#genomeinstability — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #genomeinstability, aggregated by home.social.
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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Join us at Social DNAing later today to hear more about telomere biology and genome instability : http://cancer.columbia.edu/dna-webinar
#Telomere #GenomeInstability #Cancer @academicchatter -
Two #RNA biogenesis pathways prevent #GenomeInstability by different mechanisms; @_becca_brown @xiaofengsu @CatherineFreud2 &co show that THO complex prevents #RNApolymerase stalling; TRAMP4-exosome prevents RPA sequestration & chrom fragility #PLOSBiology https://plos.io/3vB4pi9
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Two #RNA biogenesis pathways prevent #GenomeInstability by different mechanisms; @_becca_brown @xiaofengsu @CatherineFreud2 &co show that THO complex prevents #RNApolymerase stalling; TRAMP4-exosome prevents RPA sequestration & chrom fragility #PLOSBiology https://plos.io/3vB4pi9
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Two #RNA biogenesis pathways prevent #GenomeInstability by different mechanisms; @_becca_brown @xiaofengsu @CatherineFreud2 &co show that THO complex prevents #RNApolymerase stalling; TRAMP4-exosome prevents RPA sequestration & chrom fragility #PLOSBiology https://plos.io/3vB4pi9