#ecdna — Public Fediverse posts on home.social

Lab Doksani @[email protected] · 2026-04-30 · 15:21 UTC

Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

#eccdna #ecdna #cancerresearch #genomeinstability #dnarepair #replicationstress

Lab Doksani @[email protected] · 2026-04-30 · 15:21 UTC

Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

#replicationstress #dnarepair #genomeinstability #cancerresearch #ecdna #eccdna

Lab Doksani @[email protected] · 2026-04-30 · 15:21 UTC

Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

#eccdna #ecdna #cancerresearch #genomeinstability #dnarepair #replicationstress

Lab Doksani @[email protected] · 2026-04-30 · 15:20 UTC

How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

#eccdna #ecdna #cancerresearch #genomeinstability #dnarepair #replicationstress

Lab Doksani @[email protected] · 2026-04-30 · 15:20 UTC

How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

#replicationstress #dnarepair #genomeinstability #cancerresearch #ecdna #eccdna

Lab Doksani @[email protected] · 2026-04-30 · 15:20 UTC

How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38

#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress

#eccdna #ecdna #cancerresearch #genomeinstability #dnarepair #replicationstress

Amelia Cervera 🧬 @[email protected] · 2025-05-18 · 21:56 UTC

Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA.

#Transposons #Retrotransposons #ExtrachromosomalCircularDNA #ecDNA #Spermatogenesis #Drosophila #Preprint

https://www.biorxiv.org/content/10.1101/2025.05.11.653319v1

#transposons #retrotransposons #extrachromosomalcirculardna #ecdna #spermatogenesis #drosophila

Amelia Cervera 🧬 @[email protected] · 2025-05-18 · 21:56 UTC

Safeguarding spermatogenesis from retrotransposon insertions by forming ecDNA.

#Transposons #Retrotransposons #ExtrachromosomalCircularDNA #ecDNA #Spermatogenesis #Drosophila #Preprint

https://www.biorxiv.org/content/10.1101/2025.05.11.653319v1

#preprint #drosophila #spermatogenesis #ecdna #extrachromosomalcirculardna #retrotransposons

Auscandoc @[email protected] · 2024-11-10 · 22:29 UTC

The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials. https://mastodon.social/@ScienceScholar/113461015147098700

#ecdna #cancers

Auscandoc @[email protected] · 2024-11-10 · 22:29 UTC

The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials. https://mastodon.social/@ScienceScholar/113461015147098700

#ecdna #cancers

Auscandoc @[email protected] · 2024-11-10 · 22:29 UTC

The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials. https://mastodon.social/@ScienceScholar/113461015147098700

#ecdna #cancers

Auscandoc @[email protected] · 2024-11-10 · 22:29 UTC

The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials. https://mastodon.social/@ScienceScholar/113461015147098700

#cancers #ecdna

Auscandoc @[email protected] · 2024-11-10 · 22:29 UTC

The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials. https://mastodon.social/@ScienceScholar/113461015147098700

#ecdna #cancers

Jochen Fromm @[email protected] · 2024-02-27 · 15:36 UTC

Extrachromosomal #DNA in form of tiny DNA circles could be key drivers of #cancer. It looks strangely similar to the DNA of most bacteria which is contained in single circular molecules, the bacterial chromosome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338009/

This recent paper is unfortunately behind a paywall. It is named "Extrachromosomal DNA in cancer"
https://www.nature.com/articles/s41568-024-00669-8

This article is a bit more accessible. After stem cells #ecDNA is the new hope of cancer researchers
https://www.the-scientist.com/cancer-may-be-driven-by-dna-outside-of-chromosomes-68590

#dna #cancer #ecdna

Jochen Fromm @[email protected] · 2024-02-27 · 15:36 UTC

Extrachromosomal #DNA in form of tiny DNA circles could be key drivers of #cancer. It looks strangely similar to the DNA of most bacteria which is contained in single circular molecules, the bacterial chromosome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338009/

This recent paper is unfortunately behind a paywall. It is named "Extrachromosomal DNA in cancer"
https://www.nature.com/articles/s41568-024-00669-8

This article is a bit more accessible. After stem cells #ecDNA is the new hope of cancer researchers
https://www.the-scientist.com/cancer-may-be-driven-by-dna-outside-of-chromosomes-68590

#dna #cancer #ecdna

Jochen Fromm @[email protected] · 2024-02-27 · 15:36 UTC

Extrachromosomal #DNA in form of tiny DNA circles could be key drivers of #cancer. It looks strangely similar to the DNA of most bacteria which is contained in single circular molecules, the bacterial chromosome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338009/

This recent paper is unfortunately behind a paywall. It is named "Extrachromosomal DNA in cancer"
https://www.nature.com/articles/s41568-024-00669-8

This article is a bit more accessible. After stem cells #ecDNA is the new hope of cancer researchers
https://www.the-scientist.com/cancer-may-be-driven-by-dna-outside-of-chromosomes-68590

#ecdna #cancer #dna

Jochen Fromm @[email protected] · 2024-02-27 · 15:36 UTC

Extrachromosomal #DNA in form of tiny DNA circles could be key drivers of #cancer. It looks strangely similar to the DNA of most bacteria which is contained in single circular molecules, the bacterial chromosome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338009/

This recent paper is unfortunately behind a paywall. It is named "Extrachromosomal DNA in cancer"
https://www.nature.com/articles/s41568-024-00669-8

This article is a bit more accessible. After stem cells #ecDNA is the new hope of cancer researchers
https://www.the-scientist.com/cancer-may-be-driven-by-dna-outside-of-chromosomes-68590

#dna #cancer #ecdna