#recombination — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #recombination, aggregated by home.social.
-
#Recombination suppression leads to genomic erosion via accumulation of deleterious #mutations. This Primer explores a @PLOSBiology study that reveals an massive increase in aberrant #splicing in non-recombining genomic regions in green #algae. Paper: https://plos.io/44vbDFI Primer: https://plos.io/4f6pIQ2
-
#Recombination suppression leads to genomic erosion via accumulation of deleterious #mutations. This Primer explores a @PLOSBiology study that reveals an massive increase in aberrant #splicing in non-recombining genomic regions in green #algae. Paper: https://plos.io/44vbDFI Primer: https://plos.io/4f6pIQ2
-
#Splicing dysfunction may represent a cryptic form of #genome erosion. This study shows that intron retention freq is much higher in #recombination -suppressed #MatingType regions in 4 #phytoplankton species, producing aberrant transcripts & functional decay @PLOSBiology https://plos.io/44vbDFI
-
#Splicing dysfunction may represent a cryptic form of #genome erosion. This study shows that intron retention freq is much higher in #recombination -suppressed #MatingType regions in 4 #phytoplankton species, producing aberrant transcripts & functional decay @PLOSBiology https://plos.io/44vbDFI
-
📣🧬 Postdoc Alert🧬📣
We are hiring a 2+ year NERC-funded postdoc at Edinburgh Uni investigating causes and consequences of sex differences in recombination in house sparrows in Norway. Informal enquiries welcome at [email protected] 🙂
Details here: https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/14307?utm_medium=jobshare
#meiosis4eva #genomics #recombination #postdoc -
📣🧬 Postdoc Alert🧬📣
We are hiring a 2+ year NERC-funded postdoc at Edinburgh Uni investigating causes and consequences of sex differences in recombination in house sparrows in Norway. Informal enquiries welcome at [email protected] 🙂
Details here: https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/14307?utm_medium=jobshare
#meiosis4eva #genomics #recombination #postdoc -
When rapid environmental change creates fitness valleys, recombination plays an ambiguous role. Wirtz et al. investigate how swift population recovery is possible, and interpret chromosomal fusions in this context.
Read now ahead of print!
https://www.journals.uchicago.edu/doi/10.1086/738517 -
When rapid environmental change creates fitness valleys, recombination plays an ambiguous role. Wirtz et al. investigate how swift population recovery is possible, and interpret chromosomal fusions in this context.
Read now ahead of print!
https://www.journals.uchicago.edu/doi/10.1086/738517 -
Local and introduced #lineages drive #MERS-CoV #recombination in Egyptian #camels, https://etidiohnew.blogspot.com/2025/12/local-and-introduced-lineages-drive.html
-
Local and introduced #lineages drive #MERS-CoV #recombination in Egyptian #camels, https://etidiohnew.blogspot.com/2025/12/local-and-introduced-lineages-drive.html
-
Came across this gem in my bookmarks...
No Sex Needed: All-Female #Lizard Species Cross Their Chromosomes to Make Babies
These southwestern lizards' asexual reproduction is no longer a secret
By Katherine Harmon
February 21, 2010"Since the 1960s scientists have known that some species of #WhiptailLizards need a male even less than a fish needs a bicycle. These all-lady lizard species (of the Aspidoscelis genus) from Mexico and the U.S. Southwest manage to produce well-bred offspring without the aid of male fertilization.
"But how do they—and the other 70 species of vertebrates that propagate this way—do it without the genetic monotony and disease vulnerability that often results from asexual reproduction? 'It has remained unclear' and 'has been the topic of much speculation,' report a team of researchers who aimed to answer just that question. Their results were published online February 21 in the journal Nature. (Scientific American is part of Nature Publishing Group.)
"These lizards and other '#parthenogenetic species are genetically isolated,' explains Peter Baumann, an associate investigator at the Stowers Institute for Medical Research in Kansas City, Mo., and co-author of the study. Species as diverse as #KomodoDragons and #HammerheadSharks do it asexually if necessary, but some species, like these little lizards, don't have a choice. 'They can't exchange genetic material, and this loss of genetic exchange is a major disadvantage to them in a changing environment,' he says. Unless an animal can recombine the DNA they already have, they will produce an offspring with an identical set of chromosomes, in which any genetic weakness, such as disease susceptibility or physical mutation, would have no chance to be overridden by outside genetic material from a mate.
"The new research by Baumann and his team reveal that these lizards maintain genetic richness by starting the reproductive process with twice the number of chromosomes as their sexually reproducing cousins. These celibate species resulted from the hybridization of different sexual species, a process that instills the parthenogenetic lizards with a great amount of #GeneticDiversity at the outset. And the researchers found that these species could maintain the diversity by never pairing their homologous chromosomes (as sexual species do by taking one set of chromosomes from each parent) but rather by combining their sister chromosomes instead. '#Recombination between pairs of sister chromosomes maintains heterozygosity' throughout the chromosome, noted the authors of the study, which was led by Aracely Lutes, a postdoctoral researcher in Baumann's lab.
"This discovery, which had until now been unconfirmed in the reptile world, means that 'these lizards have a way of distinguishing sister from homologous chromosomes,' Baumann says. How do they do it? That's something the group is now investigating.
"Another big unknown is precisely how the lizards end up with double the amount of chromosomes in the first place. Baumann suspects that it could happen over two rounds of replication or if two sex cells combine forces before the division process starts."
Read more:
https://www.scientificamerican.com/article/asexual-lizards/#AsexualReproduction #NatureIsQueer #NatureIsGay #NatureIsCool! #Lizards
-
Came across this gem in my bookmarks...
No Sex Needed: All-Female #Lizard Species Cross Their Chromosomes to Make Babies
These southwestern lizards' asexual reproduction is no longer a secret
By Katherine Harmon
February 21, 2010"Since the 1960s scientists have known that some species of #WhiptailLizards need a male even less than a fish needs a bicycle. These all-lady lizard species (of the Aspidoscelis genus) from Mexico and the U.S. Southwest manage to produce well-bred offspring without the aid of male fertilization.
"But how do they—and the other 70 species of vertebrates that propagate this way—do it without the genetic monotony and disease vulnerability that often results from asexual reproduction? 'It has remained unclear' and 'has been the topic of much speculation,' report a team of researchers who aimed to answer just that question. Their results were published online February 21 in the journal Nature. (Scientific American is part of Nature Publishing Group.)
"These lizards and other '#parthenogenetic species are genetically isolated,' explains Peter Baumann, an associate investigator at the Stowers Institute for Medical Research in Kansas City, Mo., and co-author of the study. Species as diverse as #KomodoDragons and #HammerheadSharks do it asexually if necessary, but some species, like these little lizards, don't have a choice. 'They can't exchange genetic material, and this loss of genetic exchange is a major disadvantage to them in a changing environment,' he says. Unless an animal can recombine the DNA they already have, they will produce an offspring with an identical set of chromosomes, in which any genetic weakness, such as disease susceptibility or physical mutation, would have no chance to be overridden by outside genetic material from a mate.
"The new research by Baumann and his team reveal that these lizards maintain genetic richness by starting the reproductive process with twice the number of chromosomes as their sexually reproducing cousins. These celibate species resulted from the hybridization of different sexual species, a process that instills the parthenogenetic lizards with a great amount of #GeneticDiversity at the outset. And the researchers found that these species could maintain the diversity by never pairing their homologous chromosomes (as sexual species do by taking one set of chromosomes from each parent) but rather by combining their sister chromosomes instead. '#Recombination between pairs of sister chromosomes maintains heterozygosity' throughout the chromosome, noted the authors of the study, which was led by Aracely Lutes, a postdoctoral researcher in Baumann's lab.
"This discovery, which had until now been unconfirmed in the reptile world, means that 'these lizards have a way of distinguishing sister from homologous chromosomes,' Baumann says. How do they do it? That's something the group is now investigating.
"Another big unknown is precisely how the lizards end up with double the amount of chromosomes in the first place. Baumann suspects that it could happen over two rounds of replication or if two sex cells combine forces before the division process starts."
Read more:
https://www.scientificamerican.com/article/asexual-lizards/#AsexualReproduction #NatureIsQueer #NatureIsGay #NatureIsCool! #Lizards
-
Came across this gem in my bookmarks...
No Sex Needed: All-Female #Lizard Species Cross Their Chromosomes to Make Babies
These southwestern lizards' asexual reproduction is no longer a secret
By Katherine Harmon
February 21, 2010"Since the 1960s scientists have known that some species of #WhiptailLizards need a male even less than a fish needs a bicycle. These all-lady lizard species (of the Aspidoscelis genus) from Mexico and the U.S. Southwest manage to produce well-bred offspring without the aid of male fertilization.
"But how do they—and the other 70 species of vertebrates that propagate this way—do it without the genetic monotony and disease vulnerability that often results from asexual reproduction? 'It has remained unclear' and 'has been the topic of much speculation,' report a team of researchers who aimed to answer just that question. Their results were published online February 21 in the journal Nature. (Scientific American is part of Nature Publishing Group.)
"These lizards and other '#parthenogenetic species are genetically isolated,' explains Peter Baumann, an associate investigator at the Stowers Institute for Medical Research in Kansas City, Mo., and co-author of the study. Species as diverse as #KomodoDragons and #HammerheadSharks do it asexually if necessary, but some species, like these little lizards, don't have a choice. 'They can't exchange genetic material, and this loss of genetic exchange is a major disadvantage to them in a changing environment,' he says. Unless an animal can recombine the DNA they already have, they will produce an offspring with an identical set of chromosomes, in which any genetic weakness, such as disease susceptibility or physical mutation, would have no chance to be overridden by outside genetic material from a mate.
"The new research by Baumann and his team reveal that these lizards maintain genetic richness by starting the reproductive process with twice the number of chromosomes as their sexually reproducing cousins. These celibate species resulted from the hybridization of different sexual species, a process that instills the parthenogenetic lizards with a great amount of #GeneticDiversity at the outset. And the researchers found that these species could maintain the diversity by never pairing their homologous chromosomes (as sexual species do by taking one set of chromosomes from each parent) but rather by combining their sister chromosomes instead. '#Recombination between pairs of sister chromosomes maintains heterozygosity' throughout the chromosome, noted the authors of the study, which was led by Aracely Lutes, a postdoctoral researcher in Baumann's lab.
"This discovery, which had until now been unconfirmed in the reptile world, means that 'these lizards have a way of distinguishing sister from homologous chromosomes,' Baumann says. How do they do it? That's something the group is now investigating.
"Another big unknown is precisely how the lizards end up with double the amount of chromosomes in the first place. Baumann suspects that it could happen over two rounds of replication or if two sex cells combine forces before the division process starts."
Read more:
https://www.scientificamerican.com/article/asexual-lizards/#AsexualReproduction #NatureIsQueer #NatureIsGay #NatureIsCool! #Lizards
-
Came across this gem in my bookmarks...
No Sex Needed: All-Female #Lizard Species Cross Their Chromosomes to Make Babies
These southwestern lizards' asexual reproduction is no longer a secret
By Katherine Harmon
February 21, 2010"Since the 1960s scientists have known that some species of #WhiptailLizards need a male even less than a fish needs a bicycle. These all-lady lizard species (of the Aspidoscelis genus) from Mexico and the U.S. Southwest manage to produce well-bred offspring without the aid of male fertilization.
"But how do they—and the other 70 species of vertebrates that propagate this way—do it without the genetic monotony and disease vulnerability that often results from asexual reproduction? 'It has remained unclear' and 'has been the topic of much speculation,' report a team of researchers who aimed to answer just that question. Their results were published online February 21 in the journal Nature. (Scientific American is part of Nature Publishing Group.)
"These lizards and other '#parthenogenetic species are genetically isolated,' explains Peter Baumann, an associate investigator at the Stowers Institute for Medical Research in Kansas City, Mo., and co-author of the study. Species as diverse as #KomodoDragons and #HammerheadSharks do it asexually if necessary, but some species, like these little lizards, don't have a choice. 'They can't exchange genetic material, and this loss of genetic exchange is a major disadvantage to them in a changing environment,' he says. Unless an animal can recombine the DNA they already have, they will produce an offspring with an identical set of chromosomes, in which any genetic weakness, such as disease susceptibility or physical mutation, would have no chance to be overridden by outside genetic material from a mate.
"The new research by Baumann and his team reveal that these lizards maintain genetic richness by starting the reproductive process with twice the number of chromosomes as their sexually reproducing cousins. These celibate species resulted from the hybridization of different sexual species, a process that instills the parthenogenetic lizards with a great amount of #GeneticDiversity at the outset. And the researchers found that these species could maintain the diversity by never pairing their homologous chromosomes (as sexual species do by taking one set of chromosomes from each parent) but rather by combining their sister chromosomes instead. '#Recombination between pairs of sister chromosomes maintains heterozygosity' throughout the chromosome, noted the authors of the study, which was led by Aracely Lutes, a postdoctoral researcher in Baumann's lab.
"This discovery, which had until now been unconfirmed in the reptile world, means that 'these lizards have a way of distinguishing sister from homologous chromosomes,' Baumann says. How do they do it? That's something the group is now investigating.
"Another big unknown is precisely how the lizards end up with double the amount of chromosomes in the first place. Baumann suspects that it could happen over two rounds of replication or if two sex cells combine forces before the division process starts."
Read more:
https://www.scientificamerican.com/article/asexual-lizards/#AsexualReproduction #NatureIsQueer #NatureIsGay #NatureIsCool! #Lizards
-
Came across this gem in my bookmarks...
No Sex Needed: All-Female #Lizard Species Cross Their Chromosomes to Make Babies
These southwestern lizards' asexual reproduction is no longer a secret
By Katherine Harmon
February 21, 2010"Since the 1960s scientists have known that some species of #WhiptailLizards need a male even less than a fish needs a bicycle. These all-lady lizard species (of the Aspidoscelis genus) from Mexico and the U.S. Southwest manage to produce well-bred offspring without the aid of male fertilization.
"But how do they—and the other 70 species of vertebrates that propagate this way—do it without the genetic monotony and disease vulnerability that often results from asexual reproduction? 'It has remained unclear' and 'has been the topic of much speculation,' report a team of researchers who aimed to answer just that question. Their results were published online February 21 in the journal Nature. (Scientific American is part of Nature Publishing Group.)
"These lizards and other '#parthenogenetic species are genetically isolated,' explains Peter Baumann, an associate investigator at the Stowers Institute for Medical Research in Kansas City, Mo., and co-author of the study. Species as diverse as #KomodoDragons and #HammerheadSharks do it asexually if necessary, but some species, like these little lizards, don't have a choice. 'They can't exchange genetic material, and this loss of genetic exchange is a major disadvantage to them in a changing environment,' he says. Unless an animal can recombine the DNA they already have, they will produce an offspring with an identical set of chromosomes, in which any genetic weakness, such as disease susceptibility or physical mutation, would have no chance to be overridden by outside genetic material from a mate.
"The new research by Baumann and his team reveal that these lizards maintain genetic richness by starting the reproductive process with twice the number of chromosomes as their sexually reproducing cousins. These celibate species resulted from the hybridization of different sexual species, a process that instills the parthenogenetic lizards with a great amount of #GeneticDiversity at the outset. And the researchers found that these species could maintain the diversity by never pairing their homologous chromosomes (as sexual species do by taking one set of chromosomes from each parent) but rather by combining their sister chromosomes instead. '#Recombination between pairs of sister chromosomes maintains heterozygosity' throughout the chromosome, noted the authors of the study, which was led by Aracely Lutes, a postdoctoral researcher in Baumann's lab.
"This discovery, which had until now been unconfirmed in the reptile world, means that 'these lizards have a way of distinguishing sister from homologous chromosomes,' Baumann says. How do they do it? That's something the group is now investigating.
"Another big unknown is precisely how the lizards end up with double the amount of chromosomes in the first place. Baumann suspects that it could happen over two rounds of replication or if two sex cells combine forces before the division process starts."
Read more:
https://www.scientificamerican.com/article/asexual-lizards/#AsexualReproduction #NatureIsQueer #NatureIsGay #NatureIsCool! #Lizards
-
Versoza et al. use WGS of pedigrees of aye-ayes to map crossover and noncrossover recombination events.
🔗 doi.org/10.1093/gbe/evaf072
-
Versoza et al. use WGS of pedigrees of aye-ayes to map crossover and noncrossover recombination events.
🔗 doi.org/10.1093/gbe/evaf072
-
If you're interested in population genetics and cooperation, you might be interested in our latest theory paper on the topic! Check it out!
⬇️ ⬇️
https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpae147/7821382
⬆️ ⬆️ -
“Broadly stated, the imagination has five steps: mimicry; abstraction/decoupling; recombination; expression; and social feedback.“
#imagination #mimicry #abstraction #recombination #expression #feedback
-
“Broadly stated, the imagination has five steps: mimicry; abstraction/decoupling; recombination; expression; and social feedback.“
#imagination #mimicry #abstraction #recombination #expression #feedback
-
#Recombination across distant #coronavirid #species and #genera is a rare #event with distinct #genomic features
Source: Journal of Virology, ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2; family Coronaviridae, genus Betacoronavirus, subgenus Sarbecovirus) has caused millions of deaths, prompting a need for better understanding of coronavirid emergence and spillover to humans. As an evaluation of how some features of SARS-CoV-2, unique among…
-
#Recombination across distant #coronavirid #species and #genera is a rare #event with distinct #genomic features
Source: Journal of Virology, ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2; family Coronaviridae, genus Betacoronavirus, subgenus Sarbecovirus) has caused millions of deaths, prompting a need for better understanding of coronavirid emergence and spillover to humans. As an evaluation of how some features of SARS-CoV-2, unique among…
-
#VideoTitle "Top Four Recent Human Evolution Discoveries", by https://youtube.com/@gutsickgibbon at https://youtu.be/ZJLm5ag7bRw
#VideoDescription
"""[…][1] Vocal labeling of others by nonhuman primates
https://www.science.org/doi/10.1126/science.adp3757[2] Early evolution of small body size in Homo floresiensis
https://www.nature.com/articles/s41467-024-50649-7[3] A 4.3-million-year-old Australopithecus anamensis mandible from Ileret, East Turkana, Kenya, and its paleoenvironmental context
https://www.sciencedirect.com/science/article/abs/pii/S0047248424000873[4] Long genetic and social isolation in Neanderthals before their extinction
https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00177-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666979X24001770%3Fshowall%3Dtrue[5] Spatial sampling bias influences our understanding of early hominin evolution in eastern Africa
https://www.nature.com/articles/s41559-024-02522-5[6] Darwin's fear was unjustified: Study suggests fossil record gaps not a major issue
https://phys.org/news/2024-08-darwin-unjustified-fossil-gaps-major.html[7] Annelid Comparative Genomics and the Evolution of Massive Lineage-Specific Genome Rearrangement in Bilaterians
https://academic.oup.com/mbe/article/41/9/msae172/7733614?login=false
"""TAGS:
[1] #Cognition #cognitiveFunction #Vocalization #vocalCall #Marmoset #Language #Communication #socialCommunication[2] #HomoGenus #H_floresiensis #H_luzonensis #MataMenge #FloresIsland #Indonesia #middlePleistocene #Pleistocene #homininFossil #Java #H_erectus #60ka #700ka
[3] #homininMandible #EastTurkana #Kenya #4_3Ma #Australopithecus #Au_anamensis #Au_afarensis #Ardipithecus #Ar_ramidus #Anagenesis #Cladogenesis
[4] #Neanderthal #Thorin #Eurasia #Gibraltar #GrotteMandrin #France #50ka #42ka #105ka
[5] #EasternAfricanRiftSystem #EARS #cercopithecinePrimate
[6] #FossilRecord #Simulation #Projection #Resolution
[7] #Genome #Genomics #Recombination #geneticRecombination #Adaptation #Speciation #bilateralSymmetry #Annelida #Clitellata #Leech #Earthworm
-
#VideoTitle "Top Four Recent Human Evolution Discoveries", by https://youtube.com/@gutsickgibbon at https://youtu.be/ZJLm5ag7bRw
#VideoDescription
"""[…][1] Vocal labeling of others by nonhuman primates
https://www.science.org/doi/10.1126/science.adp3757[2] Early evolution of small body size in Homo floresiensis
https://www.nature.com/articles/s41467-024-50649-7[3] A 4.3-million-year-old Australopithecus anamensis mandible from Ileret, East Turkana, Kenya, and its paleoenvironmental context
https://www.sciencedirect.com/science/article/abs/pii/S0047248424000873[4] Long genetic and social isolation in Neanderthals before their extinction
https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00177-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666979X24001770%3Fshowall%3Dtrue[5] Spatial sampling bias influences our understanding of early hominin evolution in eastern Africa
https://www.nature.com/articles/s41559-024-02522-5[6] Darwin's fear was unjustified: Study suggests fossil record gaps not a major issue
https://phys.org/news/2024-08-darwin-unjustified-fossil-gaps-major.html[7] Annelid Comparative Genomics and the Evolution of Massive Lineage-Specific Genome Rearrangement in Bilaterians
https://academic.oup.com/mbe/article/41/9/msae172/7733614?login=false
"""TAGS:
[1] #Cognition #cognitiveFunction #Vocalization #vocalCall #Marmoset #Language #Communication #socialCommunication[2] #HomoGenus #H_floresiensis #H_luzonensis #MataMenge #FloresIsland #Indonesia #middlePleistocene #Pleistocene #homininFossil #Java #H_erectus #60ka #700ka
[3] #homininMandible #EastTurkana #Kenya #4_3Ma #Australopithecus #Au_anamensis #Au_afarensis #Ardipithecus #Ar_ramidus #Anagenesis #Cladogenesis
[4] #Neanderthal #Thorin #Eurasia #Gibraltar #GrotteMandrin #France #50ka #42ka #105ka
[5] #EasternAfricanRiftSystem #EARS #cercopithecinePrimate
[6] #FossilRecord #Simulation #Projection #Resolution
[7] #Genome #Genomics #Recombination #geneticRecombination #Adaptation #Speciation #bilateralSymmetry #Annelida #Clitellata #Leech #Earthworm
-
[Correspondence] #Recombination as an evolutionary #driver of #MERS-related #coronavirus emergence https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00461-4/fulltext?rss=yes
The emergence of MERS-CoV in #camels and humans was preceded by an important recombination event, in which the ancestral #receptor binding domain was replaced with that of a different merbecovirus lineage, thereby altering receptor usage.
-
[Correspondence] #Recombination as an evolutionary #driver of #MERS-related #coronavirus emergence https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00461-4/fulltext?rss=yes
The emergence of MERS-CoV in #camels and humans was preceded by an important recombination event, in which the ancestral #receptor binding domain was replaced with that of a different merbecovirus lineage, thereby altering receptor usage.
-
🧬 New recombination review 🧬
Genetic variation is essential for evolution. So what do we know about genetic variation underlying recombination rates & distribution? I've written a perspective for MBE on why its important, what we have learned, & open questions for the future.https://academic.oup.com/mbe/article/41/7/msae112/7705493?login=false
-
🧬 New recombination review 🧬
Genetic variation is essential for evolution. So what do we know about genetic variation underlying recombination rates & distribution? I've written a perspective for MBE on why its important, what we have learned, & open questions for the future.https://academic.oup.com/mbe/article/41/7/msae112/7705493?login=false
-
Hi everybody,
I am pleased to share with you my latest work in collaboration with Augustin Cléssin and Nicolas Lartillot:
https://www.biorxiv.org/content/10.1101/2024.06.21.600052v1
GC-biased gene conversion (gBGC) is a process that distorts the segregation of heterozygous AT:GC polymorphisms during meiotic #recombination. This genome-wide non-Mendelian segregation has been shown to be a major source of #genetic load, earning the nickname of “Achille’s heel” of #genomes. (1/2)
-
Hi everybody,
I am pleased to share with you my latest work in collaboration with Augustin Cléssin and Nicolas Lartillot:
https://www.biorxiv.org/content/10.1101/2024.06.21.600052v1
GC-biased gene conversion (gBGC) is a process that distorts the segregation of heterozygous AT:GC polymorphisms during meiotic #recombination. This genome-wide non-Mendelian segregation has been shown to be a major source of #genetic load, earning the nickname of “Achille’s heel” of #genomes. (1/2)
-
New lab preprint: GWAS on crossover dynamics in pigs led by Cathrine Brekke. We explored individual variation in rate, positioning and interference and found a few significant loci in females🐷:
📈👯♀️ Rate & interference associated with RNF212 (+ small rate effects at CTCF & REC114/REC8/CCNB1IP1)
📌 Broad-scale positioning at MEI4, SYCP2, PRDM9 (+ small effects at ZCWPW1 & ZCWPW2)
#meiosis #pigs #GWAS #recombination #meiosis4eva
https://biologists.social/@biorxivpreprint/112673500288980099
-
New lab preprint: GWAS on crossover dynamics in pigs led by Cathrine Brekke. We explored individual variation in rate, positioning and interference and found a few significant loci in females🐷:
📈👯♀️ Rate & interference associated with RNF212 (+ small rate effects at CTCF & REC114/REC8/CCNB1IP1)
📌 Broad-scale positioning at MEI4, SYCP2, PRDM9 (+ small effects at ZCWPW1 & ZCWPW2)
#meiosis #pigs #GWAS #recombination #meiosis4eva
https://biologists.social/@biorxivpreprint/112673500288980099
-
Researchers study the intricacies of #homologous #recombination and abnormal #chromosome_bridges.
https://phys.org/news/2024-05-intricacies-homologous-recombination-abnormal-chromosome.html
-
Researchers study the intricacies of #homologous #recombination and abnormal #chromosome_bridges.
https://phys.org/news/2024-05-intricacies-homologous-recombination-abnormal-chromosome.html
-
@knittingknots2 the dna fragments and pervasiveness show how widespread it is - yeah stay away from raw milk - it has been going on for 36 mos supposedly and is infecting dolphins - hopefully will not infect armadillos and combine with leprosy to form a potent new supervirus/bacteria #gordian knots #recombination
-
Hello everyone,
I'm glad to share this preprint:
https://www.biorxiv.org/content/10.1101/2024.03.06.583651v1
PRDM9 is a gene that determines the location of most meiotic #recombination events through local histone methylation in humans and mice. It is also one of the fastest evolving gene in mammals.
In this preprint, we show that its molecular function in #meiosis is the same in salmonids!
This suggests that PRDM9's rapid #evolution has been going on for hundreds of Mys.
-
`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`
-
`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`
-
What are the dynamics of #recombination in natural bacterial populations? Zhiru Liu & @benjaminhgood use #metagenomics to quantify the recombination landscape in ~30 common species of human #GutBacteria, revealing widespread variation within and across species #PLOSBiology https://plos.io/3wbs5NP
-
What are the dynamics of #recombination in natural bacterial populations? Zhiru Liu & @benjaminhgood use #metagenomics to quantify the recombination landscape in ~30 common species of human #GutBacteria, revealing widespread variation within and across species #PLOSBiology https://plos.io/3wbs5NP
-
Now available ahead of print! "A Numerical Model Supports the Evolutionary Advantage of Recombination Plasticity in Shifting Environments" by Rybnikov et al. https://www.journals.uchicago.edu/doi/10.1086/728405
#evolution #advantage #recombination #plasticity #numericalModel
-
Now available ahead of print! "A Numerical Model Supports the Evolutionary Advantage of Recombination Plasticity in Shifting Environments" by Rybnikov et al. https://www.journals.uchicago.edu/doi/10.1086/728405
#evolution #advantage #recombination #plasticity #numericalModel
-
Hello Mastodon people,
I wanted to mention that I have a new preprint out on bioRxiv:
https://www.biorxiv.org/content/10.1101/2024.01.16.575829v1
I think it could be really useful for people interested in the consequences of #Recombination on #Genome #Evolution, but more generally in interpreting DFEs, positive selection and dN/dS.
I will take the time to make a thread once the final paper is published (I hope it will).
For those who will take the time to read it, don't hesitate to give me feedback 😊
-
Hello Mastodon people,
I wanted to mention that I have a new preprint out on bioRxiv:
https://www.biorxiv.org/content/10.1101/2024.01.16.575829v1
I think it could be really useful for people interested in the consequences of #Recombination on #Genome #Evolution, but more generally in interpreting DFEs, positive selection and dN/dS.
I will take the time to make a thread once the final paper is published (I hope it will).
For those who will take the time to read it, don't hesitate to give me feedback 😊
-
-- we identify three #recombination hotspots of #Delta – #Omicron BA.1 intra-host recombinants.
-
-- we identify three #recombination hotspots of #Delta – #Omicron BA.1 intra-host recombinants.
-
Systematic #detection of #coinfection and intra-host #recombination in more than 2 million #global #SARS-CoV-2 samples https://www.nature.com/articles/s41467-023-43391-z
-
Systematic #detection of #coinfection and intra-host #recombination in more than 2 million #global #SARS-CoV-2 samples https://www.nature.com/articles/s41467-023-43391-z
-
In many euraryotes, #recombination events are not evenly distributed across the genome and tend to be concentrated in so-called recombination hotspots. In humans and mice, nearly all recombination hotspots are determined by the protein PRDM9. In species lacking PRDM9, recombiation tends to occur in promoter-like features such as CpG islands (default hotspots). In this study, we have shown that these default hotspots are also active in the presence of PRDM9 in many placental mammals. (2/8)
-
I am very pleased to share with the mastodon community the first part of my PhD work:
High prevalence of Prdm9-independent recombination hotspots in placental #mammals
https://www.biorxiv.org/content/10.1101/2023.11.17.567540v1
This work was done in collaboration with @djivanprentout Alexandre Laverré, Théo Tricou and @duret_lbbe. (1/8)