#ecdna — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ecdna, aggregated by home.social.
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Thrilled to see our work featured on the cover of Molecular Cell.
The image: an electron micrograph of an i-loop, the DNA structure we propose as a source of eccDNA formation. Almost like catching circular DNA formation in the act.
#MolecularCell #eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair @MolecularCell
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Huge congratulations to @EZ_eta for leading the experimental work, and a big thank you to our collaborators at IIT for their Nanopore expertise, as well as to Michele Giannattasio head of the EM on Single Molecules Facility for his contribution to the structural analysis.
#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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How do cancer-associated extrachromosomal circular DNAs arise?
In our new manuscript, we show that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer.
https://authors.elsevier.com/a/1n0wG3vVUPZO38#eccDNA #ecDNA #CancerResearch #GenomeInstability #DNARepair #ReplicationStress
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The papers, published simultaneously in Nature on Nov. 6, detail the prevalence and prognostic impact of the circles, called #ecDNA for extrachromosomal DNA, in nearly 15,000 human #cancers; highlight a novel mode of inheritance that overthrows a fundamental law of genetics; and describe an anti-cancer therapy targeting the circles that is already in clinical trials. https://mastodon.social/@ScienceScholar/113461015147098700
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Postdoc Position in Cancer Extrachromosomal DNA Biology, Sihan Wu Lab @CRI_UTSW
A postdoc position is available in Sihan Wu lab. We study ecDNA in cancer. #postdoc #cancer #genomics #genetics #ecDNA
#ScienceJobs #job #post...
https://jobrxiv.org/job/university-of-texas-southwestern-medical-center-27778-postdoc-position-in-cancer-extrachromosomal-dna-biology-sihan-wu-lab/?feed_id=43200 -
Postdoc Position in Cancer Extrachromosomal DNA Biology, Sihan Wu Lab @CRI_UTSW
A postdoc position is available in Sihan Wu lab. We study ecDNA in cancer. #postdoc #cancer #genomics #genetics #ecDNA
#ScienceJobs #job #post...
https://jobrxiv.org/job/university-of-texas-southwestern-medical-center-27778-postdoc-position-in-cancer-extrachromosomal-dna-biology-sihan-wu-lab/?feed_id=41298 -
‘Bond villain’ #DNA could transform #cancer treatment, scientists say - https://www.theguardian.com/science/2023/feb/18/bond-villain-dna-could-transform-cancer-treatment-scientists-say #ecDNA #health