#recombination — Public Fediverse posts

Local and introduced #lineages drive #MERS-CoV #recombination in Egyptian #camels, https://etidiohnew.blogspot.com/2025/12/local-and-introduced-lineages-drive.html

#Recombination across distant #coronavirid #species and #genera is a rare #event with distinct #genomic features

Source: Journal of Virology, ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2; family Coronaviridae, genus Betacoronavirus, subgenus Sarbecovirus) has caused millions of deaths, prompting a need for better understanding of coronavirid emergence and spillover to humans. As an evaluation of how some features of SARS-CoV-2, unique among…

https://etidioh.wordpress.com/2024/11/19/recombination-across-distant-coronavirid-species-and-genera-is-a-rare-event-with-distinct-genomic-features/

🧬 New recombination review 🧬
Genetic variation is essential for evolution. So what do we know about genetic variation underlying recombination rates & distribution? I've written a perspective for MBE on why its important, what we have learned, & open questions for the future.

https://academic.oup.com/mbe/article/41/7/msae112/7705493?login=false

#recombination #meiosis #meiosis4eva

New lab preprint: GWAS on crossover dynamics in pigs led by Cathrine Brekke. We explored individual variation in rate, positioning and interference and found a few significant loci in females🐷:

📈👯‍♀️ Rate & interference associated with RNF212 (+ small rate effects at CTCF & REC114/REC8/CCNB1IP1)

📌 Broad-scale positioning at MEI4, SYCP2, PRDM9 (+ small effects at ZCWPW1 & ZCWPW2)

#meiosis #pigs #GWAS #recombination #meiosis4eva

https://biologists.social/@biorxivpreprint/112673500288980099

Hello everyone,

I'm glad to share this preprint:

https://www.biorxiv.org/content/10.1101/2024.03.06.583651v1

PRDM9 is a gene that determines the location of most meiotic #recombination events through local histone methylation in humans and mice. It is also one of the fastest evolving gene in mammals.

In this preprint, we show that its molecular function in #meiosis is the same in salmonids!

This suggests that PRDM9's rapid #evolution has been going on for hundreds of Mys.

#PopGen

`HCR3 encodes J3, a co-chaperone..which acts to target protein aggregates & biomolecular #condensates to the disassembly chaperone HSP70..promoting proteasomal degradation..a network of HCR3 & HSP70 chaperones facilitates #proteolysis of HEI10, thereby regulating interference & the #recombination landscape. These results reveal a new role for the HSP40/J3-HSP70 chaperones in regulating #chromosome-wide dynamics of recombination via control of HEI10 proteolysis`

https://www.nature.com/articles/s41477-024-01633-y

#meiosis

Julia Salzman from Stanford
http://salzmanlab.stanford.edu/

now explaining
SPLASH: Statistically Primary aLignment Agnostic Sequence Homing

We want to rapidly survey large #genomic areas, for regulatory sites, #splicing, etc. How do we look at sequencing data today? Through a lens of alignment with reference genomes. This can fail (e.g. cancer cells with shattered genomes, #V(D)J #recombination in immune cells)

Her metaphor: we need ground penetrating radar for #genomics

#CSSingleCells23

1/2

In an unexpected twist, Zhang et al. reveal that in #Maize, FIGL1 coordinates with dosage-sensitive #BRCA2 in modulating #meiotic #recombination, unlike their antagonistic relationship in #Arabidopsis.
https://doi.org/10.1111/jipb.13541
@wileyplantsci
#PlantSci #evolution #DNArepair #JIPB #plantscience

Local enhancers of the #PAIR4 regulatory module promote distal V-H gene #recombination at the #Igh locus and contribute to #Bcell receptor repertoire diversification

Louisa Hil et al Busslinger lab @IMPvienna

https://www.embopress.org/doi/full/10.15252/embj.2022112741

The February issue is online:

https://embopress.org/toc/14693178/2023/24/2…

The cover features work by Quinghua Shi and co-workers showing that the #meiosis arresting #protein M1AP interacts with the ZZS complex and promotes #male meiotic #recombination.

-> https://www.embopress.org/doi/abs/10.15252/embr.202255778

New paper with @CCWendling Co-transfer of functionally interdependent genes contributes to genome mosaicism in lambdoid phages - we use an approach that does not rely on the core genome phylogeny to infer gene transfers, and then detect co-transferred genes in lambdoid phages, we highlight known and novel co-transfer examples

#phage #evolution #recombination #HGT #Epistasis
https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000915

So about this #introduction : I work on #statistics for #genetics at #INRAE in the #animal genetics division. I am interested in understanding the #evolution of quantitative traits in #livestock populations, with a specific interest for #recombination. I do #DataAnalysis and method development in #popgen and #QuantitativeGenetics. I like #programming in #python and playing with #R