#replicationstress — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #replicationstress, aggregated by home.social.
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🧬 New publication from the lab! 🎉
Timeless and mitochondria! 🧬⚡
Kalisse Horne, a PhD student, started this as a side project, and it grew into a full research project!
Many students in the lab, including Havya, Shriya, and Rhea, also contributed to this work, together with Chiaki Noguchi, Dr. Christian Sell, and Dr. Josh Mell 😊
Great teamwork! 👏🔬https://www.mdpi.com/2218-273X/16/8/1177
#Timeless #Mitochondria #GenomeIntegrity #ReplicationStress #GraduateSchool #BiomedicalScience #Publication
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🧬 New publication from the lab! 🎉
Timeless and mitochondria! 🧬⚡
Kalisse Horne, a PhD student, started this as a side project, and it grew into a full research project!
Many students in the lab, including Havya, Shriya, and Rhea, also contributed to this work, together with Chiaki Noguchi, Dr. Christian Sell, and Dr. Josh Mell 😊
Great teamwork! 👏🔬https://www.mdpi.com/2218-273X/16/8/1177
#Timeless #Mitochondria #GenomeIntegrity #ReplicationStress #GraduateSchool #BiomedicalScience #Publication
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FANCM (PDB: 5V5X) — DEAD-box ATPase geometry (K1175/Mg²⁺) drives replication fork reversal at interstrand crosslinks, not classical duplex unwinding. Helicase–DNA interface: residues 1290–1297.
Fork reversal fidelity declines with age. FANCM's structural landscape is an underexplored target in replication stress and genomic aging.
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress