reversal fidelity declines with age. FANCM's structural landscape is an underexplored target in replication stress and genomic aging.
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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WRN helicase (PDB: 2QZ2) — Walker A/B and Sensor 1 motifs coordinate ADP–Mg²⁺ in the post-hydrolysis state. C-terminal tail (L514) couples helicase and exonuclease activities.
WRN loss → Werner syndrome + simultaneous acceleration of telomere attrition, epigenetic dysregulation, and stem cell exhaustion. A structural window into multi-hallmark aging.
#WRN #WernerSyndrome #StructuralBiology #LongevityBiology #DNARepair #Biogerontology #AgingHallmarks
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PARP1 (PDB: 4DQY) — catalytic core resolves NAD⁺ positioning (H133/E134/Mg²⁺) and substrate interface (326–332) as structurally separable sites. E134 as the ADP-ribose acceptor base.
Age-associated DNA damage → PARP1 hyperactivation → NAD⁺ depletion → SIRT1/3 inactivation → mitochondrial dysfunction. A structurally grounded feedforward loop in biological aging.
#PARP1 #NAD #StructuralBiology #LongevityBiology #Aging #DNARepair #Biogerontology #Sirtuins
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https://www.europesays.com/ie/453381/ A Protein Found In Whales Could Help Humans Live Up To 200 Years: Study #AgingResearch #AntiAging #BowheadWhale #CancerResistance #CirbpProtein #DNARepair #Éire #HumanLongevity #IE #Ireland #Science #Wildlife
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https://www.europesays.com/ie/391260/ Whale protein discovery may unlock human lifespans of 200 years, scientists say #AntiAgingProtein #BowheadWhale #CancerPrevention #CirbpProtein #ColdTherapyAging #DnaMutation #DNARepair #Éire #HumanLifespan #HumanLongevityScience #IE #Ireland #LongevityResearch #NatureStudyAging #Science #WhaleProtein
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Greenland sharks maintain vision for centuries through DNA repair mechanism
https://phys.org/news/2026-01-eye-greenland-sharks-vision-centuries.html
#HackerNews #GreenlandSharks #DNARepair #VisionCenturies #MarineBiology #OceanConservation
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Bowhead Whales' 200-Year Lifespan Secret https://techlife.blog/posts/bowhead-whales-can-live-for-more-than-200-years/ #DNArepair #bowheadwhale #ageing #science
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Live long and prosper: Chinese scientists find age-well protein in naked mole-rats
The remarkable longevity and disease resistance of naked mole rats are linked to a version of a protein…
#UnitedStates #US #USA #ageing #america #cancer #CentralSouthUniversity #cGAS #ChineseAcademyofSciences #DNArepair #Fruitflies #FudanUniversity #humans #Lifespan #mice #Nakedmolerats #science #shanghai #technology #tongjiuniversity #unitedstatesofamerica
https://www.europesays.com/2507621/ -
Naked mole rats are resistant to cancer, deterioration of the brain and spinal cord, and arthritis.
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🧬 Can controlling PARP1 turn CRISPR from a gene scissor into a gene sculptor?
🔗 Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.001
📚 CSBJ: https://www.csbj.org/
#CRISPR #GenomeEditing #Genomics #DNARepair #PARP1 #GeneticEngineering #MolecularBiology #GeneTherapy #CellBiology #SyntheticBiology #TherapeuticEditing
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Scientists Are Using AI for Improved Gene Hacking
Gene editing has made huge leaps in recent years, such as treating the congenital blood disorders sickle cell…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #blooddisorders #bloodtransfusions #DNArepair #Geneediting #Pythia #Science #sicklecellanemia #UniversityofZurich
https://www.newsbeep.com/us/89200/ -
Scientists Are Using AI for Improved Gene Hacking
Gene editing has made huge leaps in recent years, such as treating the congenital blood disorders sickle cell…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #blooddisorders #bloodtransfusions #DNArepair #Geneediting #Pythia #Science #sicklecellanemia #UniversityofZurich
https://www.newsbeep.com/us/89200/ -
DNA Methylation and Hydroxymethylation: The Molecular Switches of Gene Expression
#DNA #Epigenetics #GeneRegulation #Methylation #Hydroxymethylation #TET enzymes #DNARepair #Neuroscience #BrainHealth #Genetics #Cognition #Biology #MolecularBiology #GeneticResearch #NeuralPlasticity
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From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
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From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
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From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
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From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
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From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
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Two newly discovered “off switches” in our cells could help create smarter cancer treatments. Here’s how they control DNA repair at the molecular level. #DNArepair #CancerResearch #Biotech
https://geekoo.news/cracking-the-code-how-cells-know-when-to-stop-repairing-dna/
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The Summit supercomputer simulated how the nucleotide excision repair pathway identifies & corrects damaged DNA strands. This enhances our understanding of their implications for genetic diseases! #DNArepair #supercomputing #genetics #research interestingengineering.com/science/us-s...
US supercomputer's 200,000 tri... -
A groundbreaking discovery by researchers reveals a newly identified protein that effectively halts DNA damage! This exciting advancement could pave the way for innovative cancer vaccines and drought-resistant crops. 🌱💉 Stay tuned for more updates on this transformative research! #Science #Innovation #CancerResearch #SustainableAgriculture #DNARepair
Bckp.:
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@Tooden Um... Not a good example... (Despite what the media and tourism wants you to think.)
Genetic and ecological studies of animals in #Chernobyl and #Fukushima
by Timothy A Mousseau, Anders P Møller
2014 Sep-Oct
"Recent advances in genetic and ecological studies of wild animal populations in Chernobyl and Fukushima have demonstrated significant genetic, physiological, developmental, and fitness effects stemming from exposure to #radioactive contaminants. The few genetic studies that have been conducted in Chernobyl generally show elevated rates of #GeneticDamage and #Mutation rates. All major taxonomic groups investigated (i.e., #birds, #bees, #butterflies, #grasshoppers, #dragonflies, #spiders, #mammals) displayed reduced population sizes in highly radioactive parts of the #ChernobylExclusionZone. In #Fukushima, population censuses of birds, butterflies, and #cicadas suggested that abundances were negatively impacted by exposure to radioactive contaminants, while other groups (e.g., dragonflies, grasshoppers, bees, spiders) showed no significant declines, at least during the first summer following the disaster.
"Insufficient information exists for groups other than insects and birds to assess effects on life history at this time. The differences observed between Fukushima and Chernobyl may reflect the different times of exposure and the significance of multigenerational mutation accumulation in Chernobyl compared to Fukushima. There was considerable variation among taxa in their apparent sensitivity to radiation and this reflects in part life history, physiology, behavior, and evolutionary history. Interestingly, for birds, population declines in Chernobyl can be predicted by historical mitochondrial #DNA base-pair substitution rates that may reflect intrinsic #DNARepair ability."
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#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability -
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability -
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability -
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability -
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability -
#ERCAdvancedGrant for Helle Ulrich of @imbmainz and @unimainz_eng: @ERC_Research grants funding worth EUR 2.5 mio. for research on #DNArepair and #GenomeStability // #LifeSciences #GenomeRegulation #ubiquitin #DNAdamage #ubiquitylation
https://nachrichten.idw-online.de/2024/06/28/erc-advanced-grant-for-helle-ulrich-for-research-on-dna-repair-and-genome-stability -
Genetic diseases: How scientists are working to make DNA repair (almost) a piece of cake
#Health #Science #DNA #Genetics #Genome #CAS9 #CRISPR #Proteins #GeneticDiseases #DNARepair #PrimeEditing #Mutations #MedicalResearch #ProteinDelivery #GeneticResearch
https://the-14.com/genetic-diseases-how-scientists-are-working-to-make-dna-repair-almost-a-piece-of-cake/ -
Genetic diseases: How scientists are working to make DNA repair (almost) a piece of cake
#Health #Science #DNA #Genetics #Genome #CAS9 #CRISPR #Proteins #GeneticDiseases #DNARepair #PrimeEditing #Mutations #MedicalResearch #ProteinDelivery #GeneticResearch
https://the-14.com/genetic-diseases-how-scientists-are-working-to-make-dna-repair-almost-a-piece-of-cake/ -
Genetic diseases: How scientists are working to make DNA repair (almost) a piece of cake
#Health #Science #DNA #Genetics #Genome #CAS9 #CRISPR #Proteins #GeneticDiseases #DNARepair #PrimeEditing #Mutations #MedicalResearch #ProteinDelivery #GeneticResearch
https://the-14.com/genetic-diseases-how-scientists-are-working-to-make-dna-repair-almost-a-piece-of-cake/ -
Genetic diseases: How scientists are working to make DNA repair (almost) a piece of cake
#Health #Science #DNA #Genetics #Genome #CAS9 #CRISPR #Proteins #GeneticDiseases #DNARepair #PrimeEditing #Mutations #MedicalResearch #ProteinDelivery #GeneticResearch
https://the-14.com/genetic-diseases-how-scientists-are-working-to-make-dna-repair-almost-a-piece-of-cake/ -
Genetic diseases: How scientists are working to make DNA repair (almost) a piece of cake
#Health #Science #DNA #Genetics #Genome #CAS9 #CRISPR #Proteins #GeneticDiseases #DNARepair #PrimeEditing #Mutations #MedicalResearch #ProteinDelivery #GeneticResearch
https://the-14.com/genetic-diseases-how-scientists-are-working-to-make-dna-repair-almost-a-piece-of-cake/ -
EXO1-mediated #DNArepair by single-strand annealing is essential for BRCA1-deficient cells, new study finds.
Preprint evaluated by Jennifer Ann Black for @preLights.
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Postdoctoral Fellow
Memorial Sloan Kettering Cancer Center
The Powell Lab at Memorial Sloan Kettering Cancer Center is seeking enthusiastic postdoctoral scientists #NYC #DNARepair
See the full job description on jobRxiv: https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-fellow/?feed_id=62436
#ScienceJobs #hiring #research
New York #UnitedStatesUS #Post...
https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-fellow/?feed_id=62436 -
Postdoctoral Fellow
Memorial Sloan Kettering Cancer Center
The Powell Lab at Memorial Sloan Kettering Cancer Center is seeking enthusiastic postdoctoral scientists #NYC #DNARepair
See the full job description on jobRxiv: https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-fellow/?feed_id=59882
#ScienceJobs #hiring #research
New York #UnitedStatesUS #Post...
https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-fellow/?feed_id=59882 -
Postdoctoral Fellow
Memorial Sloan Kettering Cancer Center
The Powell Lab at Memorial Sloan Kettering Cancer Center is seeking enthusiastic postdoctoral scientists #NYC #DNARepair
See the full job description on jobRxiv: https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-fellow/?feed_id=58742
#ScienceJobs #hiring #research
New York #UnitedStatesUS #Postd...
https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-fellow/?feed_id=58742 -
In an unexpected twist, Zhang et al. reveal that in #Maize, FIGL1 coordinates with dosage-sensitive #BRCA2 in modulating #meiotic #recombination, unlike their antagonistic relationship in #Arabidopsis.
https://doi.org/10.1111/jipb.13541
@wileyplantsci
#PlantSci #evolution #DNArepair #JIPB #plantscience -
In an unexpected twist, Zhang et al. reveal that in #Maize, FIGL1 coordinates with dosage-sensitive #BRCA2 in modulating #meiotic #recombination, unlike their antagonistic relationship in #Arabidopsis.
https://doi.org/10.1111/jipb.13541
@wileyplantsci
#PlantSci #evolution #DNArepair #JIPB #plantscience -
In an unexpected twist, Zhang et al. reveal that in #Maize, FIGL1 coordinates with dosage-sensitive #BRCA2 in modulating #meiotic #recombination, unlike their antagonistic relationship in #Arabidopsis.
https://doi.org/10.1111/jipb.13541
@wileyplantsci
#PlantSci #evolution #DNArepair #JIPB #plantscience -
In an unexpected twist, Zhang et al. reveal that in #Maize, FIGL1 coordinates with dosage-sensitive #BRCA2 in modulating #meiotic #recombination, unlike their antagonistic relationship in #Arabidopsis.
https://doi.org/10.1111/jipb.13541
@wileyplantsci
#PlantSci #evolution #DNArepair #JIPB #plantscience -
Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565 -
Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565 -
Extensive multivalent interactions between intrinsically disordered regions in the #BRCA1/#BARD1 #E3 #ligase and #nucleosome substrates facilitate #chromatin recruitment and contribute to histone H2A #ubiquitylation and #DNArepair
Sam Witus, Rachel Klevit, Weixing Zhao et al
https://www.embopress.org/doi/10.15252/embj.2023113565