#eccdna — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #eccdna, aggregated by home.social.
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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A comprehensive atlas of full-length Arabidopsis eccDNA populations identifies their genomic origins and epigenetic regulation.
#ExtrachromosomalCircularDNA #eccDNA #Transposons #Arabidopsis #MethylationMutants #LongReadSequencing
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003275
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Previous studies of extrachromosomal circular DNA #eccDNA in #plants are based on short-read seq. @vanderschuren-lab.bsky.social uses long-read seq to obtain a map of full-length eccDNAs from #Arabidopsis, identifying their genomic origins & epigenetic regulation @PLOSBiology plos.io/44Mq3RI